Using a transgenic mouse system, the group of Professor Akira SHIBUYA of Tsukuba University has found that gut dysbiosis initiated by dosing antibiotics and leading to fungal growth in the intestine promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE2
JST news release, January 16, 2014
Tsukuba group elucidates mechanism for aggravation of allergic diseases upon disturbance of gut bacteria by antibiotic ingestion