The team of Professor Hiromitsu NAKAUCHI at Tokyo University’s Institute of Medical Science achieved the In vitro generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs), opening a potential to provide novel therapeutic approaches for replacing bone marrow (BM) transplantation without rejection or graft versus host disease. When the HSCs were transplanteid into X-SCID mice, immunodeficiency of the mice was reverted.

Molecular Therapy, May 14, 2013, doi:10.1038/mt.2013.71