University of Kyoto’s CiRA prepare human killer T cells through iPS technology

Immunotherapy has become a fourth treatment method for cancer in addition to surgical treatment, radiation treatment and chemotherapy. For immunotherapy, a large supply of antigen-specific killer T cells are required. A team around Kaneko SHINZO at CiRA showed that when they used an iPS cell stock not derived from T cells (a HLA homologous iPS cell stock) and introduced T-cell receptors with appropriate antigen information, they could prepare regenerative killer T cells with full antigen specificity. The T-iPS cells were successfully tested in mouse models

AMED news release, November 16, 2018

University of Kyoto’s CiRA prepare human killer T cells through iPS technology
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