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# window-to-japan.eu

Window to Japan

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## Posts

- [Archive](https://window-to-japan.eu/archive-2/) - [et_pb_section bb_built="1" _builder_version="3.0.47"][et_pb_row _builder_version="3.0.47" background_size="initial" background_position="top_left" background_repeat="repeat"][/et_pb_row][/et_pb_section]
- [Inexpensive enzymes allow for economic bioethanol production from local biomass](https://window-to-japan.eu/2023/06/11/inexpensive-enzymes-allow-for-economic-bioethanol-production-from-local-biomass/) - https://www.eng.nipponsteel.com/news/2023/20230602.html The Next Generation Green CO2 Fuel Technology Research Association is a research association formed by ENEOS, Suzuki, Subaru, Daihatsu, Toyota Motor, Toyota Tsusho, and Mazda, and has been developing bioethanol for some time. The facility is expected to be fully operational in 2024. Kao will supply saccharification enzymes used in the production of bioethanol
- [Bausteine für die Welt von morgen - Wissenschaftsseminar am 5. 1. 2026 in Stuttgart](https://window-to-japan.eu/2025/10/21/bausteine-fur-die-welt-von-morgen-wissenschaftsseminar-am-5-1-2026-in-stuttgart/) - Einladung 20251026
- [Cs-contaminated Fukushima soil shown to be decontaminated by heat treatment with NaCl under vacuum](https://window-to-japan.eu/2025/10/21/cs-contaminated-fukushima-soil-shown-to-be-decontaminated-by-heat-treatment-with-nacl-under-vacuum/) - https://sj.jst.go.jp/news/202510/n1021-01p.html https://www.sciencedirect.com/science/article/abs/pii/S0301479725020365?via%3Dihub Soil from Fukushima contaminated with radioactive Cs was effectively decontaminated through heat treatment with NaCl under vacuum. The decontamination ratio reached over 90% after heat treatment at 1073 K under vacuum. Under vacuum, decontamination progressed through rapid ion exchange in clay minerals which is facilitated by the sublimation of NaCl and the expansion
- [Umami Bioworks organizes sensory evaluation meeting of cultured eel and other fish products in Tokyo](https://window-to-japan.eu/2025/10/21/umami-bioworks-organizes-sensory-evaluation-meeting-of-cultured-eel-and-other-fish-products-in-tokyo/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/10/20/13863/ Umami Bioworks is a Singapore-based company developing cultured fish meat, https://umamibioworks.com/ . The company held a sensory evaluation event in Tokyo to evaluate the taste of three types of cellular foods, including cultured eel. Currently, Japan has no rules in place to recognize cellular foods as food, and the products are not sold, making
- [A Japanese consortium presents a hydrogen-fuelled engine for ships](https://window-to-japan.eu/2025/10/21/a-japanese-consortium-presents-a-hydrogen-fuelled-engine-for-ships/) - https://www.nedo.go.jp/news/press/AA5_101895.html Under support of NEDO, Kawasaki Heavy Industries, Yanmar Power Solutions and Japan Engine Corporation have developed installed a demonstration liquefied hydrogen fuel supply facility and tested a marine hydrogen engine on land. Kawasaki Heavy Industries stores and gasifies liquefied hydrogen and supplies hydrogen fuel at high or low pressure to each company's engines. This
- [A synthetic protein removes unwanted cells in the body by inducing phagocytosis](https://window-to-japan.eu/2025/10/21/a-synthetic-protein-removes-unwanted-cells-in-the-body-by-inducing-phagocytosis/) - https://www.nature.com/articles/s41551-025-01483-9 https://sj.jst.go.jp/news/202510/n1020-02k.html A research groupfrom the Institute for Integrated Cell-Material Sciences (iCeMS) at Kyoto University has developed a "Crunch" protein that removes unwanted but living cells in the body through phagocytosis. "Crunch" is based on protein S, a secreted factor that also binds to the Mer tyrosine kinase (MerTK) on phagocytes when during the process
- [Yokogawa Electric reduces fermentation time for beer brewing by 28% using an AI algorithm for temperature control](https://window-to-japan.eu/2025/10/19/yokogawa-electric-reduces-fermentation-time-for-beer-brewing-by-28-using-an-ai-algorithm-for-temperature-control/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/10/14/13843/ At the beer production facility of CRAFT BANK, Fukuchiyama City, Yokogawa Electric has carried out demonstration experiments using the company's artificial intelligence (AI) to optimize the beer fermentation process. Typically, beer production involves brewing, filtering, boiling, adding hops, and cooling, before moving on to the fermentation and aging processes. In the demonstration experiments, Yokogawa
- [32 out of 36 sampling sites in 11 Japanese prefectures contained tire-derived microplastics](https://window-to-japan.eu/2025/10/18/32-out-of-36-sampling-sites-in-11-japanese-prefectures-contained-tire-derived-microplastics/) - https://sj.jst.go.jp/news/202510/n1016-04k.html https://doi.org/10.1016/j.watres.2025.124278 A research group at the Material Cycles Division of the National Institute for Environmental Studies and colleagues has clarified the contamination status of tire-derived microplastics (MPs) across Japan. The researchers examined the concentration of MPs in sediments at 36 sites across 11 prefectures from Hokkaido to Okinawa, including coastal marine areas and lakes,
- [Polymers containing periodic keto groups are thermally stable but degradable by UV](https://window-to-japan.eu/2025/10/18/polymers-containing-periodic-keto-groups-are-thermally-stable-but-degradable-by-uv/) - https://www.jst.go.jp/pr/announce/20251017-2/pdf/20251017-2.pdf https://pubs.acs.org/doi/10.1021/jacs.5c13090 A group in Kyoto University has developed a synthetic method for polymers containing periodically introduced ketone carbonyl groups through sequence-controlled radical copolymerization and post-polymerization modification. The resulting polymers were thermally stable and degradable by ultraviolet (UV) light. The authors expect that the ketone skeleton can be used as a motif for polymer degradation,
- [2025/09 A Japanese team wins Ig Nobel for painting stripes on cattle to reduce fly bites](https://window-to-japan.eu/2025/10/14/2025-09-a-japanese-team-wins-ig-nobel-for-painting-stripes-on-cattle-to-reduce-fly-bites/) - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223447 https://improbable.com/the-35th-first-annual-ig-nobel-prize-ceremony/ In a paper published in 2020, a group of Japanese researchers has shown that cows painted with black and white stripes on their body could avoid biting fly attacks and show fewer fly-repelling behaviors. Six Japanese Black cows were assigned to treatments with black-and-white painted stripes, black painted stripes, and no stripes, respectively.
- [Kao's ScentVista400 is based on 400 human olfactory receptors and analyses scents and odors through bioluminescence](https://window-to-japan.eu/2025/10/14/kaos-scentvista400-is-based-on-400-human-olfactory-receptors-and-analyses-scents-and-odors-through-bioluminescence/) - https://www.kao.com/jp/newsroom/news/release/2025/20250924-001/ Kao has developed a technology that can comprehensively analyze the response of human olfactory receptors to odorants, by creating an in vitro model expressing approximately 400 types of human olfactory receptors in cultured cells and analyzing their responses to odorants. In the human nose, olfactory receptors localize to the cell membrane and detect odorants
- [A graphene-based ion-gating reservoir reduces computing loads hundredfold](https://window-to-japan.eu/2025/10/14/a-graphene-based-ion-gating-reservoir-reduces-computing-loads-hundredfold/) - https://pubs.acs.org/doi/10.1021/acsnano.5c06174 An ion-gel/graphene electric double layer (EDL) transistor-based ion-gating reservoir (IGR) demonstrated an exceptionally broad responsive range, from 1 MHz to 20 Hz, while maintaining a high information processing capacity and adaptability across multiple time scales. Principal component analysis revealed that the IGR’s superior performance stems from its high-dimensionality, driven by the ultrawideband responses of
- [MabGenesis and Nippon Soda will develop antibody drugs for cats and dogs](https://window-to-japan.eu/2025/09/26/mabgenesis-and-nippon-soda-will-develop-antibody-drugs-for-cats-and-dogs/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/09/24/13768/ MabGenesis, a developer of antibody drugs for humans and animals, and Nippon Soda have signed a collaborative research agreement to develop monoclonal antibody drugs for dogs and cats. MabGenesis has antibody libraries for dogs, cats, and camels. Its unique features include its proprietary phage display antibody library construction technology. Under the agreement, MabGenesis will utilize
- [Japanese researchers achieve complete decomposition of Teflon](https://window-to-japan.eu/2025/09/26/japanese-researchers-achieve-complete-decomposition-of-teflon/) - https://sj.jst.go.jp/news/202509/n0925-01k.html https://doi.org/10.1016/j.radphyschem.2025.113029 A research group at the National Institutes for Quantum Science and Technology (QST) has achieved complete decomposition of Teflon (PTFE), by treating it with a combination of irradiation and heating, while reducing CO2 emissions by half compared with conventional high-temperature pyrolysis methods. They aim to develop separation methods for decomposition products and scale up
- [A Japanese team wins Ig Nobel for painting stripes on cattle to reduce fly bites](https://window-to-japan.eu/2025/09/26/a-japanese-team-wins-ig-nobel-for-painting-stripes-on-cattle-to-reduce-fly-bites/) - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223447 https://improbable.com/the-35th-first-annual-ig-nobel-prize-ceremony/ In a paper published in 2020, a group of Japanese researchers has shown that cows painted with black and white stripes on their body could avoid biting fly attacks and show fewer fly-repelling behaviors. Six Japanese Black cows were assigned to treatments with black-and-white painted stripes, black painted stripes, and no stripes, respectively.
- [An AI-based generate-make-test-learn cycle will provide millions of new drug discoveries](https://window-to-japan.eu/2025/09/19/an-ai-based-generate-make-test-learn-cycle-will-provide-millions-of-new-drug-discoveries/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/09/16/13742/ https://www.nature.com/articles/s42004-025-01640-w Yasuhito Sakakibara, Professor of the Artificial Intelligence Laboratory, Kitasato University, has developed an artificial intelligence (AI) system that trains on data from over 12 million compounds and generates tens of millions of compound candidates with novel structures. When it comes to drug discovery using compounds, there have been "first resources (libraries)" derived from
- [Microbiota-driven antitumour immunity mediated by dendritic cell migration](https://window-to-japan.eu/2025/09/18/microbiota-driven-antitumour-immunity-mediated-by-dendritic-cell-migration/) - https://sj.jst.go.jp/news/202509/n0917-02p.html https://www.nature.com/articles/s41586-025-09249-8 A joint research group from the National Cancer Center Japan and other institutions have discovered a new gut microbiota that enhance the treatment effectiveness of "cancer immunotherapy," which strengthens the immune system's ability to attack cancer cells. About 20% of Japanese people are believed to carry these bacteria. The research group aims to
- [Sanatec Life Sciences registers genome-edited yellow tomato with high GABA content](https://window-to-japan.eu/2025/09/18/sanatec-life-sciences-registers-genome-edited-yellow-tomato-with-high-gaba-content/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/09/11/13721/ https://bio.nikkeibp.co.jp/atcl/biodatabase/091000041/ The startup Sanatech Life Sciences, renamed from Sanatec Seed in January 2024, registered a new genome-edited tomato as a food product. The company has previously introduced deletion mutations in the autoinhibitory domain of GABA synthase in two different tomato varieties, Sicilian Rouge and Esproso, to create new varieties with activated GABA synthase. These have
- [2025/08 NEDO adds sourcing projects to its bio-manufacturing program](https://window-to-japan.eu/2025/09/02/2025-08-nedo-adds-sourcing-projects-to-its-bio-manufacturing-program/) - https://www.nedo.go.jp/news/press/AA5_101876.html NEDO's "Bio-Manufacturing Revolution Program" supports the development and demonstration of technologies necessary for building a biomanufacturing value chain, including the collection and conversion of unused resources into raw materials, microbial modification technologies, production, separation, purification, and processing technologies, and the systems and standardization necessary for social implementation. Biomanufacturing is expected to become the next-generation
- [Blick nach Asien 2025/09](https://window-to-japan.eu/2025/09/02/blick-nach-asien-2025-09/) - blick nach asien 2025:09
- [Sawai introduces alcohol reduction app "Haudy"](https://window-to-japan.eu/2025/09/02/sawai-introduces-alcohol-reduction-app-haudy/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/08/30/13682/ https://www.sawai.co.jp/release/detail/000904.html https://cureapp.blogspot.com/2025/08/haudy1202591-2.html On September 1, 2025, Sawai Pharmaceutical launched "HAUDY," an alcohol reduction treatment support app for which CureApp received manufacturing and marketing approval from the Ministry of Health, Labor and Welfare on February 13 of the same year. An information session was held on August 27th. HAUDY is a treatment app consisting of
- [Unique fullerene derivatives improve the durability of PEM membranes for fuel cells](https://window-to-japan.eu/2025/09/01/12334/) - https://sj.jst.go.jp/news/202509/n0901-01k.html https://sj.jst.go.jp/news/202509/n0901-01k.html A research group led by Professor Yutaka Matsuo and Designated Professor Masaya Kawasumi from the Graduate School of Engineering at Nagoya University has developed a technology that dramatically improves the durability of polymer electrolyte membranes (PEMs), which are the heart of proton exchange membrane fuel cells (PEMFC), using uniquely developed water-soluble fullerene derivatives.
- [A Sino-Japanese laboratory will research supercritical CO2 energy cycles and related fields](https://window-to-japan.eu/2025/09/01/a-sino-japanese-laboratory-will-research-supercritical-co2-energy-cycles-and-related-fields/) - https://www.cas.cn/cm/202508/t20250827_5080495.shtml A kick-off meeting for a China-Japan Joint Laboratory for Supercritical Energy and Environmental Technology was recently held in Beijing. The laboratory is a joint project between the CAS Institute of Engineering Thermophysics and Tohoku University in Japan. The laboratory will do research in areas such as heat and mass transfer, and efficient energy conversion
- [Genome editing procedure reduces diabetes risk in obese mice](https://window-to-japan.eu/2025/09/01/genome-editing-procedure-reduces-diabetes-risk-in-obese-mice/) - https://www.nature.com/articles/s43856-025-00959-8 https://sj.jst.go.jp/news/202508/n0825-03k.html Exenatide, a GLP1 receptor agonist, is known to have high efficacy in suppressing appetite and reducing weight, but requires regular injections, and weight returns to baseline when treatment is discontinued. A research group at Osaka University has used obese mice and expressed exenatide in their liver, as an in-body factory. They developed a genome
- [Japan's first osmotic power plant starts operation in Fukuoka](https://window-to-japan.eu/2025/09/01/japans-first-osmotic-power-plant-starts-operation-in-fukuoka/) - https://sj.jst.go.jp/news/202508/n0825-01n.html Japan's first osmotic power plant that uses the difference in salt concentration between seawater and fresh water to generate electricity began operations in early August in a southwestern prefecture. The Fukuoka District Waterworks Agency, the world's second operator to use the technology following a Danish firm that began doing so in 2023, describes it
- [Lactic acid bacteria from Japanese pickles shown to regulate immune function](https://window-to-japan.eu/2025/08/22/lactic-acid-bacteria-from-japanese-pickles-regulate-immune-function/) - https://journals.asm.org/doi/10.1128/msystems.01575-24 Lactic acid bacteria exhibit immunomodulatory effects on interleukin-10 (IL-10) and interleukin-12 (IL-12) production. Researchers at the Tokyo Institute of Technology have now shown the immunomodulatory capability at the genome level of L. plantarumand L. pentosus strains isolated from Japanese pickles. The bacteria contain genes which encode the enzyme TagF2, which is crucial for synthesizing
- [Sumitomo Rubber develops elastic material which can be used in 3D printers](https://window-to-japan.eu/2025/08/22/sumitomo-rubber-develops-elastic-material-which-can-be-used-in-3d-printers/) - https://www.srigroup.co.jp/newsrelease/2025/sri/2025_044.html Sumitomo Rubber Industries has developed a novel rubber material that can be processed with a 3D printer. Until now, it was not possible to create rubber products using a 3D printer. Liquid rubber material that hardens in a short time under ultraviolet light has been developed as a rubber-like material for creating high-precision three-dimensional
- [NTT and Niigata University: collaborative research on remote palpation technology](https://window-to-japan.eu/2025/08/21/ntt-and-niigata-university-collaborative-research-on-remote-palpation-technology/) - https://group.ntt/jp/newsrelease/2025/06/30/250630a.html NTT and Niigata University are taking on the challenge of remotely performing palpation, a technique that has been difficult to achieve through telemedicine. By elucidating and digitizing the palpation technique, they aim to establish technology that can reproduce the softness and feel of the affected area even remotely. The goal is to clarify the
- [Japan's AIST promotes biomanufacturing in companies  through Tsukuba incubator](https://window-to-japan.eu/2025/08/21/japans-aist-promotes-biomanufacturing-in-companies-through-tsukuba-incubator/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/08/09/13627/ https://bprc.aist.go.jp/en/bprc On August 5, 2025, the National Institute of Advanced Industrial Science and Technology (AIST) held the opening ceremony of the Biomanufacturing Research Building within the institute's Tsukuba Center. The Center is meant as a microbial exploration base to develop untapped biological resources, houses specialised equipment and AIST researchers and features four dedicated labs
- [NEDO adds sourcing projects to its bio-manufacturing program](https://window-to-japan.eu/2025/08/06/nedo-adds-sourcing-projects-to-its-bio-manufacturing-program/) - https://www.nedo.go.jp/news/press/AA5_101876.html NEDO's "Bio-Manufacturing Revolution Program" supports the development and demonstration of technologies necessary for building a biomanufacturing value chain, including the collection and conversion of unused resources into raw materials, microbial modification technologies, production, separation, purification, and processing technologies, and the systems and standardization necessary for social implementation. Biomanufacturing is expected to become the next-generation
- [Chitons synthesize their ultra-sharp magnetite teeth through enzymatic formation of iron oxide on a chitin matrix](https://window-to-japan.eu/2025/08/09/chitons-synthesize-their-ultra-sharp-magnetite-teeth-through-enzymatic-formation-of-iron-oxide-on-a-chitin-matrix/) - https://www.jst.go.jp/pr/announce/20250808-5/index.html https://www.science.org/doi/10.1126/science.adu0043 Chitons are marine mollusks also sometimes known as sea cradles or coat-of-mail shells or suck-rocks. They have a shell composed of eight separate shell plates which overlap at the front and back edges, and yet articulate well with one another. Because of this, the shell provides protection at the same time as permitting the chiton to flex upward
- [Sumitomo Pharma and Racthera apply for manufacturing and marketing of iPS cell-derived dopaminergic progenitor cells "raguneprocel"](https://window-to-japan.eu/2025/08/06/sumitomo-pharma-and-racthera-apply-for-manufacturing-and-marketing-of-ips-cell-derived-dopaminergic-progenitor-cells-raguneprocel/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/08/05/13606/ Sumitomo Pharma and RACTHERA, a joint venture between Sumitomo Pharma and Sumitomo Chemical, have filed an application for manufacturing and marketing approval in Japan for allogeneic iPS cell-derived dopaminergic progenitor cells (generic name: raguneprocel). Dopaminergic neural progenitor cells are induced and generated by Kyoto University or Sumitomo Pharma from the allogeneic iPS cell line
- [In the Nature Science Index 2025, University of Tokyo ranks 23, Kyoto University 55.](https://window-to-japan.eu/2025/08/04/in-the-nature-science-index-2025-university-of-tokyo-ranks-23-kyoto-university-55/) - https://sj.jst.go.jp/news/202507/n0731-01k.html In the global rankings of the Nature Science Index, Japan maintained its 5th place position, but its paper share decreased by 9% from the previous year. Among the world's top 50 research institutions, the University of Tokyo ranked 23. Kyoto University had moved to position 55. RIKEN ranked at position 111. Canada, France, Switzerland,
- [2025/07 Yokohama University opens "plant biomanufacturing center" for recombinant proteins](https://window-to-japan.eu/2025/07/29/2025-07-yokohama-university-opens-plant-biomanufacturing-center-for-recombinant-proteins/) - https://www.nedo.go.jp/news/press/AA5_101866.html Yokohama National University has opened a plant biomanufacturing unit for recombinant proteins, which functions in collaboration with AIST, Kajima Corporation, Denka Co., the University of Tokyo, and Hokkaido University. It will develop technologies from plant cultivation to gene expression and extraction and purification of target substances. The center is intended as a core center
- [Daio Paper Corporation begins commercial production of cellulose nanofiber composite resin](https://window-to-japan.eu/2025/07/29/daio-paper-corporation-begins-commercial-production-of-cellulose-nanofiber-composite-resin/) - https://www.nedo.go.jp/news/press/AA5_101870.html Daio Paper Corporation has developed a manufacturing process for CNF composite resin manufacturing with an annual production capacity of 2,000 tons. The operation of this commercial plant will enable a stable supply of CNF for applications such as automotive components and home appliances, leveraging its light and strong properties. Daio Paper manufactures everything from
- [Kansai Electric Power plans geological study in preparation for construction of a nuclear power plant](https://window-to-japan.eu/2025/07/28/kansai-electric-power-plans-geological-study-in-preparation-for-construction-of-a-nuclear-power-plant/) - https://sj.jst.go.jp/news/202507/n0728-02n.html If realized, it would be the country's first nuclear plant since the 2011 Fukushima disaster. The power company serving the greater Osaka region is looking to carry out the survey on the premises of the Mihama nuclear power station in Fukui Prefecture, the sources said. The utility will brief the town of Mihama on
- [University team finds nylon fishing lines biodegradable and contributing to the "ghost gear" problem](https://window-to-japan.eu/2025/05/18/university-team-finds-nylon-fishing-lines-biodegradable-and-contributing-to-the-ghost-gear-problem/) - https://www.nedo.go.jp/news/press/AA5_101850.html We have discovered that commercially available fishing lines, which were previously thought to be indegradable, can biodegrade in the ocean. As "ghost gear", they remain in the ocean or on the seabed for a long time, causing adverse effects on ecosystems due to entanglement with wildlife such as waterfowl and sea turtles, and marine
- [2025/05 University team finds nylon fishing lines biodegradable and contributing to the "ghost gear" problem](https://window-to-japan.eu/2025/07/25/2025-05-university-team-finds-nylon-fishing-lines-biodegradable-and-contributing-to-the-ghost-gear-problem/) - https://www.nedo.go.jp/news/press/AA5_101850.html We have discovered that commercially available fishing lines, which were previously thought to be indegradable, can biodegrade in the ocean. As "ghost gear", they remain in the ocean or on the seabed for a long time, causing adverse effects on ecosystems due to entanglement with wildlife such as waterfowl and sea turtles, and marine
- [2025/06 Oxygenation of a polycyclic substrate through digestion by an insect](https://window-to-japan.eu/2025/07/25/2025-06-oxygenation-of-a-polycyclic-substrate-through-digestion-by-an-insect/) - https://www.jst.go.jp/pr/announce/20250606/pdf/20250606.pdf https://www.science.org/doi/10.1126/science.adp9384 The insertion of oxygen atoms into carbon belt and ring molecules was achieved after feeding the substrates to tobacco cutworm (Spodoptera litura). The insects processed a carbon nanoring, methylene-bridged [6]cycloparaphenylene, through a xenobiotic pathway. Of those tested, only S. litura survived, and examination of its excretions showed that it converted this molecule to an unusual
- [Oxygenation of a polycyclic substrate through digestion by an insect](https://window-to-japan.eu/2025/06/11/oxygenation-of-a-polycyclic-substrate-through-digestion-by-an-insect/) - https://www.jst.go.jp/pr/announce/20250606/pdf/20250606.pdf https://www.science.org/doi/10.1126/science.adp9384 The insertion of oxygen atoms into carbon belt and ring molecules was achieved after feeding the substrates to tobacco cutworm (Spodoptera litura). The insects processed a carbon nanoring, methylene-bridged [6]cycloparaphenylene, through a xenobiotic pathway. Of those tested, only S. litura survived, and examination of its excretions showed that it converted this molecule to an unusual
- [An organic polymer photocatalyst converts CO2 to formic acid with 32 % quantum yield](https://window-to-japan.eu/2025/07/25/an-organic-polymer-photocatalyst-converts-co2-to-formic-acid-with-32-quantum-yield/) - https://sj.jst.go.jp/news/202507/n0723-02k.html https://pubs.acs.org/doi/10.1021/jacs.5c04222 A research group from several Japanese universities has developed an organic polymer photocatalyst that enables highly efficient carbon dioxide conversion. They selected three types of combinations suitable as donor, π-spacer, and acceptor from diverse conjugated organic molecular frameworks, connected them in appropriate sequences, and introduced reaction centers consisting of metal complexes to the
- [Yokohama University opens "plant biomanufacturing center" for recombinant proteins](https://window-to-japan.eu/2025/07/20/yokohama-university-opens-plant-biomanufacturing-center-for-recombinant-proteins/) - https://www.nedo.go.jp/news/press/AA5_101866.html Yokohama National University has opened a plant biomanufacturing unit for recombinant proteins, which functions in collaboration with AIST, Kajima Corporation, Denka Co., the University of Tokyo, and Hokkaido University. It will develop technologies from plant cultivation to gene expression and extraction and purification of target substances. The center is intended as a core center
- [Diversity and synchronisation makes groups stronger - insights from insects](https://window-to-japan.eu/2025/07/08/diversity-and-synchronisation-makes-groups-stronger-insights-from-insects/) - https://www.nature.com/articles/s41467-025-61313-z https://www.jst.go.jp/pr/announce/20250708/index.html A research team led by Project Assistant Professor Sato Kiyoaki and Associate Professor Takahashi Yuma of Chiba University has analyzed how fruit flies respond to visual threats such as predators, and revealed that the behavior of surrounding individuals greatly influences their fear response and its alleviation. They also discovered that diversity in the
- [Chiyoda Corp. launches "plant biofoundry" in Yokohama, producing human type II collagen](https://window-to-japan.eu/2025/07/08/chiyoda-corp-launches-plant-biofoundry-in-yokohama-producing-human-type-ii-collagen/) - https://www.nedo.go.jp/news/press/AA5_101865.html https://www.chiyodacorp.com/en/media/assets/250707_e.pdf In the framework of NEDO's "Development of Bio-derived Product Production Technology to Accelerate the Realization of Carbon Recycling", Chiyoda Corporation has constructed a demonstration facility for the production of human type II collagen from tobacco plants. This technology can also produce a variety of other products such as vaccines, pharmaceuticals, regenerative medicine products,
- [Blick nach Asien 2025/07](https://window-to-japan.eu/2025/07/06/blick-nach-asien-2025-07/) - Blick nach Asien 2025:07
- [Kanto 3000 L biofoundry is ready to support expansion of Japan's biomanufacturing industry](https://window-to-japan.eu/2025/07/06/kanto-3000-l-biofoundry-is-ready-to-support-expansion-of-japans-biomanufacturing-industry/) - https://www.nedo.go.jp/news/press/AA5_101863.html https://window-to-japan.eu/wp-content/uploads/2023/05/Smart-cells.pdf As part of NEDO's "Development of Bio-based Product Production Technology to Accelerate the Realization of Carbon Recycling" project, Green Earth Institute, Inc. (GEI) is proceeding with the "Kanto Biofoundry Base" in Mobara City, Chiba Prefecture. In this project, scale-up of production processes and sample production for smart cells owned by companies and universities
- [Zeon steps up R&D on green rubber](https://window-to-japan.eu/2025/07/06/zeon-steps-up-rd-on-green-rubber/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/06/25/13457/ https://www.riken.jp/en/news_pubs/research_news/rr/20210806_1/index.html https://www.zeon.co.jp/en/news/assets/pdf/250609.pdf Chemical manufacturer Zeon built a new research building at its base in Yonezawa, Yamagata Prefecture. In collaboration with tire manufacturer Yokohama Rubber, the company is developing technology to produce butadiene and isoprene, the raw materials for rubber, from renewable resources. The development is centered around two pillars: (1) technology to chemically synthesize butadiene
- [A mitochondria-targeting nanoparticle porter may help for gene therapy of mitochondrial diseases](https://window-to-japan.eu/2025/06/24/a-mitochondria-targeting-nanoparticle-porter-may-help-for-gene-therapy-of-mitochondrial-diseases/) - https://www.jst.go.jp/pr/announce/20250619/index.html https://www.nature.com/articles/s41598-025-03671-8 Mitochondrial genome mutations are associated with various diseases and gene therapy targeted to mitochondria has the potential to effectively treat such diseases. A team around Yuma Yamada at Hokkaido University has succeeded to develop a nanocapsule (MITO-Porter) to deliver a genome editing device directly to mitochondria. This achievement of a specific genome cleavage
- [Research team achieves direct reprogramming of mouse fibroblast to alveolar epithelial-like cells](https://window-to-japan.eu/2025/06/24/research-team-achieves-direct-reprogramming-of-mouse-fibroblast-to-alveolar-epithelial-like-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/06/19/13435/ https://www.nature.com/articles/s41536-025-00411-4 A research team from Nagoya University and Keio University has succeeded in creating lung cells from mouse embryonic fibroblasts in a short period of time. The fibroblasts were directly reprogrammed and induced to become stem cells that are the source of lung cells. This could lead to the development of cell medicines derived
- [Blick nach Asien 2025/06](https://window-to-japan.eu/2025/06/11/blick-nach-asien-2025-06/) - blick nach asien 2025:06
- [NEDO introduces simple international standard for plastic biodegradation in oceans and lakes](https://window-to-japan.eu/2025/05/14/nedo-introduces-simple-international-standard-for-plastic-biodegradation-in-oceans-and-lakes/) - https://www.nedo.go.jp/news/press/AA5_101847.html NEDO has introduced the international standard ISO16636:2025 for evaluation methods to demonstrate biodegradation in aquatic environments such as oceans and lakes. This evaluation method was developed by the National Institute of Advanced Industrial Science and Technology (AIST). The method differs from conventional methods, as it does not require large-scale test equipment and is simple.
- [2025/04: A Japanese team develops defectless and uniform micro cellulose](https://window-to-japan.eu/2025/05/02/2025-04-a-japanese-team-develops-defectless-and-uniform-micro-cellulose/) - https://pubs.acs.org/doi/10.1021/acs.nanolett.4c06483 https://www.jst.go.jp/pr/announce/20250408/index.html A group of doctoral students from the University of Tokyo and Kyoto University has succeeded in producing high-quality cellulose nanofibers with regular twists by identifying and suppressing some of the causes of defects. Among the steps to produce more regular cellulose nanofibers, it was found important to carry out the process of extracting
- [Chemical synthesis of virus capsids by self-organizing peptides](https://window-to-japan.eu/2025/05/02/chemical-synthesis-of-virus-capsids-by-self-organizing-peptides/) - https://www.jst.go.jp/pr/announce/20250502/index.html https://www.cell.com/chem/fulltext/S2451-9294(25)00145-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2451929425001457%3Fshowall%3Dtrue A research team consisting of the University of Tokyo and Ochanomizu University has constructed a spherical shell with a geometric structure of regular dodecahedral links by self-organizing peptides with metal ions. Spherical shell molecular structures, such as those found in virus capsids, have the ability to encapsulate and transport molecules. This research group
- [Blick nach Asien 2025/05](https://window-to-japan.eu/2025/05/02/blick-nach-asien-2025-05/) - https:www.gdch.de:fileadmin:blaetterkatalog:catalogs:Heft_05_25:pdf:complete_print
- [A demonstrator in Gifu for high-performance biochar from rice husks](https://window-to-japan.eu/2025/04/24/a-demonstrator-in-gifu-for-high-performance-biochar-from-rice-husks/) - https://www.nedo.go.jp/news/press/AA5_101844.html NEDO, Yanmar Energy Systems Co. and Gifu Agricultural Cooperative have installed a test machine for highly efficient rice husk biochar production and began with production. The challenge in getting farmers to use biochar widely is reducing costs. In response to this, Yanmar Energy Systems is working on the development of a "high-efficiency rice husk
- [Kyoto University Hospital and Orizuru Therapeutics have started phase 1 clinical trials with transplanted iPS-cell-derived islet cells](https://window-to-japan.eu/2025/04/22/kyoto-university-hospital-and-orizuru-therapeutics-have-started-phase-1-clinical-trials-with-transplanted-ips-cell-derived-islet-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/04/15/13201/ https://orizuru-therapeutics.com/en/newsroom/20250415124/ Kyoto University Hospital and T-CiRA's Orizuru have completed transplantation of the first patient with allogeneic iPS cell-derived islet cells in a physician-initiated clinical trial. Orizuru Therapeutics is a startup developing regenerative medicine derived from allogeneic iPS cells and was established in April 2021 with the aim of commercializing projects outside of Takeda Pharmaceutical's
- [Sumitomo Pharma will apply for iPS cell-derived therapy of Parkinson's disease](https://window-to-japan.eu/2025/04/22/sumitomo-pharma-will-apply-for-ips-cell-derived-therapy-of-parkinsons-disease/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/04/17/13212/ https://www.nature.com/articles/s41586-025-08700-0 Kyoto University Hospital recently announced that it had obtained data on safety and efficacy in an investigator-initiated clinical trial of allogeneic iPS cell-derived dopamine neural progenitor cell transplantation for Parkinson's disease, which began in 2018. In terms of efficacy, the secondary endpoint, motor function improved during the drug treatment break in four of
- [Mitsubishi Electric awarded for a chip that reduces power consumption from air conditioners by 41 %](https://window-to-japan.eu/2025/04/15/mitsubishi-electric-awarded-for-a-chip-that-reduces-power-consumption-from-air-conditioners-by-41/) - https://www.nedo.go.jp/news/press/AA5_101841.html Mitsubishi Electric Corporation has developed an intelligent power module that can significantly reduce the power consumption of the inverter circuit that drives the compressor of an air conditioner. This improvement was achieved by installing a high-performance SiC (silicon carbide) power semiconductor chip, which can contribute to more efficient operation of the air conditioner, in addition
- [2025/03 Japanese consortium starts demonstration facility for biojet fuel from waste cooking oil](https://window-to-japan.eu/2025/04/09/2025-03-japanese-consortium-starts-demonstration-facility-for-biojet-fuel-from-waste-cooking-oil/) - https://www.nedo.go.jp/news/press/AA5_101818.html Under NEDO's biojet project, JGC Holdings Corporation, Cosmo Oil Co., Ltd., Revo International Co., Ltd., JGC Corporation, and SAFFAIRE SKY ENERGY LLC have completed the first large-scale production demonstration facility in Japan to produce SAF (sustainable aviation fuel) from waste cooking oil at the Cosmo Oil Sakai Refinery. The purpose of this project is
- [JST initiates social care systems program RISTEX](https://window-to-japan.eu/2025/04/09/jst-initiates-social-care-systems-program-ristex/) - https://www.jst.go.jp/pr/info/info1762/pdf/info1762.pdf JST has established and recruits for a new R&D area named "Social Systems Where Care Takes Root" (RISTEX). The aim is to build a society where "care" that supports each other naturally spreads in order to survive in a society with a declining birthrate and aging population. Professor Yumi Nishimura of Tokyo Metropolitan University
- [Hokkaido team designs inexpensive robot for chemical synthesis based on 3D printer and open software](https://window-to-japan.eu/2025/04/09/hokkaido-team-designs-inexpensive-robot-for-chemical-synthesis-based-on-3d-printer-and-open-software/) - https://www.jst.go.jp/pr/announce/20250409/pdf/20250409.pdf https://pubs.acs.org/doi/10.1021/acsaenm.5c00084 A research group from Hokkaido University has developed a material synthesis robot called "FLUID" that can be fully self-made using a 3D printer. It that can be constructed only with general-purpose parts that are inexpensive and available to everyone. Most of the parts were printed with a 3D printer and could be assembled
- [A Japanese team develops defectless and uniform micro cellulose](https://window-to-japan.eu/2025/04/08/a-japanese-team-develops-defectless-and-uniform-micro-cellulose/) - https://pubs.acs.org/doi/10.1021/acs.nanolett.4c06483 https://www.jst.go.jp/pr/announce/20250408/index.html A group of doctoral students from the University of Tokyo and Kyoto University has succeeded in producing high-quality cellulose nanofibers with regular twists by identifying and suppressing some of the causes of defects. Among the steps to produce more regular cellulose nanofibers, it was found important to carry out the process of extracting
- ["Carbon Recycling Factory" at Osaka-Kansai Expo prepares city gas from CO2](https://window-to-japan.eu/2025/04/08/carbon-recycling-factory-at-osaka-kansai-expo-prepares-city-gas-from-co2/) - https://www.nedo.go.jp/news/press/AA5_101839.html The Research Institute of Innovative Technology for the Earth (RITE), Kyushu University, and Nagoya University will show a demonstration for Direct Air Capture (DAC), a technology that directly captures carbon dioxide (CO2) from the atmosphere, at the Osaka-Kansai Expo. At the "Carbon Recycling Factory" at the Expo site, RITE's DAC demonstration machine will capture
- [Blick nach Asien 2025/03](https://window-to-japan.eu/2025/03/01/blick-nach-asien-2025-02-2/) - https:www.gdch.de:fileadmin:blaetterkatalog:catalogs:Heft_03_25:pdf:complete_print
- [Japanese team develops heart-rate sharing device](https://window-to-japan.eu/2025/04/02/japanese-team-develops-heart-rate-sharing-device/) - https://www.nedo.go.jp/news/press/AA5_101832.html The Japanese AI-startup Adansons https://adansons.co.jp/en/#about and academic partners have developed a haptic system that can be used for skills training but also as a heart rate sharing app. It works two-way and combines an ultra-thin haptic MEMS device with haptic signal editing technology to measure haptic information. As practical examples based on this, the
- [Blick nach Asien 2025/04](https://window-to-japan.eu/2025/04/02/blick-nach-asien-2025-04/) - Nachrichten 2025.04
- [Hydrogen co-firing power generation will in part energise the Osaka-Kansai World Expo](https://window-to-japan.eu/2025/03/29/hydrogen-co-firing-power-generation-will-in-part-energise-the-osaka-kansai-world-expo/) - https://www.nedo.go.jp/news/press/AA5_101828.html Kansai Electric Power Co will begin a hydrogen co-firing power generation demonstration at Himeji No. 2 Power Plant from April 2025. This demonstration will utilize the existing large-scale gas turbine power generation equipment at the plant and aims to establish operational technologies such as operation, maintenance, and safety measures for hydrogen power generation. The
- [Sumitomo Bakelite develops "solid novolac" resins from pulp manufacturing lignin](https://window-to-japan.eu/2025/03/29/sumitomo-bakelite-develops-solid-novolac-resins-from-pulp-manufacturing-lignin/) - https://www.nedo.go.jp/news/press/AA5_101827.html Sumitomo Bakelite Co. has been developing core technologies for resin synthesis using plant-derived raw materials and industrial applications. As a result, the company has succeeded in mass production of "solid novolac type" lignin-modified phenolic resin using lignin and has begun commercial sales for the first time in the world. It has already been adopted
- [J-TEC develops intestinal organoids from human iPS cells as in-vitro model](https://window-to-japan.eu/2025/03/25/j-tec-develops-intestinal-organdies-from-human-ips-cells-as-in-vitro-model/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/03/24/13119/ J-TEC offers the "Labosite" series as a product to replace animal testing with in vitro experimental models in the development of cosmetics and pharmaceuticals. Currently, skin and cornea models are available, and a new intestinal epithelium model is being developed. The model will be produced by (1) inducing differentiation of human iPS cells into
- [Japanese consortium provides datasets for XR-supported remote rehabilitation](https://window-to-japan.eu/2025/03/25/japanese-consortium-provides-datasets-for-xr-supported-remote-rehabilitation/) - https://www.nedo.go.jp/news/press/AA5_101824.html Remote rehabilitation projects using online video calls and non-immersive VR are increasing, and XR rehabilitation is also progressing overseas, but there are not many international cases where remote and XR have been combined. The reason cited for this is that the user experience, such as wearing XR equipment such as head-mounted displays, using rehabilitation
- [Tandem gene arrays allow for strong amplification of individual genes within yeast and human genomes](https://window-to-japan.eu/2025/03/23/tandem-gene-arrays-allow-for-strong-amplification-of-individual-genes-within-yeast-and-mammalian-genomes/) - https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00067-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666979X25000679%3Fshowall%3Dtrue https://www.jst.go.jp/pr/announce/20250321/pdf/20250321.pdf A team at Kyushu University has developed a new genome editing technology called BITREx that highly expands structures in which the same gene is repeated tandemly (tandem gene arrays) by destroying the replication forks, the site of DNA replication. When the potential of BITREx was examined using budding yeast as a model, they
- [Kuraray offers new micro carriers for regenerative cell expansion](https://window-to-japan.eu/2025/03/21/kuraray-offers-new-micro-carriers-for-regenerative-cell-expansion/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/03/20/13104/ Kuraray has introduced Scapova, a bead-shaped scaffolding material (microcarrier) derived from polyvinyl alcohol (PVA), for efficient cell proliferation through 3D culture. The beads are made by chemically modifying and crosslinking PVA to form beads with a diameter of 200 μm, which are then coated with collagen for cell adhesion. The cells can move autonomously
- [A lactic acid bacteria strain activates the human immune system and reduces subjective cold symptoms](https://window-to-japan.eu/2025/03/19/a-lactic-acid-bacteria-strain-activates-the-human-immune-system-and-reduces-subjective-cold-symptoms/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/03/17/13089/ https://academic.oup.com/bbb/article-abstract/89/3/459/7923509?redirectedFrom=fulltext&login=false https://www.mdpi.com/2072-6643/17/1/101 Ezaki Glico has announced that in its bacterial library it had discovered Lactobacillus helveticus GCL1815 strain that activates the human body's immune system. Clinical research has confirmed that it also reduces subjective cold symptoms. The company searched through a library of approximately 10,000 strains of lactic acid bacteria to find a strain
- [Okinawa opens flight route using sustainable aviation fuel manufactured from Okinawa shrub seeds](https://window-to-japan.eu/2025/03/19/okinawa-opens-flight-route-using-sustainable-aviation-fuel-manufactured-from-okinawa-shrub-seeds/) - https://www.nedo.go.jp/news/press/AA5_101821.html A flight using domestically produced SAF made from inedible plant seeds collected in Okinawa Prefecture will be operated on a route within Okinawa Prefecture (JTA565 / Naha to Miyakojima) on March 25th. The SAF is made from inedible plant seeds (Calicoa japonica and Pongamia) collected in Okinawa Prefecture as part of the fuel. J-Oil
- [JBA launches "bio-monozukuri" forum for bio-manufacturing](https://window-to-japan.eu/2025/03/15/jba-launches-bio-monozukuri-forum-for-bio-manufacturing/) - https://www.jba.or.jp/activity/study_group/green_bio/ https://bio.nikkeibp.co.jp/atcl/news/p1/25/03/13/13074/ The Japan Bioindustry Association (JBA)has launched the "Bio-monozukuri Forum" to solve problems that companies face when starting up businesses in the bio-manufacturing field. The government's Integrated Innovation Strategy Promotion Council decided on the "Bioeconomy Strategy" in June 2024. The strategy outlines a policy to expand the bioeconomy market by utilizing Japan's strengths, leading
- [Miniature immunodeficient pigs could facilitate producing organs for xenotransplantation](https://window-to-japan.eu/2025/03/09/miniature-immunodeficient-pigs-could-facilitate-producing-organs-for-xenotransplantation/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/03/04/13034/ The National Agriculture and Food Research Organization (NARO) is developing immunodeficient pigs for the purpose of reproducing human pathological models and producing organs for transplantation into humans. Recently, the organization has miniaturized immunodeficient pigs to make them easier to use in experiments. Since 2012, NARO develops immunodeficient pigs in collaboration with RIKEN and Primetech.
