In a future doctor-led trial, cartilage of a patient’s knee is collected with an arthroscope, and self-laminated chondrocyte cell sheets (2 or more) are manufactured at the hospital’s cell culture center. At the time of high tibial oseotomy, defective tissue is excised and self-laminated chondrocyte sheets are transplanted following bone marrow stimulation. The number of subject cases is 20. The main endpoint is the effectiveness at 1 year after operation. Implementation period is 4 years for case registration, and 5 years for total observation period, totaling nine years.
Nikkei Biotech news release, October 23, 2018