In order to prepare PDX, specimen of tumors of cancer patients collected by biopsy or surgical operation are transplanted into immunocompromised mice. After the cancer cells proliferate in the mouse body, passages are done two or three times with another mouse. The cell line for PDX thus obtained is stored frozen, thawing the cell when necessary, and transplanting the PDX strain to the model mouse to prepare a PDX model mouse. PDX model mouse is used for screening development drug candidates and evaluating the efficacy of nonclinical trials. LSI Medience, a Mitsubishi company, will develop a base that can store PDX stock within a facility that complies with GLP, and will offer consignment for non-clinical trials using these PDX model mice. It is anticipated that this will be commercialized in about a year.
LSI Medience news release, February 21, 2018