- [Japanese consortium starts demonstration facility for biojet fuel from waste cooking oil](https://window-to-japan.eu/2025/03/09/japanese-consortium-starts-demonstration-facility-for-biojet-fuel-from-waste-cooking-oil/) - https://www.nedo.go.jp/news/press/AA5_101818.html Under NEDO's biojet project, JGC Holdings Corporation, Cosmo Oil Co., Ltd., Revo International Co., Ltd., JGC Corporation, and SAFFAIRE SKY ENERGY LLC have completed the first large-scale production demonstration facility in Japan to produce SAF (sustainable aviation fuel) from waste cooking oil at the Cosmo Oil Sakai Refinery. The purpose of this project is
- [A "post-5G chip" will allow to control robots from an AI server in real time](https://window-to-japan.eu/2025/03/04/a-post-5g-chip-will-allow-to-control-robots-from-an-ai-server-in-real-time/) - https://www.nedo.go.jp/news/press/AA5_101817.html Magna Wireless Co., Ltd., in collaboration with Osaka University (and the National Institute of Information and Communications Technology (NICT) has developed a post-5G semiconductor chip that achieves ultra-low latency communication. The post-5G chip reduces the processing time (latency time) of 5G wireless communication from approximately 10 milliseconds to 0.2 milliseconds or less, a 50th of
- ["Deep nanometers" detects rare particles such as polystyrene or cancer-derived extracellular vesicles (EV) in serum](https://window-to-japan.eu/2025/02/22/deep-nanometers-detects-rare-particles-such-as-polystyrene-or-cancer-derived-extracellular-vesicles-ev-in-serum/) - https://www.nature.com/articles/s41467-025-56812-y https://www.jst.go.jp/pr/announce/20250221/index.html A Japanese-British team has developed a high-speed, high-sensitivity particle measurement technology called "Deep Nanometry (DNM)" that combines optical and fluid hardware technology with unsupervised deep learning denoising technology. It achieves the world's highest level of sensitivity and speed, capable of detecting more than 100,000 particles per second with a minimum diameter of 30
- [Digital twin of macaque brain simulates anaesthesia and awakening in real time](https://window-to-japan.eu/2025/02/22/digital-analog-model-of-macaque-brain-simulates-anaesthesia-and-awakening-in-real-time/) - https://www.jst.go.jp/pr/announce/20250210/index.html https://www.nature.com/articles/s41746-025-01444-1 A Japanese research team has developed a new "digital twin brain simulator" that simulates macaque brain activity in real time and monitors the state of awakening. This simulator models latent brain activity in different layers of the brain and generates highly accurate predictions and invasive electrocorticogram (ECoG) signals. Furthermore, by inferring latent states
- [2025/02 Digital twin of macaque brain simulates anaesthesia and awakening in real time](https://window-to-japan.eu/2025/03/01/2025-02-digital-analog-model-of-macaque-brain-simulates-anaesthesia-and-awakening-in-real-time/) - https://www.jst.go.jp/pr/announce/20250210/index.html https://www.nature.com/articles/s41746-025-01444-1 A Japanese research team has developed a new "digital twin brain simulator" that simulates macaque brain activity in real time and monitors the state of awakening. This simulator models latent brain activity in different layers of the brain and generates highly accurate predictions and invasive electrocorticogram (ECoG) signals. Furthermore, by inferring latent states
- [A vision of automated delivery robots](https://window-to-japan.eu/2025/02/26/a-vision-of-automated-delivery-robots/) - https://www.nedo.go.jp/news/press/AA5_101814.html NEDO, Japan's New Energy and Industrial Technology Development Organization, has published a concept for the "Realization of Delivery Services Using Automated Delivery Robots" Automated delivery robots deliver various packages and products to logistics centers and retail stores. Aiming to solve issues such as labor shortages and people with shopping difficulties in the logistics field, NEDO
- [Telemedicine: remote palpation between Japanese University and Singapore hospital ("contact reality")](https://window-to-japan.eu/2025/02/22/telemedicine-remote-palpation-between-japanese-university-and-singapore-hospital-contact-reality/) - https://www.nedo.go.jp/news/press/AA5_101810.html Contact Reality (CR) is the reproduction of contact between people in a virtual space, which takes into account not only the information obtained by touch but also the psychological effects that occur when people touch each other. It can be used to realize a palpation system focused on pain and abnormal joint diagnosis of
- [Quantum computer "Reimei" is fully operational at RIKEN](https://window-to-japan.eu/2025/02/12/quantum-computer-reimei-is-fully-operational-at-riken/) - https://www.riken.jp/pr/news/2025/20250212_1/index.html https://www.quantinuum.com/press-releases/riken-selects-quantinuum-system-model-h1-for-large-scale-hybrid-quantum-supercomputing-platform-in-japan Quantinuum from Colorado, USA, and RIKEN have announced the completion of the installation of Quantinuum's quantum computer "Reimei" at the RIKEN Wako Campus in Saitama Prefecture. RIKEN has designed, prepared and built a world-class facility for ion-trap quantum computers. This facility is expected to lead to even higher performance quantum systems in the
- [AdvanSentinel sampling kit collects low concentration of environmental DNA including bird flu](https://window-to-japan.eu/2025/02/05/advansentinel-sampling-kit-collects-low-concentration-of-environmental-dna-including-bird-flu/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/01/29/12906/ AdvanSentinel, a joint venture between Shionogi and Shimadzu, released a sampling kit called "QuickConc Vacuum" that can recover environmental DNA in water with a high yield. It is useful for environmental DNA analysis of samples with low concentrations of environmental DNA, such as seawater. The company is also focusing on developing technology to detect
- [A novel yeast species, Hanseniaspora drosophilae sp. nov., from Okinawa](https://window-to-japan.eu/2025/02/05/a-novel-yeast-species-hanseniaspora-drosophilae-sp-nov-from-okinawa/) - https://www.jst.go.jp/pr/announce/20250205-2/index.html https://www.microbiologyresearch.org/content/journal/ijsem/10.1099/ijsem.0.006661 A new yeast species, Hanseniaspora drosophilae sp. nov., was discovered in Okinawan fruit flies, and its characteristics are different from related species. Yeasts of the genus Hanseniaspora have an apiculate (lemon-shaped) cell morphology, are often found in grape juice before fermentation, and are used in winemaking. Research on interactions with insects has also
- [Ministry of Environment in 2025 will pursue "blue carbon" and a "local renewable hydrogen utilisation" projects](https://window-to-japan.eu/2025/02/05/ministry-of-environment-in-2025-will-pursue-blue-carbon-and-a-local-renewable-hydrogen-utilisation-projects/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400016/013000376/ The Ministry of the Environment's 2025 budget is 343.7 billion JP¥, an increase of 5.8 billion JP¥ from the initial budget for 2024. Among its bio-related budgets is a project to grasp greenhouse gas emissions and absorption, and to consider and evaluate new sinks. There will also be research on blue carbon, which refers
- [2025/01 Canine alpha interferon expressed in strawberries: a first in plant-biomanufactured veterinary drugs](https://window-to-japan.eu/2025/02/03/2025-01-canine-alpha-interferon-expressed-in-strawberries-a-first-in-plant-biomanufactured-veterinary-drugs/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/01/17/12857/ Hokusan Co. has developd an animal medicine "Interberry α," made from genetically modified strawberries. It will be released on the Korea market in February 2025. Interberry α is an animal medicine made by introducing the canine interferon gene into strawberries, and the freeze-dried powder is applied to the gums. It was approved as a
- [NEDO Green Innovation Fund adds two pyrolysis projects on microwave technology and on carbon black recycling](https://window-to-japan.eu/2025/01/28/nedo-green-innovation-fund-adds-two-projects-on-carbon-black-recycling/) - https://www.nedo.go.jp/news/press/AA5_101804.html Within its Green Innovation Fund Project/Development of technology to manufacture plastic raw materials using CO2, etc., NEDO has adapted two new themes. They will involve the development of microwave technology to directly manufacture basic chemicals from mixed plastics and the development of technology to regenerate carbon black from waste tires and other materials. Both
- [Streptococcus salivarius in the gut may prevent metabolic diseases by turning excess sucrose into exopolysaccharides](https://window-to-japan.eu/2025/02/02/streptococcus-salivari-in-the-gut-may-prevent-metabolic-diseases-by-turning-excess-sucrose-into-exopolysaccharides/) - https://www.nature.com/articles/s41467-025-56470-0 https://www.jst.go.jp/pr/announce/20250131/index.html A research group at Kyoto University and Tokyo University of Agriculture and Technology has extracted fecal samples from approximately 500 healthy and obese people to identify Streptococcus salivarius (S. salivarius), a type of bacteria that commonly resides in the human digestive tract, as a biomarker that suppresses sugar (sucrose)-induced obesity. It was revealed
- [J-Oil Mills develops sustainable aviation fuel SAF from Okinawa shrubs](https://window-to-japan.eu/2025/02/02/j-oil-mills-develops-sustainable-aviation-fuel-saf-from-okinawa-shrubs/) - https://www.nedo.go.jp/news/press/AA5_101805.html In the NEDO project "Demonstration Study for the Construction and Expansion of an SAF Supply Chain Model Using Vegetable Oils that Do Not Compete with Food" , J-Oil Mills, Inc. has succeeded in producing 100% biomass-derived SAF using oil extracted and refined from the seeds of Calophyllum indicum and Pongamia, inedible subtropical plants that
- [NEDO awards 14 companies for energy saving technology](https://window-to-japan.eu/2025/02/02/nedo-awards-14-companies-for-energy-saving-technology/) - https://www.nedo.go.jp/news/press/AA5_101806.html NEDO awards 14 companies for the 2024 "NEDO Energy Saving Technology Development Award," which recognizes companies that have achieved outstanding results that contribute to energy conservation. The following awards were forwarded: Chairman's Award: Development of intelligent power module for home appliances Mitsubishi Electric Corporation Special Award Small/Medium-Sized/Startup Award: Development of small turbo compressor device
- [Japan's government will spend 10% more on R&D in FY2025](https://window-to-japan.eu/2025/02/02/japans-government-will-spend-10-more-on-rd-in-fy2025/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400016/012800371/ The government approved the 2025 R&D budget proposal at a cabinet meeting on December 27, 2024. The government's overall science and technology promotion budget will increased by 12.9 billion yen from the previous fiscal year to 1.4221 trillion yen. According to a survey in Nikkei Biotech, Japan's bio-budget will be down around around 3
- [Blick nach Asien 2025/02](https://window-to-japan.eu/2025/02/02/blick-nach-asien-2025-02/) - https:www.gdch.de:fileadmin:blaetterkatalog:catalogs:Heft_02_25:pdf:complete
- [Canine alpha interferon expressed in strawberries: a first in plant-biomanufactured veterinary drugs](https://window-to-japan.eu/2025/01/24/canine-alpha-interferon-expressed-in-strawberries-a-first-in-plant-biomanufactured-veterinary-drugs/) - https://bio.nikkeibp.co.jp/atcl/news/p1/25/01/17/12857/ Hokusan Co. has developd an animal medicine "Interberry α," made from genetically modified strawberries. It will be released on the Korea market in February 2025. Interberry α is an animal medicine made by introducing the canine interferon gene into strawberries, and the freeze-dried powder is applied to the gums. It was approved as a
- [Enzyme engineering increases yield of stevia rebaudioside D and M in model plant](https://window-to-japan.eu/2025/01/18/enzyme-engineering-increases-yield-of-stevia-rebaudioside-d-and-m-in-model-plant/) - https://doi.org/10.1021/acs.jafc.4c09392 Stevia, an herb plant of the Asteraceae family, accumulates the sweeteners rebaudioside D and rebaudioside M, but the accumulation of these sweeteners within the stevia plant is limited. By using an improved enzyme in which one amino acid in UGT91D2, the enzyme that synthesizes rebaudioside D and rebaudioside M, was replaced, the accumulation of
- [Blick nach Asien 2025/01](https://window-to-japan.eu/2025/01/11/blick-nach-asien-2025-01/) - https:www.gdch.de:fileadmin:blaetterkatalog:catalogs:Heft_01_25:pdf:complete_print
- [Blood flow keeps stem cells dormant](https://window-to-japan.eu/2025/01/11/blood-flow-keeps-stem-cells-dormant/) - https://www.jst.go.jp/pr/announce/20250107/index.html https://www.nature.com/articles/s41586-024-08352-6 A research team from Nagoya University and Harvard University has discovered that hematopoietic stem cells with high nitric oxide (NO) expression (NOhiHSC) maintain dormancy under steady-state conditions, avoid attack from immune cells, and show robust long-term regenerative ability when transplanted. Three-dimensional bone marrow imaging technology revealed that NOhiHSC are abundant in the bone
- [RIKEN, Kaneka and others: mass cell culture of suspended iPS cells](https://window-to-japan.eu/2024/12/12/riken-kaneka-and-others-mass-cell-culture-of-suspended-ips-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/11/22/12660/ https://elifesciences.org/articles/89724 A joint research group of RIKEN (RIKEN), Kyoto University iPS Cell Research Foundation, and Kaneka has developed a method for suspension culture of iPS cells while suppressing spontaneous differentiation. They have succeeded in consistently performing the process of establishing iPS cells from human peripheral blood mononuclear cells and mass culturing clinical-grade human iPS
- [2024/12 RIKEN, Kaneka and others: mass cell culture of suspended iPS cells](https://window-to-japan.eu/2025/01/02/2024-12-riken-kaneka-and-others-mass-cell-culture-of-suspended-ips-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/11/22/12660/ https://elifesciences.org/articles/89724 A joint research group of RIKEN (RIKEN), Kyoto University iPS Cell Research Foundation, and Kaneka has developed a method for suspension culture of iPS cells while suppressing spontaneous differentiation. They have succeeded in consistently performing the process of establishing iPS cells from human peripheral blood mononuclear cells and mass culturing clinical-grade human iPS
- [A review on GMO silkworm and agricultural products in Japan](https://window-to-japan.eu/2024/12/28/a-review-on-gmo-silkworm-and-agricultural-products-in-japan/) - https://bio.nikkeibp.co.jp/atcl/column/16/031700078/102300034/ Genetically modified crops and foods, 2024 will see movement with the release of fluorescent protein silk and cedar pollen rice Yoshiko Sasa, Managing Director of the NPO Kurashi to Bio Plaza 21, summarized the trends in the cultivation and regulation of genetically modified crops in Japan. In 2024, a new product made from genetically
- [A review on genome-edited foods in Japan](https://window-to-japan.eu/2024/12/28/a-review-on-genome-edited-foods-in-japan/) - https://bio.nikkeibp.co.jp/atcl/column/16/031700078/102300035/ Yoshiko Sasa, Managing Director of the NPO Kurashito Bio Plaza 21, has recently summarized the trends in the development status of genome-edited foods in Japan and published an article on this subject in Nikkei Biotech. In 2021, genome-edited foods were put into practical use for the first time in Japan. In 2020-2021, Sanatec Life
- [RIKEN: technology to degrade target proteins in vivo in mice](https://window-to-japan.eu/2024/12/16/riken-technology-to-degrade-target-proteins-in-vivo-in-mice/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/12/10/12737/ https://www.nature.com/articles/s41467-024-54308-9 A collaborative research group of the RIKEN Center for Integrative Medical Sciences and the National Institute of Genetics has developed a technology to degrade target proteins in vivo in mice using a degron sequence recognized by the ubiquitin ligase complex. The technology makes it possible to efficiently evaluate drug efficacy and side effects in
- [Gut bacteria of 1 month old babies are associated with food allergen sensitisation](https://window-to-japan.eu/2024/12/16/gut-bacteria-of-1-month-old-babies-are-associated-with-food-allergen-sensitisation/) - https://www.jacionline.org/article/S0091-6749(24)01173-4/fulltext A collaborative research group consisting of the Mucosal System Research Team at the RIKEN Center for Integrative Medical Sciences and the Center for Preventive Medicine, Chiba University, has revealed that a gut microbiota enterotype dominated by Bifidobacterium genus in one-month-old children is associated with lower food allergen sensitization and a lower risk of developing
- [Blick nach Asien 2024/12](https://window-to-japan.eu/2024/12/13/blick-nach-asien-2024-12/) - Blick nach Asien 2024:12
- [Long-term memory in mice requires signal transmission among multiple brain regions](https://window-to-japan.eu/2024/12/12/long-term-memory-in-mice-requires-signal-transmission-among-multiple-brain-regions/) - https://www.riken.jp/press/2024/20241209_2/index.html https://www.nature.com/articles/s41467-024-54273-3 A team at the RIKEN Center for Brain Science discovered that dynamic neural activity transmission patterns between the hippocampus, prefrontal cortex, and amygdala reflect the time when fear memories are formed in mice. The results of this research are expected to contribute to elucidating the full picture of the complex long-term memory mechanism
- [PolMed Tech transplants kidney from genetically modified pig into monkey](https://window-to-japan.eu/2024/12/12/polmed-tech-transplants-kidney-from-genetically-modified-pig-into-monkey/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/11/25/12666/ PolMed Tech in Kawasaki City, a startup of Meiji University aiming to commercialize xenotransplantation, announced on November 25, 2024 that it had transplanted one kidney from a genetically modified pig for organ xenotransplantation into a cynomolgus monkey and confirmed urinary excretion. The monkey's overall condition after surgery is said to be good. Since February 2024,
- [Making rainbow trout give birth to salmon](https://window-to-japan.eu/2024/05/27/making-rainbow-trout-give-birth-to-salmon/) - https://www.science.org/doi/10.1126/sciadv.adm8713 https://bio.nikkeibp.co.jp/atcl/news/p1/24/05/22/11937/ A research team led by Professor Goro Yoshizaki at the Tokyo University of Marine Science and Technology has succeeded in laying salmon eggs in rainbow trout using a surrogate broodstock technique that involves transplanting reproductive stem cells between different species. It is based on the observation that when a cell population containing germline
- [2024/05 Pharma Foods succeeds to prepare fiber materials from eggshell membranes](https://window-to-japan.eu/2024/06/01/2024-05-pharma-foods-succeeds-to-prepare-fiber-materials-from-eggshell-2/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/05/04/11872/ https://www.pharmafoods.co.jp/products/ovoveil 2.63 million tons of chicken eggs are used annually in Japan, and about half are sold as raw eggs for home use, while the remaining half are used as liquid eggs for commercial use. During the manufacturing process of liquid eggs, am estimated amount of 260,000 t of eggshells and 10,000 t of
- [Green Earth Institute completes pilot plant in Kanto Biofoundry Center, shortens scale-up](https://window-to-japan.eu/2024/06/07/green-earth-institute-completes-pilot-plant-in-kanto-biofoundry-center-shortens-scale-up/) - https://gei.co.jp/ja/kobo/release/nedo_biofoundry_jisho0531.pdf NEDO and Green Earth Institute, Inc. (GEI) are currently verifying the functionality of the Kanto Biofoundry Center, which was completed in Mobara City, Chiba Prefecture, as part of the "Development of Bio-based Product Production Technology to Accelerate the Realization of Carbon Recycling" . Thanks to the Center's know-how in experimental design and production systems
- [Germ cells may regulate aging in vertebrates](https://window-to-japan.eu/2024/06/15/germ-cells-may-regulate-aging-in-vertebrates/) - https://www.science.org/doi/10.1126/sciadv.adi1621 https://bio.nikkeibp.co.jp/atcl/news/p1/24/06/12/12030/ A research team at Osaka University has uncovered the mechanism by which females live longer than males. They found that the reproductive cells of both males and females control their lifespan, and that eggs have a molecular mechanism that leads to longer lifespans which is not available to sperm cells. The research team
- [Tohoku ToMMo megabank completes 100.000 full genome sequences of Japanese](https://window-to-japan.eu/2024/06/24/tohoku-tommo-megabank-completes-100-000-full-genome-sequences-of-japanese/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/06/19/12062/ Tohoku Medical Megabank Organization (ToMMo) announced on June 19, 2024 that the number of genomes analyzed in the Japanese whole genome analysis project has exceeded 100,000. Tohoku Medical Megabank has accumulated health information and biological samples of 150,000 local residents, mainly in Miyagi and Iwate prefectures, and ToMMo is analyzing them. In August 2015,
- [2024/06 Tohoku ToMMo megabank completes 100.000 full genome sequences of Japanese](https://window-to-japan.eu/2024/06/30/2024-06-tohoku-tommo-megabank-completes-100-000-full-genome-sequences-of-japanese/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/06/19/12062/ Tohoku Medical Megabank Organization (ToMMo) announced on June 19, 2024 that the number of genomes analyzed in the Japanese whole genome analysis project has exceeded 100,000. Tohoku Medical Megabank has accumulated health information and biological samples of 150,000 local residents, mainly in Miyagi and Iwate prefectures, and ToMMo is analyzing them. In August 2015,
- [A phage-derived endolysin suppresses graft-versus-host disease GVHD](https://window-to-japan.eu/2024/07/13/a-phage-derived-endolysin-suppreses-graft-versus-host-disease-gvhd/) - https://www.nature.com/articles/s41586-024-07667-8 A research team from Osaka Municipal University and the University of Tokyo has discovered an intestinal bacterium involved in the development of graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation, a highly toxic strain of Enterococcus faecalis, a common resident bacterium.Patients with an increased level of this strain had a higher incidence of GVHD.
- [Cyfuse and Iwatani Corporation develop technology to freeze organized regenerative medicine products](https://window-to-japan.eu/2024/07/13/cyfuse-and-iwatani-corporation-develop-technology-to-freeze-organized-regenerative-medicine-products/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/07/10/12134/ Cyfuse and Iwatani Corporation announced on July 10, 2024 that they have developed a technology that can freeze three-dimensionally organized regenerative medicine products, which Cyfuse is developing, with liquid nitrogen. Cyfuse uses "bio 3D printing" technology, which stacks spheroids three-dimensionally using a 3D printer. Currently, they are developing three types of autologous regenerative medicine
- [Can green tea ingredients protect from hearing loss by regenerating cochlear hair cells?](https://window-to-japan.eu/2024/07/21/can-green-tea-ingredients-protect-from-hearing-loss-by-regenerating-cochlear-hair-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/01/22/11525/ https://pubmed.ncbi.nlm.nih.gov/25593106/ ITO EN and a research group led by Professor Masato Fujioka and Lecturer Kazusuke Nagao of Kitasato University School of Medicine have started a joint industry-academy study on the efficacy of green tea ingredients for age-related hearing loss. The goal is to develop foods with functional claims and foods for specific health applications.C
- [JGC Holdings to establish biomanufacturing R&D Center with a focus on hydrogen bacteria](https://window-to-japan.eu/2024/07/21/jgc-holdings-to-establish-biomanufacturing-rd-center-with-a-focus-on-hydrogen-bacteria/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/07/18/12162/ https://www.jgc.com/jp/news/2024/20240717.html https://www.b2i.co.jp/en/ JGC Holdings (JGC HD), a large oil and gas company, will establish a new "Bioprocess Research Institute (JBX)" on Port Island in Kobe City. The first building (JBX1) is a three-story building with a total floor area of ​​approximately 4,000 square meters, will have multiple culture tanks of several liters to several
- [ReproCell starts offering human iPS-based exosomes aimed at anti-aging effects](https://window-to-japan.eu/2024/07/28/reprocell-starts-offering-human-ips-based-exosomes-aimed-at-anti-aging-effects/) - https://www.reprocell.com https://bio.nikkeibp.co.jp/atcl/news/p1/24/07/19/12165/ https://reprocell.co.jp/ipsexosome/ Exosomes, ranging in size from 30 to 150 nanometers, are membrane-bound extracellular vesicles (EVs) that are produced in the endosomal compartment of most eukaryotic cells. In multicellular organisms, exosomes and other EVs are found in biological fluids including saliva, blood, urine and cerebrospinal fluid. EVs have specialized functions in physiological processes, from coagulation
- [NEDO: result of second call for the "Bio-manufacturing Revolution Promotion Project"](https://window-to-japan.eu/2024/07/28/nedo-result-of-second-call-for-the-bio-manufacturing-revolution-promotion-project/) - https://www.nedo.go.jp/news/press/AA5_101764.html Since 2022, NEDO supports a 10 year project for the conversion of manufacturing processes to bio-manufacturing. The total cost of this project (companies and public support) is estimated on 300 billion JP¥ (1.8 billion €). Now the second list of grants has been published on the following themes Bio-manufacturing using unused resources such as
- [Redox-active cyclodextrin exhibits excellent chaperone activities during protein folding](https://window-to-japan.eu/2024/08/02/redox-active-cyclodextrin-exhibits-excellent-chaperone-activities-during-protein-folding/) - https://pubs.rsc.org/en/content/articlelanding/2024/sc/d4sc02123a A research team from Tokyo University of Agriculture and Technology, Tokushima University, Tohoku University has developed a compound that promotes correct protein folding in a highly concentrated solution. The sulfide-bonds containing cyclodextrin βCDWSH has binding properties to a variety of proteins and suppresses intermolecular aggregation while promoting the formation of three-dimensional structures, such as
- [An AMED-led consortium of 17 pharmaceutical companies has high hopes in AI-based drug discovery](https://window-to-japan.eu/2024/08/02/an-amed-led-consortium-of-17-pharmaceutical-companies-has-high-hopes-in-ai-based-drug-discovery/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/07/29/12195/ AMED in 2019 had initiated a project where artificial intelligence (AI) has been trained to learn not only public databases but also assay data, including structural formulas, held by 17 domestic pharmaceutical companies, in order to develop an integrated drug discovery AI platform. The application and verification of this AI platform has begun for
- [2024/07 NEDO: result of second call for the "Bio-manufacturing Revolution Promotion Project"](https://window-to-japan.eu/2024/08/02/2024-07-nedo-result-of-second-call-for-the-bio-manufacturing-revolution-promotion-project/) - https://www.nedo.go.jp/news/press/AA5_101764.html Since 2022, NEDO supports a 10 year project for the conversion of manufacturing processes to bio-manufacturing. The total cost of this project (companies and public support) is estimated on 300 billion JP¥ (1.8 billion €). Now the second list of grants has been published on the following themes Bio-manufacturing using unused resources such as
- [Japanese saw mill and pulp biorefinery partners obtain certificate for local sustainable aviation fuel](https://window-to-japan.eu/2024/08/28/japanese-saw-mill-and-pulp-biorefinery-partners-obtain-certificate-for-local-sustainable-aviation-fuel/) - https://www.nedo.go.jp/news/press/AA5_101773.html As part of the NEDO-funded "Demonstration Project for Integrated Production and Supply Chain Construction of Domestic Sustainable Aviation Fuel (SAF) from Pulp", Sanyu Plant Services Co., Ltd. and Biomaterial in Tokyo Co., Ltd., have demonstrated a supply chain for SAF, from procuring pulp from domestic raw materials to producing SAF via bioethanol and supplying
- [Hyperion FoodTech achieves production of bovine skeletal muscle cells without using feeder cells](https://window-to-japan.eu/2024/08/29/hyperion-foodtech-produces-bovine-skeletal-muscle-cells-from-beef-cells-without-using-feeder-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/08/19/12263/ Hyperion FoodTech, a startup in Nara City, has succeeded in 3D culture of pluripotent stem cells (ES cells) derived from domestic bovine embryos. In July 2023, the company established ES cells from fertilized embryos of domestic beef cattle and named them as "BEEF cells (Bovine Embryo-derived stem cell for Engineered Food or Bovine Embryo-derived
- [Kirin HD develops skin model from human fibroblasts and iPS macrophages](https://window-to-japan.eu/2024/09/12/kirin-hd-develops-skin-model-from-human-fibroblasts-and-ips-macrophages/) - https://www.kirinholdings.com/jp/newsroom/release/2024/0911_01.html Kirin Holdings (HD) has developed a skin model using human fibroblasts and human iPS cell-derived macrophages, in a joint research course with FANCL and Juntendo University Graduate School of Medicine and Institute of Environmental Medicine. In order to reproduce inflammatory reactions in an in vitro skin model, it is important to include macrophages in
- [2024/08 Hyperion FoodTech achieves production of bovine skeletal muscle cells without using feeder cells](https://window-to-japan.eu/2024/09/12/2024-08-hyperion-foodtech-achieves-production-of-bovine-skeletal-muscle-cells-without-using-feeder-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/08/19/12263/ Hyperion FoodTech, a startup in Nara City, has succeeded in 3D culture of pluripotent stem cells (ES cells) derived from domestic bovine embryos. In July 2023, the company established ES cells from fertilized embryos of domestic beef cattle and named them as "BEEF cells (Bovine Embryo-derived stem cell for Engineered Food or Bovine Embryo-derived
- [Japan presents world's first 100% biomass-derived SAF from inedible coconut oil](https://window-to-japan.eu/2024/09/21/japan-presents-worlds-first-100-biomass-derived-saf-from-inedible-coconut-oil/) - https://www.nedo.go.jp/news/press/AA5_101778.html Under a contract from NEDO, Japan Green Power Development Co., Ltd. has succeeded in producing 100% biomass-derived SAF using a catalyst being developed in collaboration with Tokyo University of Agriculture and Technology and HighChem Co., Ltd. The neat SAF produced this time complies with the international quality standard "ASTM D7566 Annex A2" . The
- [Stem Cell & Device Laboratory develops iPS cell-derived Schwann cells for regenerative medicine for nerve repair](https://window-to-japan.eu/2024/09/21/stem-cell-device-laboratory-develops-ips-cell-derived-schwann-cells-for-regenerative-medicine-for-nerve-repair/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/09/13/12361/ Stem Cell & Device Laboratory (Kyoto City, CEO Kato Kensuke, hereinafter SCAD), a startup from Kyoto University, is developing human iPS cell-derived Schwann cells as a regenerative medicine product to treat damaged nerves. The first target is carpal tunnel syndrome, and the plan is to begin investigator-led clinical trials after 2026. On September 6,
- [On-Chip Biotechnologies develop fluorescent stain to detect microorganisms during droplet separation](https://window-to-japan.eu/2024/10/08/on-chip-biotechnologies-develop-fluorescent-stain-to-detect-microorganisms-during-droplet-separation/) - https://www.nedo.go.jp/news/press/AA5_101781.html AIST and On-Chip Biotechnologies, Inc. have developed technology that detects and separates microorganisms inside water-in-oil droplets by fluorescently staining the membrane components of microorganisms. The detection reagent used in this technology will be commercialized by On-Chip Biotechnologies and will be on sale from October 1st.
- [Osaki CoolGen Corp builds integrated biomass-coal gasification plant with CCS](https://window-to-japan.eu/2024/10/08/osaki-coolgen-corp-builds-integrated-biomass-coal-gasification-plant-with-ccs/) - https://www.nedo.go.jp/news/press/AA5_101769.htm NEDO and Osaki CoolGen Corporation began demonstration testing of the world's first "Development of Biomass Co-Gasification Technology in IGCC with CO2 Separation and Capture". The purpose of this project is to link the results obtained through the demonstration test to the social implementation of biomass co-gasification technology, and to confirm and verify the impact of
- [NEDO and partners start building "plant biofoundry" for Biomanufacturing](https://window-to-japan.eu/2024/10/08/nedo-and-partners-start-building-plant-biofoundry-for-biomanufacturing/) - https://www.nedo.go.jp/news/press/AA5_101784.html As part of NEDO's "Development of bio-based product production technology to accelerate the realization of carbon recycling" (hereinafter referred to as this project), Chiyoda Corporation is currently constructing a demonstration facility for a new fundamental technology to produce useful proteins using plants. The plan is to develop this demonstration facility so that it can
- [Can tuna be faster hatched in surrogate mackerels?](https://window-to-japan.eu/2024/10/08/can-tuna-be-faster-hatched-in-surrogate-mackerels/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/10/02/12442/ Professor Goro Yoshizaki of the Department of Marine Bioresources, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, and his colleagues announced that they have succeeded in making bluefin tuna sperm in spotted mackerel, a fish that matures in a shorter time than bluefin tuna, by using the "surrogate
- [Sunbake Co. introduces lignin-modified phenolic resin for plywood and laminated products](https://window-to-japan.eu/2024/10/13/sunbake-co-introduces-lignin-modified-phenolic-resin-for-plywood-and-laminated-products/) - https://www.nedo.go.jp/news/press/AA5_101786.html Sumitomo Bakelite Co. has been developing core technologies for resin synthesis using various lignins and industrial applications. As a result of this industrial application development, Sumitomo Bakelite group company Sunbake Co. has begun selling the lignin-modified phenolic resin "Sumitac® PL-700 Series," in which part of the phenol, a raw material derived from fossil resources,
- [2024/09 NEDO and partners start building "plant biofoundry" for Biomanufacturing](https://window-to-japan.eu/2024/10/13/2024-10-nedo-and-partners-start-building-plant-biofoundry-for-biomanufacturing/) - https://www.nedo.go.jp/news/press/AA5_101784.html As part of NEDO's "Development of bio-based product production technology to accelerate the realization of carbon recycling" (hereinafter referred to as this project), Chiyoda Corporation is currently constructing a demonstration facility for a new fundamental technology to produce useful proteins using plants. The plan is to develop this demonstration facility so that it can
- [2024/10 Sunbake Co. introduces lignin-modified phenolic resin for plywood and laminated products](https://window-to-japan.eu/2024/11/11/2024-10-sunbake-co-introduces-lignin-modified-phenolic-resin-for-plywood-and-laminated-products/) - https://www.nedo.go.jp/news/press/AA5_101786.html Sumitomo Bakelite Co. has been developing core technologies for resin synthesis using various lignins and industrial applications. As a result of this industrial application development, Sumitomo Bakelite group company Sunbake Co. has begun selling the lignin-modified phenolic resin "Sumitac® PL-700 Series," in which part of the phenol, a raw material derived from fossil resources,
- [A hydrothermal reaction field enhances efficiency of electrochemical CO2 reduction](https://window-to-japan.eu/2024/11/23/a-hydrothermal-reaction-field-enhances-efficiency-of-electrochemical-co2-reduction/) - https://www.jst.go.jp/pr/announce/20241108-2/index.html https://onlinelibrary.wiley.com/doi/10.1002/adsu.202400489 A research team at Tohoku University, the National Institute of Advanced Industrial Science and Technology, and Utsunomiya University has demonstrated that the efficiency of electrochemical CO2 reduction reaction (CO2RR) can be significantly improved by using a high-temperature, high-pressure water environment (a hydrothermal reaction field). Technology assessment showed that this process can be used
- [Euglena will sell in Japan SAF manufactured by EcoCeres](https://window-to-japan.eu/2024/11/23/euglena-will-sell-in-japan-saf-manufactured-by-ecoceres/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/11/18/12643/ Euglena announced that it will sell in Japan sustainable aviation fuel (SAF) and next-generation biodiesel fuel (HVO) manufactured by EcoCeres in China. EcoCeres https://www.eco-ceres.com/ manufactures and sells HVO and SAF made from residual biomass such as waste cooking oil in China and other countries. During the biofuel demonstration project phase in Japan (2019-2024), Euglena
- [Plasma-derived atomic hydrogen enables CO2 methanation at low temperatures](https://window-to-japan.eu/2024/11/23/plasma-derived-atomic-hydrogen-enables-co2-methanation-at-low-temperatures/) - https://www.jst.go.jp/pr/announce/20241121-2/index.html https://pubs.acs.org/doi/10.1021/jacsau.4c00857 A research team from Tokyo University of Science, Osaka University, and Hokkaido University, has realized a plasma catalytic reaction system that converts carbon dioxide (CO2) to methane (CH4)("methanation"), and elucidated the reaction mechanism. They applyied a non-equilibrium plasma, which simultaneously generates vibrationally excited CO2 and hydrogen atoms at low temperature, to a catalytic
- [Blick nach Asien 2024/10](https://window-to-japan.eu/2024/10/13/blick-nach-asien-2024-10/) - Bildschirmfoto 2024-10-06 um 15.55.32
- [Japan tests smart mobility system using AI in the Philippines](https://window-to-japan.eu/2024/09/21/japan-tests-smart-mobility-system-using-ai-in-the-philippines/) - https://www.nedo.go.jp/news/press/AA5_101774.html NEDO is working with the Philippine Bases Conversion and Development Authority (BCDA) on the "Demonstration Study of Smart Mobility Aimed at Changing Energy Consumption Behavior (Philippines)" . Zenmov Inc., the grant recipient of this demonstration study, has completed the introduction of the cloud-based traffic control system "Smart Mobility Operation Cloud" (SMOC) developed by Zenmov
- [Sumitomo Osaka Cement tests low-carbon pavement](https://window-to-japan.eu/2024/09/21/sumitomo-osaka-cement-tests-low-carbon-pavement/) - https://www.nedo.go.jp/news/press/AA5_101777.html Under a NEDO contract, Sumitomo Osaka Cement Co., Ltd. as the lead company is working on the development of "Establishment of carbonation technology using various calcium sources " which is part of NEDO's Green Innovation Fund project "Development of concrete manufacturing technology using CO2." This project has already achieved the production of high-quality artificial limestone that
- [Update on bioplastic development in Japan](https://window-to-japan.eu/2024/09/12/update-on-bioplastic-development-in-japan/) - Excerpts from an article in Nikkei Biotech on Bioplastics, cases where biodegradability is lower than expected https://bio.nikkeibp.co.jp/atcl/column/16/031700078/090600030/ Business Innovation Partners (Kawasaki City) sells "HEMIX," a biomass plastic made from hemicellulose. Hemicellulose is a component that accounts for 20-30% of plant cell walls, but the company is focusing on it as "it has no specific uses
- [Japan tests "smart mobility operating cloud" SMOC in the Clark area, Philippines](https://window-to-japan.eu/2024/09/12/japan-tests-smart-mobility-operating-cloud-smoc-in-the-clark-area-philippines/) - https://www.nedo.go.jp/news/press/AA5_101774.html In the Philippines economic growth and population growth are remarkable, but traffic conditions such as a rapid increase in users in the transportation sector and traffic congestion and congestion caused by self-discretion by privately-owned drivers have become social issues. The Philippine government has launched a public transportation vehicle modernization program as a transportation policy,
- [Hi-Tec shrimp aquaculture system opens in Vietnam, supported by NEDO](https://window-to-japan.eu/2024/08/18/hi-tec-shrimp-aquaculture-system-opens-in-vietnam-supported-by-nedo/) - https://www.nedo.go.jp/news/press/AA5_101768.html NEDO is subsidising a "Demonstration Study on Advanced Energy-Saving Shrimp Aquaculture System Using Local Biomass" as part of the "International Demonstration Project for Japanese Technologies Contributing to Decarbonization and Energy Transition". A fully operated "Energy-Saving Shrimp Aquaculture Integrated System" using biomass was now opened by TH AQUA Co., Ltd., a local company in Tien
- [Biotech institute breeds genome-edited “super crickets”](https://window-to-japan.eu/2022/01/25/biotech-institute-uses-breeds-genome-edited-super-crickets/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/01/20/09049/
- [Blick nach Asien 2024/07](https://window-to-japan.eu/2024/07/07/blick-nach-asien-2024-07/) - https:www.gdch.de:fileadmin:blaetterkatalog:catalogs:Heft_07_24:pdf:complete_print
- [Blick nach Asien 2024/06](https://window-to-japan.eu/2024/06/07/blick-nach-asien-2024-06/) - Bildschirmfoto 2024-06-05 um 18.23.27
- [Japan's NARO develops new apple tree variety suitable for automatic harvesting](https://window-to-japan.eu/2024/06/15/japans-naro-develops-new-apple-tree-variety-suitable-for-automatic-harvesting/) - https://www.naro.go.jp/publicity_report/press/laboratory/nifts/163351.html Japan's National Agricultural Research Organization NARO has developed a new apple variety that has compact fruit tree branches that do not spread out horizontally. It has been named "Benitsurugi." The apple trees can be planted close together and the movement during harvesting can be simplified, making it suitable for automatic harvesting. Although the coloring
- [Pharma Foods succeeds to prepare fiber materials from eggshell](https://window-to-japan.eu/2024/05/17/pharma-foods-succeeds-to-prepare-fiber-materials-from-eggshell/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/05/04/11872/ https://www.pharmafoods.co.jp/products/ovoveil 2.63 million tons of chicken eggs are used annually in Japan, and about half are sold as raw eggs for home use, while the remaining half are used as liquid eggs for commercial use. During the manufacturing process of liquid eggs, am estimated amount of 260,000 t of eggshells and 10,000 t of
- [NEDO's Energy Saving and Non-Fossil Energy Conversion Technology Strategy 2024](https://window-to-japan.eu/2024/05/24/nedos-energy-saving-and-non-fossil-energy-conversion-technology-strategy-2024/) - https://www.nedo.go.jp/news/press/AA5_101741.html NEDO and the Agency for Natural Resources and Energy of the Ministry of Economy, Trade and Industry have identified important technologies that will significantly contribute to energy conservation and non-fossil energy conversion in the future. In order to effectively promote the research, development and dissemination of energy conservation technology and non-fossil energy conversion technology,
- [IQVIA: Japan's pharmaceutical market 2023](https://window-to-japan.eu/2024/05/24/iqvia-japans-pharmaceutical-market-2023/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/05/21/11930/ According to a market survey by ISQIA,"anti-tumor drugs" ranked first at 1,959.4 billion yen. The market is overwhelmingly large and continues to grow strongly, approaching 2 trillion yen. Its share of the total market was 17.2%. IQVIA said that in addition to Imfinzi, the anti-CD79b monoclonal antibody conjugated to a microtubule inhibitor, Polivee (polatuzumab
- [Human vaccination with micro algae vaccines?](https://window-to-japan.eu/2024/05/24/human-vaccination-with-micro-algae-vaccines/) - https://bio.nikkeibp.co.jp/atcl/column/16/041300080/042400011/ Professor Shinya Miyagijima of the National Institute of Genetics and colleagues have established a new haploid cell line from the microalgae Cyanidium calgarum discovered in acidic hot springs in Japan. The established haploid strain does not have a cell wall. Therefore, it is easy to perform genetic recombination. There is no need to disrupt
- [2024/04 Mitsui Chemicals starts producing chemicals from pyrolyzed bio & waste plastic oil, and cooperates with Kao on polymer recycling](https://window-to-japan.eu/2024/05/18/2024-04-mitsui-chemicals-starts-producing-chemicals-from-pyrolyzed-bio-waste-plastic-oil-and-cooperates-with-kao-on-polymer-recycling/) - https://jp.mitsuichemicals.com/jp/release/2024/2024_0322/index.htm Mitsui Chemicals has started to use pyrolyzed oil (hereinafter referred to as waste plastic decomposed oil) procured from CFP Co. in its cracker at Osaka factory (Takaishi City, Osaka Prefecture) for mass production of a wide range of products (chemicals and plastics). Waste plastic cracked oil ("RePlayer"), like petroleum-derived naphtha and biomass naphtha ("BePlayer"), is
- [Sumitomo announces clinical tests with universal influenza type A vaccine in Belgium](https://window-to-japan.eu/2024/05/17/sumitomo-announces-clinical-tests-with-universal-influenza-type-a-vaccine-in-belgium/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/05/15/11904/ Sumitomo Pharma and the National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN) will start Phase I clinical trials for fH1/DSP-0546LP, a universal influenza vaccine for influenza type A, even if a mutation occurs. Membrane-fused hemagglutinin will be used as the antigen. The membrane-fused hemagglutinin used as an antigen is made by changing the
- [TOWING and Mitsubishi Research Institute: field test of carbon farming using a high performance biochar](https://window-to-japan.eu/2024/04/07/towing-and-mitsubishi-research-institute-field-test-of-carbon-farming-using-a-high-performance-biochar/) - https://bio.nikkeibp.co.jp/atcl/release/24/03/21/19810/ TOWING and Mitsubishi Research Institute have started a field demonstration of carbon farming using TOWING's high-performance biochar "Soratan" in Miyazaki Prefecture on March 1. The application of the high-functional biochar will improve the quality of farmland soil and increase productivity, as well as reduce greenhouse gas emissions through soil carbon sequestration.
