Using transgenic mice models, a research team around Professor Yutaka ITO found that Sema3A regulates bone remodelling indirectly by modulating sensory nerve development, but not directly by acting on osteoblasts.
Toru Fukuda et al., Nature May 5, 2013, doi:10.1038/nature12115
Keio University team clarify role of semaphorin 3A in bone metabolism control