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Our news cover the latest topics from the past 30 days, as retrieved from Japanese-language press releases and other information sources.

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High yield production of tetrahydropapaveroline, a pharmaceutical raw material, using synthetic biology and metabolic engineering

The group of Akihiko KONDO at Kobe University has used computer simulations, newly designed metabolic pathways and introduction of an engineered silkworm enzyme into E. coli to produce tetrahydropapaveroline (THP), a precursor compound of various benzylisoquinoline alkaloids which are used as analgesics. The project was carried out within NEDO’s “smart cell industry” program.

NEDO news release, May 7, 2019

Nature Communications (2019) DOI: 10.1038/s41467-019-09610-2


 

MHLW approves two gene therapies in Japan

The two items approved were Anges Co. HGF gene therapy for treatment of critical limb ischemia (AMG0001, beperminogene perplasmid)Novartis CAR-T cell therapy Kymriah (Tisagenlecleucel) for the treatment of acute lymphoblastic B-cell leukemia Nikkei Biotech news...

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RIKEN team develops novel self-healing polymers

A team at RIKEN’s Center for Environmental Resources Science has developed a precise copolymerization of ethylene and anisylpropylenes by using a proprietary rare earth catalyst. The new polymer exhibits high elongation (2200%) and excellent self-repairing...

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