Katsuhiro SHIRATAKE of Nagoya University and coworkers from RIKEN have achieved the development of a high-fructose tomato by disrupting the INVINH gene, encoding an invertase inhibitor. As genome editing tools, a CRISPR / Cas9 vector and Target-AID vector targeting INVINH were used. In some  transformants, the increase in sugar content was up to 2fold.

Lecture at 37th Annual Meeting of the Japanese Society for Plant Cell Molecular Biology in Kyoto, September 8, 2019