https://www.jst.go.jp/pr/announce/20250210/index.html

https://www.nature.com/articles/s41746-025-01444-1

A Japanese research team has developed a new “digital twin brain simulator” that simulates macaque brain activity in real time and monitors the state of awakening. This simulator models latent brain activity in different layers of the brain and generates highly accurate predictions and invasive electrocorticogram (ECoG) signals. Furthermore, by inferring latent states in real time based on the error between prediction and observation and updating the predictions, a simulation was realized that reflects the brain state at that time in real time. By utilizing this model, it was shown that it is possible to carry out virtual drug simulations (anesthesia with ketamine and medetomidine) and estimate the functional network behind the ECoG signal. This research, which aims to clarify the information processing mechanism of each individual brain in real time, is expected to be applied to personalized medicine in the future.