The enzyme is an ecdysteroid-inactivating enzyme ecdysteroid-22-oxidase (E22O) from the entomopathogenic fungus Nomuraea rileyi which upon injection into Bombyx mori and other insects reduces ecdysteroid titer thereby controlling insect development.

Kamimura et al., The Journal of Biological Chemistry, 287, 16488-16498 (2012). Japan Patent No. 3530495