RIKEN SACLA center pioneers 3D protein structure phasing without heavy metal substitution

Based on the SACLA’s X-ray free electron laser facility (XFEL) which allows for continuous femtosecond crystal structure analysis of crystals only 7 – 10 μm in size, the structure of lysozyme could be resolved at 2,1 A precision without support of heavy metal substituted protein analogues, using a sulfor atom single-wavelength anomalous dispersion method (S-SAD).

RIKEN news release, November 30, 2015

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