Osaka team develops life imageing based on bioluminescence resonance energy transfer(BRET)

Using Renilla luciferase (“nano lantern”) and chemiluminescence, the group could image Ca2+, cyclic adenosine monophosphate and adenosine 5′-triphosphate dynamics in environments where the use of fluorescent indicators was not feasible. With this technology, cancer tissues of a mouse could be observed in vivo and real time at video rates.

Nature Communications doi:10.1038/ncomms2248