When the function of the hypothalamus and the posterior pituitary gland is insufficient, vasopressin secretion decreases, and urine secretion is largely increased (Diabetes insipidus). A group around Hiroshi ARIMA succeeded in maturing hypothalamic precursor cells derived from human ES cells and differentiating them into hormone-producing neurons. From the dorsal hypothalamus , vasopressin neurons could be induced which responded to secretion stimuli and secreted vasopressin.

AMED news release, February 26, 2018