- [Mitsui Chemicals starts producing chemicals from pyrolyzed bio & waste plastic oil, and cooperates with Kao on polymer recycling](https://window-to-japan.eu/2024/04/07/mitsui-chemicals-starts-producing-chemicals-from-a-cracker-using-bio-pyrolyzed-waste-plastic-oil-and-cooperates-with-kao/) - https://jp.mitsuichemicals.com/jp/release/2024/2024_0322/index.htm Mitsui Chemicals has started to use pyrolyzed oil (hereinafter referred to as waste plastic decomposed oil) procured from CFP Co. in its cracker at Osaka factory (Takaishi City, Osaka Prefecture) for mass production of a wide range of products (chemicals and plastics). Waste plastic cracked oil ("RePlayer"), like petroleum-derived naphtha and biomass naphtha ("BePlayer"), is
- [NITE and NEDO launch Green Innovation Forum for CO2-based applied industrial microbiology](https://window-to-japan.eu/2024/04/07/nite-and-nedo-launch-green-innovation-forum-for-co2-based-applied-industrial-microbiology/) - https://www.nite.go.jp/nbrc/information/release/20240326.html The National Institute of Technology and Evaluation (NITE) has launched a new project, "Green Innovation", in which microorganisms that contribute to the production of useful substances from carbon dioxide (CO2) and related information (growth conditions, genome information, useful gene information, etc.) will be made available to companies from the project period. The New Energy
- [Kao develops mosquito skin repellant based on silicone](https://window-to-japan.eu/2024/04/07/kao-develops-mosquito-skin-repellant-based-on-silicone/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/03/15/11690/ Kao has commercialized an insect repellent in Thailand and Singapore using silicone oil. The cream-like formulation contains silicone oil and citronella oil. It is well received for its non-irritating and easy-to-like scent.In the regions where it was released, people have a lifestyle of using body lotion to moisturize after bathing, so by using Mos
- [Sumitomo Pharma begins Phase 1/2 of allogeneic iPS cell-derived dopaminergic neural progenitor cells in the USA](https://window-to-japan.eu/2024/04/07/sumitomo-pharma-begins-phase-1-2-of-allogeneic-ips-cell-derived-dopaminergic-neural-progenitor-cells-in-the-usa/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/03/29/11755/ The company filed a clinical trial application (IND) in February 2024, and recently completed a 30-day investigation by the U.S. Food and Drug Administration (FDA). This corporate clinical trial uses frozen allogeneic iPS cell-derived dopaminergic neural progenitor cells. Allogeneic iPS cells will be induced to differentiate at Sumitomo Pharma's regenerative and cell therapy manufacturing
- [Vetanic Co. develops regenerative medicine products using dog and cat iPS cell production technology](https://window-to-japan.eu/2024/04/07/vetanic-co-develops-regenerative-medicine-products-using-dog-and-cat-ips-cell-production-technology/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/03/29/11757/ The company's basic technology involves introducing an animal reprogramming factor into cells using a plasmid vector and culturing it under specific conditions to create iPS cells. The company is currently developing regenerative medicine products using canine iPS cells. As a candidate for the next pipeline, it also succeeded in producing cat iPS cells. In
- [Yamaguchi University's Institute for Cell Design and Medical Science develops cell and gene therapy for humans and companion animals](https://window-to-japan.eu/2024/03/07/yamaguchi-universitys-institute-for-cell-design-and-medical-science-develops-cell-and-gene-therapy-for-humans-and-companion-animals/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/02/29/11648/ Yamaguchi University's Institute for Cell Design and Medical Science is focused on cell and gene therapy for both humans and companion animals. The research structure consists of advanced cell therapy research that is responsible for the production of modified cells such as chimeric antigen receptor T cells (CAR-T), the development of automatic culture technology,
- [Seven Japanese companies form microbiome consortium focused on short-chain fatty acids](https://window-to-japan.eu/2024/03/07/seven-japanese-companies-form-microbiome-consortium-focused-on-short-chain-fatty-acids/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/03/02/11654/ Seven Japanese companies have initiated an "Intestinal Design Co-Creation Project" with a focus on short-chain fatty acids. Short-chain fatty acids are a general term for metabolic substances produced by intestinal bacteria when they break down dietary fibers and oligosaccharides, and mainly include acetic acid, propionic acid, and butyric acid. Participants are Metagen, Ezaki Glico, Calbee,
- [2024/03 NEDO initiates program on ammonia fuel ship engines](https://window-to-japan.eu/2024/03/07/2024-03-nedo-initiates-program-on-ammonia-fuel-ship-engines/) - https://www.nedo.go.jp/news/press/AA5_101727.html The shipping industry is one of the priority areas of the green growth strategy. Approximately 700 million tons of CO2 are emitted annually from international shipping, accounting for approximately 2.1% of the world's total CO2 emissions (as of 2018). The commercial operation of next-generation ships powered by hydrogen, ammonia, LNG, and other fuels will
- [Blick nach Asien 2024/03](https://window-to-japan.eu/2024/03/07/blick-nach-asien-2024-03/) - Blick nach Asien 2024:03
- [Solar thermal decomposition of CO2 using CeO2 and hercynite](https://window-to-japan.eu/2024/02/07/thermal-decomposition-of-co2-using/) - https://www.nedo.go.jp/news/press/AA5_101720.html As part of the NEDO-funded "International Collaborative Research and Development of Solar Heat Collection Reactor for Carbon Dioxide Decomposition" Niigata University, the Institute of Industrial Science of the University of Tokyo, Shinshu University and the University of Colorado Boulder have developed a technology that uses a new reactive substance to decompose carbon dioxide by
- [A reconstructed ancestral sortase permits for conjugation of protein to protein or protein to carrier](https://window-to-japan.eu/2024/02/24/a-reconstructed-ancestral-sortase-permits-for-conjugation-of-protein-to-protein-or-protein-to-carrier/) - https://pubs.acs.org/doi/10.1021/acscatal.4c00487 Sortases are prokaryotic enzymes that modify surface proteins by recognizing and cleaving a carboxyl-terminal sorting signal. A team of Japanese scientists has reconstructed an ancestral sortase E, named AcSE5, through a combination of sequence data mining and ancestral sequence reconstruction. AcSE5 is a Ca2+ independent sortase and recognizes donors with LAETG at their C-termini. It
- [NEDO initiates program on carbon neutrality in waste and resource circulation](https://window-to-japan.eu/2024/02/15/nedo-initiates-project-on-carbon-neutrality-in-waste-and-resource-circulation/) - https://www.nedo.go.jp/content/100972177.pdf The announced budget is 44.5 billion yen (– 275 million €) for the period of 2023 – 2030. The current four project groups and their leaders are Project name Project leader 1 Development of an overall Carbon Nitrogen waste incineration system based on CO2 separation and recovery Nittetsu Engineering Corporation 2 Development of
- [Biotech budgets 2024 of the Japanese government](https://window-to-japan.eu/2024/02/07/biotech-budgets-2024-of-the-japanese-government/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400016/012500325/ Nikkei Biotech has reviewed the biotech budgets of the Japanese government for 2024. Japan's bio-related budget for 2024 remains unchanged at 180.4 billion yen, strengthening cranial nerve disease research and food security Ministry of Health, Labor and Welfare promotes research into elucidating the pathology and diagnosis of dementia. Ministry of Economy, Trade and Industry
- [Current status of antibody development towards COVID-10 variants](https://window-to-japan.eu/2024/02/07/current-status-of-antibody-development-towards-covid-10-variants/) - https://bio.nikkeibp.co.jp/atcl/column/16/052700070/011500024/ An excellent review up to the end of 2023 (in Japanese)
- [Blick nach Asien 2024/02](https://window-to-japan.eu/2024/02/07/blick-nach-asien-2024-02/) - Bildschirmfoto 2024-02-07 um 09.36.42.png
- [2024/01 Japan: a survey on current clinical trials for cell medicines and cell sheets](https://window-to-japan.eu/2024/02/02/2024-01-japan-a-survey-on-current-clinical-trials-for-cell-medicines-and-cell-sheets/) - In a recent article in Nikkei Biotech, the state of registration of regenerative medicine products in Japan was summarized and discussed. https://bio.nikkeibp.co.jp/atcl/report/16/082400016/010900318/ At present, there are 16 products of which 2 were conditionally approved and 14 are in various stages of clinical testing. Current CAR-T-related and gene therapy studies were not included in this list.
- [2ß23/12 Kao introduces gallic acid made by synthetic biology](https://window-to-japan.eu/2024/02/02/2s23-12-kao-introduces-gallic-acid-made-by-synthetic-biology/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/12/13/11409/ On December 13, 2023, Kao announced that it will begin B-to-B sales of gallic acid in Japan (product name: GA-100 BIO), produced by utilizing genetically engineered coryneform bacteria. Gallic acid is an aromatic compound found in the insect galls of the poison ivy plant, and is used as a chemical necessary for semiconductor circuit
- [Kao introduces gallic acid made by synthetic biology](https://window-to-japan.eu/2023/12/16/11451/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/12/13/11409/ On December 13, 2023, Kao announced that it will begin B-to-B sales of gallic acid in Japan (product name: GA-100 BIO), produced by utilizing genetically engineered coryneform bacteria. Gallic acid is an aromatic compound found in the insect galls of the poison ivy plant, and is used as a chemical necessary for semiconductor circuit
- [NEDO consortium pioneers ground improvement with CO2-fixed cement](https://window-to-japan.eu/2024/02/02/nedo-consortium-pioneers-ground-improvement-with-co2-fixed-cement/) - https://www.nedo.go.jp/news/press/AA5_101721.html In Japan, approximately 8 million tons or approximately 20% of domestic cement demand are used annually for ground improvement. Takenaka, Kajima and Denka Corporation are developing carbon negative concrete CUCO® that emits virtually no carbon dioxide (CO2) during the concrete manufacturing process. Takenaka Corporation has recently developed a "CUCO®-CO2 fixation ground improvement method which
- [Nikkei Biotech publishes  2024 "sumo ranking" of Japanese pharma](https://window-to-japan.eu/2024/01/29/nikkei-biotech-publishes-2024-sumo-ranking-of-japanese-pharma/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400017/012500075/ According to this analysis, the strongest companies ("Ozeki") in Kansai are Eisai and Astellas, in Kanto Daiichi Sankyo and Chugai Pharma. The analysis contains many interesting details on Japan's pharmaceutical industry, including pharma-related startups.
- [Cultured meat from pluripotent fat cells: Ebara](https://window-to-japan.eu/2024/01/26/cultured-meat-from-pluripotent-fat-cells-ebara/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/01/17/11509/ Nihon University and Ebara Corporation study pluripotent cells made from fat cells to produce cultured meat. Using a specific method, dedifferentiated fat cells DFAT' can be differentiated into mesodermal tissues. DFAT is a pluripotent cell that can be created by enzymatically decomposing adipose tissue, fractionating it, removing the adipocytes, and culturing them using a
- [Silk Strand Pharma uses silkworms for the preclinical testing of new antibiotics](https://window-to-japan.eu/2024/01/25/silk-strand-pharma-uses-silkworms-for-the-preclinical-testing-of-new-antibiotics/) - https://bio.nikkeibp.co.jp/atcl/column/16/021500017/012300318/ Silk Strand Pharma, a startup in Tokyo that develops antibacterial and antiviral drugs to fight infectious diseases, uses silkworms for toxicity testing The use a "S-cubic system" to find antibiotics active against gram-positive bacteria resistant to methicillin and discovered Lysocin E, a new antibacterial candidate against Staphylococcus aureus (MRSA). Based on these results, Silk
- [Consortium achieves manufacture of "carbon negative" tetrapods for wave dissipation](https://window-to-japan.eu/2024/01/25/consortium-achieves-manufacture-of-carbon-negative-tetrapods-for-wave-dissipation/) - https://www.nedo.go.jp/news/press/AA5_101715.html A consortium from Kajima, Denka and Takenaka Corporation, under a contract of NEDO, develop CUCO® concrete manufacturing, a carbon negative concrete that emits less than zero carbon dioxide (CO2) during the concrete manufacturing process. Fudo Tetra Co., Ltd., a joint partner of Kajima and this project, manufactures and ships carbon negative concrete at a
- [iPS cell technology may replace animal tests in some drug screening](https://window-to-japan.eu/2024/01/24/ips-cell-technology-instead-of-animal-tests-in-drug-screening/) - https://bio.nikkeibp.co.jp/atcl/news/p1/24/01/22/11525/ A research group led by Professor Masato Fujioka and Lecturer Kazuo Nagao of Kitasato University School of Medicine and ITO EN announced the start of industry-academia joint research on the efficacy of green tea ingredients for age-related hearing loss. They aim to develop the product as a functional food or food for specified health
- [Japan: a survey on current clinical trials for cell medicines and cell sheets](https://window-to-japan.eu/2024/01/15/japan-a-survey-on-current-clinical-trials-for-cell-medicines-and-cell-sheets/) - In a recent article in Nikkei Biotech, the state of registration of regenerative medicine products in Japan was summarized and discussed. https://bio.nikkeibp.co.jp/atcl/report/16/082400016/010900318/ At present, there are 16 products of which 2 were conditionally approved and 14 are in various stages of clinical testing. Current CAR-T-related and gene therapy studies were not included in this list.
- [Blick nach Asien 2024/01](https://window-to-japan.eu/2024/01/13/blick-nach-asien-2024-01/) - Bildschirmfoto 2024-01-13 um 18.27.01.png
- [Remote palpitation will help telemedicine](https://window-to-japan.eu/2024/01/13/remote-palpitation-will-help-telemedicine/) - https://www.nedo.go.jp/news/press/AA5_101711.html Hokkaido University, BIPROGY Corporation, and Technoface Co. have developed a remote palpation system (hereinafter referred to as this system) that integrates information and examination videos and shares them between remote doctors. We have recently successfully demonstrated remote palpation connecting three locations: Hokkaido University Hospital (Sapporo City, Hokkaido), Obihiro Kosei Hospital (Obihiro City, Hokkaido), and
- [Sumitomo starts clinical trial on iPS cell-derived dopamine neural progenitor cells in the USA](https://window-to-japan.eu/2023/12/29/sumitomo-starts-clinical-trial-on-ips-cell-derived-dopamine-neural-progenitor-cells-in-the-usa/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/12/26/11462/ Sumitomo Pharma announced that the Stanford Stem Cell Institute CIRM will start a physician-initiated clinical trial for Parkinson's disease treatment using heterologous iPS cells. The clinical trial will use iPS cells derived from a QHJI donor and provided by the Kyoto University iPS Cell Research Foundation. Sumitomo Pharma will produce dopamine neural progenitor cells
- [Sysmex acquires Megakaryon and aims for fast commercialization of iPS platelets](https://window-to-japan.eu/2023/12/29/sysmex-acquires-megakaryon-and-aims-for-fast-commercialization-of-ips-platelets/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/12/21/11450/ Sysmex has acquired additional shares of Megakaryon, a company with technology to generate platelets from iPS cells, making it a consolidated subsidiary as of December 20, 2023. Megakaryon is a startup established in September 2011 to commercialize the research results of Professor Hiroyuki Eto and his team at the Center for iPS Cell Research
- [Euglena Co. to sell algal feed and fertiliser](https://window-to-japan.eu/2023/12/29/euglena-co-to-sell-algal-feed-and-fertiliser/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/12/18/11422/ Euglena announced that it will start to utilize Euglena powdering the agri-business field because of its low environmental impact and high value-added. The company's agri-tech business has two pillars: animal feed and crop fertilizers. The company has obtained various data showing that the addition of Euglena activates the function of lactic acid bacteria, and
- [Blick nach Asien 2023/12](https://window-to-japan.eu/2023/12/14/blick-nach-asien-2023-12/) - Bildschirmfoto 2023-12-14 um 13.48.28.png
- [iFactory allows for on-demand continuous production of pharmaceuticals](https://window-to-japan.eu/2023/12/14/ifactory-allows-for-on-demand-continuous-production-of-pharmaceuticals/) - https://www.nedo.go.jp/news/press/AA5_101710. As part of the NEDO-subsidized "Strategic Energy Saving Technology Innovation Program" , Takasago Chemical Co., Ltd., Mitsubishi Tanabe Pharma Co., Ltd., Konica Minolta Chemical Co., Ltd., Yokogawa Solution Service Co., Ltd., and Tech Project Service Co., Ltd. Taisei Corporation, Shimadzu Corporation, Mitsubishi Kakoki Co., Ltd., and the National Institute of Advanced Industrial Science and
- [2023/11 CCUS: Japan inaugurates ship for liquid CO2 sea transport](https://window-to-japan.eu/2023/12/02/2023-11-ccus-japan-inaugurates-ship-for-liquid-co2-sea-transport/) - https://www.nedo.go.jp/news/press/AA5_101705.html The CO2 transport test ship "Ekusukuru", which incorporates a marine cargo tank system for transporting carbon dioxide (CO2) and was developed as part of the "CCUS Research, Development and Verification Project" commissioned by NEDO, was completed, and a naming and delivery ceremony was held. (NGL) and the Engineering National Association of Japan (ENAA), which
- [Three leading bio/healthcare startups: Spiber, Inovacel and CureApp](https://window-to-japan.eu/2023/12/02/three-leading-bio-healthcare-startups-spiber-inovacel-and-cureapp/) - A recent article in the magazine Nikkei Biotech looks at the situation of Japanese start-ups in bio and healthcare. https://bio.nikkeibp.co.jp/atcl/news/p1/23/11/24/11338/ The funding environment for startups in Japan is less mature than in Europe and the United States, and the amounts raised per funding round are generally small. Recently, however, some Japanese bio/healthcare startups have raised
- [CCUS: Japan inaugurates ship for liquid CO2 sea transport](https://window-to-japan.eu/2023/11/29/ccus-japan-inaugurates-ship-for-liquid-co2-sea-transport/) - https://www.nedo.go.jp/news/press/AA5_101705.html The CO2 transport test ship "Ekusukuru", which incorporates a marine cargo tank system for transporting carbon dioxide (CO2) and was developed as part of the "CCUS Research, Development and Verification Project" commissioned by NEDO, was completed, and a naming and delivery ceremony was held. (NGL) and the Engineering National Association of Japan (ENAA), which
- [Shimadzu subsidiary launches screening tests for newborn](https://window-to-japan.eu/2023/11/24/shimadzu-subsidiary-launches-screening-tests-for-newborn/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/11/21/11323/ Shimadzu Corporation announced that its subsidiary Shimadzu Diagnostics will begin selling the TKSneoFinder detection reagent set, a PCR reagent kit for newborn screening tests. In conjunction with the sales of the kit, Shimadzu Techno-Research, a subsidiary of Shimadzu Corporation, plans to launch a contract newborn screening testing business within FY2023. TKSneoFinder is a PCR
- [Green Earth Institute GEI announces new focus areas](https://window-to-japan.eu/2023/11/24/green-earth-institute-gei-announces-new-focus-areas/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/11/21/11321/ During a financial results meeting for the fiscal year ending September 30, 2023, the company introduced the pipeline it is currently developing and explained the areas it will focus on in the future. The company's FY09/2023 sales were 897 million yen (+53.4% YoY), with an operating loss of 106 million yen (vs. an operating
- [Japanese student team wins world synthetic biology competition with production of antidepressants by E. coli](https://window-to-japan.eu/2023/11/24/japanese-student-team-wins-world-synthetic-biology-competition-with-production-of-antidepressants-by-e-coli/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/11/15/11297/ The International Genetically Engineered Machine competition (iGEM), an event in which students from around the world compete for research ideas and results in the field of synthetic biology, was held in France from November 2-5, 2023, and a team of Japanese junior and senior high school students won. The team, called "Japan-United," was headed
- [2023/10 RIKEN to use generative AI in search for exhaustive hypotheses that exceed human cognitive abilities](https://window-to-japan.eu/2023/11/07/2023-10-riken-to-use-generative-ai-in-search-for-exhaustive-hypotheses-that-exceed-human-cognitive-abilities/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/09/06/11054/ A new program “Development and sharing of generative AI models for scientific research” aims to train RIKEN’s experimental/measurement data and paper data to generate hypotheses, experimental plans, etc. Researchers brush up their hypotheses by interacting with AI. First, the policy is to develop for the life/medical science field and the material/physical science field. The
- [Euglena biofuel production plant moving towards commercialization](https://window-to-japan.eu/2023/11/07/euglena-biofuel-production-plant-moving-towards-commercialization/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/10/31/11231/ Euglena is used to produce biofuels such as Sustainable Aviation Fuel (SAF), biodiesel fuel, and bionaphtha by adding fats and oils extracted from the microalgae Euglena to used cooking oil. Biofuels are being produced at a biofuel manufacturing demonstration plant in Yokohama City. The plant is scheduled to close by the end of January
- [Blick nach Asien 2023/10](https://window-to-japan.eu/2023/11/07/blick-nach-asien-2023-10/)
- [Takenaka's CUCO cement features over 80% reduction of CO2 emissions during production](https://window-to-japan.eu/2023/10/19/takenakas-cuco-cement-features-over-80-reduction-of-co2-emissions-during-production/) - https://www.nedo.go.jp/news/press/AA5_101698.html As part of NEDO's Green Innovation Fund project "Development of concrete manufacturing technology using CO2", Takenaka Corporation, together with Kajima Corporation and Denka Corporation, will develop carbon negative concrete that emits less than zero carbon dioxide (CO2) during the concrete manufacturing process. They have developed a concrete product called CUCO-precast material for construction that
- [2023/09 Sakana Dream Co. develops high-value aquaculture fish through reproductive stem cell transplantation](https://window-to-japan.eu/2023/10/07/2023-09-sakana-dream-co-develops-high-value-aquaculture-fish-through-reproductive-stem-cell-transplantation/) - https://bio.nikkeibp.co.jp/atcl/column/16/021500017/100300305/ https://sakana-dream.com/english Sakana Dream (Tateyama City, Chiba Prefecture) is developing and marketing new cultured fish by applying a surrogate fish parent technique that transplants reproductive stem cells between different species. The technology is based on that of Professor Goro Yoshizaki of the Tokyo University of Marine Science and Technology, who is known for his "research
- [Sakana Dream Co. develops high-value aquaculture fish through reproductive stem cell transplantation](https://window-to-japan.eu/2023/10/07/sakana-dream-co-develops-high-value-aquaculture-fish-through-reproductive-stem-cell-transplantation/) - https://bio.nikkeibp.co.jp/atcl/column/16/021500017/100300305/ https://sakana-dream.com/english Sakana Dream (Tateyama City, Chiba Prefecture) is developing and marketing new cultured fish by applying a surrogate fish parent technique that transplants reproductive stem cells between different species. The technology is based on that of Professor Goro Yoshizaki of the Tokyo University of Marine Science and Technology, who is known for his "research
- [Idemitsu Kosan establishes joint research department at Kobe University for smart cells for making agrochemicals and oils](https://window-to-japan.eu/2023/10/07/idemitsu-kosan-establishes-joint-research-department-at-kobe-university-for-smart-cells-for-making-agrochemicals-and-oils/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/10/02/11138/ Idemitsu Kosan has established the Idemitsu Joint Research Division for Biotech Manufacturing at Kobe University's Center for Advanced Biotechnology Research. The joint research division will work on the development of smart cells (genetically modified microorganisms and cells) for the production of biofuels, bio-chemicals, and bio-agrochemicals, with the aim of building a bio-manufacturing value chain.
- [Japan: bioplastics production increases due to government support](https://window-to-japan.eu/2023/10/07/japan-bioplastics-production-increases-due-to-government-support/) - https://bio.nikkeibp.co.jp/atcl/column/16/031700078/092600020/ Bioplastics, which are made from renewable resources and are biodegradable, have been rapidly gaining popularity in recent years. With the Japanese government's promotion of bioplastics, companies are increasing production of existing products and developing new ones. The challenges are to further reduce the environmental impact of manufacturing and use, and to improve functionality in
- [Kirin offers MicroBio Me gut bacteria test](https://window-to-japan.eu/2023/10/07/kirin-offers-microbio-me-gut-bacteria-test/) - https://bio.nikkeibp.co.jp/atcl/column/16/020100064/090600018/ The MicroBio Me kit is a gut bacteria test offered by Kirin HD. This test was developed by Thorne, a company that manufactures and sells supplements and conducts a variety of other tests. The test is characterized by the use of shotgun metagenomic sequencing, which directly reads the genome sequence, rather than the 16S rRNA
- [Kajima develops extraction system for proteins from GEM plants](https://window-to-japan.eu/2023/10/07/kajima-develops-extraction-system-for-proteins-from-gem-plants/) - https://www.nedo.go.jp/news/press/AA5_101695.html Kajima Corporation is participating in joint research on the "Demonstration and Development of a Large-Scale Production System for Useful Materials Using Genetically Modified Plants" under NEDO's "Development of Bio-based Product Production Technology to Accelerate the Realization of Carbon Recycling". As part of this research, Kajima has recently developed an integrated extraction system that can
- [A hybrid stirrer system allows for cultivation of mycelia in a single-use bioreactor](https://window-to-japan.eu/2023/10/07/a-hybrid-stirrer-system-allows-for-cultivation-of-mycelia-in-a-single-use-bioreactor/) - https://www.nedo.go.jp/news/press/AA5_101694.html Satake Multimix Corporation, Tohoku University and Godo Shusei Co. as part of NEDO's "Development of Bio-based Product Production Technology to Accelerate the Realization of Carbon Recycling" project have established a stirring system that can efficiently stir the culture medium with lower power and ensure aeration volume. By establishing a stirring system that can efficiently agitate the culture
- [CarbGem introduces AI to determine antibiotic resistance upon bacterial infection](https://window-to-japan.eu/2023/08/07/carbgen-introduces-ai-to-determine-antibiotic-resistance-upon-bacterial-infection/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/07/30/10951/ https://carbgem.com/en/ CarbGem and its parent company, NexGen have filed for manufacturing and marketing approval for AI software that estimates the bacterial species of bacterial infections and supports diagnosis and selection of therapeutic agents. The AI software analyzes Gram-stained images of urine tests to estimate the species of bacteria. the AI software is linked to
- [CarbGem has developed a 5 min automatic GRAM staining device](https://window-to-japan.eu/2023/09/04/carbgen-has-developed-a-5-min-automatic-gram-staining-device/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/08/29/11028/ https://carbgem.com/en/ The startup CarbGem uses AI and other technologies to test for infectious disease. The company now has developed a compact automated Gram staining device called PoCGS-iE. In addition to research institutions, the company will also sell the product to food companies, livestock farms, and other companies with a need to confirm bacterial species.
- [BioPhenolics Co. aims at mass production of dozens of aromatic chemicals using "smart cells"](https://window-to-japan.eu/2023/09/10/biophenolics-co-aims-at-mass-production-of-dozens-of-aromatic-chemicals-using-smart-cells/) - https://bio.nikkeibp.co.jp/atcl/column/16/021500017/090500297/ https://bio-phenolics.com/?page_id=68 BioPhenolics is a startup from the University of Tsukuba that is conducting research and development of technology to produce aromatic hydrocarbon chemicals with benzene rings using improved microorganisms ("smart cells"). Currently, BioPhenolics has a pipeline of more than 10 chemical products that it is independently researching and developing, and when combined with the
- [RIKEN to use generative AI in search for exhaustive hypotheses that exceed human cognitive abilities](https://window-to-japan.eu/2023/09/10/riken-to-use-generative-ai-in-search-for-exhaustive-hypotheses-that-exceed-human-cognitive-abilities/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/09/06/11054/ In 2024, MEXT will fund a project (“Development and sharing of generative AI models for scientific research”) at RIKEN to develop generative AI that forms hypotheses through dialogue with researchers. The project aims to train RIKEN’s experimental data and published data to generate hypotheses, experimental plans, etc., to help researchers brush up their hypotheses
- [Takara Bio establish technology to manufacture CAR-T cells within 2 days](https://window-to-japan.eu/2023/09/10/takara-bio-establish-technology-to-manufacture-car-t-cells-within-2-days/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/09/05/11051/ Takara Bio has announced that it has established a technology to rapidly produce chimeric antigen receptor T cells (CAR-T cells). By shortening the culture period to two days, it is possible to produce CAR-T cells with higher cytotoxic activity than usual, and the company plans to utilize this in its CDMO business. The company's CDMO
- [Chitose and Kyowa Hakko Bio improve fermentation yields by 10% using AI](https://window-to-japan.eu/2023/09/10/chitose-and-kyowa-hakko-bio-improve-fermentation-yields-by-10-using-ai/) - https://www.nedo.go.jp/news/press/AA5_101685.html Fermentation production of food materials requires the wisdom, know-how, and so-called "craftsmanship" of experts to ensure stable production, such as setting optimal culture conditions. On the other hand, it takes a very long time to inherit and acquire the "craftsmanship" of such skilled workers, the aging of skilled workers, and the outflow of technology
- [2023/08 Japan's Fermelanta to produce bio-based pharmaceutical and cosmetic ingredients using E. coli](https://window-to-japan.eu/2023/09/04/2023-08-japans-fermelanta-to-produce-bio-based-pharmaceutical-and-cosmetic-ingredients-using-e-coli/) - https://fermelanta.com https://bio.nikkeibp.co.jp/atcl/column/16/021500017/080100292/ Firmelanta is a startup from Ishikawa Prefectural University that uses E. coli bacteria to create biotech products. The company is currently constructing various recombinant E. coli strains for the production of pharmaceutical and cosmetic ingredients. In addition to its own production of pharmaceutical and cosmetic ingredients using the strains it has developed, the
- [Japanese consortium: flavor of cultured meat needs improvement](https://window-to-japan.eu/2023/09/04/japanese-consortium-flavor-of-cultured-meat-needs-improvement/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/08/31/11042/ According to a joint poster presentation at the 5th Cellular Agriculture Conference by Professor Noriya Matsuzaki and his team from Osaka University, Toppan Printing, Shimadzu Corporation and Itoham, the taste of cultured meat still needs some improvement. Prof. Matsuzaki and his colleagues have developed technology to produce cultured meat using a 3D printer. Muscle
- [Astellas pioneers use of double-armed robot Mahoro in cell culture R&D](https://window-to-japan.eu/2023/08/22/astellas-pioneers-use-of-double-armed-robot-mahoro-in-cell-culture-rd/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/08/18/11005/ According to Nikkei Biotech, Astellas Pharma Inc. held a media tour at the Tsukuba Biotechnology Research Center on August 7, 2023. During the tour, robot Mahoro was shown to the media operating a culture plate. Mahoro is a dual-armed robot developed by the Robotic Biology Institute (Koto, Tokyo; Kenji Matsuguma, President) and the National
- [Japan's Fermelanta to produce bio-based pharmaceutical and cosmetic ingredients using E. coli](https://window-to-japan.eu/2023/08/18/japans-fermelanta-to-produce-bio-based-pharmaceutical-and-cosmetic-ingredients-using-e-coli/) - https://fermelanta.com https://bio.nikkeibp.co.jp/atcl/column/16/021500017/080100292/ Firmelanta is a startup from Ishikawa Prefectural University that uses E. coli bacteria to create biotech products. The company is currently constructing various recombinant E. coli strains for the production of pharmaceutical and cosmetic ingredients. In addition to its own production of pharmaceutical and cosmetic ingredients using the strains it has developed, the
- [Japan's NEDO goes for carbon-neutral ammonia-combusting industrial furnaces](https://window-to-japan.eu/2023/08/18/japans-nedo-goes-for-carbon-neutral-ammonia-combusting-industrial-furnaces/) - https://www.nedo.go.jp/news/press/AA5_101678. As part of the Green Innovation Fund Project, NEDO will launch the "Decarbonization of Thermal Processes in the Manufacturing Sector" project (total budget: 30.41 billion yen) with the aim of achieving "carbon neutrality by 2050. The project will work on the establishment of combustion technologies required for carbon-neutral industrial furnaces, and technologies for reducing
- [2023/07 Mahoro humanoid robot improves the handling of cell cultures](https://window-to-japan.eu/2023/08/18/2023-07-mahoro-humanoid-robot-improves-the-handling-of-cell-cultures/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/06/29/10868/ The general-purpose humanoid robot "Mahoro" is one of the most well-known of all experimental automation devices. Mahoro has a long history of development and was first announced in its current form in 2012. Since then, it has been gradually introduced to companies and research institutes. Mahoro excels at delicate work, and it can also
- [Japan demonstrates battery controller for solar roads](https://window-to-japan.eu/2023/08/07/japan-demonstrates-battery-controller-for-solar-roads/) - https://www.nedo.go.jp/news/press/AA5_101674.html Under NEDO's "Technology Research and Development Project for Discovery and Commercialization of New Energy and Other Seeds", MIRAI-LABO Co., Ltd. has developed the "Solar Mobiway," a solar power generation panel that can be laid on the road surface, and EV Repurpose, which reuses batteries discharged from used electric vehicles (EVs). The Autonomous Intelligent Road
- [Bifidobacterium bifidum administered to newborns forms bifidobacteria-dominant flora: Morinaga](https://window-to-japan.eu/2023/07/30/bifidobacterium-bifidum-administered-to-newborns-forms-bifidobacteria-dominant-flora-morinaga/) - https://bio.nikkeibp.co.jp/atcl/column/16/052000031/072700119/ Morinaga Milk Industry has confirmed that early administration of Bifidobacterium bifidum to healthy full-term infants promotes the formation of bifidobacteria-dominant flora. In addition, beneficial physiological functions were also observed, such as a decrease in the frequency of defecation and an increase in the secretion of acetic acid and secretory immunoglobulin A (sIgA) in the
- [Blick nach Asien 2023/07](https://window-to-japan.eu/2023/07/21/blick-nach-asien-2023-07/) - Blick nach Asien 2023:07
- [Chugai's new research center is full of laboratory automation](https://window-to-japan.eu/2023/07/20/chugais-new-research-center-is-full-of-laboratory-automation/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/07/18/10912/ On July 18, 2023, Chugai Pharmaceutical held a media tour of its new research base, Chugai Life Science Park Yokohama. The new research base was completed on October 15, 2022, and began full-scale operations in April 2023. The center plans to advance drug discovery research based on laboratory automation and AI drug discovery. During
- [Mahoro humanoid robot may improve the handling of cell cultures](https://window-to-japan.eu/2023/07/18/mahoro-humanoid-robot-may-improve-the-handling-of-cell-cultures/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/06/29/10868/ The general-purpose humanoid robot "Mahoro" is one of the most well-known of all experimental automation devices. Mahoro has a long history of development and was first announced in its current form in 2012. Since then, it has been gradually introduced to companies and research institutes. Mahoro excels at delicate work, and it can also
- [JGC and Bacchus Co to cooperate on green chemicals from biofoundries](https://window-to-japan.eu/2023/07/18/jgc-and-bacchus-co-to-cooperate-on-green-chemicals-from-biofoundries/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/07/08/10893/ JGC Holdings (HD), which focuses on engineering, procurement, and construction (EPC) of plants, and Bacchus BioInnovation (Kobe, President Mikio Tanji), a Kobe University startup, announced that they will collaborate in the biofoundry business, which produces useful substances using microbes and other materials. Bacchus, of which Professor Akihiko Kondo of Kobe University's Graduate School serves
- [Hyperion FoodTech establishes bovine ES cells for application to cultured meat](https://window-to-japan.eu/2023/07/10/hyperion-foodtech-establishes-bovine-es-cells-for-application-to-cultured-meat/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/07/05/10883/ Hyperion FoodTech (Nara City, President Kazuhiro Takekita), a company involved in the research and development of new food materials such as cultured meat, announced the establishment of pluripotent stem cells (ES cells) from fertilized embryos from domestic cattle. Bovine ES cells will be differentiated into bovine skeletal muscle cells, which will be used to
- [Spraying of yeast esterase accelerates degradation of biodegradable mulch films](https://window-to-japan.eu/2023/07/10/spraying-of-yeast-esterase-accelerates-degradation-of-biodegradable-mulch-films/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/07/05/10885/ Biodegradable mulch film has been commercially available for about 20 years. Hiroko Kitamoto and her team from theNational Institute of Agro-Environmental Sciences had discovered that Pseudozyma Antarctica which is ubiquitous on plant surfaces, break down biodegradable plastics by a secreted esterase PaE . This degrading enzyme, PaE, was known to degrade polybutylene succinate adipate
- [2023/06: Shimadzu test-markets intestinal bacteria co-culture device](https://window-to-japan.eu/2023/06/30/2023-06-shimadzu-test-markets-intestinal-bacteria-co-culture-device/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/06/21/10838/ Shimadzu Corporation begins test marketing of its "Intestinal Bacteria Co-Culture Device", which can co-culture intestinal bacteria and intestinal epithelial cells. In recent years, the development of pharmaceuticals and foods that utilize intestinal bacteria has been gaining momentum. Research on intestinal bacteria requires reproduction of the intestinal environment consisting of intestinal microflora and intestinal epithelium,
- [Shimadzu test-markets intestinal bacteria co-culture device](https://window-to-japan.eu/2023/06/30/shimadzu/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/06/21/10838/ Shimadzu Corporation begins test marketing of its "Intestinal Bacteria Co-Culture Device," which can co-culture intestinal bacteria and intestinal epithelial cells. In recent years, the development of pharmaceuticals and foods that utilize intestinal bacteria has been gaining momentum. Research on intestinal bacteria requires reproduction of the intestinal environment consisting of intestinal microflora and intestinal epithelium,
- [Japan's Fermelanta to produce new plant chemicals in E. coli using synthetic biology](https://window-to-japan.eu/2023/06/30/japans-fermelanta-to-produce-new-plant-chemicals-in-e-coli-using-synthetic-biology/) - https://www.nedo.go.jp/news/prehttps://fermelanta.com/ss/AA5_101655.html https://fermelanta.com There are many rare and useful components in substances extracted from plants and microorganisms, but the production of substances in nature is unstable in supply and costly. In particular, agricultural production methods are a major barrier to industrial production due to the time-consuming cultivation of the plants, as well as the limited cultivation
- [NEDO supports study on LCA of cellulose nanofiber materials CNF](https://window-to-japan.eu/2023/06/30/nedo-supports-study-on-lca-of-cellulose-nanofiber-materials-cnf/) - https://www.nedo.go.jp/news/press/AA5_101659.html NEDO supports five R&D themes for the "Study and Evaluation of Evaluation Methods for Life Cycle Assessment (LCA) of Cellulose Nanofiber Materials" to accelerate the social implementation of cellulose nanofibers (CNF), and has begun full-scale implementation. The project aims to accelerate CNF-related businesses by visualizing the results of comparisons of CNF's features, such as
- [Japanese consortium applies ammonia combustion to architectural glass production](https://window-to-japan.eu/2023/06/30/japanese-consortium-applies-ammonia-combustion-to-architectural-glass-production/) - https://www.nedo.go.jp/news/press/AA5_101666.html As part of NEDO's "Development of Fuel Ammonia Utilization and Production Technology", AGC Corporation, Taiyo Nippon Sanso Corporation, AIST, and Tohoku University have recently succeeded in the world's first demonstration test of glass production using ammonia as fuel in an actual production reactor. In this demonstration, tests were conducted using a burner developed by
- [B-MED develops "paste-only artificial pancreas" with microneedles releasing insulin](https://window-to-japan.eu/2023/06/30/b-med-develops-paste-only-artificial-pancreas-with-microneedles-releasing-insulin/) - https://bio.nikkeibp.co.jp/atcl/column/16/021500017/062100285/ The company is working on the development of a "microneedle insulin patch," an artificial pancreas made of acrylamide gel containing phenylboronic acid (phenylboronic acid gel), as a new option for diabetes treatment. The microneedle insulin patch is a patch made by forming phenylboronic acid gel into a microneedle shape and filling it with insulin.
- [Qualips targets approval of cardiomyocyte cell sheets derived from heterologous iPS cells](https://window-to-japan.eu/2023/06/30/qualips-targets-approval-of-cardiomyocyte-cell-sheets-derived-from-heterologous-ips-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/06/27/10855/ Qualipse, a developer of iPS cell-derived cardiomyocyte sheets, was founded in March 2017 based on the research findings of Yoshiki Sawa, a specially-appointed professor at Osaka University Graduate School of Medicine, and his colleagues. The company is developing iPS cell-derived cardiomyocyte sheets derived from other iPS cells provided from the iPS cell stock of
- [Regional Fish Co. and NTT cooperate on land-based aquaculture and sales of genome-edited fish and shellfish](https://window-to-japan.eu/2023/06/30/regional-fish-co-and-ntt-cooperate-on-land-based-aquaculture-and-sales-of-genome-edited-fish-and-shellfish/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/06/27/10852/ Regional Fish and NTT announced the establishment of a joint venture company to produce and sell improved seafood on a commercial scale and to start operations on July 1, 2023. Regional Fish markets edible portion-enhanced red sea bream and high-growth tiger pufferfish as genome-edited foods, and has been collaborating with NTT on the breeding
- [NEDO starts wide program on quantum-AI hybrid technology](https://window-to-japan.eu/2023/06/30/nedo-starts-wide-program-on-quantum-ai-hybrid-technology/) - https://www.nedo.go.jp/news/press/AA5_101665.html NEDO has begun development and demonstration of applications and libraries that can address issues that are difficult to solve with conventional technologies, utilizing "Quantum-AI Hybrid Technology" that combines quantum technology and artificial intelligence (AI) in the "Cyber-Physical Development Project for Quantum-AI Hybrid Technology. The focus is on "Materials Development," "Manufacturing," and "Logistics/Transportation". The project
- [HiBD Co. produces certified biojet fuel from waste cooking oil](https://window-to-japan.eu/2023/06/08/11232/) - https://www.nedo.go.jp/news/press/AA5_101656.html The City University of Kitakyushu and HiBD Research Institute have jointly developed a technology for the commercialization of sustainable aviation fuel (SAF) using the patented HiJET technology that conforms to "Annex 2" of ASTM D7566, the international standard for Sustainable Aviation Fuel. This technology uses animal and vegetable fats and oils such as waste
- [GEI opens Biofoundry Manufacturing Plant](https://window-to-japan.eu/2023/06/08/gei-opens-biofoundry-manufacturing-plant/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/06/06/10774/ https://www.nedo.go.jp/news/press/AA5_101654.html On June 2, 2023, Green Earth Institute inaugurated the Biofoundry Research Institute, part of the New Energy and Industrial Technology Development Organization (NEDO) Biofoundry Project, at the Mitsui Chemicals Mobara Branch Plant in Mobara City, Chiba Prefecture. NEDO's biopharmaceutical foundry project aims to establish and demonstrate the technologies necessary to build biomanufacturing using
- [Blick nach Asien 2023/06](https://window-to-japan.eu/2023/06/01/blick-nach-asien-2023-06/) - Blick nach Asien 2023:06
- [2023/05 Kobe's BioPalette develops genetically modified enterobacteria for microbiome therapy](https://window-to-japan.eu/2023/05/31/2023-05-kobes-biopalette-develops-genetically-modified-enterobacteria-for-microbiome-therapy/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/04/25/10628/ https://www.biopalette.co.jp BioPalette is a Kobe University startup established in February 2017 based on research results from Kobe University. Professor Keiji Nishida and his research team at Kobe University's Research Center for Advanced Biotechnology have developed "Target-AID" and "Target-G," base-editing technologies that can rewrite bases without cutting DNA, among other genome editing technologies. Target-AID" uses
- [Kobe's BioPalette develops enterobacteria for microbiome therapy](https://window-to-japan.eu/2023/05/01/kobes-biopalette-develops-enterobacteria-for-microbiome-therapy/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/04/25/10628/ https://www.biopalette.co.jp BioPalette is a Kobe University startup established in February 2017 based on research results from Kobe University. Professor Keiji Nishida and his research team at Kobe University's Research Center for Advanced Biotechnology have developed "Target-AID" and "Target-G," base-editing technologies that can rewrite bases without cutting DNA, among other genome editing technologies. Target-AID" uses
- [NEDO supports ammonia-cofired ship engine development](https://window-to-japan.eu/2023/05/18/nedo-supports-ammonia-cofired-ship-engine-development/) - https://www.nedo.go.jp/news/press/AA5_101651.html NEDO has started the world's first ammonia fuel mixing test using an actual marine 4-stroke engine with an 80% ammonia fuel mixing ratio, which is planned to be installed on an actual vessel. IHI Power Systems is in charge of the development. The actual engine and its peripheral equipment will undergo operational tests to
- [Singapore Umami Meats develops "cultured fish meat"](https://window-to-japan.eu/2023/05/18/singapore-umami-meats-develops-cultured-fish-meat/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/05/15/10688/ Singapore-based Umami Meats, a developer of cultured fish meat, has developed cultured fish fillets using a 3D printer in collaboration with Israel-based Steakholder Foods. The two companies held a tasting event in Israel on the same day, and while efforts to develop cultured beef using 3D printers are underway in Japan, the development of
- [Moderna and IBM use quantum computing and MolFormer-XL, a generative AI, for mRNA medicine](https://window-to-japan.eu/2023/05/18/moderna-and-ibm-use-quantum-computing-and-molformer-xl-a-generative-ai-for-mrna-medicine/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/05/02/10648/ Moderna and IBM announced on April 20, 2023 that they have entered into an agreement to collaborate on the design of safe and effective mRNA medicines. Under the agreement, Moderna plans to leverage next-generation technologies such as quantum computing and generative AI (Generative AI) to accelerate progress in mRNA drug research and development. Over
- [NEDO launches program on new plastics biodegradable in marine waters](https://window-to-japan.eu/2020/09/14/nedo-launches-program-on-new-plastics-biodegradable-in-marine-waters/) - With a fund of NEDO, a consortium of companies, universities and national institutes will develop new plastics biodegradable in the oceans. The program includes analytical procedures, new materials including composites, and new bio-manufacturing processes. As a goal, a domestic market of 200,000 tons for new marine biodegradable plastics should be reached by 2030. NEDO news release,
- [RIKEN team explores PHB bioplastics for tissue engineering](https://window-to-japan.eu/2016/09/01/riken-team-explores-phb-bioplastics-for-tissue-tissue-engineering/) - The RIKEN team around Keiji NUMATA copolymerized a PHBVDB bioplastic from 3 hydroxybutyricacid, 3-hydroxyvaleric acid and a small amoutn of dihydroxybutanoic acid, resulting in a rather hydrophilic surface and high elasticity. Human mesenchymal stem cells grown on this materials did not show any abnormal cell morphology, and dead cells were not observed after several days
- [Kewpie and Hiroshima University create ovomucoid-free chicken eggs by genome editing](https://window-to-japan.eu/2023/05/01/kewpie-and-hiroshima-university-ovomucoid-free-chicken-eggs-by-genome-editing/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/04/26/10634/ Kewpie and Hiroshima University have removed ovomucoid in chicken egg by genome editing. They succeeded in completely eliminating the obomucoid epitope by placing a deletion just behind the translation start point and causing a frameshift. They have also succeeded in suppressing off-target cleavage by using the TALEN technology of Platinum Bio. The obomucoid accounts
- [Galdiera - a red microalgae useful for gold extraction from waste water and micro-mining](https://window-to-japan.eu/2023/05/01/galdiera-a-red-microalgae-useful-for-gold-extraction-from-waste-water-and-micro-mining/) - https://bio.nikkeibp.co.jp/atcl/column/16/021500017/042000276/ Galdieria sulphuraria is a heterotrophic red alga found in sulfuric hot springs. It is a member of the Aedes aegypti Galderia is a startup that aims to cultivate and process Galdieria sulphuraria, and market it as a metal adsorbent for gold, palladium, and other metals. Galdieria sulphuraria is a unicellular red alga that lives
- [2023/04 Chitose Carbon Capture Central (C4) starts 7 ha microalgae cultivation facility in Kuching, Malaysia](https://window-to-japan.eu/2023/05/01/2023-04-chitose-carbon-capture-central-c4-starts-7-ha-microalgae-cultivation-facility-in-kuching-malaysia/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400016/041900285/ Across the road is a thermal power plant, and the CO2 in its exhaust gas is used to cultivate algae in photo bio reactors on 4,54 ha, with the total capacity reaching 4,060 tons (photo courtesy of Chitose Institute). C4 was established on behalf of the New Energy and Industrial Technology Development Organization (NEDO),
- [Toray and Mitsui Sugar realize bagasse-to-sugar plant in Thailand](https://window-to-japan.eu/2023/05/01/toray-and-mitsui-sugar-realize-bagasse-to-sugar-plant-in-thailand/) - https://www.nedo.go.jp/news/press/AA5_101636.html Toray Ltd. and DM Mitsui Sugar have jointly developed a system to produce plant-derived sugar from sugarcane residue (bagasse) generated at sugar refineries in Thailand as part of NEDO's "Demonstration Project on Energy-saving Cellulose Sugar Production System from Surplus Bagasse Raw Material. This system will make it possible to replace petroleum-derived chemicals with chemicals
- [CHITOSE Carbon Capture Central (C4) starts 7 ha microalgae cultivation facility in Kuching, Malaysia](https://window-to-japan.eu/2023/05/01/chitose-carbon-capture-central-c4-starts-7-ha-microalgae-cultivation-facility-in-kuching-malaysia/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400016/041900285/ Across the road is a thermal power plant, and the CO2 in its exhaust gas is used to cultivate algae in photo bio reactors on 4,54 ha, with the total capacity reaching 4,060 tons (photo courtesy of Chitose Institute). C4 was established on behalf of the New Energy and Industrial Technology Development Organization (NEDO),
- [Blick nach Asien 2023/05](https://window-to-japan.eu/2023/05/01/blick-nach-asien-2023-05/) - Blick nach Asien 2023:05.png
- [Japan's bioeconomy: "smart cells," optimized production processes and a shared infrastructure](https://window-to-japan.eu/2023/05/01/japans-bioeconomy-smart-cells-optimized-production-processes-and-a-shared-infrastructure/) - Biofoundry en
- [Bioökonomie in Japan - Bioschmieden und Handwerkskunst](https://window-to-japan.eu/2023/05/01/biookonomie-in-japan-bioschmieden-und-handwerkskunst/) - Nachrichten aus der Chemie, Mai 2023 Smart cells
- [Taisei Corp. makes Synechococcus produce extracellular fatty acids](https://window-to-japan.eu/2023/04/13/taisei-corp-produces-extracellular-algae-oil/) - https://www.nedo.go.jp/news/press/AA5_101632.html A research team, consisting of Taisei Corporation, Saitama University, Chubu University, and Kazusa DNA Research Institute, succeeded in producing microalgae that produce free fatty acids outside the cells without introducing foreign genes, by suppressing or enhancing the expression of specific genes in the cyanobacterial strain Synechococcus elongatus PCC 7942. Conventional algae biofuel production involves
- [Kao Corp: gallic acid and 4,3-AHBA from glucose](https://window-to-japan.eu/2023/04/13/11160/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/04/12/10582/ At the JSBBA conference 2023, Kao has announced the production of gallic acid, a raw material for semiconductors and other products, and of 4-amino-3-hydroxybenzoic acid (4,3-AHBA), a raw material for plastics, both from glucose. Corynebacteria are used for production, and a dedicated metabolic pathway has been constructed for each compound. Gallic acid is an
- [Plastics to fertilizer: guiding principles for fully bio-based polycarbonates](https://window-to-japan.eu/2023/04/12/plastics-to-fertilizer-guiding-principles-for-fully-bio-based-polycarbonates/) - https://www.jst.go.jp/pr/announce/20230412/pdf/20230412.pdf https://pubs.rsc.org/en/content/articlelanding/2023/PY/D3PY00079F A research team led by Associate Professor Daisuke Aoki of Chiba University Poly has synthesised isosorbide carbonates (PICs) from non-toxic and biodegradable isosorbide (ISB), which is derived from glucose. PICs can be degraded by ammonolysis to give a mixture of isosorbide and urea, which can be directly used as a fertilizer. In this
- [A clinical support company tests ChatGPT for dialogues with patients](https://window-to-japan.eu/2023/04/12/a-clinical-support-company-in-japan-tests-chatgpt-for-dialogues-with-patients/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/04/10/10569/ HOKUTO in Tokyo is a provider of clinical support apps for physicians. The company's clinical support app "HOKUTO" https://hokuto.app/offers free access to search medical information such as guidelines and drug information, calculation tools such as dosage of antibacterial drugs according to renal function, and medical article databases (PubMed, etc.). As of February 2023, the
- [Shimadzu and MyCan Technologies develop kit for febrile substance testing](https://window-to-japan.eu/2023/04/11/shimadzu-and-mycan-technologies-develop-test-kit-for-febrile-substance-testing/) - Shimadzu Diagnostics and MyCan Technologies intend to jointly market in Japan and Europe a test kit for drug safety testing using human cells . The test aims to replace the febrile substance testing currently conducted on rabbits and horseshoe crabs with human cells. It uses immortalized myeloid cells (Mylc cells) developed by MyCan and named
- [A human immunoreceptor recognises carbon nanotubes](https://window-to-japan.eu/2023/04/11/a-human-immunoreceptor-recognises-carbon-nanotubes/) - https://www.nature.com/articles/s41565-023-01363-w CNTs have been used in a wide variety of fields as a next-generation nanomaterial with great potential. Some Multi-Walled CNTs (MWCNTs) have been reported to exhibit inflammatory toxicity similar to asbestos in animal studies. However, it was not known how MWCNTs are recognized in vivo and induce inflammation, nor whether similar inflammatory toxicity is
- [Brain tumor treatment with iPS cell-derived neural stem cells transfected with suicide genes?](https://window-to-japan.eu/2023/04/11/brain-tumor-treatment-with-ips-cell-derived-neural-stem-cells-transfected-with-suicide-genes/) - iXgene, a startup from Keio University, is currently developing suicide gene-transfected iPS cell-derived neural stem cells for the treatment of malignant brain tumors. The tNSCs contain suicide fusion genes from yeast cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT), which are introduced into iPS cells derived from a healthy donor using genome editing technology. The cells
- [Blick nach Asien 2023/04](https://window-to-japan.eu/2023/04/10/blick-nach-asien-2023-04/) - Blick nach Asien 2023:04
- [Ajinomoto develops RNA pesticides manufactured in C. glutamicum](https://window-to-japan.eu/2023/04/06/ajinomoto-develops-rna-pesticides-manufactured-in-c-glutamicum/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/04/04/10547/ A research group at Ajinomoto has established a mass production system for RNA pesticides using RNA interference and has confirmed growth-inhibitory activity against pests in a joint study with the National Institute for Basic Biology in Okazaki, Aichi Prefecture. RNA interference (RNAi) is a phenomenon in which double-stranded RNA (dsRNA) acts specifically on RNA
- [2023/03 Suntory pioneers bowel analysis through gut sound recorded by smartphone](https://window-to-japan.eu/2023/04/02/2023-04-suntory-pioneers-bowel-analysis-through-gut-sound-recorded-by-smartphone/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/03/09/10478/ The Suntory Group has released "Gut Note," a smartphone application utilizing gut sound analysis technology which records the sound of bowel movements through the iPhone's microphone and analyzes it using artificial intelligence (AI) to understand the state of the bowel, and combines it with information such as frequency of bowel movements and condition of
- [Suntory pioneers bowel analysis through gut sound recorded by smartphone](https://window-to-japan.eu/2023/03/15/suntory-pioneers-bowel-analysis-through-gut-sound-by-smartphone/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/03/09/10478/ The Suntory Group has released "Gut Note," a smartphone application utilizing gut sound analysis technology which records the sound of bowel movements through the iPhone's microphone and analyzes it using artificial intelligence (AI) to understand the state of the bowel, and combines it with information such as frequency of bowel movements and condition of
- [NEDO initiates program on "smart microorganisms" producing value products from CO2](https://window-to-japan.eu/2023/04/02/nedo-initiates-program-on-smart-microorganisms-producing-value-products-from-co2/) - https://www.nedo.go.jp/news/press/AA5_101619.html As part of the Green Innovation Fund project, NEDO will start the "Promotion of carbon recycling using CO2 as a direct raw material using bio-manufacturing technology" (total budget: 176.7 billion yen). In this project, NEDO will focus on ``sophistication of platform technology for modifying microorganisms to accelerate the development of useful microorganisms,'' ``development and
- [Kidwell Bio prepares clinical study for treatment of cerebral palsy with stem cells](https://window-to-japan.eu/2023/04/02/kidwell-bio-prepares-clinical-study-for-treatment-of-cerebral-palsy-with-stem-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/03/24/10518/ Kidswell Bio will soon conduct clinical research using autologous cells for cerebral palsy at Nagoya University regarding the company's ongoing research on a therapy using deciduous dental pulp stem cells (SHED). In October 2022, Nagoya University and the company jointly applied for a patent for the treatment of cerebral palsy using HED, for which the
- [Shimadzu Corporation and others establish a consortium to develop cultured meat](https://window-to-japan.eu/2023/04/02/shimadzu-corporation-and-others-establish-a-consortium-to-develop-cultured-meat/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/03/29/10532/ The consortium is named the "Cultivated Meat Future Creation Consortium" and has a research promotion base at Osaka University. Professor Noriya Matsuzaki of the Graduate School of Engineering at Osaka University, Shimadzu Corporation, and Sigmaxys have been working together to commercialize cultured meat using a 3D printer (see related article below for manufacturing technology).
- [New alloy melts over 2000 C, useful for OLED production processes](https://window-to-japan.eu/2023/04/02/new-alloy-melts-over-2000-c-useful-for-oled-production-processes/) - https://www.nedo.go.jp/news/press/AA5_101621.html Under NEDO's "Strategic Energy Conservation Technology Innovation Program," Sunrick, in collaboration with Tohoku University and Yamagata University, has been developing vacuum evaporation cells for the formation of organic and metal thin films for organic EL. ) and its single-crystal wire fabrication process, which can be processed at room temperature. The new alloy has a
- [Shipping and receiving locations for Japan's liquefied hydrogen supply chain](https://window-to-japan.eu/2023/03/19/shipping-and-receiving-locations-for-japans-liquefied-hydrogen-supply-chain/) - https://www.nedo.go.jp/news/press/AA5_101612.html As part of NEDO's Green Innovation Fund Project "Large-Scale Hydrogen Supply Chain Construction Project," Japan Hydrogen Energy Corporation, Iwatani Corporation, and ENEOS Corporation are engaged in the "Demonstration of Commercialization of a Liquefied Hydrogen Supply Chain. Currently, a technical study is being conducted to prepare for the start of construction and demonstration operations. The
- [2023/01: A 1 µm green microalgae, Medakamo hakoo, holds promise for synthetic biology](https://window-to-japan.eu/2023/01/27/2023-01-a-1-µm-green-microalgae-medakamo-hakoo-holds-promise-for-synthetic-biology/) - https://www.jst.go.jp/pr/announce/20230127/pdf/20230127.pdf https://www.nature.com/articles/s42003-022-04367-9 A team from the University of Tokyo and the Tokyo University of Science has cultured a new type of microalgae from the water in a tank where goldfish and killifish were kept, and identified its genome sequence. The photosynthetic microalgae has only 7629 genes, the lowest number of genes among all freshwater green
- [2023/02: A digital twin achieves productivity improvement and reduced human workload](https://window-to-japan.eu/2023/02/02/2023-01-a-digital-twin-achieves-productivity-improvement-and-reduced-human-workload/) - https://www.nedo.go.jp/news/press/AA5_101606.html In order to address labor shortages in Japan, where the working-age population is declining more rapidly than anywhere else in the world, the National Institute of Advanced Industrial Science and Technology (AIST) has developed a digital twin that can sustainably improve productivity and reduce the burden on people. The digital twin reflects in a
- [Blick nach Asien 2023/03](https://window-to-japan.eu/2023/03/07/blick-nach-asien-2023-03/) - Bildschirmfoto 2023-03-07 um 18.47.15.png
- [NEDO explores AI to improve the quality of seedlings for plant factories](https://window-to-japan.eu/2023/03/07/nedo-explores-ai-to-improve-the-quality-of-seedlings-for-plant-factories/) - https://www.nedo.go.jp/news/press/AA5_101613.html In conventional plant factories, the judgment of whether a seedling is good or bad depends on the subjective judgment of the operator, and only low-precision sorting is possible. This technology uses two AI models, one that estimates the height, width, and weight of spinach seedlings from their images, and the other that estimates the
- [iPS-derived cartilage shown to repair cartilage defects in monkeys](https://window-to-japan.eu/2023/02/22/ips-derived-cartilage-shown-to-repair-cartilage-defects-in-monkeys/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/02/18/10421/ A research team led by Kyoto University's Kengo Abe and Professor Noriyuki Tsumaki (Osaka University) showed that iPS cells of cynomolgus monkeys could be differentiated into chondrocytes to prepare cartilage tissue which was successfully transplanted to other individuals. Cartilage does not contain blood vessels and is difficult for immune cells to reach, so it
- [Regional Fish and NTT establish joint venture for aquaculture and breeding of genome-edited seafood](https://window-to-japan.eu/2023/02/22/regional-fish-and-ntt-establish-joint-venture-for-aquaculture-and-breeding-of-genome-edited-seafood/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/02/20/10431/ Regional Fish, Kyoto and Nippon Telegraph and Telephone Corporation (NTT) announced on February 9, 2023, that they will establish a joint venture to produce and sell improved seafood on a commercial scale. The two companies have been jointly promoting the breeding and onshore cultivation of fish and algae using genome editing. So far, they
- [Interberry Alpha, a canine interferon, gains acceptance for treatment of canine and feline gingivitis](https://window-to-japan.eu/2023/02/22/interberry-alpha-a-canine-interferon-gains-acceptance-for-treatment-of-canine-and-feline-gingivitis/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/02/13/10395/ The plant-based veterinary drug Interberry Alpha has gained an indication for the treatment of feline gingivitis in addition to the existing indication for canine gingivitis. Information on the expanded indication was made public on February 13, 2023 in the database of the Veterinary Drug Inspectorate of the Ministry of Agriculture, Forestry and Fisheries of
- [Genome-edited tiger puffer fish accepted as food in Japan](https://window-to-japan.eu/2022/01/11/1-11-genome-edited-tiger-puffer-fish-accepted-as-food-in-japan-2/) - Regional Fish, Kyoto, have received acceptance from the Ministry of Agriculture, Forestry and Fisheries and the Ministry of Health, Labor and Welfare for genome-edited tiger puffer fish. In the genome-edited fish strain, a leptin receptor regulating appetite was removed, leading to growth at double speed and improved feed utilization efficiency. The high-growth tiger puffer
- [Blick nach Asien 2023/02](https://window-to-japan.eu/2023/02/02/blick-nach-asien-2023-02/) - Bildschirmfoto 2023-02-04 um 18.10.45
- [Japan Renesas Electronics Corporation develops power-efficient AI chip](https://window-to-japan.eu/2022/12/08/japan-renesas-electronics-corporation-develops-power-efficient-ai-chip/) - https://www.nedo.go.jp/news/press/AA5_101596.html Under a contract from NEDO, Renesas has developed an AI chip with a dynamic reconfiguration processor (DRP) that handles complex tasks in real time. The power efficiency is 10 trillion operations per second (TOPS) per Watt consumed. This makes it possible to install the chip in a variety of devices such as security cameras,
- [A digital twin achieves productivity improvement and reduced human workload](https://window-to-japan.eu/2023/02/02/a-digital-twin-achieves-productivity-improvement-and-reduced-human-workload/) - https://www.nedo.go.jp/news/press/AA5_101606.html In order to address labor shortages in Japan, where the working-age population is declining more rapidly than anywhere else in the world, the National Institute of Advanced Industrial Science and Technology (AIST) has developed a digital twin that can sustainably improve productivity and reduce the burden on people. The digital twin reflects in a
- [A 1 µm green microalgae, Medakamo hakoo, holds promise for synthetic biology](https://window-to-japan.eu/2023/01/27/a-1-µm-green-microalgae-medaka-hakoo-holds-promise-for-synthetic-biology/) - https://www.jst.go.jp/pr/announce/20230127/pdf/20230127.pdf https://www.nature.com/articles/s42003-022-04367-9 A team from the University of Tokyo and the Tokyo University of Science has cultured a new type of microalgae from the water in a tank where goldfish and killifish were kept, and identified its genome sequence. The photosynthetic microalgae has only 7629 genes, the lowest number of genes among all freshwater green
- [CureApp launches phase 3 of an alcoholism treatment app in Japan](https://window-to-japan.eu/2023/01/27/cureapp-launches-phase-3-of-an-alcoholism-treatment-app-in-japan/) - CureApp began developing Digital Therapeutics (DTx) to assist in the treatment of alcoholism by non-specialists. By expanding opportunities for alcoholism treatment outside of specialized medical facilities, CureApp aims to improve access to treatment and achieve early intervention. The app is designed to help people get sober. The app is intended for mildly alcoholic patients who
- [NUProtein supplies growth factors to Singapore Umami Meats for cultured fish meat](https://window-to-japan.eu/2023/01/27/nuprotein-supplies-growth-factors-to-singapore-umami-meats-for-cultured-fish-meat/) - https://bio.nikkeibp.co.jp/atcl/news/p1/23/01/25/10342/ Singapore's Umami Meats is developing cultured fish meat such as eel, tuna, and snapper using cell culture technology. The development targets mainly high-end fish that cannot be farmed. NUProtein, a Tokyo startup, excels in growth factors for cell-free protein synthesis. Umami Meats has a research system that uses digital models of cultured fish meat with artificial
- [Graphite enhances catalytic oxidation of methane: Nagoya University](https://window-to-japan.eu/2023/01/27/graphite-enhances-catalytic-oxidation-of-methane-nagoya-university/) - https://www.jst.go.jp/pr/announce/20230112-2/index.html Graph: Structure of a methane oxidation catalyst with two-story molecules adsorbed on graphite in a stacking configuration and its reaction active species. A team around Yasuyuki Yamada at Nagoya University has dramatically increased the methane oxidation activity of catalytic molecules by utilizing their interaction with graphite, and achieved a catalytic activity for methane oxidation comparable
- [Keio University: Bacteroides uniformis are abundant in microbiome of Japanese long-distance runners](https://window-to-japan.eu/2023/01/27/keio-university-bacteroides-uniformis-are-abundant-in-microbiome-of-japanese-long-distance-runners/) - https://www.jst.go.jp/pr/announce/20230126-3/pdf/20230126-3.pdf A research team around Kinji Fukuda at Keio University has found that Bacteroides uniformis was abundant in the intestines of Japanese long-distance runners and was associated with their running times. Bacteroides uniformis produces short-chain fatty acids such as acetic acid and propionic acid in the intestine, which may contribute to endogenous glucose production in the liver,
- [FAST thermoelectric materials may offer an environmental friendly option for roadside sensors in autonomous driving: NEDO](https://window-to-japan.eu/2023/01/27/fast-thermoelectric-materials-may-offer-an-environmental-friendly-option-for-roadside-sensors-in-autonomous-driving-nedo/) - https://www.nedo.go.jp/news/press/AA5_101604.html Meti's project house Nedo is sponsoring a collaborative project to improve the performance and reduce the cost of thermoelectric modules made of iron (Fe), aluminum (AI) and silicon (Si) (FAST materials) that do not use rare and toxic metals. The consortium has now unveiled a 2 cm2 ceramic thermoelectric module that harvests enough power
- [IDDK Spacelab develops biotech test formats for space](https://window-to-japan.eu/2023/01/17/iddk-spacelab-develops-biotech-test-formats-for-space/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/12/21/10284/ https://iddk.co.jp/app-def/S-102/iddk_wp/?page_id=3846&lang=en The Tokyo-based startup IDDK has developed and commercialized a new microscope that combines optical and semiconductor technologies. A sample is placed on the black part in the center for observation. In the back is the base for controlling the microscope including peripheral devices. With a resolution of 1.2 µm, it is said to
- [2022/12 Japanese team wins first prize in European competition on artificial photosynthesis](https://window-to-japan.eu/2023/01/10/2022-12-japanese-team-wins-first-prize-in-european-competition-on-artificial-photosynthesis/) - https://www.nedo.go.jp/news/press/AA5_101598.html The University of Tokyo and INPEX Co., partners in NEDO's project "Technology Development for the Production of Key Chemicals Using Carbon Dioxide as Raw Material" and with the support of the Research Association for Artificial Photosynthetic Chemistry Process Technology (ARPChem) have won the first place out of 22 teams in the competition "Fuel from
- [Blick nach Asien 2023/01](https://window-to-japan.eu/2023/01/10/blick-nach-asien-2023-01/) - Blick nach Asien 2023:01
- [Japanese team wins first prize in European competition on artificial photosynthesis](https://window-to-japan.eu/2022/12/06/japanese-team-wins-first-prize-in-european-competition-on-artificial-photosynthesis/) - https://www.nedo.go.jp/news/press/AA5_101598.html The University of Tokyo and INPEX Co., partners in NEDO's project "Technology Development for the Production of Key Chemicals Using Carbon Dioxide as Raw Material" and with the support of the Research Association for Artificial Photosynthetic Chemistry Process Technology (ARPChem) have won the first place out of 22 teams in the competition "Fuel from
- [HZI Alumni interview](https://window-to-japan.eu/2022/12/16/hzi-alumni-interview/) - Interview R_Schmid_002
- [Kyoto Prefectural University startup to sell "short rice" suitable for plant factories](https://window-to-japan.eu/2022/12/07/kyoto-prefectural-university-startup-to-sell-short-rice-suitable-for-plant-factories/) - Kyoto Prefectural University has begun offering a strain of "short rice" that is easy to use for plant-based material production and other applications. It is suitable for cultivation in plant factories because it can significantly reduce the cultivation space. A university start-up Miraishoku Research and Development Center will be established, where it will be marketed
- [Cultured Meat Industry submits proposal for legislation on "cellular foods"](https://window-to-japan.eu/2022/12/06/cultured-meat-industry-submits-proposal-for-legislation-on-cellular-foods/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/12/01/10210/ "Proposal on Rules for the Sale of Cellular Foods and Legislation to be Developed in Japan" The The scope of the proposal covers meat, eggs, milk, and seafood produced by cell culture, collectively referred to as "cellular foods". The report emphasizesthat these foods have fewer disadvantages, such as environmental impact, than conventional livestock-derived products,
- [Reconstructed intestinal flora of 787 Japanese shows relationship to diet and disease](https://window-to-japan.eu/2022/12/02/reconstructed-intestinal-flora-of-787-japanese-shows-relationship-to-diet-and-disease/) - https://www.riken.jp/press/2022/20221201_1/index.html A research group led by Yoshihiko Tomofuji, Ph.D. (Genetic Statistics), Osaka University , and Zuzo Okada, Ph.D. (Genetic Statistics / Team Leader, Systems Genetics Team, RIKEN Center for Biomedical Research has identified the intestinal microflora and reconstructed bacterial and viral genome sequences of 787 Japanese. Through integrated analysis of the newly developed database and
- [2022/11 Osaka University team prints edible QR code into cookies](https://window-to-japan.eu/2022/12/01/2022-12-osaka-university-team-prints-edible-qr-code-into-cookies/) - https://www.jst.go.jp/pr/announce/20221017/pdf/20221017.pdf Kosuke Sato and colleagues have embedded "edible information" into cookies using a 3D printer. 2D codes, or AR markers, are created through cavities when the food is printed and remain intact during baking. They can be read again when the back of the cookies are exposed to high-frequency light, and not only store data
- [Blick nach Asien 2022/12](https://window-to-japan.eu/2022/12/01/blick-nach-asien-2022-12/) - Blick nach Asien 2022:12
- [METI secures 2 billion € fund to promote biomanufacturing (bio monozukuri)](https://window-to-japan.eu/2022/11/14/meti-secures-2-billion-e-fund-to-promote-biomanufacturing-bio-monzukuri/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/11/08/10133/ METI will allocate 300 billion yen (2 billion €) to a new fund that will support companies that develop manufacturing technologies using bioprocesses based on waste and other raw materials. Specifically, it is envisioned that microorganisms will be used to produce fiber, ethanol, resins, and other products from waste clothing, municipal solid waste, food
- [Nagase and Hitachi collaborate for commercialization of ergothioneine](https://window-to-japan.eu/2022/11/19/nagase-and-hitachi-collaborate-for-commercialization-of-ergothioneine/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/11/04/10118/ Ergothioneine has antioxidant activity and is believed to improve brain function, thus of interest for applications in functional foods, cosmetics, and pharmaceuticals. Ergothioneine is produced only in very small amounts by mushrooms and microorganisms. In the joint project, Nagase produces ergothioneine from highly genetically modified Escherichia coli. Hitachi Plant Services uses computing and machine learning to
- [Microwave Chemical Co. completes 1 t/d demonstration facility for microwave-based recycling of plastics](https://window-to-japan.eu/2022/11/19/microwave-chemical-co-completes-1-t-d-demonstration-facility-for-microwave-based-recycling-of-plastics/) - https://www.nedo.go.jp/news/press/AA5_101587.html Under a contract from NEDO, Microwave Chemical Co. has completed Japan's first general-purpose microwave demonstration facility for the recovery of monomers from polymers with a processing capacity of 1 ton per day. In 2021, the company had completed a small-scale demonstration facility with a processing capacity of about 5 kg per hour. The process will be further scaled
- [NEDO initiates program on blue ammonia production](https://window-to-japan.eu/2022/11/17/nedo-initiates-program-on-blue-ammonia-production/) - https://www.nedo.go.jp/news/press/AA5_101590.html According to Japan’s "Sixth Basic Energy Plan" of October 2021 hydrogen and ammonia power generation is expected to account for about 1% of Japan's power mix in FY2030. Following this target, NEDO and INPEX Corp. will construct a "blue ammonia" facility at the INPEX Higashi-Kashiwazaki gas field in Kashiwazaki City, Niigata Prefecture. A demonstration
- [Osaka University team prints edible QR code into cookies](https://window-to-japan.eu/2022/11/08/osaka-university-team-prints-edible-qr-code-into-cookies/) - https://www.jst.go.jp/pr/announce/20221017/pdf/20221017.pdf Kosuke Sato and colleagues have embedded "edible information" into cookies using a 3D printer. 2D codes, or AR markers, are created through cavities when the food is printed and remain intact during baking. They can be read again when the back of the cookies are exposed to high-frequency light, and not only store data
- [High yields of biologics from an “egg factory”](https://window-to-japan.eu/2022/10/31/high-yields-of-biologics-from-an-egg-factory/) - The team of Isao Oishi at the National Institute of Advanced Industrial Science and Technology (AIST) in Osaka has developed an “egg factory” which produces up to 500 mg of recombinant proteins such as human interferon beta, cytokines, and a human HER2 antibody per chicken egg. The method is based on knocking in the target gene
- [2022/10 Cyfuse reports progress on 3D printed organoids](https://window-to-japan.eu/2022/10/30/2022-10-cyfuse-reports-progress-on-3d-printed-organoids/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/10/27/10073/ https://en.cyfusebio.com Cyfuse was established in 2010 and is focused on 3D cell technology that uses a bio 3D printer to laminate cell clumps (spheroids) consisting of an average of 10,000 cells in a 3D manner without the use of artificial scaffolds. The company has 3 business fields: to develop a pipeline of regenerative medicine
- [Cyfuse raises about 13 million € for 3D printed organoids](https://window-to-japan.eu/2022/10/30/cyfuse-raises-about-13-million-e-for-3d-printed-organoids/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/10/27/10073/ https://en.cyfusebio.com Cyfuse was established in 2010 and is focused on 3D cell technology that uses a bio 3D printer to laminate cell clumps (spheroids) consisting of an average of 10,000 cells in a 3D manner without the use of artificial scaffolds. The company has 3 business fields: to develop a pipeline of regenerative medicine
- [Blick nach Asien 2022/11](https://window-to-japan.eu/2022/10/30/blick-nach-asien-2022-11/) - Blick nach Asien 2022:11
- [Stretchable and self-healing polymer gels formed by a facile one-step synthesis](https://window-to-japan.eu/2022/10/23/stretchable-and-self-healing-polymer-gels-formed-by-a-facile-one-step-synthesis/) - https://www.science.org/doi/10.1126/sciadv.add0226 Researchers at the National Institute for Material Sciences have formed highly stretchable and self-healing polymer gels solely by physical entanglements of ultrahigh–molecular weight (UHMW) polymers fabricated through a facile one-step process. Radical polymerization of vinyl monomers in ionic liquids under very low initiator concentration conditions produced UHMW polymers of more than 106 g/mol with
- [Osaka University will establish "digital twin" for human organ interactions](https://window-to-japan.eu/2022/10/23/osaka-university-will-establish-digital-twin-for-human-organ-interactions/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/10/14/10030/ https://www.youtube.com/watch?v=unvKIcKTBuY Osaka University's "Human Metabolic Disease Research Center" will establish a "digital twin" for organoids created mainly from iPS cells, and their diseases. The response of organoids to disease states will be comprehensively investigated using multi-omics analysis, single-cell analysis, quantum sensing, The bio-digital twins created will be shared by constructing a new metaverse space. The
- [Hydrogen ministerial meeting held in Tokyo](https://window-to-japan.eu/2022/10/21/hydrogen-ministerial-meeting-held-in-tokyo/) - The Hydrogen Ministerial, a global ministerial dedicated to hydrogen, is working towards the Global Action Agenda goal of 10 million fuel cell systems and 10,000 hydrogen stations in 10 years, with more than 540,000 fuel cell systems installed and more than 1,100 hydrogen stations installed. Reported progress and added an additional goal of at least
- [Blick nach Asien 2022/10](https://window-to-japan.eu/2022/10/17/blick-nach-asien-2022-10/)
- [Blick nach Asien 2022/09](https://window-to-japan.eu/2022/10/17/blick-nach-asien-2022-09/)
- [Advances in diabetes-1 treatment by cell technology](https://window-to-japan.eu/2022/10/17/advances-in-diabetes-1-treatment-by-cell-technology/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400016/100500253/ The group around Tetsuya Ikemoto, a GI surgeon at the University Hospital of Fukushima, prepares for an investigator-initiated clinical trial on insulin-producing cells (IPC) derived from autologous fat cells of human patients. He has finished safety evaluation and proof-of-concept experiments using diabetic mice and pigs. The insulin-producing cells under study are adipose-derived stem cells taken
- [2022/09 Sekisui converts waste to ethanol](https://window-to-japan.eu/2022/10/06/sekisui-converts-waste-to-ethanol-2/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/09/21/09955/ Sekisui Chemical plans to commercialize a technology that uses microorganisms to convert combustible garbage into ethanol by 2025. In April 2022, a 1/10th demonstration plant in Kuji, Iwate Prefecture, began operating, marking the start of the final stage of verification testing toward practical application. About 800 l ethanol are produced from 20 t of
- [High-level S&T meeting between China and Japan on zero CO2 emissions](https://window-to-japan.eu/2022/09/28/eight-high-level-st-meeting-between-china-and-japan-8-zero-co2-emissions/) - http://j.people.com.cn/n3/2022/0926/c95952-10151765.html The "2021-22 China-Japan High-Level Researchers Exchange Meeting (Decarbonization and Growth)," jointly organized by the Ministry of Science and Technology (MOST), the Japan Science and Technology Agency (JST) and Tsinghua University, took place on September 21 in Beijing. Nearly 30 researchers and business representatives from China and Japan participated in the activity, which focused on
- [NEDO defines 5 "moonshot" projects to accelerate natural CO2 adsorption](https://window-to-japan.eu/2022/09/27/nedo-defines-5-moonshot-projects-to-accelerate-natural-co2-adsorption/) - NEDO has adopted five projects to identify new technologies to achieve the Moonshot Goal 4 "Achieve sustainable resource recycling for global environmental regeneration by 2050". The five adopted projects will determine the potential of technology to efficiently capture and absorb CO2 by artificially accelerating the natural carbon dioxide absorption capacity (artificial acceleration of natural processes).
- [Pathogenic microorganisms in sewage: several "wastewater surveillance" programs in Japan](https://window-to-japan.eu/2022/09/27/pathogenic-microorganisms-in-sewage-several-wastewater-surveillance-programs-in-japan/) - https://bio.nikkeibp.co.jp/atcl/report/16/011900001/22/09/21/00447/ "Wastewater Surveillance" is an epidemiological survey method that measures nucleic acids of pathogenic microorganisms, including viruses, in sewage to determine the occurrence and prevalence of various diseases. Japan's National Institute of Infectious Diseases and the Regional Institutes of Health have conducting polio environmental water surveillance since 2013 to monitor the spread of poliovirus, and
- [Sekisui converts waste to ethanol](https://window-to-japan.eu/2022/09/27/sekisui-converts-waste-to-ethanol/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/09/21/09955/ Sekisui Chemical plans to commercialize a technology that uses microorganisms to convert combustible garbage into ethanol by 2025. In April 2022, a 1/10th demonstration plant in Kuji, Iwate Prefecture, began operating, marking the start of the final stage of verification testing toward practical application. About 800 l ethanol are produced from 20 t of
- [Ecologie Co. commercializes chocolate with cricket powder](https://window-to-japan.eu/2022/09/21/ecologie-co-commercializes-chocolate-with-cricket-powder/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/09/20/09950/ Ecologgie https://ecologgie.com/en/ produces food ingredients using edible crickets and have started to commercialize a chocolate containing cricket powder. The company will begin offering the product via crowdfunding and aims to sell it at retail stores in the future. The company has contracted with Cambodian farmers to buy locally produced crickets and process them into powder and
- [Bioökonomie in China und Japan](https://window-to-japan.eu/2022/08/24/biookonomie-in-china-und-japan/) - For download: Bioeconomy China-Japan https://doi.org/10.1002/nadc.20224122591
- [NEDO starts evaluation of "household type" CO2 absorbers](https://window-to-japan.eu/2022/09/20/nedo-starts-evaluation-of-household-type-co2-absorbers/) - https://www.nedo.go.jp/news/press/AA5_101572.html In collaboration with the Research Institute of Innovative Technology for the Earth (RITE) and Mitsubishi Heavy Industries, NEDO has jointly engaged in a "moonshot-type R&D project for directly capturing carbon dioxide (CO2) from the atmosphere on the scale of several kilograms per day. It is planned to design a pilot-scale direct air capture (DAC) test apparatus and evaluate
- [Japans Biotech-Ökosystem](https://window-to-japan.eu/2022/09/20/japans-biotech-okosystem/) - japans-biotech-oekosystem.pdf;jsessionid=969772A2D7A84D965F6D182E7748404E
- [CureApp launches hypertension treatment app as 6-month instructional program](https://window-to-japan.eu/2022/09/06/cureapp-launches-hypertension-treatment-app-as-6-month-instructional-program/) - https://cureapp-en.blogspot.com/2022/05/worlds-first-medical-device-regulatory.html https://bio.nikkeibp.co.jp/atcl/news/p1/22/09/03/09888/ On September 1, 2022, CureApp launched the "CureApp HT Hypertension Treatment Assistance App", an application to assist in the treatment of hypertension. The six-month program is priced at 2,910 yen for the first month for patients who pay 30% of the total cost, and 2,490 yen per month for the following five months. In
- [CellSeed: soon clinical trial of allogenic bone cell sheets for knee osteoarthritis treatment](https://window-to-japan.eu/2022/08/30/cellseed-soon-clinical-trial-of-allogenic-bone-cell-sheets-for-knee-osteoarthritis-treatment/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/08/29/09868/ The company plans to start clinical trials in 2023 for allogeneic soft bone cell sheets for knee osteoarthritis. CellSeed develops regenerative medical products based on a technology invented by Professor Mitsuo Okano of Tokyo Women's Medical University that enables cells to be cultured in sheet form. While selling cell culture equipment, the company is
- [Energiekonzepte: Japan sett auf Wasserstoff](https://window-to-japan.eu/2017/10/08/energiekonzepte-japan-sett-auf-wasserstoff/) - https://doi.org/10.1002/nadc.20174067537 Download: Japan Wasserstoff 1
- [Energie: Japans Masterplan](https://window-to-japan.eu/2019/10/08/energie-japans-masterplan-2/) - W2J 19:10 WasserstoffJapanhttps://doi.org/10.1002/nadc.20194088810 Download: W2J 19:10 WasserstoffJapan
- [Wasserstoff-Technologie in Deutschland und Japan](https://window-to-japan.eu/2022/08/24/wasserstoff-technologie-in-deutschland-und-japan/) - Download: Wasserstoff D-J
- [What's on with China's "hydrogen consortium" and Japan's "hydrogen society"?](https://window-to-japan.eu/2022/08/28/whats-on-with-chinas-hydrogen-consortium-and-japans-hydrogen-society/) - I will show the attached poster at a "Hydrogen Symposium" in Germany on Aug. 29 For download: 20220823 Heraeus
- [2022/08 A microarray measures COVID antibody levels in blood in 8 minutes](https://window-to-japan.eu/2022/08/20/a-microarray-measures-covid-antibody-levels-in-blood-in-8-minutes/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/08/15/09819/ https://link.springer.com/article/10.1007/s44211-022-00161-z The system developed by a joint research group from the RIKEN Center for Emergent Matter Science and Chiba University Graduate School of Medicine uses a synthetic polymer that is photoreactive and inhibits nonspecific adsorption which is coated on a chip, and viral proteins are placed on the chip in the form of spots. The
- [12-9 Moonshot program for human well-being](https://window-to-japan.eu/2021/09/13/moonshot-program-for-human-well-being/) - Download: Moonshot program Japan, 09:2021
- [Kyoto startup Symbiobe produces spider silk in recombinant marine phototrophic bacteria](https://window-to-japan.eu/2022/08/25/kyoto-startup-symbiobe-produces-spider-silk-in-marine-phototrophic-bacteria/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/08/24/09846/ https://www.symbiobe.jp https://www.nature.com/articles/s41428-022-00675-3.pdf?proof=t2020-6-29 Symbiobe is a Kyoto University startup commercializing technology for bio refineries based on marine photosynthetic bacteria. Technology is based on the research results of Professor Keiji Numata of the Department of Materials Chemistry, Kyoto University. Using carbon dioxide and atmospheric nitrogen as raw materials, the company plans to develop four businesses: (1) services
- [Toray ready to scale technology for 100 % bio-based adipic acid](https://window-to-japan.eu/2022/08/24/toray-ready-to-scale-technology-for-100-bio-based-adipic-acid/) - https://www.toray.com/global/news/details/20220818103248.html Adipic acid is a key material for the production of polyamide 66 (nylon). Unlike petroleum-derived adipic acid, bio adipic acid synthesized by this method does not emit any nitrous oxide (N2O). Toray Industries, with support from NEDO, is developing a highly efficient microbial fermentation process based on metabolically engineered Pseudomonas strain and an energy-saving purification method
- [Microbiome bacteria frequent in Japanese reduce obesity and diabetes symptoms in diabetic mice](https://window-to-japan.eu/2022/08/20/microbiome-bacteria-frequent-in-japanese-reduce-obesity-and-diabetes-symptoms-in-diabetic-mice/) - https://www.nature.com/articles/s41467-022-32015-7 https://bio.nikkeibp.co.jp/atcl/news/p1/22/08/18/09831/ A Japanese team has found bacteria in the microbiome of Japanese people that may improve obesity and diabetes symptoms in a joint study with Waseda University and others. In a cohort study, Blautia wexlerae was identified as an intestinal bacterium that is less common in obese and type 2 diabetic Japanese and more common
- [Nagase improves synthesis of ergothioneine 1000fold by synthetic biology](https://window-to-japan.eu/2022/07/08/nagase-improves-synthesis-of-ergothioneine-1000fold-by-synthetic-biology/) - Ergothioneine is a rare amino acid used as an antioxidant in food, cosmetics, and pharmaceuticals. In 2015, Nagase Sangyo Cobegan development of an environmentally friendly bioproduction process capable of providing a stable supply of inexpensive ergothioneine by microbial fermentation. In 2019, Nagase joined NEDO's Smart Cell Project to accelerate this program and, using synthetic biology,
- [Japan's NEDO launches 6 industrial demonstrators for bio-manufactured products](https://window-to-japan.eu/2022/07/29/japans-nedo-launches-6-industrial-demonstrators-for-bio-manufactured-products/) - https://www.nedo.go.jp/news/press/AA5_101562.html The products and the project coordinators are Oil and fat production technology from inedible biomass using yeast, Idemitsu Kosan Co A rose flavor production system using a growth-independent bioprocess and continuous isolation, Takasago International Corp Mass production technology in plants for highly modified proteins, Chiyoda Corporation Production system for useful flavor and fragrance intermediates,
- [Genome-edited tomatoes and fish meet marketing challenges in Japan](https://window-to-japan.eu/2022/07/27/genome-edited-tomatoes-and-fish-meet-marketing-challenges-in-japan/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/07/26/09752/ https://bio.nikkeibp.co.jp/atcl/news/p1/22/07/25/09744/ By May 2022, Sanatec Seed https://sanatech-seed.com/en/ plans to sell four types of genome-edited Sicilian Rouge High GABA tomato puree with the following claims: lower blood pressure in people with high blood pressure relieve temporary mental stress caused by work or study help improve sleep quality (depth of sleep and refreshed awakening) maintain skin
- [TAKEO - a restaurant chain based on edible insects](https://window-to-japan.eu/2022/07/21/takeo-a-restaurant-chain-based-on-edible-insects/) - https://bio.nikkeibp.co.jp/atcl/column/16/021500017/072000249/ TAKEO, a Tokyo-based startup company, develops and sells edible insects and commercializes a wide variety of insects as food ingredients. One of the company's unique features is its "Domestic Insect Series," made from edible insects coming from various parts of Japan and processed using proprietary methods. The products range from crickets to silkworm chrysalis,
- [2022/07 ToMMo completes whole genome analysis of 50,000 Japanese](https://window-to-japan.eu/2022/07/19/2022-07-tommo-completes-whole-genome-analysis-of-50000-japanese/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/07/04/09683/ Tohoku University Tohoku Medical Megabank Organization (ToMMo) announced on June 30, 2022, that it has completed the analysis of the whole genome information of 50,000 Japanese. The Tohoku Medical Megabank has accumulated health information and biological samples of 150,000 local residents, mainly in Miyagi and Iwate prefectures, and ToMMo is currently analyzing them. ToMMo
- [Japan's Food Safety Law on genetically modified food](https://window-to-japan.eu/2022/07/19/japans-food-safety-law-on-genetically-modified-food/) - https://bio.nikkeibp.co.jp/atcl/report/16/011900001/22/07/15/00407/ Genetically modified foods must undergo a safety review by the Ministry of Health, Labor and Welfare before they can be sold. The Food Safety Commission conducts a safety review to determine the impact of the food on human health. When a genetically modified organism is used as a food for humans, if the foreign
- [ToMMo completes whole genome analysis of 50,000 Japanese](https://window-to-japan.eu/2022/07/05/tommo-completes-whole-genome-analysis-of-50000-japanese/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/07/04/09683/ Tohoku University Tohoku Medical Megabank Organization (ToMMo) announced on June 30, 2022, that it has completed the analysis of the whole genome information of 50,000 Japanese. The Tohoku Medical Megabank has accumulated health information and biological samples of 150,000 local residents, mainly in Miyagi and Iwate prefectures, and ToMMo is currently analyzing them. ToMMo
- [Gesundheitsmarkt Japan - Arzneimittel und Biopharmazeutika](https://window-to-japan.eu/2018/07/09/gesundheitsmarkt-japan-arzneimittel-und-biopharmazeutika/) - https://www.exportinitiative-gesundheitswirtschaft.de/EIG/Redaktion/DE/Publikationen/PDF/gesundheitsmarkt-japan.html
- [Industrial (“White”) Biotechnology in Japan: Company Activities and Government Programs – and How to Become Involved. A Primer for European SMEs](https://window-to-japan.eu/2016/02/08/industrial-white-biotechnology-in-japan-company-activities-and-government-programs-and-how-to-become-involved-a-primer-for-european-smes/) - This report is accessible free of cost to EU companies which have registered to the “EU Business in Japan” website as a member via: http://www.eubusinessinjapan.eu/user/register Download the Table of Contents of this article
- [Japanese Competence Centers in Bioinformatics and Computational Biology: A primer for European SMEs](https://window-to-japan.eu/2015/05/08/japanese-competence-centers-in-bioinformatics-and-computational-biology-a-primer-for-european-smes/) - This report is accessible free of cost to EU companies which have registered to the “EU Business in Japan” website as a member via: http://www.eubusinessinjapan.eu/user/register Download the Table of Contents of this article
- [Biotechnology-related food & agricultural products in Japan](https://window-to-japan.eu/2014/01/08/biotechnology-related-food-agricultural-products-in-japan/) - This report is accessible free of cost to EU companies which have registered to the “EU Business in Japan” website as a member via: http://www.eubusinessinjapan.eu/user/register Download the Table of Contents of this article
- [Cell technology, cell therapy, tissue engineering and gene therapy in Japan](https://window-to-japan.eu/2015/03/08/cell-technology-cell-therapy-tissue-engineering-and-gene-therapy-in-japan/) - This report is accessible free of cost to EU companies which have registered to the “EU Business in Japan” website as a member via: http://www.eubusinessinjapan.eu/user/register Download the Table of Contents of this article
- [Update on cell technology, cell therapy, tissue engineering and gene therapy in Japan](https://window-to-japan.eu/2017/03/08/update-on-cell-technology-cell-therapy-tissue-engineering-and-gene-therapy-in-japan/) - This report is accessible free of cost to EU companies which have registered to the “EU Business in Japan” website as a member via: http://www.eubusinessinjapan.eu/user/register Download the Table of Contents to this article
- [The Biopharmaceuticals sector in Japan: Government regulations, the competitive situation and how to find an entry point - A primer for European SMEs.](https://window-to-japan.eu/2019/07/08/the-biopharmaceuticals-sector-in-japan-government-regulations-the-competitive-situation-and-how-to-find-an-entry-point-a-primer-for-european-smes/) - This report is accessible free of cost to EU companies which have registered to the “EU Business in Japan” website as a member via: http://www.eubusinessinjapan.eu/user/register Download the Table of Contents to this article
- [Latest Trends in Biotechnology Research in Japan](https://window-to-japan.eu/2021/05/08/latest-trends-in-biotechnology-research-in-japan/) - This report is accessible free of cost to EU companies which have registered to the “EU Business in Japan” website as a member via: http://www.eubusinessinjapan.eu/user/register Download the Table of Contents to this article
- [2021/03 Will artificial intelligence help us to healthier intestinal microbiomes?](https://window-to-japan.eu/2021/03/19/will-artificial-intelligence-help-us-to-healthier-intestinal-microbiomes/) - AuB, a Tokyo startup whose president Keita Suzuki is a former member of Japan’s national soccer team, has analyzed the stool of over 700 athletes and analyzed the type, number and composition of their intestinal bacteria, combined with information on eating habits and weight gains. As a result, a new species of Bifidobacterium longum was found
- [2021/04 RIKEN-industry consortium tailors E. coli by synthetic biology to produce 1,3-butadiene from glucose](https://window-to-japan.eu/2021/04/19/14-4-riken-industry-consortium-tailors-e-coli-by-synthetic-biology-to-produce-13-butadiene-from-glucose/) - The team of Yutaro MORI at RIKEN, in collaboration with Yokohama Rubber and ZEON Co., has developed a technology to produce 1,3-butadiene from glucose by recombinant Escherichia coli. Butadiene is currently produced at 12 million t/y worldwide and over 1 million t/y in Japan from petrochemical resources. The recombinant Escherichia coli strain used in this
- [2021/01 Spider silk „moon parka” on limited sale from Goldwin, Japan](https://window-to-japan.eu/2021/01/15/spider-silk-containing-moon-parka-limited-edition-on-sale-from-goldwin-japan/) - In collaboration with the startup company Spiber https://www.spiber.jp, Japan’s sportswear producer Goldwin has offered a web-based lottery for the purchase of 50 pieces of a ski jacket named “moon parka” made from 3 layers, the outermost one of Spiber’s “spider silk” protein. Price with tax is 150,000 ¥ (about 1260 €). The two companies had already released
- [2020/12 Kawasaki Heavy Industries launches first liquid hydrogen carrier tanker](https://window-to-japan.eu/2019/12/12/kawasaki-heavy-industries-launches-first-liquid-hydrogen-carrier-tanker/) - The Japanese CO2 Free Hydrogen Supply Chain Promotion Organization HySTRA (Members: Iwatani Corporation, Kawasaki Heavy Industries Ltd., Shell Japan Corporation, Power Supply Development Corportion) has launched the first liquefied hydrogen carrier ship. It will transport liquefied hydrogen cooled to minus 253 ° C, leading to a volume of 1/800 of the gas at ambient temperature, safely
- [2021/05 Sanatec starts to distribute free seedlings of genome-edited “Sicilian Rouge High GABA” tomatos](https://window-to-japan.eu/2021/04/30/30-4-sanatec-starts-to-distribute-free-seedlings-of-genome-edited-sicilian-rouge-high-gaba-tomatos/) - Sanatec Seeds, a venture spin-out of the Japan’s University of Tsukuba, is the first company in the world to commercialize genome-edited tomatoes, "Sicilian Rouge High GABA" "Sicilian Rouge High GABA" is a strain (variety registration pending) that contains four to five times more gamma aminobutyric acid (GABA), an antihypertensive, than its parent strain, Sicilian Rouge
- [2022/03 MHLW approves CureApp's software for hypertension control](https://window-to-japan.eu/2022/03/09/2022-03-mhlw-approves-cureapps-software-for-hypertension-control-2/) - On March 9, 2022, the Ministry of Health, Labor, and Welfare approved CureApp's HT hypertension control, the first software digital therapy (DTx) in Japan. Approval is expected for April 2022 and is The app is meant to assist in non-pharmacological therapy for patients with essential hypertension. It consists of two components: (1) an app for
- [2021/02 Kobe University installs „smart cell” pilot lab](https://window-to-japan.eu/2021/02/25/17-2-kobe-university-installs-smart-cell-pilot-lab/) - In this pilot lab, supported by funds from NEDO; smart cells can be developed in less than one-fifth of the conventional time by combining proprietary long-chain DNA synthesis technology, high-throughput recombination technology, and high-speed, high-precision cell metabolite measurement technology. By using these systems to acquire enormous amounts of cell characteristics at high speed with high
- [2021/07 Demonstration plant for materials from PEG-modified lignin](https://window-to-japan.eu/2021/07/01/1-7-demonstration-plant-for-manufacturing-materials-from-peg-modified-lignin/) - Based on technology of the Forest Research Institute, the plant will be operated by a consortium consisting of seven companies, including Ligno Materia (Shinjuku, Tokyo, President Zenji Miura). A method was developed for extracting lignin using polyethylene glycol (PEG) and acid. As a result, "glycol lignin" in which PEG is bound to lignin is produced.
- [2021/08 Japanese consortium achieves solar hydrogen production on 100 m2 scale](https://window-to-japan.eu/2021/08/26/26-8-japanese-consortium-achieves-solar-hydrogen-production-on-100-m2-scale/) - A consortium of ARPChem, Fujifilm, TOTO, Mitsubishi Chemicals and the University of Tokyo, supported by NEDO, has installed and operated, since August 2019, a demonstrator for photocatalytic water splitting and succeeded in separating and recovering high-purity „solar hydrogen“ from the mixture of hydrogen and oxygen generated by water decomposition. The system consists of a photocatalytic
- [Bioökonomie - mehr als Fermentieren](https://window-to-japan.eu/2019/09/08/biookonomie-mehr-als-fermentieren/) - https://doi.org/10.1002/nadc.20194091722
- [Stammzelltechnik: Japans systematischer Ansatz](https://window-to-japan.eu/2018/04/04/stammzelltechnik-japans-systematischer-ansatz/) - https://doi.org/10.1002/nadc.20184072781
- [2022/02 Nanocarriers may lead to pest-resistant crops without changing the plant genome](https://window-to-japan.eu/2022/02/27/nanocarrier-sprays-may-lead-to-pest-resistant-crops-without-changing-the-plant-genome/) - https://www.riken.jp/en/news_pubs/research_news/pr/2022/20220223_1/index.html Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) have shown that cell-penetrating peptides (CPP*) can be used to introduce plasmid DNA into plants by spraying. Depending on the DNA carried by the plasmid, the researchers showed that they could express foreign proteins in the plant, introduce interfering RNA which silences specific
- [2022/01 NEDO will reduce CO2 emissions in the concrete and cement industries](https://window-to-japan.eu/2022/01/04/29-1-nedo-initiates-program-to-reduce-co2-emissions-in-the-concrete-and-cement-industries/) - https://www.nedo.go.jp/news/press/AA5_101510.html The Japanese Ministry of Economy is financing a ten-year joint project with JP¥ 55 billion (approx. € 390 million) to reduce CO2 emissions in concrete construction in a cost-neutral manner and to recover CO2 from limestone. The CO2 is then to be reprocessed into carbonates and these into cement. Seven Japanese companies and two
- [2022/03: MHLW approves CureApp's software for hypertension control](https://window-to-japan.eu/2022/03/01/2022-03-mhlw-approves-cureapps-software-for-hypertension-control/) - On March 9, 2022, the Ministry of Health, Labor, and Welfare approved CureApp's HT hypertension control, the first software digital therapy (DTx) in Japan. Approval is expected for April 2022 and is The app is meant to assist in non-pharmacological therapy for patients with essential hypertension. It consists of two components: (1) an app for
- [CureApps hypertension DTx approved](https://window-to-japan.eu/2022/03/11/cureapps-hypertension-dtx-approved/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/03/10/09248/
- [Japan’s model for a bioeconomy - a primer for European SMEs](https://window-to-japan.eu/2016/06/08/japans-model-for-a-bioeconomy-a-primer-for-european-smes/) - This report is accessible free of cost to EU companies which have registered to the “EU Business in Japan” website as a member via: http://www.eubusinessinjapan.eu/user/register https:::www.eubusinessinjapan.eu:sites:default:files:2019-11-japan-model-for-a-bioeconomy-eubij
- [Dictionary of Biotechnology: in English - Japanese German](https://window-to-japan.eu/1986/10/08/dictionary-of-biotechnology-in-english-japanese-german/)
- [Biotechnology in Japan: A Comprehensive Guide](https://window-to-japan.eu/1991/01/08/biotechnology-in-japan-a-comprehensive-guide/)
- [Globale Umweltprojekte in Japan](https://window-to-japan.eu/1993/04/08/globale-umweltprojekte-in-japan/) - https://doi.org/10.1002/nadc.19930410406
- [Bio-Cluster und -Start-ups - eine japanische Innovationsoffensive](https://window-to-japan.eu/2010/12/08/bio-cluster-und-start-ups-eine-japanische-innovationsoffensive/) - https://doi.org/10.1002/nadc.20060541014
- [Vereint sind auch die Schwachen mächtig](https://window-to-japan.eu/1993/07/08/vereint-sind-auch-die-schwachen-machtig/) - https://doi.org/10.1002/nadc.19930410721
- [Verbundforschung in Japan](https://window-to-japan.eu/1991/10/08/verbundforschung-in-japan/) - https://doi.org/10.1002/nadc.19910391006
- [Die japanische Kamera-Industrie diversifiziert in die Biomedizin](https://window-to-japan.eu/2017/07/18/die-japanische-kamera-industrie-diversifiziert-in-die-biomedizin/) - Der Markt für Kompaktkameras wird zunehmend bedroht durch die immer leistungsfähigeren Kameras in Smartphones, deren Bilder auch gleich in soziale Netzwerke hochgeladen werden können. Alle japanischen Kamera-Hersteller investieren deshalb nachhaltig in neue Geschäftsfelder, meist im Bereich der Biomedizin und versuchen damit, einem Technologiewandel durch Diversifikation zu begegnen.
- [Japanischem Konsortium gelingt die Konstruktion einer stabilen 1 kW Ammoniak-Brennstoffzelle](https://window-to-japan.eu/2017/07/19/japanischem-konsortium-gelingt-die-konstruktion-einer-stabilen-1-kw-ammoniak-brennstoffzelle/) - Einem Konsortium von fünf japanischen Unternehmen ist es unter Führung der Kyoto Universität (Koichi EGUCHI, Faculty of Engineering) gelungen, 30 kleinere Ammoniak- Brennstoffzellen so zu skalieren, daß die SOFC-Anlage (solid oxide fuel cell) eine gleichmäßige Leistung von 1 kW über 1000 Stunden aufwies, bei 50 % Wirkungsgrad (Stromerzeugnis in % des Energiegehalts des verbrauchten Ammoniaks).
- [Synthetische Polymere aus Lignin?](https://window-to-japan.eu/2017/07/19/synthetische-polymere-aus-lignin/) - Aus cis,cis-Muconsäure können zahlreiche Polymerbausteine wie Terephtal-, Adipin- oder Lävulinsäure, Caprolacton oder –lactam hergestellt werden. Die Arbeitsgruppen von Tomonori SONOKI an der Hirosaki University und Eiji MASAI von der Nagaoka Technical University haben nun Mutanten von Pseudomonas putida und Sphingobium sp. erzeugt, die aus verschiedenen Lignin-Typen in guten Ausbeuten cis, cis-Muconsäure bilden. Als Lignin verwendeten
- [Neuartiges leitfähiges Elastomer ermöglicht Entwicklung Sensor-bestückter Sportkleidung und Roboter-Teile](https://window-to-japan.eu/2017/07/19/neuartiges-leitfaehiges-elastomer-ermoeglicht-entwicklung-sensor-bestueckter-sportkleidung-und-roboter-teile/) - Eine Gruppe an der University of Tokyo hat im Elektronenmikroskop beobachtet, daß µm-große Silberflocken beim Mischen mit Kautschuk in Nanopartikel zerfallen und recht gleichmäßig verteilen. Das gedopte Elastomer hatte eine Leitfähigkeit von fast 5000 S/cm und erreiche selbst nach fünffacher Streckung beinahe 1000 S/cm. Die Forscher rüsteten nun durch Schmelzkleben Textilien mit Temperatur- und Drucksensoren
- [Schanghai lässt sich ein Stammzellforschungszentrum bauen – von Japan!](https://window-to-japan.eu/2017/07/23/schanghai-laesst-sich-ein-stammzellforschungszentrum-bauen-von-japan/) - Allerdings geht es dabei nur um die Energiesteuerung des Gebäudes, aber die hat es in sich. Die Energieversorgung für 16.000 m2 Laborfläche benötigt 55,3 TJoule/Jahr und erfolgt durch Geothermie. Das Energiemanagent erfolgt durch ein Energiemanagement-System im internationalen Standard IEEE 1888. Die Hocheffizienz-LED-Leuchten werden im Standby-Modus kabellos über Bewegungssensoren abgedunkelt. Energie zur Luftkühlung spart man durch
- [Medizinische Versorgung über das Smartphone: Startup MEDACA](https://window-to-japan.eu/2017/07/25/medizinische-versorgung-ueber-das-smartphone-startup-medaca/) - Die Geschäftsidee der Medical Data Card Co., Tokio, lautet best medical care anytime, anywhere" - also über das Smartphone. Dazu werden alle relevanten Daten des Kunden mittels SSL und TLS (transport layer security) in der Cloud von Amazon Web Services AWS gespeichert und können sowohl vom Kunden wie auch von medizinische Dienstleistern (Krankenhäuser, Ärzte, Apotheken)
- [Hitachi Zosen setzt auf 20 kW Brennstoffzellen für Gebäude und Gewerbe](https://window-to-japan.eu/2017/07/25/hitachi-zosen-setzt-auf-20-kw-brennstoffzellen-fuer-gebaeude-und-gewerbe/) - Nach 4000 Stunden Betriebsdauer im Feldtest, bei dem ein Wirkungsgrad von 90 % erzielt wurde, will das Unternehmen seine Brennstoffzelle nun marktnah in verschiedenen Einrichtungen von Osaka testen und damit ein längerfristiges Projekt des Industrieministeriums METI und der Stadt Osaka zur Energieversorgung mit reformiertem Methan- und Wasserstoffgas vorantreiben. Die hier getestete Brennstoffzelle von 2.2 ×
- [Die digitale Haut verstärkt den Trend zum “Quantified self” Xenoma Co., eine Ausgründung der Universität Tokio, bringt e-skin auf den Markt](https://window-to-japan.eu/2017/07/28/die-digitale-haut-verstaerkt-den-trend-zum-quantified-self-xenoma-co-eine-ausgruendung-der-universitaet-tokio-bringt-e-skin-auf-den-markt/) - Die künstliche Haut besteht aus einem Textil, das mit 14 ultradünnen Dehnungssensoren ausgerüstet ist. Sie sind über gedruckte Leiterbahnen aus in Kautschuk eingebetteten Silber-Nanopartikel geschaltet. Der Aufbau der einzelnen Module und der Einbau weiterer Sensoren für pH, Temperatur oder Druck wird auf der Webseite des Projekts geschildert, https://www.jst.go.jp/erato/someya/en/research_results/index.html. Die e-skin hält eine Reinigung in Waschmaschinen
- [Wird Wasserstoff der Energieträger der Zukunft? Japanisches Konsortium beginnt Demonstrationsprojekt für eine internationale Wasserstoff-Lieferkette](https://window-to-japan.eu/2017/07/28/wird-wasserstoff-der-energietraeger-der-zukunft-japanisches-konsortium-beginnt-demonstrationsprojekt-fuer-eine-internationale-wasserstoff-lieferkette/) - Wird Wasserstoff der Energieträger der Zukunft? Japanisches Konsortium beginnt Demonstrationsprojekt für eine internationale Wasserstoff-Lieferkette Ein Konsortium der Chiyoda Corp. mit Mitsubishi, Mitsui und der NYK Line, hat mit einem Demonstrationsprojekt zur marinen Versorgung Japans mit Wasserstoff begonnen. Grundlage dafür ist der bei Chiyoda entwickelte SPERA-Prozeß*, bei dem Methylcyclohexan als Wasserstoff-Träger eingesetzt wird. 2019 soll in
- [Können Stammzellen bei Schlaganfall helfen? JCR Pharma setzt auf Stammzellen aus der Zahnpulpa.](https://window-to-japan.eu/2017/08/03/koennen-stammzellen-bei-schlaganfall-helfen-jcr-pharma-setzt-auf-stammzellen-aus-der-zahnpulpa/) - JCR Pharma hat seit 2015 die Zulassung für ein mesenchymales Stammzellpräparat im japanischen Markt erhalten (TemCellHS). Es wird aus Knochenmark gewonnen und verhindert die Immunabwehr bei Knochenmarkstransplantationen. Die Behandlung eines Erwachsenen kostet über 100.000 €. Durch Arbeiten der Advanced Cell Technology and Engineering Ltd. (ACTE) hat sich nun herausgestellt, daß die Zahnpulpa ein noch viel
- [Bluttransfusion ohne Blutspender durch Zelltechnologie?](https://window-to-japan.eu/2017/08/12/bluttransfusion-ohne-blutspender-durch-zelltechnologie/) - [b]Megakaryon Co. in Japan findet einen Weg, Blutplättchen aus immortalisierten iPS-Zellen zu erzeugen, und bildet ein Konsortium für die neue Wertschöpfungskette [/b] Dem in Tokyo ansässigen Unternehmen, mit einem Cell Processing Center in Kyoto, gelang es, aus menschlichen iPS-Zellen (induzierte pluripotente Stammzellen) hämatopoetische Vorläuferzellen herzustellen und diese durch die Einklonierung von drei Genen zu immortalisieren.
- [Japan verliert an Boden im internationalen Wissenschaftsbetrieb](https://window-to-japan.eu/2017/08/18/japan-verliert-an-boden-im-internationalen-wissenschaftsbetrieb/) - Ein umfangreicher Bericht der japanischen Technologiebehörde (National Institute of Science and Technology Policy, NISTEP) kommt zu dem Schluß, daß Japan bei wissenschaftlichen Veröffentlichungen in den letzten 20 Jahren deutlich zurückgefallen ist und insbesondere bei häufig zitierten Veröffentlichungen nur noch Platz 9 der Weltrangliste belegt – 2004 war es noch Platz 4. Wissenschaftliche Berichte mit internationaler
- [Japan erprobt „vertikale Landwirtschaft“ mit Robotern und AI](https://window-to-japan.eu/2017/08/23/japan-erprobt-vertikale-landwirtschaft-mit-robotern-und-ai/) - Im landarmen, technologisch hochgerüsteten Japan hat die „vertikale Landwirtschaft“ mit über 150 „Pflanzenfabriken“ bereits Fuß gefasst. Dort werden in hydroponischer Kultur unter LED-Licht und bei streng regulierter Temperatur und Luftfeuchtigkeit Salate, Erdbeeren, Gemüsepflanzen und Gewürze über 365 Tage im Jahr hergestellt. Der wichtigste Vorteil wird in hohen Erträgen bei gleichbleibender Qualität gesehen. Der nächste Schritt
- [Japanisches Startup misst Blutzucker ohne zu pieksen](https://window-to-japan.eu/2017/09/01/japanisches-startup-misst-blutzucker-ohne-zu-piksen/) - Als Lichtquelle dient dabei ein im mittleren Infrarot arbeitender Festkörper-Laser (Ytterbium-dotiertes Ittrium) mit optisch parametrischer Oszillation, dessen Licht von der Aldehyd-Gruppe der Glucose weit stärker als von den Hydroxylgruppen des Wassers oder von Alkoholen absorbiert wird. Die Empfindlichkeit und Präzision dieser von Koichi YAMAKAWA bereits 2015 beschriebenen Technologie konnte seither gerätetechnisch soweit optimiert werden, daß
- [Japan erprobt fahrbare Altfett-zu-Strom-Generatoren](https://window-to-japan.eu/2017/09/08/japan-erprobt-fahrbare-altfett-zu-strom-generatoren/) - TBM, ein führender japanischer Turbinenhersteller, hat einen fahrbaren Stromgenerator der 100 KVA-Klasse entwickelt, der sich aus Fett- und Ölrückständen speist. Das mit Projektmitteln des Industrieministeriums METI entwickelte Fahrzeug wird derzeit bei verschiedenen Veranstaltungen erprobt, wo es aus den eingesammelten Rückständen von Fettabscheidern Strom für Beleuchtung, Kochgeräte und Kühlaggregate erzeugt. Bis zu den Olympischen Spielen in
- [Genom-Editierung könnte die Blumenzüchtung beschleunigen](https://window-to-japan.eu/2017/09/14/genom-editierung-koennte-die-blumenzuechtung-beschleunigen/) - Ein japanisches Team an der Universität Tsukuba hat mit der CRISPR/Cas9-Genomeditier-Methode weiße und andersfarbige Varianten der japanischen Prunkwinde (Ipomoea (Pharbitis) nil) hergestellt. Dazu wurde Dihydroflavonol-4-reduktase B (DFR-B) als Ziel ausgewählt, ein Schlüsselenzym der Anthocyanin-Biosynthese. Etwa 75 % der transgenen Pflanzen bildeten Anthocyanin-freie weiße Blüten mit bi-allelen Mutationen im für DFR-B-kodierenden Gen, in geringerem Umfang auch blaßfarbene
- [Analyse von Japans Science and Technology Agency (JST): China wird zur globalen Wissenschafts- und Technologiemacht](https://window-to-japan.eu/2017/09/17/analyse-von-japans-science-and-technology-agency-jst-china-wird-zur-globalen-wissenschafts-und-technologiemacht/) - Die Zahl der Patentanmeldungen in China überschritt 2015 erstmals eine Million und stieg bis 2016 auf 1.339.000, mehr als doppelt so viele wie die etwa 600.000 aus den USA und mehr als das Vierfache der 318.000 japanischen Anmeldungen; der Anteil Chinas an den Patentanmeldungen in der Welt lag bei über 40 %. Patente zu wissenschaftlichen
- [Solarenergie für Sensoren und Displays im T-Shirt](https://window-to-japan.eu/2017/09/19/solarenergie-fuer-sensoren-und-displays-im-t-shirt/) - Ein Team des RIKEN und der Universität Tokio haben ultradünne organische Solarzellen entwickelt, die sich dehnen und waschen lassen. Eine nur 3 µ dicke Siegelfolie besteht aus einem Thiazolothiazol-/Naphthobisthiadiazol-Halbleitercopolymer, der beidseitig in Parylen eingebettet ist; sie ist wasserfest, kann ohne Verlust ihrer Funktionalität geknickt oder zerschnitten werden und lässt sich in Textilgewebe einarbeiten. Der Wirkungsgrad
- [Japanisches Konsortium stellt erstmals serienmäßig Fahrgestelle aus Carbonfasern her](https://window-to-japan.eu/2017/10/16/japanisches-konsortium-stellt-erstmals-serienmaessig-fahrgestelle-aus-carbonfasern-her/) - Das um Toyota gruppierte Konsortium benutzte eine vom Fraunhofer-Institut für Chemische Technology in Pfinztal (FhG-ICT) entwickelte Technik (LFT-D), bei der Carbonfasern kontinuierlich mit thermoplastischen Kunststoff-Pellets verknetet werden, und entwickelte daraus eine Autoklaviertechnik, die innerhalb von 1 Minute zu einem fertigen Chassis führte, das sich mit Roboter-gesteuerten Ultraschall-Schweißsystemen verarbeiteten ließ. NEDO news release, October 16, 2017
- [Japans Überalterung wird dramatische Folgen haben…](https://window-to-japan.eu/2017/11/01/japans-ueberalterung-wird-dramatische-folgen-haben/) - Die Überalterung der japanischen Gesellschaft wird enorme Auswirkungen auf Industrie, medizinische Versorgung, Pflege usw. haben. Ein von der Chiba University durchgeführtes Projekt erlaubt eine Computer-gestützte Vorschau auf die Folgen des Bevölkerungsrückgangs für jede Präfektur bis zum Jahr 2040. Sie soll bereits in den höheren Schulklassen und an den Universitäten dazu benutzt werden, die Jugendlichen auf
- [Japan revitalisiert seine Seiden-Industrie](https://window-to-japan.eu/2017/11/12/japan-revitalisiert-seine-seiden-industrie/) - Japan hat eine lange Tradition für die Herstellung qualitativ sehr hochwertiger Naturseiden („Japanseide“), die z. B. zur Herstellung von Kimonos verwendet werden. Die japanische Seiden-Industrie, vor allem in den Präfekturen Gunma und Kumamoto beheimatet, erlebte allerdings mit der Entwicklung synthetischer Polymere einen Niedergang. Seit vielen Jahren arbeitet das Landwirtschaftsministerium MAFF und andere daran, unter dem
- [Otsuka Pharmaceutical erhält FDA-Zulassung für das erste digitale Medikament" mit Sensor"](https://window-to-japan.eu/2017/11/15/otsuka-pharmaceutical-erhaelt-fda-zulassung-fuer-das-erste-digitales-medikament-mit-sensor/) - In Otsukas oral eingenommenem Antipsychotikum ABILIFY (Aripipiprazol) ist ein Miniatursensor integriert, der über ein Pflaster erfasst, ob das Medikament überhaupt eingenommen wurde, und mit Zustimmung des Patienten über ein webbasiertes Portal für Gesundheitsdienstleister und Pflegepersonal auch Daten über die Aktivität des Patienten sowie über die selbstberichtete Ruhe und Stimmung weitergibt. In einem ersten Schritt sollen
- [Low-pressure ammonia synthesis makes progress](https://window-to-japan.eu/2018/01/23/low-pressure-ammonia-synthesis-makes-progress/) - The group around Hideo HOSONO at Tokyo Institute of Technology has succeeded to further optimize a catalyst which permits to produce ammonia from molecular nitrogen and hydrogen at relatively mild conditions (400 C, 0.1 MPa = 1 bar). The best catalyst found so far is an intermetallic “electride” compound compoised of lanthanum, cobalt and silicium
- [NEC: bioplastic turned into splendid Japan black lacquerware (urushi) for luxury items](https://window-to-japan.eu/2018/02/06/nec-bioplastic-turned-into-splendid-japan-black-lacquerware-urushi-for-luxury-items/) - In collaboration with Mr. Yutaro Shimode, a professor at Kyoto Sangyo University, NEC has developed a lacquer black tone with the beauty of urushi-like traditional craft lacquerware. The bioplastic (NeCycle R) is composed of polylactic acid and a grounded extract of cashew nuts containing cellulose and cardanol, a phenolic lipid based on anacardic acid. A
- [Kyoto University develops global land altitude database from satellite big data, useful for Tsunami risk prediction and water resources management](https://window-to-japan.eu/2018/02/18/kyoto-university-develops-global-land-altitude-database-based-on-satellite-big-data-useful-for-tsunami-risk-prediction-and-water-resources-management/) - In cooperation with two Japanese space-related research organizations, researchers at the school of bioinformatics of Kyoto University have developed a „world mesh code“ where world position information is linked with latitude, longitude and area division, based on satellite big data compressed to 1/337 at high speed. The global land area altitude data were taken from
- [Toray develops wearable power supply which can be directly pasted on clothes by hot melt method](https://window-to-japan.eu/2018/04/17/toray-develops-wearable-power-supply-which-can-be-directly-pasted-on-clothes-by-hot-melt-method/) - In collaboration with researchers at the University of Tokyo and at the University of California in Santa Barbara, a group around Daisuke KITAZAWA at Toray has synthesized a new semiconductor polymer PBDTTT-OFT" that is heat resistent and shows high energy conversion efficiency. PBDTTT - OFT has a skeleton similar to "PBDTTT - EFT (or PTB
- [Nihon University develops low-cost technology for shallow geothermal heat utilization](https://window-to-japan.eu/2018/06/25/nihon-university-develops-low-cost-technology-for-shallow-geothermal-heat-utilization/) - Under support of NEDO, Nihon University’s College of Engineering and Nissho Techno Co. have found a new construction method digging into depth of less than 20 m. The two features of this procedure are a rotary burial construction method, where steel pipes used as underground heat exchanger penetrate the underground while rotating; unlike in ordinary
- [Shareholder’s meeting of Takeda confirms acquisition of Shire](https://window-to-japan.eu/2018/12/05/shareholders-meeting-of-takeda-confirms-acquisition-of-shire/) - If Shire’s shareholders agree as well, the acquisition is expected to be completed by January 5, 2019, and will turn te company into the 9thlargest pharmaceutical company of the world, exceeding 3 trillion yen in sales. Nikkei Biotech news release, December 5, 2018
- [Fujifilm to establish iPS cell manufacturing facility for clinical use in the USA](https://window-to-japan.eu/2018/12/20/fujifilm-to-establish-ips-cell-manufacturing-facility-for-clinical-use-in-the-usa/) - Fujifilm announced on December 20 that their subsidiary Fujifilm Cellular Dynamics will invest about 2.5 billion Yen (~20 million €) in Madison, Wisconsin. Targets are regenerative medical products in the area of ​​age-related macular degeneration, retinal pigment degeneration, Parkinson's disease, heart disease and cancer using high-quality iPS cells produced at this facility from 2019 on. Fujifilm
- [NEDO starts major new program in bioeconomy focusing on biofoundries](https://window-to-japan.eu/2020/09/14/nedo-starts-major-new-program-in-bioeconomy-focusing-on-biofoundries/) - In 2019, Japan has formulated a new Bio-Strategy with the goal of achieving the world's most advanced bio-economy by 2030. Major targets are bioplastics and high-performance chemicals manufactured by "smart cells" of plant and microbial origin and integrated bioproduction processes – so-called biofoundries. The 4 years program will include data-driven creation of new enzymes, integrated
- [Tokyo Institute of Technology launches program on artificial E. coli genome](https://window-to-japan.eu/2020/09/17/tokyo-institute-of-technology-launches-program-on-artificial-e-coli-genome/) - In the "Bacterial Genome Architect Project (BGD)", a synthetic genome of E. coli will be prepared by conventional method with desired characteristics for industrial applications. Project leader is Associate Professor Yasunori AIZAWA, industrial partner is Logomix Inc., a synthetic biology startup company founded in Tokyo in 2019, based on the IP of Dr. Yasunori Aizawa. Nikkei
- [16-9 Cultured meat industry will submit proposals on safety standards and IP](https://window-to-japan.eu/2021/09/19/16-9-cultured-meat-industry-will-submit-proposals-on-safety-standards-and-ip/) - A Cell Farming Study Group was established in January 2020 by Tama University as a forum for experts to discuss food production using cell culture. More than 70 organizations are participating, including domestic and foreign companies engaged in cultured meat production and companies interested in entering the industry in the future. Major issues under discussion
- [14-9 MHLW will establish a „Genome Medical Support Center Japan“](https://window-to-japan.eu/2021/09/19/14-9-mhlw-will-establish-a-genome-medical-support-center-japan/) - The center (tentative name) will be an organization under the national government. In a whole genome analysis execution plan for cancer and intractable diseases, patient samples will be provided by cooperating medical institutions, and the samples and clinical information will be shared with the organizations that carry out whole genome analysis. The executing organization performs
- [16-9 NEC plans to grow healthcare and life science business to a value of 500 billion JP¥ in 2020](https://window-to-japan.eu/2021/09/19/16-9-nec-plans-to-grow-healthcare-and-life-science-business-to-a-value-of-500-billion-jp¥-in-2020/) - According to Mr Seiko Kitase, CEO of NEC, the focus of NEC’s related plans are Medical care business, e. g. analysis of image data by AI, Lifestyle support business, e. g. walking analysis of seniors (gait analysis), Life science business, such as AI-supported drug discovery Nikkei Biotech news release, September 16, 2021
- [Nissin reports on Japan’s first cultured steak meat with original flavor and texture](https://window-to-japan.eu/2022/04/05/9932/) - [et_pb_section fb_built="1" theme_builder_area="post_content" _builder_version="4.16.1" _module_preset="default"][et_pb_row _builder_version="4.16.1" _module_preset="default" theme_builder_area="post_content"][et_pb_column _builder_version="4.16.1" _module_preset="default" type="4_4" theme_builder_area="post_content"][et_pb_text _builder_version="4.16.1" _module_preset="default" theme_builder_area="post_content" hover_enabled="0" sticky_enabled="0"] Nissin reports on Japan’s first cultured steak meat with original flavor and texture [/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row _builder_version="4.16.1" _module_preset="default" theme_builder_area="post_content"][et_pb_column _builder_version="4.16.1" _module_preset="default" type="4_4" theme_builder_area="post_content"][et_pb_image src="https://window-to-japan.eu/wp-content/uploads/2022/04/Nissin-reports-on-Japans-first-cultured-steak-meat-with-original-flavor-and-texture.png" _builder_version="4.16.1" _module_preset="default" theme_builder_area="post_content" alt="Nissin reports on Japan’s first cultured steak meat with original flavor and texture"
- [Shimadzu and Sigmaxis collaborate on 3D printing of artificial meat](https://window-to-japan.eu/2022/04/11/shimadzu-and-sigmaxis-collaborate-on-3d-printing-of-artificial-meat/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/04/08/09354/
- [University team creates nano-semiconductors derived from wood with customizable electrical properties and 3D structure](https://window-to-japan.eu/2022/04/27/university-team-creates-nano-semiconductors-derived-from-wood-with-customizable-electrical-properties-and-3d-structure/) - https://www.jst.go.jp/pr/announce/20220427/index.html
- [Dai Nippon Printing: thin and stretchable skin displays](https://window-to-japan.eu/2018/02/25/dai-nippon-printing-thin-and-stretchable-skin-displays/) - Based on developments at the University of Tokyo (JST ERATO Someya Project*) the company is developing a thin and stretchable skin display which it plans to market within 3 years**. In this device, 16 × 24 px micro light emitting diodes and stretchable wires are mounted on a rubber sheet. The size of the micro
- [Smart drones in a 4G LTE network as airborne police: Japan](https://window-to-japan.eu/2018/03/18/smart-drones-in-a-4g-lte-network-as-airborne-police-japan/) - NEDO, KDDI, Teradrone and SECOM, utilizing a 4 G LTE standard, conducted security experiments on multiple autonomously flying drones in Kanagawa Prefecture and succeeded in remote patrol security. By remote monitoring of camera images installed in the drones from the operation control room, it was possible to identify suspicious individuals. It was also possible to
- [Kobe city quarter: hydrogen only for 2 days, a next step towards Japan’s „hydrogen society“](https://window-to-japan.eu/2018/04/22/kobe-city-quarter-uses-hydrogen-only-for-2-days-a-next-step-towards-japans-hydrogen-society/) - On April 19th and 20th, hydrogen was used as the only fuel to provide 2800 kW of heat and 1100 kW of electricity to the two facilities of Kobe Port Island central civic hospital, to Port Island sports center, and to Kobe International Exhibition Hall. The performance of each device and system in actual supply
- [A multimodal dialogue control system makes androids more human-like: meet Erica and Ibuki](https://window-to-japan.eu/2018/07/31/a-multimodal-dialogue-control-system-makes-androids-more-human-like-meet-erica-and-ibuki/) - Within the ERATO Ishiguro project on Human Robot Interaction, a team of ATR, Osaka and Kyoto University developed a multimodal dialogue control system making full use of cameras and microphones to improve a natural presence in daily situations of the android "ERICA" and enhanced the sense of dialogue by the social dialog robot "CommU". In
- [Japanese startup develops simple cancer pre-diagnosis using C. elegans, raises 1.4 billion yen (11 million €)](https://window-to-japan.eu/2018/08/08/japanese-startup-develops-simple-cancer-pre-diagnosis-using-c-elegans-raises-1-4-billion-yen-11-million-e/) - The N-NOSE test developed by Takuya HIROZU monitors if C. elegans roundworms evade or come closer to a drop of urine obtained from a test person. C. elegans has significantly more smell receptors than dogs and evades healthy urine but not the urine of cancer patients. In tests so far an accuracy of over 95
- [Ajinomoto introduces health app with photographic meal recognition based on AI](https://window-to-japan.eu/2018/08/08/ajinomoto-introduces-health-app-with-photographic-meal-recognition-based-on-ai/) - The app カラダわかるNavi („understand your body“) requests to enter daily diet and exercise records on a smartphone, then evaluates calorie intake and nutritional balance and provides advices on meal improvement and best time for next meal. Meal composition is analyzed by recognizing the menu (about 250 kinds) and AI-based automatic analysis of food components. Meal
- [NEDO consortium plans „Hydrogen Energy Research Field“ in Fukushima](https://window-to-japan.eu/2018/08/09/nedo-consortium-plans-hydrogen-energy-research-field-in-fukushima/) - A NEDO-supported consortium of Toshiba Energy Systems, Tohoku Electric Power and Iwatani Industry will establish by 2020 the "Fukushima Hydrogen Energy Research Field" which manufactures and supplies up to 900 tons of hydrogen annually generated by 10,000 kW hydrogen production equipment using adjacent photovoltaic power generation and grid power. The greatest challenge of this demonstration
- [Clinical applications of iPS cell technology have made a step forward](https://window-to-japan.eu/2018/08/27/clinical-applications-of-ips-cell-technology-have-made-a-step-forward/) - According to a survey by Nikkei Biotech, there are now seven cases of doctor-initiated clinical trials based in iPS cells in Japan. The most recent one is Jun Takahashi of CiRA’s clinical trial, in collaboration with Dainippon Sumitomo Pharma, using heterologous dopamine progenitor cells for the treatment of Parkinsons’s diseases at patients in Kyoto University
- [Torays new carbon fiber reinforced plastic (CFRP) supports iron to polymer (ItoP) EV concept car](https://window-to-japan.eu/2018/09/28/torays-new-carbon-fiber-reinforced-plastic-cfrp-supports-iron-to-polymer-itop-ev-concept-car/) - In the concept car, which is jointly developed by Toray, Mitsubishi Chemical, Sumitomo Chemical, AGC, Bridgestone, polymers will constute 47 % of the car, reducing the vehicle weight to 850 kg. The car has an egg-shaped cabin and a separate front wheel cover, a large window area, and a large opening door. The interior of
- [Nagoya University group develops contact lens for self-sustained continuous blood glucose monitoring](https://window-to-japan.eu/2018/10/19/nagoya-university-group-develops-contact-lens-for-self-sustained-continuous-blood-glucose-monitoring/) - Associate Professor Kiichi NIITSU of the Graduate School of Engineering, Nagoya University and his group have developed a miniaturized blood glucose sensor in form of a contact lens. It contains a solid-state element of 0.6 millimeter square that performs power generation and sensing at the same time by producing electricity of about 1 nano Watt
- [METI held wordwide competition on products for “well-aging” and selected 8 finalists](https://window-to-japan.eu/2018/10/19/meti-held-wordwide-competition-on-products-for-well-aging-and-selected-8-finalists/) - On October 9, METI held a pitch contest on products designed to support aging people (“First Well-Aging Society Summit Asia-Japan”). The following eight companies were selected as finalists: GYENNO Technologies, Israel: electronic spoon "GYENNO SPOON" for patients with Parkinson's disease, a spoon for trembling hands, http://www.gyenno.com/spoon-en.html Intuition Robotics, Israel: social robot "ElliQ" which secures connection
- [Euglena Co. completes demonstration plant for biojet and diesel fuel](https://window-to-japan.eu/2018/11/02/euglena-co-completes-demonstration-plant-for-biojet-and-diesel-fuel/) - The production capacity of the demonstration plant is 125 kL per year, and the manufacturing cost is about 10,000 yen/L. A commercial plant scheduled for 2025 will raise the production capacity 20 fold, aiming at 250,000 kL per year. Currently, raw material cost of Euglena is 110 yen/L, higher than the raw material cost of
- [Kao finds 13,000 kinds of undegraded RNA in sebum, hopes to develop "personalized cosmetics"](https://window-to-japan.eu/2018/11/27/kao-finds-13000-kinds-of-undegraded-rna-in-sebum-hopes-to-develop-personalized-cosmetics/) - During a technical presentation, Kao presented a number of innovations including the finding that a wide variety of undegraded RNA can be isolated from sebum. Kao expects that this finding will help analyze early diseases such as atopic dermatitis even before symptoms appear, and thus to care from the earliest stage. Also, since RNA changes
- [Kowa Co. and NARO develop fibers stronger than spiders’ thread from bagworm moths](https://window-to-japan.eu/2018/12/05/kowa-co-and-naro-develop-fibers-stronger-than-spiders-thread-from-bagworm-moths/) - The caterpillar larvae of bagworm moths (Tineoidea, jp. Minomushi) form bags f from silk and bamboo material. In collaboration with the National Agriculture Research Organization, Kowa Co. has managed to isolate long fibers from this network, without killing the larvae, and established an effective yarn drawing method. Compared to spider's silk, this fibre is about 2.2
- [NEDO implements biojet fuel project, commercialization around 2030](https://window-to-japan.eu/2018/12/03/nedo-implements-biojet-fuel-project-commercialization-around-2030/) - NEDO has started a new program integrating former projects on microalgae biojet fuel (see: IHI and and biomass hydrothermal gasification with Showa Shell Oil, a company which commercializes jet fuel already. Partners will be 5 companies and the Japan Aerospace Exploration Agency JAXA. First, pure biojet fuel produced in pilot plants will have to conform
- [Toyota-led consortium reaches > 50 % net maximum thermal efficiency in both gasoline and diesel cars](https://window-to-japan.eu/2019/01/16/toyota-led-consortium-reaches-50-net-maximum-thermal-efficiency-in-both-gasoline-and-diesel-cars/) - A Japanese R&D consortium under the Japanese Agency of Science Technology and led by Toyota estimates that even in 2040, in spite of the advance of electric vehicles, internal combustion engines will be installed in about 89% of the world's total cars, including hybrid vehicles and plug-in hybrid vehicles. Thus, the optimization of thermal efficiency
- [Machines will learn about human communication from data sets including speech, voice, gaze and body expressions: NEDO and Tokyo Denki University](https://window-to-japan.eu/2019/02/06/machines-will-learn-about-human-communication-from-data-sets-including-speech-voice-gaze-and-body-expressions-nedo-and-tokyo-denki-university/) - In a program on next-generation AI and robot core technologies, cameras, microphones and sensors will collect abundant data from a group of students involved in discussions, such as remarks, facial expressions, gestures such as arms rising and falling, and gaze. By annotating speech and behavior, it is scheduled to design the next generation AI systems.
- [DENSO partners with Euglena Corp. on micro algae R&D](https://window-to-japan.eu/2019/02/23/denso-partners-with-euglena-corp-on-micro-algae-rd/) - Within a comprehensive alliance for business development of microalgae, both companies will cover 1. Development of biofuels business (“Green Oil Japan”), 2. R&D of micro algae culture technology, 3. Use of algae for foods and cosmetics, and 4. Production of substances by microalgae. The partnership will comprise Euglena’s focus on Euglena algae, and Denso’s on
- [Japan to create its bioeconomy from “bio-digital integration” (バイオとデジタルの融合)](https://window-to-japan.eu/2019/08/03/japan-to-create-its-bioeconomy-from-bio-digital-integration-バイオとデジタルの融合/) - The term will serve as a unifying concept leading to “smart cells” of plants and microorganisms by combining genome analysis, genome editing and metabolic engineering of cells supported by robotics, cloud computing, big data informatics and artificial intelligence. These technologies will allow to modify living cells and improve genomic selection for a wide range of applications
- [Japan's "hydrogen society" - a concise development plan for fuel-cell based mobility and home energy supply](https://window-to-japan.eu/2019/09/28/japans-hydrogen-society-a-concise-development-plan-for-fuel-cell-based-mobility-and-home-energy-supply/) - H2 Japan Okt. 2019Download
- [2022/04 Japan opens demonstration center for CO2 recycling at Osaki Power Plant](https://window-to-japan.eu/2022/04/07/japan-opens-at-osaki-power-plant-a-demonstration-and-research-center-for-co2-recycling/) - https://www.nedo.go.jp/news/press/AA5_101530.html, https://greenproduction.co.jp/archives/5604
- [5-11 NEDO launches R&D program for hydrogen aircrafts](https://window-to-japan.eu/2021/11/05/5-11-nedo-launches-rd-program-for-hydrogen-aircrafts/) - The project aims to increase the ratio of participation in international joint development of airframes and engines (currently about 20-30%) by maximizing the strengths of Japan's elemental technologies, such as hydrogen and materials. The project will also contribute to the decarbonization of the aviation sector. Implementation period: FY2021 - FY2030 Budget: 21.08 billion yen (scale
- [Blick nach Asien 12/2021](https://window-to-japan.eu/2021/12/02/blick-nach-asien-12-2021/) - Blick-nach-Asien-2021-12Download
- [Blick nach Asien 11/2021](https://window-to-japan.eu/2021/11/09/blick-nach-asien-11-2021/) - Blick-nach-Asien-112021Download
- [Blick nach Asien 2022/1](https://window-to-japan.eu/2022/01/10/blick-nach-asien-1-2022/) - Blick-nach-Asien-12022Download
- [Blick nach Asien 2022/2](https://window-to-japan.eu/2022/02/06/blick-nach-asien-2022-02/) - Nachrichten-202202Download
- [Blick nach Asien 2022/3](https://window-to-japan.eu/2022/03/12/blick-nach-asien-03-22/) - Blick-nach-Asien-0322Download
- [Blick nach Asien 2022/5](https://window-to-japan.eu/2022/05/02/blick-nach-asien-2022-5/)
- [Blick nach Asien 2022/4](https://window-to-japan.eu/2022/05/02/blick-nach-asien-2022-4/)
- [Blick nach Asien 2022/6](https://window-to-japan.eu/2022/06/16/blick-nach-asien-2022-6/)
- [Blick nach Asien 2022/07](https://window-to-japan.eu/2022/06/30/blick-nach-asien-2022-07/)
- [15-10 NEDO adds projects on use of CO2 as raw material](https://window-to-japan.eu/2021/10/15/15-10-nedo-adds-projects-on-use-of-co2-as-raw-material/) - The project house NEDO of the Japanese Ministry of Economy and Trade METI is funding further topics on the use of CO2 as a raw material with a total of about €100 million over 5 years: 1. Synthesis of lower olefins (IHI) and methanol from CO2 (JFE Steel, RITE), 2. Methane from CO2 via large-scale
- [18-11 Green Earth Institute uses Corynebacterium resting cells to prepare green chemicals from formaldehyde](https://window-to-japan.eu/2021/11/18/18-11-green-earth-institute-uses-corynebacterium-resting-cells-to-prepare-green-chemicals-from-formaldehyde/) - In an artificial metabolic system, the formaldehyde is added via aldolase, to appropriate cosubstrates forming 2,4-dihydroxybutyric acid (DHB), homoserine (hSer), and 1,3-propanediol (PDO). As an aldolase, hpal from Escherichia coli was used. It accepts also other aldehydes. The study is considered a proof of principle that high-cell density cultures of resting cells of C. glutamicum
- [Mitsui Chemicals begins manufacturing bio-polypropylene (bio-PP) from biomass naphtha](https://window-to-japan.eu/2021/12/18/16-12-mitsui-chemicals-begins-manufacturing-bio-polypropylene-bio-pp-from-biomass-naphtha/) - The biomass naphtha prepared from vegetable oil waste and residual oil is supplied from Finland’s Neste. Mitsui Chemicals studies since many years a bio-based process for the production of isopropanol from biomass, using recombinant E. coli as a catalyst. Isopropanol is then further processed to bio-PP. The process is currently run at 1500 L scale
- [NEDO will reduce CO2 emissions in the concrete and cement industries](https://window-to-japan.eu/2022/01/06/nedo-will-reduce-co2-emissions-in-the-concrete-and-cement-industries/) - https://www.nedo.go.jp/news/press/AA5_101510.html The Japanese Ministry of Economy is financing a ten-year joint project with JP¥ 55 billion (approx. € 390 million) to reduce CO2 emissions in concrete construction in a cost-neutral manner and to recover CO2 from limestone. The CO2 is then to be reprocessed into carbonates and these into cement. Seven Japanese companies and two
- [Japan starts 8 years program to use hydrogen in steel-making](https://window-to-japan.eu/2022/01/07/japan-starts-8-years-program-to-use-hydrogen-in-steel-making/) - https://www.nedo.go.jp/news/press/AA5_101503.html
- [Japan starts 8 years program to secure cheap ammonia production for hydrogen generation](https://window-to-japan.eu/2022/01/07/japan-starts-8-years-program-to-secure-cheap-ammonia-production-for-hydrogen-generation/) - https://www.nedo.go.jp/koubo/EV3_100238.html
- [Japan’s NEDO initiates program on fuel ammonia supply chain](https://window-to-japan.eu/2022/01/10/7-1-japans-nedo-initiates-program-on-fuel-ammonia-supply-chain/) - As ammonia, like hydrogen, does not emit CO2 when burned, it is expected to be used as a decarbonized fuel for power generation and ships to achieve carbon neutrality. In particular, ammonia is expected to replace conventional fossil fuels in power generation, thereby promoting the decarbonization of thermal power generation. Ammonia can also be used
- [NEDO initiates program for using hydrogen in steelmaking](https://window-to-japan.eu/2022/01/10/7-1-nedo-initiates-program-for-using-hydrogen-instead-of-natural-gas-in-steelmaking/) - The steel industry emits as much as 40% of Japan's industrial sector's CO2 during the manufacturing process. The blast furnace method, which is currently used in steel mills in Japan, uses mainly coke (coal) to reduce iron ore to produce steel, leading to CO2 emissions. NEDO has been working on a hydrogen reduction process technology
- [Offshore windpower program started](https://window-to-japan.eu/2022/01/21/offshore-windpower-program-started/) - https://www.nedo.go.jp/koubo/FF3_100336.html
- [NEDO awards 13 industrial programs on energy conservation](https://window-to-japan.eu/2022/01/28/nedo-awards-13-industrial-programs-on-energy-conservation/) - https://www.nedo.go.jp/news/press/AA5_101509.html
- [Cement from carbon recycling – Japan starts 8 years program](https://window-to-japan.eu/2022/01/29/cement-from-carbon-recycling-japan-starts-8-years-program/) - https://www.nedo.go.jp/news/press/AA5_101510.html
- [Shimazu and Shionogi establish Advan Sentinel, a joint venture for sewage monitoring of COVID](https://window-to-japan.eu/2022/02/09/9-2-shimazu-and-shionogi-establish-advan-sentinel-a-joint-venture-for-sewage-monitoring-of-the-new-corona/) - The company Advan Sentinel in Osaka will provide sewage monitoring-related services to the national and local governments, companies, etc., aiming for sales of 1 billion JP¥ (~7.6 million €) in the next 2-3 years. Shimadzu has developed a „PoP-CoV“ sampler which is installed in manholes for continuous collection over 1 or 2 days. The sample
- [CO2 to plastic raw materials – Japan starts 10 years program](https://window-to-japan.eu/2022/02/18/co2-to-plastic-raw-materials-japan-starts-10-years-program/) - https://www.nedo.go.jp/news/press/AA5_101517.html
- [Hydrogen generation from electrolysis: enhancing catalyst lifetime by Co2MnO4](https://window-to-japan.eu/2022/02/21/hydrogen-generation-from-electrolysis-enhancing-catalyst-lifetime-by-co2mno4/) - https://www.nature.com/articles/s41929-021-00732-9
- [Japan starts 1 billion € program on “green power” semiconductors and data centers](https://window-to-japan.eu/2022/02/25/japan-starts-1-billion-e-program-on-green-power-semiconductors-and-data-centers/) - https://www.nedo.go.jp/news/press/AA5_101513.html
- [Guidelines for the Introduction of Biomass Energy Local Self-Sustaining Systems, NEDO](https://window-to-japan.eu/2022/03/14/guidelines-for-the-introduction-of-biomass-energy-local-self-sustaining-systems-nedo/) - https://www.nedo.go.jp/news/press/AA5_101522.html
- [“Act for Sky” consortium to cooperate on sustainable aviation fuel](https://window-to-japan.eu/2022/03/03/act-for-sky-consortium-to-cooperate-on-sustainable-aviation-fuel/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/03/02/09220/
- [Green Earth Institute and NEDO inaugurate “Kanto Biofoundry Base” for bioprocess optimization](https://window-to-japan.eu/2022/04/06/green-earth-institute-and-nedo-inaugurate-kanto-biofoundry-base-for-bioprocess-optimization/) - As part of NEDO's "Development of Production Technologies for Bio-based Products to Accelerate the Realization of Carbon Recycling, The Green Earth Institute, Inc. https://gei.co.jp/en/ is constructing a demonstration base for microbial bioproduction processes (“The Kanto Biofoundry Base”) using two locations in Chiba Prefecture, its subsidiary in Kisarazu City and the Mobara Plant of Mitsui Chemicals. The Kanto
- [NEDO roadmap for fuel-cell heavy duty vehicles](https://window-to-japan.eu/2022/04/18/nedo-roadmap-for-fuel-cell-heavy-duty-vehicles/) - https://www.nedo.go.jp/news/press/AA5_101524.html
- [University of Tokyo develops finger-shaped robot covered with cultured skin](https://window-to-japan.eu/2022/06/13/university-of-tokyo-develops-finger-shaped-robot-covered-with-cultured-skin-worlds-first/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/06/10/09602/ To construct cultured skin on a flat surface, a collagen solution in which dermal cells are suspended is first gelatinized, and then dermal tissue is cultured on the gel. Then, epidermal cells are seeded on the surface of the cultured dermis to form an epidermal layer. In order to align the flat cultured skin
- [2022/06 Dr Foods offers vegetable-based foie-gras burger](https://window-to-japan.eu/2022/06/30/dr-foods-offers-vegetable-based-foie-gras-burger/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/06/28/09664/ Dr. Foods (Shinjuku, Tokyo), a developer of cultured meat and plant-derived meat, announced on June 28, 2022, that it will launch its first product, a plant-derived alternative foie gras. Although not a product made from cultured animal cells, the company used the name "cultured foie gras" because microorganisms are cultured in the manufacturing process.
- [Nagahama Institute of Bio-Science and Technology aims to create "Super Crickets" for food and feed through genome breeding](https://window-to-japan.eu/2022/01/06/nagahama-institute-of-bio-science-and-technology-aims-to-create-super-crickets-for-food-and-feed-through-genome-breeding/) - Crickets are being utilized as edible insects, and a research team led by Professor Jun Ogura of Nagahama Institute of Bio-Science and Technology has been working on species improvement through genome breeding. The plan is to create a variety that can be called a "super cricket," and the team aims to produce such a variety
- [CureApps hypertension DTx approved](https://window-to-japan.eu/2022/03/06/cureapps-hypertension-dtx-approved/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/03/10/09248/
- [2021/12 Nagahama Institute of Bio-Science and Technology aims to create "Super Crickets" for food and feed through genome breeding](https://window-to-japan.eu/2022/01/01/2022-01-nagahama-institute-of-bio-science-and-technology-aims-to-create-super-crickets-for-food-and-feed-through-genome-breeding/) - Crickets are being utilized as edible insects, and a research team led by Professor Jun Ogura of Nagahama Institute of Bio-Science and Technology has been working on species improvement through genome breeding. The plan is to create a variety that can be called a "super cricket," and the team aims to produce such a variety
- [2022/02: NEDO initiates 10 year 900 million € fund for CO2 recycling in the chemical industry, mostly to plastics](https://window-to-japan.eu/2022/02/01/2022-02-nedo-initiates-10-year-900-million-e-fund-for-co2-recycling-in-the-chemical-industry-mostly-to-plastics/) - In October 2020, the Japanese government set a goal of zero greenhouse gas emissions by 2050. This goal needs to greatly accelerate current efforts and innovation through bold investment. To this end, the Ministry of Economy, Trade and Industry (METI) has created a fund totaling 2 trillion yen at the New Energy and Industrial Technology
- [2022/04: Two Japanese groups report progress on cultured beef muscle meat](https://window-to-japan.eu/2022/04/01/2022-04-two-japanese-groups-report-progress-on-cultured-beef-muscle-meat/) - Osaka University, Shimadzu, and Sigmaxis Collaborate on Automated 3D Printed Cultured Meat Production Professor Noriya Matsuzaki of Osaka University, Shimadzu Corporation, and consulting firm Sigmaxis are collaborating to develop automated manufacturing technology for cultured meat using 3D printing. They use Professor Matsuzaki’s technology where myocytes, adipocytes, and vascular endothelial cells are extracted from beef-cells, and
- [2022/05 Green Earth Institute and NEDO inaugurate “Kanto Biofoundry Base” for bioprocess optimization](https://window-to-japan.eu/2022/05/29/2022-05-green-earth-institute-and-nedo-inaugurate-kanto-biofoundry-base-for-bioprocess-optimization/) - As part of NEDO's "Development of Production Technologies for Bio-based Products to Accelerate the Realization of Carbon Recycling, The Green Earth Institute, Inc. https://gei.co.jp/en/ is constructing a demonstration base for microbial bioproduction processes (“The Kanto Biofoundry Base”) using two locations in Chiba Prefecture, its subsidiary in Kisarazu City and the Mobara Plant of Mitsui Chemicals. The Kanto
- [Review on Annual Meeting of the Japanese Society of Regenerative Medicine](https://window-to-japan.eu/2022/04/11/review-on-annual-meeting-of-the-japanese-society-of-regenrative-medicine/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400016/040600220/
- [Technology to prevent chicken-egg allergy with egg white enzyme degradation products](https://window-to-japan.eu/2022/06/16/technology-to-prevent-chicken-egg-allergy-with-egg-white-enzyme-degradation-products/) - https://bio.nikkeibp.co.jp/atcl/column/16/052000031/060900090/ A group led by Takashi Igarashi, president of the National Institute of Child Health and Development (NICHD), and Yoshihide Hata, president of Nippon Ham (NIHON HAM), has successfully developed a technology to prevent egg allergy, which is a problem among infants and young children. At present, the research results are from mice (published online
- [Japan's functional food labeling applications exceed 5,000, and the market size exceeds 300 billion yen (2.13 billion €)](https://window-to-japan.eu/2022/06/13/japans-functional-food-labeling-applications-exceed-5000-and-the-market-size-exceeds-300-billion-yen-2-13-billion-e/) - https://bio.nikkeibp.co.jp/atcl/report/16/011900001/22/06/06/00392/
- [Several Japanese companies enter the digital health market DTx - review](https://window-to-japan.eu/2022/06/13/major-japanese-companies-enter-the-digital-health-market-dtx-review/) - https://bio.nikkeibp.co.jp/atcl/report/16/082400016/060900225/index.html https://bio.nikkeibp.co.jp/atcl/report/16/082400016/060900225/
- [Hirotech Corp. achieves direct binding of fluoropolymers to stainless steel, providing super lubric surfaces for civil engineering applications](https://window-to-japan.eu/2022/05/31/hirotech-corp-achieves-direct-binding-of-fluoropolymers-to-stainless-steel-providing-super-lubric-surfaces-for-civil-engineering-applications/) - https://www.nedo.go.jp/news/press/AA5_101546.html
- [Astellas uses AI and robotics for drug discovery research using iPS cells](https://window-to-japan.eu/2022/05/26/astellas-uses-ai-and-robotics-for-drug-discovery-research-using-ips-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/05/24/09534/
- [Alumina-supported alpha-iron(III) oxyhydroxide as a recyclable solid catalyst for CO2 photoreduction under visible light](https://window-to-japan.eu/2022/05/16/alumina-supported-alpha-ironiii-oxyhydroxide-as-a-recyclable-solid-catalyst-for-co2-photoreduction-under-visible-light/) - https://onlinelibrary.wiley.com/doi/10.1002/anie.202204948
- [Shimadzu and TIT develop world's smallest luminescent enzyme and provide samples](https://window-to-japan.eu/2022/04/26/shimadzu-and-tit-develop-worlds-smallest-luminescent-enzyme-and-provide-samples/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/04/25/09417/
- [Government institute provides cocktails of human indigenous microorganisms for health research](https://window-to-japan.eu/2022/01/19/government-institute-provides-cocktails-of-human-indigenous-microorganisms-for-health-research/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/01/13/09029/
- [iPS cell-derived kidney tissue: Kyoto startup Regenfro](https://window-to-japan.eu/2022/02/08/ips-cell-derived-kidney-tissue-kyoto-startup-regenfro/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/02/07/09134/
- [Corona monitoring from sewage: Shionogi and Shimadzu’s joint venture AdvanSentinel ](https://window-to-japan.eu/2022/02/09/corona-monitoring-from-sewage-shionogi-and-shimadzus-joint-venture-advansentinel-/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/02/08/09139/
- [Antibody-covered masks allow for real-time detection of Corona infection](https://window-to-japan.eu/2022/02/10/antibody-covered-masks-allow-for-real-time-detection-of-corona-infection/) - https://www.jst.go.jp/pr/announce/20220210-2/index.html
- [Cellular medicine for fecal incontinence: Austrian Innovacell Biotechnologie venture starts phase III clinical studies in Japan](https://window-to-japan.eu/2022/02/21/cellular-medicine-for-fecal-incontinence-austrian-innovacell-biotechnologie-venture-starts-phase-iii-clinical-studies-in-japan/) - https://bio.nikkeibp.co.jp/atcl/column/16/021500017/022100228/
- [Plants can be transfected by spraying, using DNA and cell-permeable peptide](https://window-to-japan.eu/2022/02/25/plants-can-be-transfected-by-spraying-using-dna-and-cell-permeable-peptide/) - https://pubs.acs.org/doi/10.1021/acsnano.1c07723
- [New spider silk textiles from Spiber and Goldwin](https://window-to-japan.eu/2022/03/30/new-spider-silk-textiles-from-spiber-and-goldwin/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/03/28/09321/
- [Nissin reports on Japan’s first cultured steak meat with original flavor and texture](https://window-to-japan.eu/2022/03/31/nissin-reports-on-japans-first-cultured-steak-meat-with-original-flavor-and-texture/) - https://www.jst.go.jp/pr/announce/20220331/pdf/20220331.pdf
- [Kyoto’s CiRA and MicroBiopharm Japan discover Actinomyces metabolites which reduce amyloid-ß (Aß) formation in-vitro, relation to gut microbiota inferred](https://window-to-japan.eu/2022/04/05/kyotos-cira-and-microbiopharm-japan-discover-actinomyces-metabolites-which-reduce-amyloid-s-as-formation-in-vitro-relation-to-gut-microbiota-inferred/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/04/04/09336/
- [Ultra-strong underwater adhesive inspired by marine organisms](https://window-to-japan.eu/2022/04/13/ultra-strong-underwater-adhesive-inspired-by-marine-organisms/) - https://www.nature.com/articles/s41467-022-29427-w
- [Crickets enter animal food market in Japan](https://window-to-japan.eu/2022/04/15/crickets-enter-animal-food-market-in-japan/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/04/14/09374/
- [AI applied to optimize lettuce growth in greenhouses](https://window-to-japan.eu/2022/04/14/ai-applied-to-optimize-lettuce-growth-in-greenhouses/) - https://www.nedo.go.jp/news/press/AA5_101532.html
- [Hitachi and Nagase will produce ergothoneine by E. coli “smart cells”](https://window-to-japan.eu/2022/04/20/hitachi-and-nagase-will-produce-ergothoneine-by-e-coli-smart-cells/) - https://bio.nikkeibp.co.jp/atcl/news/p1/22/04/19/09390/
- [Japan prepares for introduction of AI into traffic control systems nationwide](https://window-to-japan.eu/2022/04/26/japan-prepares-for-introduction-of-ai-into-traffic-control-systems-nationwide/) - https://www.nedo.go.jp/news/press/AA5_101538.html
- [Japan approves digital therapy of hypertension](https://window-to-japan.eu/2022/03/12/japan-approves-digital-therapy-of-hypertension/) - CureApp, a startup in Tokyo, is expected to obtain approval this April for its non-pharmacological digital therapy (DTx) of hypertension (rather: support of therapy). The medical device consists of two components: 1. an app to be used by the patient, and 2. an app for the physician to review the patient’s data. The patient enters
- [18-11 Japan reports progress on transgenic pollen-free cedars](https://window-to-japan.eu/2021/11/18/18-11-japan-reports-progress-on-transgenic-pollen-free-cedars/) - The Forest Research Institute's Forest Biotechnology Research Center (Hitachi City, Ibaraki Prefecture) reports progress on the development of a pollen-less cedar by genome editing of "seminal trees" which grow fast and straight. In the transgenic plant, a single nucleotide has been deleted by CRISPR/Cas9 in the gene responsible for the outer wall of the pollen,
- [9-11 NeuroSky and Dainippon Sumitomo Pharma will develop wearable electroencephalographs](https://window-to-japan.eu/2021/11/09/9-11-neurosky-and-dainippon-sumitomo-pharma-will-develop-wearable-electroencephalographs/) - The medical device will be used for the prevention and diagnosis of neuropsychiatric diseases such as sleep disorders, depression, attention deficit/hyperactivity disorder (ADHD), and dementia at an early stage. At the same time, a version for healthcare use by the general public will be developed which is based on the successful product „Nekomimi“ (a manga
- [1-11 Genome-edited tiger puffer fish accepted as food in Japan](https://window-to-japan.eu/2021/11/01/1-11-genome-edited-tiger-puffer-fish-accepted-as-food-in-japan/) - Regional Fish Co., Kyoto, has received acceptance from the Ministry of Agriculture, Forestry and Fisheries and the Ministry of Health, Labor and Welfare for sales of genome-edited tiger puffer fish. In the genome-edited fish strain, a leptin receptor reducing appetite was removed, leading to growth at double speed and improved feed utilization efficiency. The high-growth
- [26-10 Japan’s „Green Innovation Fund“ launches construction of „zero-emission“ ships and a supply chain for hydrogen and ammonia fuels](https://window-to-japan.eu/2021/10/26/26-9-japans-green-innovation-fund-launches-construction-of-zero-emission-ships-and-a-supply-chain-for-hydrogen-and-ammonia-fuels/) - NEDO, the project house of METI, will launch a 32 billion JP¥ (242 million €) program on „next generation ships“, which includes the development of engines fueled by hydrogen and ammonia. In the future, „zero-emission ships“ will emit virtually no greenhouse gases in their operation. According to NEDO, international shipping accounts for about 2.1% of
- [18-9 Japan permits marketing of genome-edited fish](https://window-to-japan.eu/2021/09/22/18-9-japan-permits-marketing-of-genome-edited-fish/) - In the red sea bream, 14 bases of the myostatin gene suppressing muscle hyperplasia were deleted, using CRISPR/Cas technology. The average amount of the edible portion was increased about 1.2 times, and the ratio of weight gain to ingested feed improved by 14%. Since the bone volume is reduced by about 31%, it is thought
- [27-8 Grillus, a startup on edible crickets for human nutrition](https://window-to-japan.eu/2021/08/27/9661/) - Grillus is a startup from the University of Tokushima that produces edible crickets and sells cricket-derived as „circular food“. Basic technology consists of mass production of a highly uniform albino strain of the Dipterocarpus cricket, which has been maintained at the University of Tokushima for generations. The crickets are then dried and grinded providing a
- [27-8 Secure storage of genome analysis data by quantum cryptography](https://window-to-japan.eu/2021/08/27/27-8-secure-storage-of-genome-analysis-data-by-quantum-cryptography/) - Toshiba and others explore a system to store personal genetic data from projects of the Tohoku Medical Megabank Organization (ToMMo) using a combination of quantum cryptography communication technology and secret distribution technology. The consortium has successfully conducted a demonstration experiment to distribute large-scale human genome analysis data to multiple locations for safe backup storage. Nikkei
- [7-9 Ministry of Agriculture inks major programs on biotech](https://window-to-japan.eu/2021/09/07/7-9-ministry-of-agriculture-inks-major-programs-on-biotech/) - Within its biotech-related 74 billion Yen (about 570 million €) budget for FY2022, the ministry aims to strengthen production capacity and improve sustainability of the domestic agriculture, forestry, and fisheries industries. Topics include: low-temperature storage systems for tea leaves and late-season tea varieties technologies for early egg collection, artificial seedling cultivation and aquaculture of eel
- [16-8 Promising ventures in Japan: The University Venture Award 2021](https://window-to-japan.eu/2021/08/16/16-8-promising-ventures-in-japan-the-university-venture-award-2021/) - Japan’s Science and Technology Agency JST and NEDO, project house of the Ministry of Economics, Trade and Industry, offer an annual award to startups, financially supported by companies. The 2021 prize was awarded to Heartseed Co. https://heartseed.jp Heartseed, a spin-off of Kyoto University, develops cardiac regeneration medicine for severe heart failure, using iPS cells. The
- [2-7 University of Tokyo team edits chloroplast genome of a plant using procedures not subject to Cartagena law regulation](https://window-to-japan.eu/2021/07/02/2-7-university-of-tokyo-team-edits-chloroplast-genome-of-a-plant-using-procedures-not-subject-to-cartagena-law-regulation/) - Shinichi Arimura and colleagues have used a TALEN tool for genome editing developed in Japan. The gene encoding a citidine deaminase (CD) is linked to the TALEN domain, and a gene encoding for delivery to the chloroplast is ligated. Using this method, single nucleotide substitutions at the target site of a chloroplast genome could be
- [11-6 Team at Tokyo University of Agriculture and Technology develops DNA aptamer that enhances luminol reaction more than 300 times](https://window-to-japan.eu/2021/06/11/11-6-team-at-tokyo-university-of-agriculture-and-technology-develops-dna-aptamer-that-enhances-luminol-reaction-more-than-300-times/) - The group around Kazunori IKEBUKURO has used the SELEX method to develop an aptamer which binds to myoglobin and changes the three-dimensional structure of the active site. As a result, the enzymatic activity of myoglobin and the substrate specificity for luminol are increased, so that the luminescence signal generated by the peroxidase reaction over 300
- [15-7 Japan plans for „dramatic expansion of fuel cell technology“](https://window-to-japan.eu/2021/07/15/15-7-japan-plans-for-dramatic-expansion-of-fuel-cell-technology/) - The program supported by METIs project house NEDO looks for an implementation in 2030 and beyond, but has organized another industry-academia consortia to improve fundamental technologies related to SOFC and PEFC fuel cells. It runs from FY2020 - FY2024 (planned), with a FY2021 budget of 6.67 billion yen (50 million €). The targets are 6
- [14-7 Novo Nordisk takes license from Heartseed Japan for iPS-derived cardiomyocytes](https://window-to-japan.eu/2021/07/14/14-7-novo-nordisk-takes-license-from-heartseed-japan-for-ips-derived-cardiomyocytes/) - Heartseed has granted Novo the exclusive rights to develop, manufacture, and sell HS-001, regenerated cardiomyocytes derived from heterologous iPS cells in the world except Japan. In Japan, Heartseed will continue to develop the product independently, while retaining the rights to develop, manufacture and market it. After obtaining approval, Heartseed will market the product jointly with
- [10-6 Japan’s NEDO publishes database on current „smart cell projects“ (genome editing etc.)](https://window-to-japan.eu/2021/06/10/10-6-japans-nedo-publishes-database-on-current-smart-cell-projects-genome-editing-etc/) - The database is available from the National Institute of Technology and Evaluation of Products (NITE) under its Data and Biological Resource Platform (DBRP) website https://www.nite.go.jp/nbrc/dbrp/taglist and currently (June 2021) contains the following projects: Title Proteome analysis_Aspergillus oryzae : Proteome analysis of Aspergillus oryzae [English] The proteome of Aspergillus oryzae RIB40 (= NBRC 100959) grown under
- [18-6 Nihon Shokubai develops catalyst for hydroxycarbonylation](https://window-to-japan.eu/2021/06/18/18-6-nihon-shokubai-develops-catalyst-for-hydroxycarbonylation/) - Formic acid can be prepared through hydrogenation of CO2. The hydroxycarbonylation reaction of alkenes using formic acid has conventionally been catalyzed by a rhodium complex, Rh2Cl2(CO)4, and additives, triphenylphosphine (PPh3) and methyl iodide (CH3I), which have high environmental impact and toxicity, and p-toluenesulfonic acid hydrate (p-TsOH, H2O), which promotes the decomposition of formic acid. Under
- [24-6 Tsukuba University Hospital launches "Genome Dock" service for genome analysis data of healthy people](https://window-to-japan.eu/2021/06/13/24-6-tsukuba-university-hospital-launches-genome-dock-service-for-genome-analysis-data-of-healthy-people/) - The service comprises initially 76 genes related to 18 diseases such as tumors, cardiomyopathy, congenital hearing loss, and immune disorders. Among these genes are APC, BRCA1 / 2, RET, SMAD4, TP53 and other genes familiar in cancer medicine, as well as the KCNH2 gene for hereditary arrhythmia / congenital long QT syndrome and the TTR
- [18-6 NEDO aviation fuel produced from wood waste and microalgae supplied to scheduled flights](https://window-to-japan.eu/2021/06/18/18-6-nedo-aviation-fuel-produced-from-wood-waste-and-microalgae-supplied-to-scheduled-flights/) - NEDO has commissioned Mitsubishi Power, JERA Corporation, Toyo Engineering, and the Japan Aerospace Exploration Agency (JAXA) for the development of fuel production technology using wood waste as raw material, and IHI Corporation for fuel production technology using microalgae as raw material, within a "Biojet Fuel Production Technology Development Project. The fuel is produced either by
- [22-6 NEDO tests ship transport of liquefied captured CO2 for later underground storage](https://window-to-japan.eu/2021/06/22/22-6-nedo-tests-ship-transport-of-liquefied-captured-co2-for-later-underground-storage/) - In this project on CO2 capture, utilization, and storage (CCUS), research and development on liquefaction and storage systems for CO2 suitable for long-distance and mass transportation will be done. From around the end of fiscal 2023, the project will verify the technologies necessary for the operation and management of an integrated transport system in which
- [6-7 NEDO tests Net Zero energy building in Yamagata](https://window-to-japan.eu/2021/07/06/6-7-nedo-tests-net-zero-energy-building-in-yamagata/) - With Japan Groundwater Development Co., and General Heat Pump Industry Co. as contractors, NEDO had built a demonstration facility as „ZEB" (zero-emission building) in Yamagata City, Yamagata Prefecture, to verify the ZEB adaptability of a total heat supply system that utilizes high-efficiency aquifer heat storage. Number of floors 2 floors above ground Building area 285
- [7-7 Japan’s NEDO adopts 14 projects for the bio-production of useful chemicals](https://window-to-japan.eu/2021/07/07/7-7-japans-nedo-adopts-14-projects-for-the-bio-production-of-useful-chemicals/) - The project titles and the responsible project coordinators are 1. Demonstrator for agrochemical active natural products produced by filamentous fungi with improved productivity Meiji Seika Pharma Co. 2. Demonstrator for implementation of infection control technology using super heat-resistant protease Saraya Co., Osaka University 3. Demonstrator for bio-isopropanol production using Corynebacteria RITE Green Earth Institute Co.
- [28-5 Japan starts genomic cohort study involving over 360,000 people](https://window-to-japan.eu/2021/06/04/28-5-japan-starts-genomic-cohort-study-involving-over-360000-people/) - Under an initiative of Japan’s Agency for Medical Research and Development AMED, this collaboration among six institutions and five sites will sequence and mutually utilize genomic cohort data of 366,000 people. The project is expected to promote the elucidation of genetic predisposition affecting the onset of diseases in the Japanese population and the construction of
- [3-6 NEDO starts million project on innovative storage batteries (2021 – 2025)](https://window-to-japan.eu/2021/06/04/3-6-nedo-starts-million-project-on-innovative-storage-batteries-2021-2025/) - In this project, the partners will conduct R&D of fluoride and zinc anode batteries that can achieve both high energy density and safety while using inexpensive materials with fewer resource constraints than lithium-based batteries. NEDO will work with industry, academia, and government to research and develop common basic technologies that cover everything from materials development
- [18-5 Researchers at CiRA develop transform universal iPS cells for allogenic T-cell-based cancer immunotherapy](https://window-to-japan.eu/2021/05/18/18-5-researchers-at-cira-develop-transform-universal-ips-cells-for-allogenic-t-cell-based-cancer-immunotherapy/) - A research group led by Professor Shin KANEKO at the Center for iPS Cell Research and Application (CiRA), Kyoto University, have developed a universal iPS cell in which multiple genes were modified by genome editing, e. g., by knocking out the PVR gene related to the regulation of NK cells, so that it can be
- [2-12 Kyoto’s RITE: 500fold increase of catechol production by synthetic biology](https://window-to-japan.eu/2021/02/25/2-12-kyotos-rite-500fold-increase-of-catechol-production-by-synthetic-biology/) - The Research Institute for Innovative Technologies for the Earth (RITE) in Kansai Science City near Kyoto claims to have achieved a breakthrough in the microbial production of catechol, financially supported by METI’s project house NEDO within the “smart cell” program. In RITE’s and NEDO’s press releases, details to the process are missing except that a
- [7-12 NIKON and Tsukuba University analyze physiological state of microorganisms through autofluorescence signatures](https://window-to-japan.eu/2021/02/25/7-12-nikon-and-tsukuba-university-analyze-physiological-state-of-microorganisms-through-autofluorescence-signatures/) - Nikon has developed a confocal laser scanning microscope system which allows to analyze the physiological state of cells at high speed in a quantitative manner. The CRIF method (for Confocal Reflection microscopy-assisted single-cell Innate Fluorescence) acquires cell position and morphology by reflection microscopy and autofluorescence signals, which are reconstructed for each cell into a fingerprint. The
- [17-2 Shimadzu developed technology to analyze cell metabolites at high speed and with high accuracy](https://window-to-japan.eu/2021/02/25/17-2-shimadzu-developed-technology-to-analyze-cell-metabolites-at-high-speed-and-with-high-accuracy/) - In collaboration with Kobe University and with support of NEDO, the project house of METI, Shimadzu has developed a "Biotransformer Extraction Total System" that can analyze 186 types of water-soluble cell metabolites at once, and a "Metabolome High-throughput evaluation system" that can find promising smart cell candidate cells in as little as one day. By
- [18-2 Hokkaido Mitsui Chemicals produces taxan intermediate by plant-cell culture in 800 l bag reactor](https://window-to-japan.eu/2021/02/25/18-2-hokkaido-mitsui-chemicals-produces-taxan-intermediate-by-plant-cell-culture-in-800-l-bag-reactor/) - Using undifferentiated plant cells from the Yew tree (Genera taxus), Hokkaido Mitsui Chemicals has developed an 800 L single-use bag reactor for their cultivation. In order to prevent the slowly propagating cells from settling down, a special tube was installed at the bottom leading to circulated water flow without using an agitator. Cultured yew cells proliferation
- [25-2 Asahi Kasei Pharma achieves high-yield production of diagnostic enzyme cholesterol esterase using “smart cell” concepts](https://window-to-japan.eu/2021/02/25/25-2-asahi-kasei-pharma-achieves-high-yield-production-of-diagnostic-enzyme-cholesterol-esterase-using-smart-cell-concepts/) - The enzyme, used for diagnostic assays of cholesterol in blood, is produced by Burkholderia stabilis from which it is secreted. By combining a novel constitutive promoter and functional modification of the host using genomic and expression control information, the company succeeded in constructing a Burkholderia stabilis smart cell with a cholesterol esterase production capacity more
- [Two Japanese groups challenge China’s licorice (glycyrrhizin) monopoly](https://window-to-japan.eu/2021/01/27/two-japanese-groups-challenge-chinas-licorice-glycyrrhizin-monopoly/) - Licorice root containing glycyrrhizin is the most prescribed crude drug in Chinese medicine, included in about 70% of Chinese herbs. It is also used in Kanpo, Japan’s equivalent of TCM. Glycyrrhizin extracted from licorice is 150 to 300 times sweeter than sugar, used as a sweetener and as a remedy to reinforce liver function. In
- [Japanese Noster Co. commercializes functional fatty acid which suppresses postprandial glucose levels](https://window-to-japan.eu/2021/01/27/japanese-noster-co-commercializes-functional-fatty-acid-which-suppresses-postprandial-glucose-levels/) - The product, 10-hydroxy-cis-12-octadecenoic acid (HYA®), had originally been detected as a metabolite of dietary lipids and fatty acids by intestinal bacteria by the group of Jun OGAWA at Kyoto University. Further research at Nitto Pharmaceutical Co. had shown that this fatty acid inhibits the rise of postprandial blood glucose levels. A process has been developed by
- [Osaka University team finds clue in microbiota for rheumatoid arthritis](https://window-to-japan.eu/2019/11/14/osaka-university-team-finds-clue-in-microbiota-for-rheumatoid-arthritis/) - Based on extracted DNA samples and shotgun sequencing collected from stool of 82 untreated rheumatoid arthritis patients and 42 healthy subjects, the team of OKADA Toshihiro at Osaka University School of Medicine has found that some species of Prevotella are significantly increased in the microbiome of rheumatoid arthritis patients. It could not be concluded whether
- [Japanese startups develop "lifestyle guidance AI system" using intestinal environment information](https://window-to-japan.eu/2019/11/14/japanese-startups-develop-lifestyle-guidance-ai-system-using-intestinal-environment-information/) - Metagen Co. and MOLCURE Co., two Japanese startups, will established an AI-based system that predicts optimal weight loss using information about an individual's intestinal environment. The AI ​​system will provide guidance and support for improving lifestyle habits (eating and regular exercise) according to the intestinal environment of the individual. Metagen (Metabologenomics) is active in microbiome analysis, Molcure onantibody-based libraries for metabolite analysis. The project is supported by NEDO. NEDO
- [NEDO starts biojet fuel feasibility test, focus on supply chain](https://window-to-japan.eu/2019/11/01/nedo-starts-biojet-fuel-feasibility-test-focus-on-supply-chain/) - In addition to establishing integrated production technology for pure bio-jet fuel, supply chain construction including raw material procurement, product supply, commercialization schemes and economic efficiency will be considered in order to promote the realization of such market in Japan. Four themes were adopted, and contractors nominated: 1. Gasification / FT synthesis technology (raw materials are
- [NEDO adopts 7 new themes for regional biomass energy use](https://window-to-japan.eu/2019/11/01/nedo-adopts-7-new-themes-for-regional-biomass-energy-use/) - In a demonstration project, Tottori Prefecture aims to build a biomass energy utilization energy which does not rely any longer on feed-in tariffs and subsidies. In this project, biomass steam boilers will be installed that use building waste chips as fuel, and waste fungal beds for mushroom cultivation. In addition, the program includes six Business
- [NEDO establishes Bioeconomy Promotion Office, adds bioeconomic unit at Technology Strategic Research Center](https://window-to-japan.eu/2019/11/01/nedo-establishes-bioeconomy-promotion-office-adds-bioeconomic-unit-at-technology-strategic-research-center/) - The overall strategic goal is “to realize the world's most advanced bio economy society in 2030”. New budget requests for FY2020 include 2 billion yen for “Development of bio-based production technology that accelerates the realization of carbon recycling”, 850 million yen for “Development of technology related to cellulose nanofibers” and 1.83 billion yen for the “Plastic
- [Hitachi Zosen builds CO2-to-methane (methanation) test facility](https://window-to-japan.eu/2019/10/23/hitachi-zosen-builds-co2-to-methane-methanation-test-facility/) - A test facility for synthesizing methane from CO2 and hydrogen was completed on the Koshijihara plant site of Nagaoka Mine in Niigata Prefecture. Tests and continuous operation will be conducted through the end of 2019. In this test facility, methane is produced by synthesizing CO2 produced during natural gas production at the Koshijihara Plant and
- [NEDO consortium improves microbial bioproduction by AI](https://window-to-japan.eu/2019/09/12/nedo-starts-project-on-optimizing-microbial-culture-by-ai-pi-is-chitose-laboratory/) - In this project, it is planned to build a data infrastructure system for collecting and sharing data which correlate optical and electrochemical sensor data that have not yet been used at bio-production sites (bioproduction management using convolutional data). An AI system will be developed that predicts the optimal culture method hitherto not possible with human
- [Showa Chemical Industry adds woody biomass module to plant's LNG heat generator](https://window-to-japan.eu/2019/09/15/showa-chemical-industry-adds-woody-biomass-module-to-lng-heat-generator/) - Under a contract from NEDO, the company has put into operation in its Okayama plant a woody biomass heat generator, using surplus woody biomass such as bark produced in local areas. Liquid natural gas (LNG) and heat from woody biomass will be used, according to fluctuations in fuel prices and procurement conditions, for the company’s
- [COTO LABO consortium strives for better life science data](https://window-to-japan.eu/2019/09/15/shimadzus-coto-labo-consortium-strives-for-better-life-science-data/) - Eight companies have joined Shimadzu Corporation in an attempt to obtain better reproducible data in the life sciences such as drug-related research. 53 ring tests among these companies had shown that reproducibility of data was indeed low. 8 companies (iPS Portal, Earth Environment Service, NTT DATA, Olympus, Kataoka Manufacturing, Taisei Corporation, Hitachi Industrial Equipment Systems,
- [Japan’s government tries to popularize genome editing by a “BioStation” website](https://window-to-japan.eu/2019/09/15/japans-government-tries-to-popularize-genome-editing-by-a-biostation-website/) - The website https://bio-sta.jp/contains information on latest breeding results and explains in much detail the technology behind these results. Projects include deletion of target genes which result in tomatoes with high GABA content, potatoes without solanine, and red sea bream with enhanced muscle meat (myostatin knock-out). The secretariat of BioStation is located at the Japan Agriculture, Forestry
- [Genome editing provides high-sugar content tomatos: Nagoya University](https://window-to-japan.eu/2019/09/12/genome-editing-provides-high-sugar-content-tomatos-nagoya-university/) - Katsuhiro SHIRATAKE of Nagoya University and coworkers from RIKEN have achieved the development of a high-fructose tomato by disrupting the INVINH gene, encoding an invertase inhibitor. As genome editing tools, a CRISPR / Cas9 vector and Target-AID vector targeting INVINH were used. In some transformants, the increase in sugar content was up to 2fold. Lecture at
- [Cellulose nanofibers one step closer to wide industrial use: NEDO, Japan](https://window-to-japan.eu/2019/08/09/cellulose-nanofibers-one-step-closer-to-wide-industrial-use-nedo-japan/) - NEDO has announced that acetylated ligno cellulose nanofiber (CNF) show high biodegradability (~90% in the OECD TG301C test), bringing this material closer to wide applications. CNF are cellulose fibers with a diameter of 3 – 10 nm obtained from woody biomass such as bamboo or other wood. They are already produced by companies such as
- [JBA's Bioindustry Award 2019 goes to Kaneka and RIKEN researchers for the development of a PHBH polymer biodegradable on soil and in seawater](https://window-to-japan.eu/2019/08/06/jbas-bioindustry-award-2019-goes-to-kaneka-and-riken-researchers-for-the-development-of-a-phbh-polymer-biodegradable-on-soil-and-in-seawater/) - The poly-hexanoate-butyrate (PHBH) copolymer is produced by Kaneka from plant oil using a recombinant strain of Cupriavidus necator at a capacity of currently 1,000 tons, with plans to increase production to 5,000 and later to 100,000 tons a year. PHBH materials decompose not only on soil, but also in seawater (90% within 6 months at 30°C) and
- [Mitsubishi's Life Science Institute (LSI) will start clinical trial on treatment of spinal cord injury with Muse cells](https://window-to-japan.eu/2019/07/10/mitsubishis-life-science-institute-lsi-will-start-clinical-trial-on-treatment-of-spinal-cord-injury-with-muse-cells/) - LSI announced that a domestic clinical trial for spinal cord injury in the subacute phase will be started using the Muse cell product “CL2020”.. The company has been conducting clinical trials already for three other diseases, acute myocardial infarction, cerebral infarction, and epidermolysis bullosa, and aims to apply for approval in 2020 and 2021 for
- [New bio-strategy of government will focus support of private investment in 10 areas](https://window-to-japan.eu/2019/05/01/new-bio-strategy-of-government-will-focus-support-of-private-investment-in-10-areas/) - As indicated by Koichi AKAISHI, Chief Policy officer of the Cabinet Office, the government’s new bio-strategy will include support of company investments in the following 10 areas: (1) high-performance biomaterials (2) bioplastics (3) sustainable primary production systems (agriculture) (4) organic waste and organic wastewater treatment (5) life improvement, healthcare and functional food (6) digital medicine
- [NEDO defines five new topics for “smart cell industry” program](https://window-to-japan.eu/2019/05/07/nedo-defines-five-new-topics-for-smart-cell-industry-program/) - The “smart cell industry” program of NEDO (2016-2020) aims to produce industrial materials from plants and microorganisms in economically viable yields based on metabolic engineering and synthetic biology. The five new topics (2019-2020) are Microbial production of polyamide materials (Toray) Cholesterol esterase derived from recombinant Burkholderia stabilis (Asahi Kasei Pharma) Microbial production of ergothioneine, a
- [High yield production of tetrahydropapaveroline, a pharmaceutical raw material, using synthetic biology and metabolic engineering](https://window-to-japan.eu/2019/05/07/high-yield-production-of-tetrahydropapaveroline-a-pharmaceutical-raw-material-using-synthetic-biology-and-metabolic-engineering/) - The group of Akihiko KONDO at Kobe University has used computer simulations, newly designed metabolic pathways and introduction of an engineered silkworm enzyme into E. coli to produce tetrahydropapaveroline (THP), a precursor compound of various benzylisoquinoline alkaloids which are used as analgesics. The project was carried out within NEDO’s “smart cell industry” program. NEDO news
- [RIKEN establishes research lab for natural products and chemical Biology in Hangzhou, China](https://window-to-japan.eu/2019/04/26/riken-establishes-research-lab-for-natural-products-and-chemical-biology-in-hangzhou-china/) - RIKEN held an opening ceremony on April 19, 2019, for a collaborative laboratory on natural products and chemical biology at Hangzhou Future Science and Technology Park. The collaborative laboratory will identify useful substances from natural compounds collected from microorganisms and plants, and conduct research that will lead to drug discovery. Since China is a Kampo/TCM
- [Dainippon Sumitomo Pharma to explore iPS-based regenerative medicine for kidney failure](https://window-to-japan.eu/2019/04/05/dainippon-sumitomo-pharma-to-explore-ips-based-regenerative-medicine-for-kidney-failure/) - The method is based on the "embryonic organ niche method" developed by the Tokyo Jikei Medical University and others. In this method, human cells are implanted at the organ development site (organ niche) of a baby pig and grown to a normal organ. Nephron precursor cells made from human iPS cells which have differentiated into
- [Tohoku Medical Megabank ToMMo and Kyoto University’s CiRA collaborate on iPS cell banking](https://window-to-japan.eu/2019/04/17/tohoku-medical-megabank-tommo-and-kyoto-universitys-cira-collaborate-on-ips-cell-banking/) - ToMMo established after the Great Eastern Earthquake so far has analyzed whole genomes of 5000 healthy local people and about 100,000 single nucleotide polymorphisms (SNPs). Since 2016, CiRA and ToMMo started collaborative research and established healthy iPS cells from somatic cells of participants in cohort surveys linked with genomic and health information. Differentiated into various
- [Kansai University develops iron oxide catalyst for high-performance organosilicon synthesis](https://window-to-japan.eu/2019/04/15/kansai-university-develops-iron-oxide-catalyst-for-high-performance-organosilicon-synthesis/) - Under a NEDO contract, the team of Yasushi ODORU at Kansai University has succeeded to substitute the conventional platinum catalyst for organosilicon synthesis by a catalyst based on iron oxide nanoparticles coated with DMF. The new catalyst has high activity even in small amounts, and can be recycled by temperature change. It can be used as a
- [Spiber and wig-maker Aderans plan to produce human wigs from spider silk](https://window-to-japan.eu/2019/03/19/spiber-and-wig-maker-aderans-plan-to-produce-human-wigs-from-spider-silk/) - Spiber, a spin-out of Keio University and successful in the scale-up of spider silk production, has teamed up with Aderans, a Tokyo-based wig-maker. The two companies plan to jointly develop a new structural material for human wigs based on recombinant spider silk. Aderans will utilize its hair-related technologies to reproduce the unique feel and properties
- [Nihon Ita Glass to launch PicoGene PCR1100 mobile RT PCR device](https://window-to-japan.eu/2019/04/12/nihon-ita-glass-to-launch-picogene-pcr1100-mobile-rt-pcr-device/) - The device allows for rapid, high-precision genetic field testing, for instance early inspection of food poisoning by bacteria. The device uses a compact fluorescence detector which applies the "SELFOC" microlens developed by the company in the 2000s as a unique core technology. Nikkei Biotech news release, April 12, 2019
- [EdiGene startup to focus on gene therapy of orphan diseases](https://window-to-japan.eu/2019/03/15/edigene-startup-to-focus-on-gene-therapy-of-orphan-diseases/) - The company is a spin-off of the University of Tokyo, using the research results of Osamu NUREKI. They develop in vivo gene therapy using adeno-associated virus (AAV) vectors for single gene diseases. https://www.j-startup.go.jp/en/startups/017_edigene.html
- [Gene Techno Science to develop dental pulp-derived stem cells for treatment of childrens’ diseases](https://window-to-japan.eu/2019/03/15/gene-techno-science-to-develop-dental-pulp-derived-stem-cells-for-treatment-of-childrens-diseases/) - Gene Technos Science Co. shareholders have approved to make Cell Technology, acquired in January 2019, a wholly-owned subsidiary. Cell Technology has a partnership with over 2000 medical institutions across Japan to provide services for dental pulp-derived and other stem cells. It supplies such cells to companies such as Daiichi Sankyo, Eisai, Nikon and Sekisui for
- [RIKEN and Hitachi succeed in automated culture of retinal pigment epithelial (RPE) cell sheets derived from human iPS cells](https://window-to-japan.eu/2019/03/14/riken-and-hitachi-succeed-in-automated-culture-of-retinal-pigment-epithelial-cell-sheets-derived-from-human-ips-cells/) - A joint research team of Hitachi and RIKEN have successfully used a completely closed automatic cell culture system for culturing RPE cell sheets derived from human iPS cells. using a culture device. By analysis of various markers it was demonstrated that these RPE cell sheets showed the same level of quality as those cultured by skilled
- [RIKEN researchers prepare adhesive silk by tyrosinase-catalysed oxidation](https://window-to-japan.eu/2019/03/11/riken-researchers-prepare-adhesive-silk-by-tyrosinase-catalysed-oxidation/) - Hiromitsu SUGAKAWA and colleagues at RIKEN Bioresources Research Center have treated an aqueous silk protein solution with tyrosinase, thereby converting tyrosine residues in silk to DOPA. Amino acid analysis by ninhydrin confirmed that the treated silk contained about 1 mol% of DOPA. The adhesiveness of this DOPA-containing silk protein was greatly improved, especially under basic conditions,
- [Olympus launches endoscope software “EndoBRAIN” based on AI data](https://window-to-japan.eu/2019/03/04/olympus-launches-endoscope-software-endobrain-based-on-ai-data/) - The imaging system will help to judge wheter a polyp detected by the endoscope is neoplastic or not. It has obtained regulatory domestic approval for sales in Japan. Nikkei Biotech news release, March 4, 2019 +
- [ToMMo publishs JG1, the “Japanese Reference Genome Sequence”](https://window-to-japan.eu/2019/02/25/tommo-publishs-jg1-the-japanese-reference-genome-sequence/) - ToMMO, the Tohoku Medical MegaBank Organization, is focused on genomic medicine, which requires to accurately analyze the genome sequence of individuals based on differences to a "reference genomic sequence". As the “international reference genome” was created based on genomes from European and African populations, ToMMo has now created its own reference genome JG 1 based
- [Tsmuk Co. introduces improved version of RODEM wheelchair](https://window-to-japan.eu/2017/11/20/tezumak-co-introduces-improved-version-of-rodem-wheelchair/) - The new version has the following improved features: • it is equipped with smartphone cooperation function by Bluetooth, and remote operation from smartphone is possible, • the height of the bed and the chair can be aligned, making it easy to move • it has a minimum turning radius, so it can flip even in
- [Shionogi to cooperate with PeptiDream Co. on peptide drug conjugates which pass blood-brain-barrier](https://window-to-japan.eu/2019/01/23/shionogi-to-cooperate-with-peptidedream-co-on-peptide-drug-conjugates-which-pass-blood-brain-barrier/) - In this collaborative research, Shionogi aims to create new peptide drug conjugates by linking drugs or drug candidate compounds to cargo peptides which are able to pass the blood-brain-barrier. Shionogi news release, January 23, 2019
- [NEDO consortium optimizes various types of hands for robots](https://window-to-japan.eu/2018/01/11/nedo-consortium-optimizes-various-types-of-hands-for-robots/) - A NEDO-supported group from Double Giken Co., Tokyo Metropolitan University and Utsunomiya College for Industrial Technology succeeded in developing Karakuri" robot lightweight hands which could stably and gently grab objects of various shapes with extremely simple control. Three kinds of such robot hands, "F-hand", "New D-hand" and "Ori gram hand" are optimized for agriculture, logistics,
- [Group at Tokyo Institute of Technology improves low pressure ammonia synthesis](https://window-to-japan.eu/2018/01/23/group-at-tokyo-institute-of-technology-improves-low-pressure-ammonia-synthesis/) - The group around Hideo HOSONO at Tokyo Institute of Technology has succeeded to further optimize a catalyst which permits to produce ammonia from molecular nitrogen and hydrogen at relatively mild conditions (400 C, 0.1 MPa = 1 bar). The best catalyst found so far is an intermetallic “electride” compound composed of lanthanum, cobalt and silicium
- [NEDO consortium develops Cu-based zeolite for NOx purification from car exhausts](https://window-to-japan.eu/2018/02/07/nedo-consortium-develops-cu-based-zeolite-for-nox-purification-from-car-exhausts/) - A NEDO consortium around Mitsubishi Chemical Co. and others has synthesized a zeolite catalyst for NOx purification in automobiles showing high durability and activity over a wide temperature zone. By combining an ultra-high speed synthesis method and formation of fine particles, a copper-zeolite was obtained which contains many active sites and extremely few defects. The
- [Hitachi Zosen will test first 20 kW SOF in Osaka under field conditions](https://window-to-japan.eu/2018/02/26/hitachi-zosen-will-test-20-kw-sof-in-osaka-under-field-conditions/) - Within NEDO’s project of a „hydrogen society“ and Osaka’s H2 Osaka Vision, the top-class solid-oxide fuel cell will be tested over 4000 hours for durability. Key data are: a. Fuel used City gas 13 A (Main component is methane) (demonstrated by medium pressure supply), b. Rated output 20 kW class, c. Power generation efficiency over
- [TOTO releases toilet than can measure urine volumen and flow](https://window-to-japan.eu/2018/05/18/toto-releases-toilet-than-can-measure-urine-volumen-and-flow/) - Urine examination is indispensable in medical institutions when examining the functions of kidney, bladder, urethra, etc. TOTO's new system measures urination volume from rising water level by means of a drain pipe with a sensor in the toilet bowl. Patient information is barcoded and stored with barcoded information from the sensor, allowing urine volume over
- [Nakagawa Pharmaceuticals introduces beverage holder „Smart Carry“ containing 10 % bio-polyethylene](https://window-to-japan.eu/2018/05/25/nakagawa-pharmaceuticals-introduces-beverage-holder-smart-carry-containing-10-bio-polyethylene/) - The company is specialized in manufacturing packaged products. From summer 2018, it will sell nationwide a bag system containing 10 % of polyethylene derived from sugar cane (Braskem). Sales point is that the plastic bag can hold hot or cold drinks without prior assembly and just hangs next to the serving machine. It is expected
- [NEDO initiates projects on solar power cost reduction](https://window-to-japan.eu/2018/05/28/nedo-initiates-projects-on-solar-power-cost-reduction/) - The 4 projects are 1. Development of technologies to reduce power generation cost for high performance and high reliability solar power generation (to 14 yen/kWh by 2020 and 7 yen/kWh by 2025), 2. Heterojunction technology, 3. Back contact technology, and 4. Solar energy in net zero energy buildings . NEDO news release, May 28, 2018
- [NEC and FiNC present wearable sensor with built-in inertia sensor](https://window-to-japan.eu/2018/06/06/nec-and-finc-present-wearable-sensor-with-built-in-inertia-sensor/) - The sensor can be installed in shoes and insole, and record walking data of people such as stride, walking speed, etc. with high accuracy. It can be used for sports and for the elderly. Based on data analysis it is aimed to provide more advanced health advice NEC news release, June 8, 2018
- [NEDO consortium develops high-efficiency aquifer thermal storage system at reduced cost](https://window-to-japan.eu/2018/06/11/nedo-consortium-develops-high-efficiency-aquifer-thermal-storate-system-at-reduced-cost/) - NEDO and Nippon Groundwater Development Co. have developed the first high-efficiency aquifer thermal storage system in Japan that stores cold energy and thermal energy in an underground aquifer and can effectively utilize it for cooling and heating . As a result of introducing this system into the air conditioning of an office building in Yamagata
- [NEDO-supported team produces first prototype of proton-conductive ceramic fuel cell](https://window-to-japan.eu/2018/07/04/nedo-supported-team-produces-first-prototype-of-proton-conductive-ceramic-fuel-cell/) - A team at NAIST has found an improved process to prepare Proton Conductive Ceramic Fuel Cells. PCFC consist of a three-layer sandwich of a ceramic electrolyte membrane, an air electrode and a fuel electrode, and use oxygen and water to generate electricity. Protons (H + ion) permeate through the ceramic electrolyte membrane, thereby operating as
- [NEDO initiates “Smart Home” project for IoT-based health promotion and nursing care support](https://window-to-japan.eu/2018/07/31/nedo-initiates-smart-home-project-for-iot-based-health-promotion-and-nursing-care-support/) - The market for this IoT household sector is forecasted by NEDO to expand from the current USD 15 billion sales worldwide to 400 billion USD by 2030. Various device manufacturers and service providers collaborate to collect and analyze life data, and develop of services ahead of individual needs is accelerating. In the NEDO-supported project which
- [NEDO defines 8 topics for „smart cell industry“](https://window-to-japan.eu/2018/07/31/nedo-defines-8-topics-for-smart-cell-industry/) - Within the "smart cell industry" project, industrial materials will be produced from plants and microbial cells. The 8 topics are: Development of robust microorganisms and simple production process JGC, Soujo University, Nara Institute of Science and Technology Research on conversion of feedstock to C4 chemical products Chitose Institute Co., Daicel Corporation Development of a plant
- [Welby Co. and Digital Garage Co. will start personally-owned health and information system](https://window-to-japan.eu/2018/08/01/welby-co-and-digital-garage-co-will-start-personally-owned-health-and-information-system/) - Digital Garage is developing next-generation technologies that focus on block chains, AI, VR/AR, security, and health. As a leading company that provides services on personal health records (PHR), Wellby plans, develops and operates treatment support digital services for patients with chronic diseases. Through this tie-up, the two companies will aim to evolve PHR services with
- [Keio and Tokyo University develop „Fusion“ – a wearable robot system which allows to share motions and skills with remote people](https://window-to-japan.eu/2018/08/09/keio-university-develops-fusion-a-wearable-robot-system-which-allows-to-share-motions-and-skills-with-remote-people/) - The „Fusion“ system creates communication through physical information by a wearable robot system, allowing operator and wearer a function to share space from nearly the same viewpoint. The configuration of the system is divided into the operator side and the wearer side. The operator side wears a ready-made head mount display (HMD) to access the
- [NEDO starts RFID-based supply chain information sharing system](https://window-to-japan.eu/2018/08/23/nedo-starts-rfid-based-supply-chain-information-sharing-system/) - In the retail industry, there are increasing trends to improve the efficiency of stocktaking and labor saving of cash registering work by attaching electronic tags (RFID) to products to be sold at stores in order to improve productivity. Meanwhile, the entire supply chain has problems with returned goods and food loss due to the fact
- [Tsmuk Co. introduces next-generation RODEM wheelchair](https://window-to-japan.eu/2018/08/28/tsmuk-co-introduces-next-generation-rodem-wheelchair/) - "RODEM" is a next-generation smart mobility wheelchair that combines robotic, mobility and wheelchair features. It allows for transfer to beds, chairs, toilets, etc. without changing the orientation of the body. 【1】It is possible to smoothly transfer from bed and chair 【2】It is easy to turn even in a narrow place 【3】Remote control with smartphone 【4】Expanding
- [Horiba develops sensitive, maintenance-free sensor for hypochlorite measurement in water](https://window-to-japan.eu/2018/08/29/horiba-develops-sensitive-maintenance-free-sensor-for-hypochlorite-measurement-in-water/) - Hypochlorous acid and sodium hypochlorite are used in the food industry for sterilizing food and cooking equipment, and the real-time measurement of effective chlorine concentration is necessary for sanitary control. Horiba Instruments, under a JST contract, has developed a diamond-based electrochemical sensor device which is not affected by pH or temperature and allows for maintenance
- [NEDO team reports on Ta3N5 photocatalyst for decomposing water by visible light (artificial photosynthesis)](https://window-to-japan.eu/2018/09/04/nedo-team-reports-on-ta3n5-photocatalyst-for-decomposing-water-by-visible-light-artificial-photosynthesis/) - The team composed of ARPChem, Tokyo and Shinshu University has developed an inexpensive and fast process to develop single crystals of tantalum nitride which decompose water using visible light in the 400 to 600 nm visible light region. Since this is the wavelength region with the highest intensity of sunlight in the vicinity of 600
- [Sekisui Chemical strengthens business alliance with Cyfuse, a 3D tissue print company](https://window-to-japan.eu/2018/09/13/sekisui-chemical-strengthens-business-alliance-with-cyfuse-a-3d-tissue-print-company/) - Sekisui Medical operates a drug discovery support business, SEKISUI XENOTECH, LLC, which is mainly based in Europe and the United States. In Japan, Sekisui Medical has collaborated with Cyfuse on R&D of 3D liver structures to be used for drug discovery research. safety testing and toxicity evaluation. As Cyfuse has come closer to commercialization of
- [University of Tokyo and RIKEN team develops solar cell-driven skin-attached ECG measurement device](https://window-to-japan.eu/2018/09/27/university-of-tokyo-and-riken-team-develops-solar-cell-driven-skin-attached-ecg-measurement-device/) - The wearable sensor was jointly developed by a team at RIKEN and the University of Tokyo. A periodic nano-grating structure was achieved on an ultra-thin substrate with a thickness of 1 μm, a height of several tens of nm and a period of about 700 nm. This periodic nanograting structure adjusts the refractive index of
- [Yamagata University develops perovskite-based quantum-dot LEDs with 20 % external quantum efficiency](https://window-to-japan.eu/2018/10/02/yamagata-university-develops-perovskite-based-quantum-dot-leds-with-20-external-quantum-efficiency/) - Perovskite quantum dots (CsPbX 3, X = Cl, Br, I) show high luminescence quantum efficiency and sharp emission spectra. They are used as next-generation light emitting device (LED) material to replace organic EL materials and cadmium type quantum dots. A feature of perovskite quantum dots is that it is easy to control their crystal size
- [AIST generates model plants with almost no lignin](https://window-to-japan.eu/2018/10/02/aist-generates-model-plants-with-almost-no-lignin/) - Shingo SAKAMOTO of Tsukuba's Industrial Technology Research Institute, an institute under METI's Agency of Industrial Science and Technology, has generated a gene-disrupted nst1 nst3 double mutant of Arabidopsis thaliana, a plant in which two NST transcription factors have been destroyed and which cannot stand upright because it can not form secondary cell walls in the
- [NEDO holds „hydrogen ministerial conference”](https://window-to-japan.eu/2018/10/17/nedo-holds-hydrogen-ministerial-conference/) - With the participation of over 300 stakeholders from 21 countries, regions, and institutions the importance of international cooperation on hydrogen was stressed, and a policy toward global utilization of hydrogen was formulated (Tokyo Declaration). Japan will host the G20 Energy and Environment Ministers Meeting in June 2019. NEDO news release, October 23, 2018
- [Japan will introduce charges for the use of plastic shopping bags from 2020](https://window-to-japan.eu/2018/10/23/japan-will-introduce-charges-for-the-use-of-plastic-shopping-bags-from-2020/) - The Ministry of Environment has decided to stop free distribution of plastic shopping bags from 2020. Appropriate replacement of bags from renewable resources such as recycled materials, paper and biomass plastics will be supported. By 2030 it is aimed to have introduced biomass plastic at a level of about 2 million tons. Nikkei Biotech news
- [Lion reports positive impact on oral health using its saliva test system SMT](https://window-to-japan.eu/2018/10/26/lion-reports-positive-impact-on-oral-health-using-its-saliva-test-system-smt/) - Lion Co. introduced its SMT test (salivary multi test) in May 2016. The test strip kit allows the simultaneous measurement of six saliva indicators within 5 minutes: cariogenic bacteria, pH and buffer capacity, leukocytes, proteins and ammonia, as an indicator related to oral cleanliness. After many field tests including 80 employees of Lion in Hirosaki
- [Team at Osaka Prefecture University develops soft wearable pH sensor](https://window-to-japan.eu/2018/11/13/team-at-osaka-prefecture-university-develops-soft-wearable-ph-sensor/) - The group of Associate Professor Kuniharu TAKEI prepared a CCD structure on a flexible film creating a wearable device that could measure the pH value of sweat with high sensitivity. It also records skin temperature and thus can be developed into a daily health management tool. The charge transfer flexible pH sensor incorporates a structure
- [Spiber to build production plant for spider silk proteins in Thailand](https://window-to-japan.eu/2018/11/28/spiber-to-build-production-plant-for-spider-silk-proteins-in-thailand/) - The facility will be built in Rayong, Thailand, with production and purification facilities 100 times larger than the company’s production facilities in Tsuruoka, Japan. Construction will start in mid-2019, and commercial production is planned for 2021. Processing of the raw material to spider silk fibers will remain in Japan. Spiber has raised 5 billion Yen
- [NEDO initiates program for Cyberspace Infrastructure Technology](https://window-to-japan.eu/2018/12/04/nedo-initiates-program-for-cyberspace-infrastructure-technology/) - “Society 5.0” is seen as a human-centered society where people can live a comfortable, vibrant and high-quality life by providing goods and services that respond to individual needs. In Society 5.0, a huge amount of information from sensors in the physical space is accumulated in the cyber space, and AI analyzes big data. The result
- [QD Laser Co. is developing an eyeglass type “retinal scanning laser eyewear”](https://window-to-japan.eu/2018/12/10/qd-laser-co-is-developing-an-eyeglass-type-retinal-scanning-laser-eyewear/) - The company, which features semiconductor laser technology, has developed an eyeglass-type "retinal scanning laser eyewear" that projects images directly onto the retina using ultra-small laser projectors. Since the image is directly projected on the retina, it is little affected by visual acuity, and could be commercialized as a support device for visually handicapped. https://www.qdlaser.com
- [Tokyo TB-M Co. introduces LIMEX-made plastic bags made mostly from limestone](https://window-to-japan.eu/2018/12/20/tokyo-tb-m-co-introduces-limex-made-plastic-bags-made-mostly-from-limestone/) - LIMEX is a limestone-derived material which consosts of 60 % CaCO3 and 40 % polypropylene. It shows excellent water resistance and good recycling capability. LIMEX plastic alternatives can be produced from LIMEX pellets. LIMEX paper can be used for books, name cards, posters or notebooks. By using polypropylene, LIMEX paper alternatives are printable with high temperature
- [Raman-based FACS and microfluidics allow for label-free sorting of over 1,000 microbial cells per second, application to astaxanthin production](https://window-to-japan.eu/2019/01/17/raman-based-facs-and-microfluidics-allow-for-label-free-sorting-of-over-1000-microbial-cells-per-second-application-to-astaxanthin-production/) - The group of Kotaro HIRAMATSU at the University of Tokyo has combined Raman-based FACS with high-throughput microfluidics. In order to accelerate Raman spectroscopy, Fast Fourier Transform Coherent Anti-Stokes Raman Scattering Spectroscopy (Fast FT-CARS Method) was used which allows to measure about 24,000 broadband Raman spectra per second. If applied to nitrogen-depleted Hematococcus strains, the production
- [Kao Corp develops new “air-in-film-built” plastic container](https://window-to-japan.eu/2019/01/17/kao-corp-develops-new-air-in-film-built-plastic-container/) - The new container claims 100 % utilization of recycled plastics and zero residual liquid. Kao Corp news release, November 28, 2018
- [Keio University team isolates intestinal bacterial strains that increase infection resistance and antitumor effect](https://window-to-japan.eu/2019/01/23/keio-university-team-isolates-intestinal-bacterial-strains-that-increase-infection-resistance-and-antitumor-effect/) - The group of Kenya HONDA has isolated eleven intestinal bacteria that activate immune cells. When administered to mice, infection resistance against pathogenic bacteria and anticancer immune response was strengthened. RIKEN news release, January 23, 2019
- [NEDO consortium achieves 5.5% solar energy conversion using Ta2N5 photoelectrode](https://window-to-japan.eu/2019/01/25/nedo-consortium-achieves-5-5-solar-energy-conversion-using-ta2n5-photoelectrode/) - Artificial Photosynthetic Chemistry Process Technology Research Association (ARPChem) reports on a red transparent oxygen generating photoelectrode capable of highly efficient decomposition of water by sunlight using a tantalum nitride (Ta3N5) photocatalyst. Tantalum nitride photocatalysts are known as a material which absorbs visible light from 400 nm to 600 nm and photocatalytically decomposes water. In the
- [Inoac Co. develops mass production of silica air gel for low-cost car insulation](https://window-to-japan.eu/2019/01/28/inoac-co-develops-mass-production-of-silica-air-gel-for-low-cost-car-insulation/) - Inoac Technical Research Institute Co. and AIST, under NEDO contract, have developed a lightweight, high-strength polypropylene and silica airgel with low thermal conductivity of 0.016 W / (m · K). It can be cut and curved and has been developed into mass production of long rolled specimen with a length of 30 meters. It is expected
- [RIKEN team develops novel self-healing polymers](https://window-to-japan.eu/2019/02/07/riken-team-develops-novel-self-healing-polymers/) - A team at RIKEN’s Center for Environmental Resources Science has developed a precise copolymerization of ethylene and anisylpropylenes by using a proprietary rare earth catalyst. The new polymer exhibits high elongation (2200%) and excellent self-repairing performance. It can be deployed as a shape memory material by temperature control and exhibits ashape recovery rate of 99%.
- [Dainippon Printing develops electronic tags for food products, improvement of supply chain management](https://window-to-japan.eu/2019/02/09/dainippon-printing-develops-electronic-tags-for-food-products-improvement-of-supply-chain-management/) - Under a NEDO contract, Dainippon printing is testing RFID tags on food and drinking products. RFID readers installed on the pricing shelf automatically read the electronic tag to identify the product whose consumption date is approaching, to the effect that cash discount will be carried out when purchasing the product, and advertisement of this product is
- [VIGO Medical Co. to test effect of pure oxygen supply with major Japanese football club](https://window-to-japan.eu/2019/02/19/vigo-medical-co-to-test-effect-of-pure-oxygen-supply-with-major-japanese-football-club/) - In a cooperative project with NEDO, the company will supply its Oxy's® oxygen generator to Japan First League Oita Trinita players for a year and perform blood tests of athletes' vital measurements (body temperature, blood pressure, heart rate, mileage, number of sprints increase and decrease). By analyzing the results, the efficacy of high concentration oxygen such
- [Hayashibara builds new enzyme and pullulan plant](https://window-to-japan.eu/2019/02/04/hayashibara-builds-new-enzyme-and-pullulan-plant/) - The factory is on Hayashibara's Okayama location, scheduled to cost about 7.5 billion yen be operational in September 2020. It is also related to a long-term partnership with Switzerland's Lonza signed in 2018. Hayashibara news release, February 4, 2019 © Hayashibara, Japan
- [Keio University team to start application of regenerative medicine for subacute spinal cord injury](https://window-to-japan.eu/2019/02/18/keio-university-team-to-start-application-of-regenerative-medicine-for-subacute-spinal-cord-injury/) - Professor Ekuo OKANO of Keio University School of Medicine and colleagues have obtained MHLW approval for clinical studies on allogenic iPS cell-derived neural progenitor cells for the treatment of subacute stage spinal cord injury. They will now investigate the safety and effectiveness by increasing the number of transplanted cells in spinal cord injury in a
- [MHLW approves two gene therapies in Japan](https://window-to-japan.eu/2019/02/21/mhlw-approves-two-gene-therapies-in-japan/) - The two items approved were Anges Co. HGF gene therapy for treatment of critical limb ischemia (AMG0001, beperminogene perplasmid) Novartis CAR-T cell therapy Kymriah (Tisagenlecleucel) for the treatment of acute lymphoblastic B-cell leukemia Nikkei Biotech news release, February 21, 2019
- [Tanabe Mitsubishi turns product development over to venture company](https://window-to-japan.eu/2019/02/14/tanabe-mitsubishi-turns-product-development-over-to-venture-company/) - Mitsubishi Tanabe announced that phase I of its antibody-drug complex MT-8633 against solid cancer will be carried out by Open Innovation Partners, a Tokyo-based venture. It is believed that this move is meant to raise development speed. Tanabe-Mitsubishi Pharma news release, February 14, 2019
- [Daiichi Sankyo to apply for approval of gene therapy for cancer treatment](https://window-to-japan.eu/2019/02/14/daiichi-sankyo-to-apply-for-approval-of-gene-therapy-for-cancer-treatment/) - The application for domestic manufacturing and marketing is based on a doctor-based interim analysis of 13 subjects (corresponding to phase II) with the oncolytic herpes simplex virus vector G47Δwhich showed a 92.3 % survival rate. Nikkei Biotech news release, February 14, 2019
- [University team develops methane dry reforming catalyst for operation at 500 C](https://window-to-japan.eu/2019/02/15/university-team-develops-methane-dry-reforming-catalyst-for-operation-at-500-c/) - The team at Kochi University and Tokyo University of Technology succeeded to develop a Ni / Y 2 O 3 catalyst which allows to produce synthesis gas from methane and CO at below 600 C without coking. The catalyst is composed of Ni and Y2O3 which are topological intertwined in a nano phase separation structure. The
- [National Institute for Physiological Sciences (NIPS) successfully uses stem cells to grow mouse kidneys inside rats](https://window-to-japan.eu/2019/02/06/national-institute-for-physiological-sciences-nips-successfully-uses-stem-cells-to-grow-mouse-kidneys-inside-rats/) - The team of Teppei GOTO found that mouse stem cells efficiently differentiated inside rat blastocysts, forming the basic structures of a kidney. After being implanted into pseudo-pregnant rats, the complemented blastocysts matured into normal fetuses. Remarkably, more than two thirds of the resulting rat neonates contained a pair of kidneys derived from the mouse stem
- [Euglena Corp. finds sulfur metabolites detrimental for biofuel production efficiency](https://window-to-japan.eu/2019/01/02/euglena-corp-finds-sulfur-metabolites-detrimental-for-biofuel-production-efficiency/) - A team of Euglena, RIKEN and tdhe University of Tsukuba have found that Euglena microalgae produce H2S as degradation products of proteins and glutathione. As the smell of sulfur compounds is detrimental both to the food and fuel use of these algae, the company will now look for technologies to supress these degradation processes. Euglena
- [NGS and machine learning elucidates 11 patterns of white blood cells in Japanese population.](https://window-to-japan.eu/2019/01/29/ngs-and-machine-learning-elucidates-11-patterns-of-white-blood-cells-in-japanese-population/) - The team of Akemi OKADA at Osaka University has used next-generation sequencing of leukocyte DNA and machine learning to analyze patterns of white blood cells in Japanese population. Based on 170,000 Japanese whose genetic data are stored in Biobank Japan, their procedure revealed that individual differences in 11 overall patterns are related to more than
- [Just 11 types of HLA types prevail in the Japanese, as shown by genome sequencing and machine learning](https://window-to-japan.eu/2019/01/01/just-11-types-of-hla-types-prevail-in-the-japanese-as-shown-by-genome-sequencing-and-machine-learning/) - A research consortium around OKADA Akemi used next-generation sequencing technology and machine learning to analyze white blood cells of 1120 Japanese for their HLA pattern. It came out that only 11 patterns of white blood cells prevail in the Japanese population. Matching with blood type patterns of 170,000 Japanese documented in BioBank and their leukocyte-related
- [NextGem venture explores self-renewing human hematopoietic stem cells](https://window-to-japan.eu/2019/01/28/nextgem-venture-explores-self-renewing-human-hematopoietic-stem-cells/) - NextGem has basic technologies to identify and isolate hematopoietic stem cells which are active over a long time, a very small portion of hematopoietic stem cells with the proportion of around 1 cell in 100,000 cells of mouse bone marrow cells. The company applies AI and bioinformatics technology including machine learning to reveal such cells
- [Gene Techno Science acquires Advanced Cell Technology and Engineering Ltd., leader in dental pulp cell banking](https://window-to-japan.eu/2019/01/17/gene-techno-science-acquires-advanced-cell-technology-and-engineering-ltd-leader-in-cental-pulp-cell-banking/) - ACTE Ltd. has established to 2,200 dental clinics in Japan and established a method to isolate and store stem cells from dental pulp cells. Gene Techno Science news release, January 17, 2019
- [Kao Corp introduces BioIOS, a novel surfactant, in detergent Attack ZERO](https://window-to-japan.eu/2019/01/23/kao-corp-introduces-bioios-a-novel-surfactant-in-detergent-attack-zero/) - BioIOS is a hydroxy sulfonated palmitic/stearic acid derived from palm oil. The hydrophilic groups are located in the middle of the hydrophobic chain, providing this new surfactant with excellent surfactant proberties. Kao news release, January 23, 2019
- [SanBio will continue development of SB623 cell therapy for chronic cerebral hemorrhage](https://window-to-japan.eu/2019/01/19/sanbio-will-continue-development-of-sb623-cell-therapy-for-chronic-cerebral-hemorrhage/) - SB623is proprietary product of SanBio, bone marrow-derived mesenchymal stem cells that have been genetically engineered to express the intracellular domain of Notch-1. When injected into neural tissue, SB623 cells seem to reverse neural damage. SanBio news release, January 19, 2019
- [Takara Bio reports good safety for treatment of unresectable pancreactic cancer using oncolytic virus C-REV](https://window-to-japan.eu/2019/01/15/takara-bio-reports-good-safety-for-treatment-of-unresectable-pancreactic-cancer-using-oncolytic-virus-c-rev/) - C-REV (former name HF10) showed good safety and excellent anti-tumor effect in combination with chemotherapy on primary treatment of 6 Japanese patients with unresectable advanced pancreatic cancer. These are intermediate results of a Phase I study. Takara Bio news release, January 15, 2018
- [Solar Frontier Co. exceeds 23 % energy conversion efficiency with CIS-based thin-film solar cells](https://window-to-japan.eu/2019/01/17/solar-frontier-co-exceeds-23-energy-conversion-efficiency-with-cis-based-thin-film-solar-cells/) - CIS type thin-film solar cells which use copper (Cu), indium (In), selenium (Se) as a light absorbing layer are thinner than crystalline silicon type solar cells. Under a NEDO contract, the company prepared cells of about 1 cm2from this material, not containing cadmium, and reached 23.235 % energy conversion efficiency. Ongoing work on scaling this
- [Both JAL and ANA announce to use biojet fuel on flights from San Francisco to Haneda](https://window-to-japan.eu/2019/01/13/both-jal-and-ana-announce-to-use-biojet-fuel-on-flights-from-san-francisco-to-haneda/) - JAL’s biofuel is supplied by Showa Shell Sekiyu. For 2020, the company announced a charter flight with domestic biojet fuel made from clothing as a raw material. The fuel will be prepared from old cotton clothes collected throughout Japan through the Green Earth Institute Co. in Tokyo via an isobutanol route. ANA’s biojet fuel was
- [Team at Tokyo Institute of Technology improves synthesis of 2,5-furandicarboxylic aid (FDCA) using ß-manganese dioxide nanoparticles](https://window-to-japan.eu/2019/01/07/team-at-tokyo-institute-of-technology-improves-synthesis-of-25-furandicarboxylic-aid-fdca-using-s-manganese-dioxide-nanoparticles/) - FDCA is a promising raw material for the synthesis of polyethylene furanoate (PEF), a substitute of PET. It can be prepared by oxidation of glucose-derived 5-hydroxymethylfurfural using a Mn catalyst. The group of Michikazu Hara at TIT has developed an amorphous ß-MnO2 catalyst with a large surface area (nanoparticles) which showed a 3fold higher activity
- [Daiichi Sankyo joins TIT in open innovation on iPS cells producing insulin](https://window-to-japan.eu/2019/01/11/daiichi-sankyo-joins-tit-in-open-innovation-on-ips-cells-producing-insulin/) - The aim is to convert stem cells into beta cells and using them as an alternative to lifelong insulin therapy for patients with type 1 diabetes.It has teamed up with a new company OiDE Beta Revive set-up by Tokyo Institute of Technology, with financial backing from Mitsubishi UFJ Capital. Tokyo Institute of Technology news release, January
- [Takara Bio will sell its mushroom business to Niigata’s Yukiguni Maitake](https://window-to-japan.eu/2018/12/17/takara-bio-will-sell-its-mushroom-business-to-niigatas-yukiguni-maitake/) - The sales agreement will comprise transfer of development, production and sales of mushrooms, licensing, and sales of active agents. The sales are based on Takara’s management plan 2019 which promotes the three business divisions of "Biotechnology support business", "Genetic medicine business" and "Medical food bio business". Takara Bio news release, December 17, 2018
- [NEDO and Sumitomo Electric test redox flow battery in California](https://window-to-japan.eu/2018/12/18/nedo-and-sumitomo-electric-test-redox-flow-battery-in-california/) - California has set a high goal for renewable energy introduction, such as by establishing the State Law SB 100 to cover 100% of the electricity in the state with energy that does not emit greenhouse gases by 2045. NEDO and Sumitomo Electric Industries will start a demonstration project where a stationary Redox Flow Battery (RF
- [Asahi Glass Co. will add 12 additional cell reactors in the US for contract manufacturing](https://window-to-japan.eu/2018/12/18/asahi-glass-co-will-add-12-additional-cell-reactors-in-the-us-for-contract-manufacturing/) - AGC will increase its contract manufacturing business CMC Biologics in Berkeley, California, by expanding manufacturing capacity, with an investment of over 10 billion Yen. The company aims at sales of 100 billion Yen in 2025 in this business field. AGC news release, December 18, 2018
- [Mitsubishi Life Sciences Institute to begin clinical trials on Muse cell therapy for Epidermolysis bullosa](https://window-to-japan.eu/2018/12/20/mitsubishi-life-sciences-institute-to-begin-clinical-trials-on-muse-cell-therapy-for-epidermolysis-bullosa/) - Muse cells are nontumorigenic pluripotent stem cells present in adult tissues discovered by Mari DEZAWA at Tohoku University in 2010. Mitsubishi Life Sciences Institute has acquired this technology and carries out clinical trials targeting acute myocardial infarction since January 2018. The company announced on December 20 that they have started clinical trials with Muse cells type
- [Keio University screens ALS drugs on disease-specific iPS-cells and starts phase I/IIa clinical trial](https://window-to-japan.eu/2018/12/03/keio-university-screens-als-drugs-on-disease-specific-ips-cells-and-starts-phase-i-iia-clinical-trial/) - ALS is a refractory neurological disorder characterized by muscle atrophy due to disorder of spinal motor neurons. A team of Keio University Hospital has generated iPS cells from tissues of patients with neurological disorders and developed a drug screening method based on these cells. Ropinirole hydrochloride, a dopamine receptor agonist, developed by GlaxoSmithKline. When ropinirole
- [Suntory sequences genome of red-wine grapes dominant in Japan](https://window-to-japan.eu/2018/12/04/suntory-sequences-genome-of-red-wine-grapes-dominant-in-japan/) - Suntory has announced that they deciphered the genome of muscat Bailey A, the most widely used red wine grapes harvested in Japan. Suntory, ASEV Japan meeting, November 18, 2018
- [Mitsubishi completes MUSE cell production facility, aims at triple sales of biodegradable plastic](https://window-to-japan.eu/2018/12/05/mitsubishi-completes-muse-cell-production-facility-aims-at-triple-sales-of-biodegradable-plastic/) - According to a business presentation meeting of Mitsubishi Chemical Holdings, the companies Life Sciences Institute LSII hs completed, in October, the facility for the manufacture of heterologous MUSE cells. For 2019, triple sales of biodegradable BioPBS (bio-based polybutylene succinate) are expected. Nikkei Biotech news release, December 5, 2018
- [RIKEN opens European Office in Brussels](https://window-to-japan.eu/2018/12/09/riken-opens-european-office-in-brussels/) - The office was opened on Nov. 1, 2018, followed by an opening ceremony on Nov. 29. RIKEN news release, December 7, 2018
- [Morinaga Milk will introduce milk products containing tripeptide MKP as blood pressure lowering agent](https://window-to-japan.eu/2018/12/07/morinaga-milk-will-introduce-milk-products-containing-tripeptide-mkp-as-blood-pressure-lowering-agent/) - The tripeptide (methionine – lysine – proline) isolated from casein degradation has been shown to be an ACE inhibitor and lower systolic blood pressure in man. This development follows up on lactotripeptide present in Calpis products since 2012, and other peptide-based developments. Nikkei Biotech news release, December 7, 2018
- [Keio University: plans for clinical study on iPS cell derived neural progenitor cells, focus on subacute spinal cord injuries](https://window-to-japan.eu/2018/11/29/keio-university-plans-for-clinical-study-on-ips-cell-derived-neural-progenitor-cells-focus-on-subacute-spinal-cord-injuries/) - Researchers at Keio University prepare for clinical studies using neuronal precursor cells derived from allogenic iPS cells. It is expected that such treatment can alleviate paralysis symptoms in patients with subacute stage spinal cord injury ("spinal cord injury 14 to 28 days after injury"). There are more than 100,000 patients in Japan, and there is
- [Tokyo Institute of Technology: highly efficient reduction of carbon dioxide with copper manganese photocatalyst](https://window-to-japan.eu/2018/11/28/tokyo-institute-of-technology-highly-efficient-reduction-of-carbon-dioxide-with-copper-manganese-photocatalyst/) - A joint team at TIT and AIST has developed a largely improved system for production of formic acid from CO2, using a Cu (I) photosensitizer and Mn (I) catalysts. The quantum yield was 57%, the turnover number 1300 times or more. JST news release, November 28, 2018
- [Olympus starts clinical trial on cultured cartilage cells with Korean JV](https://window-to-japan.eu/2018/11/29/olympus-starts-clinical-trial-on-cultured-cartilage-cells-with-korean-jv/) - Olympus has built a joint venture with Korea’s Sewon Cellontech under the name of Olympus RMS Co., Ltd. This JV has developed in Japan from autologous tissue a CCI kit (Cultured Chondrocyte Implantation kit), for the treatment of traumatic cartilage defects of the knee joint and transdermable osteochondritis, and will start clinical trials in Japan.
