https://bio.nikkeibp.co.jp/atcl/news/p1/25/03/24/13119/

J-TEC offers the “Labosite” series as a product to replace animal testing with in vitro experimental models in the development of cosmetics and pharmaceuticals. Currently, skin and cornea models are available, and a new intestinal epithelium model is being developed.

The model will be produced by (1) inducing differentiation of human iPS cells into intestinal epithelial cells, (2) culturing and growing the cells in a spherical organoid state, (3) dissociating the grown cells and seeding them on a cell culture insert, and (4) forming a membrane in which the intestinal epithelial cells are arranged in a single layer. This will allow to verify how compounds are absorbed and metabolized in the small intestinal epithelium.

J-TEC so far sells models of the epidermis and cornea, but by developing models derived from iPS cells, would like to add models that can be used in pharmaceutical development. In addition to the intestinal epithelium model, J-TEC would also like to develop oral mucosal epithelium models, airway epithelium models, models of blood vessels and the blood-brain barrier, and models of the liver and kidneys.