The 10 center team generated influenza viruses expressing fluorescent proteins of different colours (‘Color-flu’ viruses) to facilitate the study of viral infection in in vivo models. On adaptation to mice, stable expression of the fluorescent proteins in infected animals allowed their detection by different types of microscopy and by flow cytometry.
Satoshi FUKUYAMA et al., Nature doi:10.1038/ncomms7600
Japanese team develops multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies