https://bio.nikkeibp.co.jp/atcl/news/p1/24/01/17/11509/

Nihon University and Ebara Corporation study pluripotent cells made from fat cells to produce cultured meat. Using a specific method, dedifferentiated fat cells DFAT’ can be differentiated into mesodermal tissues. DFAT is a pluripotent cell that can be created by enzymatically decomposing adipose tissue, fractionating it, removing the adipocytes, and culturing them using a specific method. Adipocytes have a lower specific gravity than other cell types and float in the culture medium, so they can be isolated at low cost. When performing “ceiling culture,” which takes advantage of the fact that isolated adipocytes float in the culture medium and culture them by adhering them to the ceiling of a culture container, dedifferentiation occurs due to the physical stimulation caused by adhesion, and they become fibroblasts. The advantage of DFAT is that it can be produced homogeneously and in large quantities at low cost, and can be produced from a variety of animal species. So far, DFAT has been created from humans, cows, pigs, sheep, chickens, horses, and tuna.

In joint research with Ebara Corporation, the team hopes to develop an inexpensive and efficient cultured meat manufacturing technology using DFAT. Compared to cultured meat from muscle satellite cells from raw meat, DFAT has as a lower cost.