https://gei.co.jp/ja/kobo/release/nedo_biofoundry_jisho0531.pdf
NEDO and Green Earth Institute, Inc. (GEI) are currently verifying the functionality of the Kanto Biofoundry Center, which was completed in Mobara City, Chiba Prefecture, as part of the “Development of Bio-based Product Production Technology to Accelerate the Realization of Carbon Recycling” . Thanks to the Center’s know-how in experimental design and production systems using scale-down models and CFD analysis, the Center has succeeded in completing the scale-up consideration period for projects that were previously thought to take about three years in about six months, which is about one-sixth of the conventional period.
In the future, the Center will aim to expand the bioeconomy through material production systems that utilize microorganisms in a wide range of fields, and will increase its demonstration experience with various production materials, including other microbial species such as filamentous fungi, in addition to E. coli and yeast, which have a proven track record.
The base can conduct scale-up considerations using fermentation tanks from 0.25 L to a maximum of 3,000 L. In order to significantly reduce the time and cost required for gradual scale-up, we are working on developing technologies for production systems in scale-down models, new pretreatment methods, and systems that calculate costs and CO2 emissions that can be implemented simply and timely, using know-how in experimental design and CFD analysis that simulates the conditions inside fermentation tanks, and we will apply these technologies to scale-up cases that are adopted as demonstration cases. The new equipment is fully operational in June 2023, and wewill be working on substance production demonstrations using microbial functions in accordance with the implementation plan until the end of this project in fiscal 2026, and in fiscal 2023, scale-up will be done in four cases, with different chemical products such as amino acids, peptides, oils and enzymes being produced.
