The proposed method is based on the synthesis of synthetic RNA with tetraethlenglykol (TEG)-modified bases which leads to the formation of inactive quadruplex structures with the target RNA. When such nucleotide-containing TEG-modified bases were added to a reverse transcription reaction solution prepared from a reverse transcriptase derived from HIV-1 virus, it was found that 70% or more of the reverse transcription reaction was inhibited.

China Bio news release, November 15, 2016