The group of Osamu KOBAYASHi used a sequence of immobilized catalysts, combined by precise flow synthesis, to synthesis the chiral product Rolipram in 8 steps (Multistep Continuous Flow Synthesis of (R) – and (S) -Rolipram Using Heterogeneous Catalysts)
Osamu Kobayashi et al, Nature 10.1038/nature14343
Group at University of Tokyo produces API material by 8-step continuous synthesis using immobilized catalysts