The group of Yoshihiro KAWAKA has created a mutant virus library of various influenza B strains and selected mutants with high proliferation potential in cultured cells instead of chicken eggs. Next, they selected hyperproliferative virus mutants from this library which contained the major antigens prevalent outdoors. Such virus strain efficiently proliferated in cultured cells frequently used in the production of cell culture vaccines.

JST news release, December 6, 2016