Month: May 2015

RIKEN – Max-Planck – Imperial College London joint team discovers binding of human gut lectin to Mycobacterium tuberculosis

The groups of Yoshiki YAMAGUCHI at RIKEN, Peter Seeberger at MPI of Colloids and Interfaces in Potsdam-Golm and TEN Feizi at Imperial College London have discovered that lectin ZG16p present in human intestines binds to phosphatidylinositol mannoside, a surface glycolipid of M. tuberculosis and modelled the interaction at the molecular level. The finding may be […]

RIKEN team succeeds to stabilize hirudin and a Fab fragment by introducing bulky phenylalanine residues

The team of Kensaku SAKAMOTO at RIKEN Yokohama has modified an E. coli strain to incorporate phenylalanine modified by bulky residues such as azide or sulfonate. To this end, 178 UAG codons were reassigned to synthetic amino acids by expressing the specific pairs of UAG-reading tRNA and aminoacyl-tRNA synthetase. As a result, hirudin molecules sulfonated […]

Mitsubishi Life Sciences Institute (LSII) acquires Clio, a bioventure around Muse cells

Muse cells (multi-lineage differentiating stress enduring cell), a type of non-tumorigenic pluripotent stem-cells recently discovered by Profesor Dezawa at Tohoku University, have already been used by LSI Medience for the preparation of diagnostic cardiomyocytes. Future plans include clinical trials in acute myocardial infarction. The prize is said to amount to „several billion Yen“. Mitsubishi Kaiteki […]

Nikon purchases Healios, a regenerative medicine company, and enters into a strategic business alliance with Lonza

Nikon, having already established a product line for cell regeneration equipment (“BioStation CT”), has acquired Healios, a spin-off of RIKEN’s Center for Developmental Biology in Kobe. Healios is centered on the development of regenerative medicine based on iPS cells. Nikon has also entered into a strategic business alliance with Lonza for global manufacturing of regenerative […]

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