Based on the genetic information of 160,000 Japanese including 6 million data on 58 clinically relevant items (blood test,s physiological function tests such as blood pressure/ electrocardiogram etc.), a GWAS targeting genetic variations was carrdied out. As a result, 1,400 genetic variations affecting clinical laboratory values were identified. In addition, epigenomic information from 220 types of cell tissues was related to 32 diseases (lifestyle diseases, autoimmune diseases, malignant tumors, psychoneurotic diseases, osteoarthritic diseases). As a result, it was found that (1) blood pressure and lipid values are closely related to lifestyle diseases and have a common genetic background, (2) regulatory T cells are involved in one case of autoimmune disease (Graves’ disease).
RIKEN news release, February 6, 2018