https://sj.jst.go.jp/news/202511/n1121-02k.html
https://www.nature.com/articles/s42255-025-01373-z
A research group of Tohoku University Graduate School of Medicine has found that the substrates used for gluconeogenesis in the liver differ according to exercise intensity. Through experiments with mice, they found that the liver performs gluconeogenesis using glycerol as a substrate during low-intensity exercise such as slow running, and lactate during high-intensity exercise such as running quickly, enabling the continuation of exercise. This is expected to lead to an increase in exercise performance and developing preventive and therapeutic approaches for obesity and sarcopenia.