The group of Yasuaki URANO at the University of Tokyo has developed a diagnostic system where gamma-gltamyl transpeptidase (GGT) active in many cancer tissues splits an imaging reagent liberating green fluorescence. Using a mouse model, small cancers of 1 mm or less were thus visualized within seconds, and surgical specimen of human breast cancer provided strong fluorescent signals within minutes. The technology is now further developed at Goryojin Kanzo bioventure in Sapporo, and clinical tests are anticipated for 2018.

Nikkei Biotech, December 7, 2017