https://www.kirinholdings.com/jp/newsroom/release/2024/0911_01.html

Kirin Holdings (HD) has developed a skin model using human fibroblasts and human iPS cell-derived macrophages, in a joint research course with FANCL and Juntendo University Graduate School of Medicine and Institute of Environmental Medicine.

In order to reproduce inflammatory reactions in an in vitro skin model, it is important to include macrophages in the skin model, but this has been difficult in the past. Normally, when trying to build skin tissue by mixing fibroblasts with macrophages, the three-dimensional structure that should be formed is not created properly.

When a compound that causes inflammatory stimuli was added to the new skin model, the production of inflammatory cytokines such as interleukin 6 and TNFα was observed, and inflammation in human skin was reproduced.