By inhibiting the transcription factor E2A by an inhibitory protein Id3, introduced in mice using a retroviral vector, the group of Hiroshi KAWAMOTO succeeded to expand blood hematopoietic stem cells very significantly. The findings are considered highly significant for possible artificial amplification of multipotent hematopoietic progenitor cells.
RIKEN news release, October 23, 2015
RIKEN team develops method to expand pluripotent hematopoietic progenitor cells