- [Konica-Minolta establishs subsidiary “Precision Medicine Japan”](https://window-to-japan.eu/2018/11/28/konica-minolta-establishs-subsidiary-precision-medicine-japan/) - The objective is to help Konica Minolta and acquired companies in decision-making for R & D, and to accelerate the development of companion diagnostic (CDx) technologies and services. Nikkei Biotech news release, November 28, 2018
- [DSM and Chr.Hansen apply for registration of recombinant chymosins in Japan](https://window-to-japan.eu/2018/11/01/dsm-and-chr-hansen-apply-for-registration-of-recombinant-chymosins-in-japan/) - The highest per capita consumption of cheese is in the world is in Greece, cheese intake per day is 85.2 g, and the intake of chymosin contained in cheese is estimated to about 5.6 μg. Japanese daily cheese intake is 6.5 g per capita and chymosin intake is estimated around 0.4 μg. In the 9th
- [University of Kyoto’s CiRA prepare human killer T cells through iPS technology](https://window-to-japan.eu/2018/11/16/university-of-kyotos-cira-prepare-human-killer-t-cells-through-ips-technology/) - Immunotherapy has become a fourth treatment method for cancer in addition to surgical treatment, radiation treatment and chemotherapy. For immunotherapy, a large supply of antigen-specific killer T cells are required. A team around Kaneko SHINZO at CiRA showed that when they used an iPS cell stock not derived from T cells (a HLA homologous iPS
- [NEDO starts new geothermal projects](https://window-to-japan.eu/2018/11/06/nedo-starts-new-geothermal-projects/) - Japan has one of the largest geothermal resource potentials in the world. Japanese resources are estimated at a maximum of 23.47 million kW. About 30 % of these resources are acidic hot water which is presently unused due to corrosion problems. NEDO will support new technologies which overcome this problems. The consortia formed include Fuji
- [Japan Agency of Science and Technology (JST) starts “dark archive” service](https://window-to-japan.eu/2018/11/21/japan-agency-of-science-and-technology-jst-starts-dark-archive-service/) - In the framework of the 2030 Agenda for Sustainable Development of the United Nations, JST has prepared a “dark archive” of published papers providing for siutations where electronic journals are cut off due to natural disasters or other events. The service is provided by Portico, a non-profit US organization, https://www.portico.org/publishers/jstage/ JST news release, November 21,
- [Toyota Motors provides license to Japan Tobacco (JT) on its unique DNA analysis technique GRAS-Di](https://window-to-japan.eu/2018/11/20/toyota-motors-provides-license-to-japan-tobacco-jt-on-its-unique-dna-analysis-technique-gras-di/) - GRAS - Di (Genotyping by Random Amplicon Sequencing – Direct) allows to amplify thousands to tens of thousands of genomes with high reproducibility by adjusting original primers. The technology was invented by Toyota in the framework of biomass-to-fuel and environmental greening projects and licensed by Eurofin Genomics in 2017. JT will use the technology to
- [Team at Kyoto University elucidates mechanism how round shape of eyeball is formed](https://window-to-japan.eu/2018/11/22/team-at-kyoto-university-elucidates-mechanism-how-round-shape-of-eyeball-is-formed/) - Satoru OKUDA and colleagues at Kyoto University’s Virus and Regenerative Medicine Research Institute have elucidated the mechanism by which the form of eye balls is shaped. First, myosin gathers on the inner surface of nerve tissue that protrudes from the brain, and the inner surface is contracted. Next, the distal end of the protruding tissue
- [Hydrogen peroxide content of breast milk may regulate the intestinal flora of babies](https://window-to-japan.eu/2018/11/16/hydrogen-peroxide-content-of-breast-milk-may-regulate-the-intestinal-flora-of-babies/) - As studied by Associate Professor Kentaro NAGAOKA and colleagues at Tokyo University of Agriculture and Technology in mouse experiments, hydrogen peroxide produced in breast milk via amino acid oxidases acts as a gatekeeper for bacteria which gradually form the baby’s microbiome. Microorganisms such as lactic acid bacteria which have catalases preferentially enter the baby’s intestine.
- [Seikagaku Kogyo initiates test with novel post-surgery wound-healing material](https://window-to-japan.eu/2018/11/12/seikagaku-kogyo-initiates-test-with-novel-post-surgery-wound-healing-material/) - SI - 449 is a crosslinked chondroitin sulfate developed as a medical device. It is an anti - adhesive material that spreads and swells after spraying it on surgical wound areas inside the abdominal cavity, etc., reducing postoperative adhesions. It is intended for use after laparotomy and endoscopic surgery. Nikkei Biotech news release, November 12,
- [Kyorin started PII for gene therapy of malignant pleural mesothelioma](https://window-to-japan.eu/2018/11/07/kyorin-started-pii-for-gene-therapy-of-malignant-pleural-mesothelioma/) - Ad-SGE-REIC is a gene therapy in which the cancer-suppressing gene REIC (Reduced Expression in Immortalized Cells) discovered at Okayama University is incorporated into an adenovirus vector. When the REIC gene is forcibly expressed, cancer cells selectively cause cell death. According to the company, 10 interim analyzes will be carried out in 10 cases during phase
- [Takeda will hold an extraordinary shareholder meeting about acquisition of Shire Inc](https://window-to-japan.eu/2018/11/13/takeda-will-hold-an-extraordinary-shareholder-meeting-about-acquisition-of-shire-inc/) - The meeting in Osaka will be simultaneous to a meeting of Shire Inc. shareholders in London and decide whether Takeda will acquire Shire. Nikkei Biotech news release, November 13, 2018
- [Fujifilm has developed iPS cell-derived intestinal epithelial cells that can be used for evaluation of absorption of oral drugs](https://window-to-japan.eu/2018/10/02/fujifilm-has-developed-ips-cell-derived-intestinal-epithelial-cells-that-can-be-evaluated-for-absorption-of-oral-drugs/) - Based on research by Tamakihide MATSUNAGA of Nagoya City University, Fujifilm has succeeded in inducing the differentiation of intestinal epithelial cells from human iPS cells. The cell line has properties similar to intestinal epithelial cells derived from human organisms such as high expression of cytochrome P450 (CYP) 3A4, peptide transporter PEPT1 and expression of the
- [GE Healthcare and Daiwa House install manufacturing facility for regenerative medicine at King Skyfront in Kawasaki](https://window-to-japan.eu/2018/10/04/ge-healthcare-and-daiwa-house-install-manufacturing-facility-for-regenerative-medicine-at-king-skyfront-in-kawasaki/) - Daiwa House Industry will provide facilities that comply with Japanese regulations on regenerative medicine and will support the rapid transition from regenerative medicine research and clinical trial to commercial manufacturing. GE Healthcare contributes a series of cell processing steps that enable reproducible production of cell and gene therapy products. In addition, "FlexFactoryTMfor Cell Therapy" is
- [RIKEN-led consortium deciphers shark genome](https://window-to-japan.eu/2018/10/09/riken-led-consortium-deciphers-shark-genome/) - The consortium composed from members of Okinawa Churaumi Aquarium, RIKEN, Osaka City University and the University of Tokyo Atmosphere and Ocean Research Institute successfully analyzed the whole genome sequence of "canine shark", "tiger shark" and "whale shark". The high-precision genomic information obtained from this research is based on studies on the occurrence and ecology of
- [Kaneka sees further potential for biodegradable polymer PHBH](https://window-to-japan.eu/2018/10/15/kaneka-sees-further-potential-for-biodegradable-polymer-phbh/) - Kaneka's Aonilex biopolymer, a bacterial copolymer from 2-hydroxybutyrate and 2-hydroxyhexanoate, will be produced at a level of 5000 t/y, but production could be raised shortly to 20,000 t, due to raising demands in Europe. The biopolymer is not only biodegradable, but also certified for food contact by FDA. Nikkei Biotech news release, October 15, 2018
- [Tokai University Hospital to test osteoarthritis treatment by autologous cartilage cell sheet transfer](https://window-to-japan.eu/2018/10/23/tokai-university-hospital-to-test-osteoarthritis-treatment-by-autologous-cartilage-cell-sheet-transfer/) - In a future doctor-led trial, cartilage of a patient's knee is collected with an arthroscope, and self-laminated chondrocyte cell sheets (2 or more) are manufactured at the hospital’s cell culture center. At the time of high tibial oseotomy, defective tissue is excised and self-laminated chondrocyte sheets are transplanted following bone marrow stimulation. The number of
- [Daicel and Chitose to collaborate on C-4 chemicals from glycerol](https://window-to-japan.eu/2018/10/24/daicel-and-chitose-to-collaborate-on-c-4-chemicals-from-glycerol/) - Daicel has collaborative research with Nihon University, using wild-type bacteria, which produce erythritol from glycerin. Chitose is a specialist in bacterial mutagenesis and has developed a process for microbial butanediol production. Both companies will collaborate to improve the yield of various C-4 compounds from glycerol. Nikkei Biotech news release, October 24, 2018
- [Pharma Foods to cooperate with Mitsubishi Tanabe on chicken-derived antibody drugs for the treatment of autoimmune diseases](https://window-to-japan.eu/2018/10/24/pharma-foods-to-cooperate-with-mitsubishi-tanabe-on-chicken-derived-antibody-drugs-for-the-treatment-of-autoimmune-diseases/) - Pharma Foods has developed a novel type of antibody directed against an autoimmune disease which was not further specified. The antibody difficult to prepare by conventional technology was prepared by Pharma Foods’ proprietary technology "ALAgene" from chicken. Pharma Foods news release, October 22, 2018
- [NEDO-supported consortium builds large-scale hybrid storage battery system in Farrel, Lower Saxony](https://window-to-japan.eu/2018/10/31/nnedo-supported-consortium-builds-large-scale-hybrid-storage-battery-system-in-farrel-lower-saxony/) - NEDO and Hitachi Kasei, Hitachi Power Solutions and NGK Insulators have completed a large-scale hybrid storage battery system in Farrel city, Lower Saxony, Germany and will start operation from November 1, 2018. The system consists of two types of storage batteries with different characteristics (lithium ion battery and sodium sulfur battery, total capacity 11.5 MW
- [Mitsui Chemicals and Chitose start joint project on plant stem cells and soil microorganisms](https://window-to-japan.eu/2018/10/29/mitsui-chemicals-and-chitose-start-joint-project-on-plant-stem-cells-and-soil-microorganisms/) - Within the “Oto1-project”, Mitsui Chemical's plant cell cultivation technology and Chitose's microorganism active cultivation technology will be jointy exploited and used for joint business development. Mitsui Chemicals news release, October 29, 2018
- [Otsuka Pharmaceuticals signs agreement on cardiomyocyte technology with Adipo Medical Technology](https://window-to-japan.eu/2018/10/30/otsuka-pharmaceuticals-signs-agreement-on-cardiomyocyte-technology-with-adipo-medical-technology/) - Adipo Medical Technology Co. (AMT), an Osaka venture company, operates an AMED-supported project on the "Development of Multiple Lineage Precursor Cells from Allogeneic Adipose Tissue as a Cellular Medicine for the Treatment of Severe Heart Failure", under project leadership of Akinobu Matsuyama at Fujita Medical University. Otsuka has announced that it has signed an agreement
- [Kaneka advances soft tissue reconstruction using stem-cell technology](https://window-to-japan.eu/2018/10/12/kaneka-advances-soft-tissue-reconstruction-using-stem-cell-technology/) - In its CellPort Clinic Yokohama acquired in 2012 Kaneka has already treated 1100 cases of soft tissue augmentation such as breast augmentation and breast cancer treatment and facial degenerative diseases using stem cells obtained from adipose tissue of the patient. Following a method developed by the University of Tokyo, mesenchymal stem cells extracted from separately
- [Tokyo Women's Medical University starts clinical trial of MSC-derived periodontal ligament](https://window-to-japan.eu/2018/10/05/tokyo-womens-medical-university-starts-clinical-trial-of-msc-derived-periodontal-ligament/) - In the doctor-initiated trial, periodontal ligament derived from allogenic mesenchymal stem cells will be used to treat a patient with severe periodontitis. Nikkei Biotech news release, October 5, 2018
- [Team of Showa University and RIKEN regenerates functional salivary glands from mouse ES cells](https://window-to-japan.eu/2018/10/12/team-of-showa-university-and-riken-regenerates-functional-salivary-glands-from-mouse-es-cells/) - Salivary glands, which are exocrine gland tissues, secrete saliva into the oral cavity. Saliva has digestive and antibacterial action and protects the oral mucosa. In xerostomia, salivary secretion is reduced. A team around Kenji MISHIMA from Showa University and RIKEN have identified, in mice, two genes (Sox9, Foxc1), which are important for the formation of
- [RIKEN team develops improved simulation software of protein 3D structures from cryo-electron microscope images](https://window-to-japan.eu/2018/10/19/riken-team-develops-improved-simulation-software-of-protein-3d-structures-from-cryo-electron-microscope-images/) - A team around Yuji SUGITA at RIKEN has developed a high-speed parallel computing algorithm for the refinement of 3D structures obtained through cryo-electron microscope images. Since this procedure does not require protein crystallization, the stereoscopic image of large biomolecules such as ribosomes and protein complexes can be solved with close to atomic resolution. The software
- [Konica Minolta exhibits prototype of cellular activity measurement system](https://window-to-japan.eu/2018/10/12/konica-minolta-exhibits-prototype-of-cellular-activity-measurement-system/) - Konica Minolta exhibited a prototype of a "Cellular Activity Evaluation System" at BioJapan 2018. It measures oxygen consumption of cells with high sensitivity and thus evaluates cell activity. Since cells can be measured nondestructively by this system, it could be used in applications such as extracorporeal artificial insemination and drug discovery. Konica Minolta exhibit at
- [Taiwan's Aprinoia Therpeutics will do clinical trial of tau PET tracer in Japan in 2019](https://window-to-japan.eu/2018/10/11/taiwans-aprinoia-therpeutics-will-do-clinical-trial-of-tau-pet-tracer-in-japan-in-2019/) - The PET-enhancing radiotracer PM-PBB 3 / APN-1 was developed by the Quantum Science and Technology Research Organization · National Institute of Radiological Sciences and recognizes aggregation and accumulation of tau protein causing neurodegenerative lesion diseases such as Alzheimer's disease. It has orphan drug status in Japan. US Eli Lilly and Merck are said to do
- [Tasuku HONJO receives Nobel award in medicine for discovery of immunocheckpoint therapy for cancer](https://window-to-japan.eu/2018/10/01/tasuku-honjo-receives-nnobel-award-in-medicine-for-discovery-of-immunocheckpoint-therapy-for-cancer/) - The prize will be jointly awarded with James Patrick Allison of MD Anderson Cancer Center. The drugs based on their work belong to a class of antibodies called checkpoint inhibitors, of which ipilimumab (brand name Yervoy), nivolumab (Opdivo) and pembrolizumab (Keytruda) are already approved. Born in 1942, Honjo studied medicine at Kyoto University, and was a
- [Shionogi licenses ROHTO's cell technology for treatment of decompensated cirrhosis](https://window-to-japan.eu/2018/09/13/shionogi-linceses-rohtos-cell-technology-for-treatment-of-decompensated-cirrhosis/) - Shionogi linceses ROHTO cell technology for treatment of decompensated cirrhosisCurrently ROHTO Pharmaceutical conducts Phase I/II for 15 patients with decompensated cirrhosis. Treathment is based on a regenerative cell product ADR - 001 that uses allogenic adipose-derived mesenchymal stem cells (MSC). To treat liver cirrhosis, humoral factors such as cytokines and growth factors produced by MSCs
- [Toray designs improved carbon-fiber reinforced plastic (CFRP)](https://window-to-japan.eu/2018/09/28/toray-designs-improved-carbon-fiber-reinforced-plastic-cfrp/) - By combining molecular design and structural analysis supported by universities and proprietary nano alloy technology owned by Toray, a research team at the company succeeded in uniformly dispersing a polyrotaxane circular polymers in the matrix resin of CFRP at the nanoscale. While maintaining the high strength and rigidity of CFRP, the new material was about 3fold
- [MHLW approves clinical research on autologous iPS cell-derived blood platelets](https://window-to-japan.eu/2018/09/25/mhlw-approves-clinical-research-on-autologous-ips-cell-derived-blood-platelets/) - The doctor-initiated study will be conducted with one patient with aplastic anemia with platelet transfusion failure complication. Production of platelets are done from the patient’s (autologous) iPS cells through megakaryocyte cells, a method developed by Hiroyuki ETO of CiRA. In his method, hematopoietic progenitor cells are induced from iPS cells and in a complex procedure
- [Japan’s bio-related national budget requests in 2019 are around 2 billion € (223.5 billion Yen), increase in medical and environmental fields](https://window-to-japan.eu/2018/09/24/japans-approximate-bio-related-national-budget-requests-in-2019-are-around-2-billion-e-223-5-billion-yen-increase-in-medical-and-environmental-fields/) - Some of the features are: AMEDs budget may increase by 20 % and include a new program on „brain and mental health“. METI plans for a big-budget „Medical Device and System R & D Project to Realize Future Medical Care“. In response to the microplastic problem, the Ministry of the Environment will promote biomass plastic.
- [Braizon Therapeutics Co. delivers drugs across the blood-brain barrier](https://window-to-japan.eu/2018/09/26/braizon-therapeutics-co-delivers-drugs-across-the-blood-brain-barrier/) - The Tokyo-based startup company, has developed glucose-modified polymeric micelles that interact with glucose transporter 1 (GLUT1) and thus allow to transport drugs through the BBB to the brain. Braizon Therapeutics URL http://www.braizon.com/en/technology/index.html
- [Hitachi starts cloud-based energy management demonstration system in Slovenia](https://window-to-japan.eu/2018/09/25/hitachi-starts-cloud-based-energy-management-demonstration-system-in-slovenia/) - Hitachi will establish and demonstrate "cloud-type energy management system (AEMS)" which will avoid power outage and secure electric power quality at factories through countermeasures against instantaneous voltage drop. Partnership is between the Ministry of Economic Development and Technology of Slovenia and NEDO, Japan (the project management organization of the Ministry of Trade, Economics and Industry
- [Veritas In Silico Co. targets low molecular weight drugs interacting with cellular nucleic acids](https://window-to-japan.eu/2018/09/26/veritas-in-silico-co-targets-low-molecular-weight-drugs-interacting-with-cellular-nucleic-acids/) - The Tokyo-based company was established in November 2016 with the aim to find new therapies based on low-molecular weight drug discovery targeting nucleic acids. Investment is from several Mitsubishi Group companies. VIS URL http://www.veritasinsilico.com/index.html
- [Mitsubishi Chemical improves polypropylene porous film for lithium batteries](https://window-to-japan.eu/2018/09/04/mitsubishi-cjhemical-improves-polypropylene-porous-film-for-lithium-batteries/) - The porous structure of polypropylene-based films was optimized in view of pore diameter, porosity, pore distribution and other structural factors, thereby improving the permeability of lithium ions. Application of this film as a separator in a lithium ion battery led to about 20% enhanced capacity of the cell while maintaining short circuit resistance against mechanical
- [Asahi Glass develops efficient fluorocarbon thin-film polymer for fuel cells](https://window-to-japan.eu/2018/09/04/asahi-glass-develops-efficient-fluorocarbon-thin-film-polymer-for-fuel-cells/) - The polymer was designed with a better understanding of film properties at the micro level. As a result, the film thickness could be reduced to 5 micrometers, 1/5 of that of conventional unreinforced membranes. The novel electrolyte thin film has a durability of 5 times or more in dry/wet cycles. Thinning the electrolyte membrane increases
- [RIKEN and Fujitsu detect fetal congenital heart diseases by AI-supported ultrasonic screening in real-time](https://window-to-japan.eu/2018/09/18/riken-and-fujitsu-detect-fetal-congenital-heart-diseases-by-ai-supported-ultrasonic-screening-in-real-time/) - The procedure is based on AI technology which can distinguish the position and classification of multiple objects appearing in an ultrasound image with high performance. In addition, a new test result display system was developed which displays the "confidence degree" of each part in a list so as to speed up the inspection and simplify
- [„Single-molecule pharmacology“: RIKEN team tracks interaction of drug with G-protein coupled receptors](https://window-to-japan.eu/2018/09/19/single-molecule-pharmacology-riken-team-tracks-interaction-of-drug-with-g-protein-coupled-receptors/) - A group at RIKEN has tracked the movement of nine types of fluorescently labeled G protein-coupled receptors (GPLC) in living cultured HEK 293 cells using a total internal reflection fluorescence microscope. It turned out that movement of nine kinds of GPCRs became slow when they were activated by drugs. In addition, the relationship between receptor
- [RIKEN/Meiji Pharmaceutical University consortium discovers yeast which produces single-cell oil from biomass](https://window-to-japan.eu/2018/09/21/riken-meiji-pharmaceutical-university-consortium-discovers-yeast-which-produces-single-cell-oil-from-biomass/) - The groups around Takashi SAKITA and Miyako TAKASHIMA have isolated over 1000 yeast strains from Okinawa. Among them, Cystibasidium irimotoense from the soils of Iriomote Island, Okinawa, was shown to metabolize glucose and xylose almost simultaneously and nearly completely in 10 days, producing up to 33 % of triglycerides. There are very few reports on
- [Chitose develops new CHO cell that can produce 5g/L or more of IgG](https://window-to-japan.eu/2018/09/08/chitose-develops-new-cho-cell-that-can-produce-5g-l-or-more-of-igg/) - According to a lecture at the 70th Annual Meeting oft he Japan Society of Bioengineering on Sept. 7, Chitose Research Laboratory has developed a CHO-MK cell line which produced 5g/L IgG within 4 days. Takayaku HORIUCHI, Chitose Research Laboratory, lecture S3Lc02
- [University of Tokyo group elucidates metabolic control network for insulin action](https://window-to-japan.eu/2018/09/11/university-of-tokyo-group-elucidates-metabolic-control-network-for-insulin-action/) - The group of Shinya KURODA and colleagues at the University of Tokyo has reconstructed a large-scale metabolic control network (transomics network) of genes whose expression conge by insulin stimulation and of (phosphorylated) proteins and metabolites whose concentrations change accordingly. They found that at high insulin concentrations gene expression is induced by transcription factor induction via
- [University of Tokyo team separates polymer mixture by porous metal complexes (MOF)](https://window-to-japan.eu/2018/09/13/university-of-tokyo-team-separates-polymer-mixture-by-porous-metal-complexes-mof/) - The group of Takashi UEMURA at the University of Tokyo has used porous metal complexes (MOF) consisting of metal ions connected in regular nano-sized spaces to separate modified and non-modified polyethylene glycol. Using MOF with a pore size of 0.57 nm as the adsorbent, PEG with unmodified terminal group OH was efficiently incorporated into the
- [RIKEN research team achieves highly accurate NMR chemical shift prediction by combining quantum theory and AI methods](https://window-to-japan.eu/2018/09/12/riken-research-team-achieves-highly-accurate-nmr-chemical-shift-prediction-by-combining-quantum-theory-and-ai-methods/) - The team of Jun KIKUCHI at RIKEN has developed a method which predicts chemical shifts in NMR in high accuracy by combining quantum chemistry theory (deductive procedure) and machine learning using 91 types of learning algorithms (inductive approach). The utility of the model was demonstrated by applying it to assignments of experimental NMR signals of
- [Mitsubishi LSI announces clinical trial for treatment of cerebral infarction with MUSE cells](https://window-to-japan.eu/2018/09/03/mitsubishi-lsi-announces-clinical-trial-for-treatment-of-cerebral-infarction-with-muse-cells/) - The Mitsubishi Life Science Institute has launched a clinical trial with MUSE cells (multi-lineage differentiating stress enduring cells) for the treatment of acute myocardial infarction in January, 2018. Now, LSI annunces a clinical trial CL2020 with MUSE cells targeting patients with cerebral infarction. In this trial, MUSE cells will be administered intravenously. LSI news release, September 3,
- [Yasuhisa ASANO receives lifelong achievement award from Japanese Society for Biotechnology](https://window-to-japan.eu/2018/08/31/yasuhisa-asano-receives-lifelong-achievement-award-from-japanese-society-for-biotechnology/) - Professor Yasuhisa ASANO, Director of the Biotechnology Research Center at the Prefectural University of Toyama and Leader of the ERATO ASANO Active Enzyme Molecule Project from 2012 - 2018, will receive the Lifelong Achievement Medal of the Japanese Society for Biotechnology at the Annual Meeting of SBJ a at Kansai University on Sept. 5th, 2018.
- [Team at Tohoku University improves protein design by AI](https://window-to-japan.eu/2018/08/31/team-at-tohoku-university-improves-protein-design-by-ai/) - The group of Mitsuo UMEZU first prepared a small number of variants of green fluorescent protein (GFP) by conventional random mutagenesis and measured their fluorescent properties in ordert o acquire learning data for artificial intelligence. Next, by Bayesian optimization, an artificial intelligence techniques, they predicted which mutation if introduced would convey the desired function. This
- [Implanta Innovations and Sumitomo Rubber: improved procedure for rubber tree genetic transformation](https://window-to-japan.eu/2018/08/31/implanta-innovations-and-sumitomo-rubber-improved-procedure-for-rubber-tree-genetic-transformation/) - The method is based on „whiskers“ prepared from potassium titanate. Genetic material used for transformation is added to such whiskers which by means of ultrasound integrate with high efficiency into the germ plasm of Para rubber, the rubber tree. As a systematic proof, the fluorescent protein gene from Chiridius poppei, a marine plankton, was introduced
- [Japan Patent Office installs "IP Acceleration Program for Startups (IPAS)"](https://window-to-japan.eu/2018/08/31/japan-patent-office-installs-ip-acceleration-program-for-startups-ipas/) - In this program, an "IP Mentoring Team" consisting of patent attorneys and venture business experts is sent to the startup for about 1 month. The patent office supports the cost. The project will be continued in FY 2019, and the estimated requested amount is 130 million yen. Nikkei Biotech news release, August 31, 2018
- [Hayashibara finds that trehalose adds to broiler breeding without antimicrobial additives](https://window-to-japan.eu/2018/08/30/hayashibara-finds-that-trehalose-adds-to-broiler-breeding-without-antimicrobial-additives/) - In collaboration with Yamanashi Prefecture and Tohoku University, Hayashibara Co. found that if trehalose was added by 0.5% to a broiler feed without antimicrobial additives, broilers became significantly heavier at the age of 43 days and productivity had improved. The gross revenue improved by 6.17 yen (8.8%) due to the addition of trehalose. Trehalose improves
- [Asta Pharmaceuticals, as subsidiary of Fuji Chemical, develops APIs from astaxanthin](https://window-to-japan.eu/2018/08/27/asta-pharmaceuticals-as-subsidiary-of-fuji-chemical-develops-apis-from-astaxanthin/) - The company, founded in 2015, has developed water-soluble derivatives of astaxanthin into APIs. In animal models, effects were seen in osteoarthritis of the knee, cerebral infarction, heart failure, amyotrophic lateral sclerosis etc.. Natural astaxanthin has stronger singlet oxygen erasing power than other carotenoids, and because it has an activity to suppress chronic inflammation, it might
- [Takeda focuses regenerative medicine projects to collaboration with CiRA (T-CiRA)](https://window-to-japan.eu/2018/08/30/takeda-focuses-regenerative-medicine-projects-to-collaboration-with-cira-t-cira/) - According to an interview with Nikkei Biotech, Takeda has reduced its staff concerned with regenerative medicine projectds to researchers in charge of T-CiRA, and other researchers have been transferred to the Central Nervous System Disease and other units of Shonan Health Innovation Park. According to the interview, the number of target researchers is estimated to
- [CellSeed expects approval of iPS-cell derived esophageal regenerating epithelial cell sheet by 2019](https://window-to-japan.eu/2018/08/27/cellseed-expects-approval-of-ips-cell-derived-esophageal-regenerating-epithelial-cell-sheet-by-2019/) - The company is focusing on autologous esophageal regenerating epithelial sheets for wounds after esophageal cancer resection endoscopic surgery (ESD). Esophageal regenerating epithelial sheets are grown from cells collected from the oral mucosa of a patient, prepared as a cell sheet using a thermoresponsive culture dish, and transplanted to the esophageal ulcer surface after ESD. They
- [NEDO research association designs photocatalyst with 12.5 % energy conversion efficiency](https://window-to-japan.eu/2018/08/27/nedo-research-association-designs-photocatalyst-with-12-5-energy-conversion-efficiency/) - NEDO’s Artificial Photosynthetic Chemistry Process Technology Research Association (ARPChem) has developed a two-stage cell in tandem arrangement comprising a hydrogen-generating photocatalyst made up from Cu, In, Ga and Se (CIGS) and an oxygen-generating photocatalyst (BiVO4). CIGS is a p-type semiconductor, and by forming an n-type semiconductor on its surface, electrons and holes are generated in
- [University of Tokyo team develops „intelligent Cell Sorter“ based on deep learning of cell images](https://window-to-japan.eu/2018/08/28/university-of-tokyo-team-develops-intelligent-cell-sorter-based-on-deep-learning-of-cell-images/) - The group of Keisuke GODA at the University of Tokyo combined a fluorescent-activated cell sorter (FACS) with high-speed micro-imaging and high-speed data processing based on a 10 Gigabit Ethernet. After cycles of deep learning with cell samples, the machine was able to discriminate cells by high-speed imaging. The system was successfully tested with microbial, animal
- [Astellas acquires British Quethera Inc. to develop gene therapy for glaucoma](https://window-to-japan.eu/2018/08/16/astellas-acquires-british-quethera-inc-to-develop-gene-therapy-for-glaucoma/) - Quethera has a technology to express therapeutic proteins in the retinal cells of glaucoma patients utilizing recombinant adeno-associated viral vector system (rAAV). Glaucoma is a disease in which damage of the optic nerve progresses, and in many cases is accompanied by an increase in intraocular pressure. It was confirmed in a preclinical study conducted by
- [Kyowa Hakko obtains approval for EPO generic applied by injection](https://window-to-japan.eu/2018/08/16/kyowa-hakko-obtains-approval-for-epo-generic-applied-by-injection/) - The "Darbepoetin alfa injection syringe" KKF contains Darbepoetin alfa, a sustained type erythropoiesis stimulating factor, and has been released as "Nesp®" in July 2007, then the main product of Kyowa Hakko Kirin. Kyowa Kirin news release, August 16, 2018
- [Jiwa Medical University and LPixel Inc. develop automatic recognition of colon polyps using AI](https://window-to-japan.eu/2018/08/17/jiwa-medical-university-and-lpixel-inc-develop-automatic-recognition-of-colon-polyps-using-ai/) - The colonoscopy system detects polyps in real time during and predicts their diagnosis using artificial intelligence (AI) technology. By reducing oversight of polyps, it is anticipated to reduce the risk of developing colorectal cancer. LPixel news release, August 17, 2018
- [Otsuka takes license for CART therapy targeting active integrin ß7](https://window-to-japan.eu/2018/08/21/otsuka-takes-license-for-cart-therapy-targeting-active-integrin-s7/) - Otsuka Pharmaceutical has entered into a worldwide exclusive license agreement with Osaka University for for receptor T cell (CART) therapy (MMG 49 CAR-T cell therapy). MMG49 is a chimeric antigen targeted to active integrin β7 found in multiple myeloma. Otsuka Pharma news release, August 21, 2018
- [NEDO initiates test of block chain technology for facilitated export operations](https://window-to-japan.eu/2018/08/23/nedo-initiates-test-of-block-chain-technology-for-facilitated-export-operations/) - Paper media and pdf files are widely used for collaboration among companies in Japanese trading operations, and it may take a lot of time and cost to manually reenter the work in the system and check or modify erroneous inputs. Also, since the process of information transmission and sharing is not advanced, it is difficult
- [RIKEN team designs organic molecules with desired absorption characteristics using AI](https://window-to-japan.eu/2018/08/24/riken-team-design-organic-molecules-with-desired-absorption-characteristics-using-ai/) - Masato SUMIDA’s team at RIKEN has used deep learning procedures (AI) to design organic molecules that absorb light at desired wavelengths. They first set the absorption wavelength to be 300 nm, 400 nm, 500 nm, 600 nm. Then, they chose structural formula of 13,000 organic molecules of about 400 m.w. constituted by hydrogen (H), carbon
- [Celgene starts phase II of CD19 targeting CART therapy in Japan](https://window-to-japan.eu/2018/08/22/celgene-starts-phase-ii-of-cd19-targeting-cart-therapy-in-japan/) - Celgene, the Japanese subsidiary of Celgene Inc., started Phase II of JCAR 017 (lisocabtagene maraleucel, liso-cel), a chimeric antigen receptor T cell (CART) therapy targeting CD 19. JCAR 017 is a self-administered CART therapy developed by Juno Therapeutics, USA. CD4 positive and CD8 positive T cells are isolated from peripheral blood of patients and activated.
- [Takara Bio licenses out oncolytic virus HF10 to Korea’s Dong-A ST](https://window-to-japan.eu/2018/08/22/takara-bio-licenses-out-oncolytic-virus-hf10-to-koreas-dong-a-st/) - C - REV (HF 10) is an oncolytic virus created by attenuating Herpes simplex virus type 1 (HSV - 1). In December 2016, Takara Bio has concluded an exclusive license agreement on development and sales in Japan with Otsuka Pharmaceutical, and this is now followed with an exclusive license agreement for Korea by Dong-A ST
- [Osaka Gas pioneers microbial production of ß-hydroxybutyric acid (D-BHB) as food additive](https://window-to-japan.eu/2018/08/30/osaka-gas-pioneers-microbial-production-of-s-hydroxybutyric-acid-d-bhb-as-food-additive/) - D-BHB belongs to the group of ketone bodies such as acetoacetic acid which are generated in the liver as metabolites of fatty acids. D-BHB made in the liver is converted into acetoacetic acid in the mitochondria and then metabolized through the TCA cycle as an an alternative source of ATP when glucose is deficient. Ketone
- [Dainippon Sumitomo Pharma to start clinical trials of allogenic RPE cells in FY 2018](https://window-to-japan.eu/2018/08/08/dainippon-sumitomo-pharma-to-start-clinical-trials-of-allogenic-rpe-cells-in-fy-2018/) - As outlined in a business interview by an executive of the company, clinical trials on the treatment of macular degeneration with RPE cells derived from allogenic iPS cells will be started jointly with Helios in FY 2018. Nikkei Biotech news release, August 8, 2018
- [Integriculture plans for 2 USD/kg for artificially cultured meat by 2026](https://window-to-japan.eu/2018/08/09/integriculture-plans-for-2-usd-kg-for-artificially-cultured-meat-by-2026/) - The Tokyo-based venture company is developing cultured meat by proprietary cell culture technology and claims to have lowered production cost to 2000 USD/kg. By collaborating with plant makers in order to develop mass production technology, the company aims to reduce production cost to 2 USD/kg by around 2026, as the company's President Yuki Hanyu revealed
- [Hirotsu Bioscience startup develops simple cancer pre-diagnosis using C. elegans, raises 1.4 billion yen (11 million €)](https://window-to-japan.eu/2018/08/07/hirotsu-bioscience-startup-develops-simple-cancer-pre-diagnosis-using-c-elegans-raises-1-4-billion-yen-11-million-e/) - The N-NOSE test monitors if C. elegans roundworms evade or come closer to a drop of urine obtained from a test person. C. elegans has significantly more smell receptors than dogs and evades healthy urine but not the urine of cancer patients. In tests so far an accuracy of over 95 % was observed. The
- [ERATO consortium develops improved multimodal dialogue control system for androids](https://window-to-japan.eu/2018/07/31/erato-consortium-develops-improved-multimodal-dialogue-control-system-for-androids/) - Within the ERATO Ishiguro project on Human Robot Interaction, a team of ATR, Osaka and Kyoto University developed a multimodal dialogue control system making full use of cameras and microphones to improve a natural presence in daily situations of the android "ERICA" and enhanced the sense of dialogue by the social dialog robot "CommU". In
- [Astellas corporate venture invests in Keio University’s Heartseed](https://window-to-japan.eu/2018/07/30/astellas-corporate-venture-invests-in-keio-universitys-heartseed/) - Heartseed, a spin-off of Keio University, targets iPS cell-derived cardiomyocytes for the treatment of heart insufficiency Heartseed news release, July 30, 2018
- [Kyoto University hospitals starts clinical trials of cellular therapy against Parkinson’s disease](https://window-to-japan.eu/2018/07/30/kyoto-university-hospitals-starts-clinical-trials-of-cellular-therapy-against-parkinsons-disease/) - In the doctor-initiated trial, dopamine neural progenitor cells derived from allogenic iPS cells are administered to patients suffering from Parkinson’s disease. The experimental design has been developed byo Jun TAKAHASHI at CiRA of Kyoto University in collaboration with Dainippon Sumitomo Pharma. Dainippon Sumitomo Pharma news release, July 31, 2018
- [EU-Japan new economic relationship will include active ingredients and biological drugs](https://window-to-japan.eu/2018/07/17/eu-japan-new-economic-relationship-will-include-active-ingredients-and-biological-drugs/) - The scope of the existing EU-Japan mutual recognition agreement (MRA), which was first signed in 2004, has been expanded to include drug substances (active ingredients), sterile drugs and biological drugs such as vaccines as a result of the signing of the new comprehensive trade deal between the EU and Japan on 17 July 2018. July
- [Kyowa Hakko Kirin develops technique to deliver siRNA specifically to immune and dendritic cells](https://window-to-japan.eu/2018/07/23/kyowa-hakko-kirin-develops-technique-to-deliver-sirna-specifically-to-immune-and-dendritic-cells/) - As outlined bei Keiji UEHARA, Director of the Nuclear Medicine Research Institute of Kyowa Hakko Kirin, in a presentation at the 4th Annual Meeting of the Japan Society of Nucleic Acid Science, the company has developed such technology based on a modified sugar chain ligand targeting CD206. Nikkei Biotech news release, July 23, 2018
- [Yokohama Rubber develops new technology to produce isoprene from biomass](https://window-to-japan.eu/2018/07/26/yokohama-rubber-develops-new-technology-to-produce-isoprene-from-biomass/) - In collaboration with RIKEN and ZEON Co., Yokohama Rubber Co., Ltd. has developed new technology capable of efficiently producing isoprene from biomass. Isoprene is used as a raw material for synthetic rubber (polyisoprene rubber). It is based on a new pathway developed in-silico pathway design, cell design and plant science technology. In nature, isoprene is
- ["Yoghurt 8020" obtains functional display to improve oral cavity](https://window-to-japan.eu/2018/07/27/yoghurt-8020-obtains-functional-display-to-improve-oral-cavity/) - The yoghurt is made using Lactobacillus rhamnosus 8020 screened and evaluated by Professor Futakawa of Hiroshima University. The display will announce that the yoghurt is suitable for those worried about the health of teeth and gums. Producer of the yoghurt is Shikoku Milk Works. Nikkei Biotech news release, July 27, 2018
- [J-TEC applies for osteoarthritis treatment using autologous chondrocyte tissue](https://window-to-japan.eu/2018/07/20/j-tec-applies-for-osteoarthritis-treatment-using-autologous-chondrocyte-tissue/) - J-TEC, as subsidiary of Fujifilm, has submitted a clinical trial plan for the treatment of osteoarthrosis by its autologous chondrocyte tissue product "Jack". Jack acquired manufacturing and marketing authorization in 2012 for traumatic cartilage defect in knee joint or transdermal osteochondritis. It was Japan's first regenerative medicine product in the orthopedics field, covered by insurance
- [Kawasaki holds "Solar Car Workshop" for school children aged 9 - 12](https://window-to-japan.eu/2018/06/28/kawasaki-holds-solar-car-workshop-for-school-children-aged-9-12/) - In a “Solar Car Workshop Class” with 10 participating children, after conducting classes on the structure of energy and solar power generation, solar cars have been made and a race competition will be organized in August. The program is supported by NEDO. NEDO news release, June 28, 2018
- [Meiji Seika Pharma and Hiroshima’s TwoCells Co. team up on osteoarthritis cell medicine](https://window-to-japan.eu/2018/06/26/meiji-seika-pharma-and-hiroshimas-twocells-co-team-up-on-osteoarthritis-cell-medicine/) - In a project limited to one year, the two companies will attempt to use bone marrow-derived mesenchymal cells (gMSC1) – a technology established by TwoCells – for the treatment of osteoarthritis. Meiji Seika Pharma is a producer of purified sodium hyaluronate for injections. TwoCells Co. news release, June 26, 2018
- [Sumitomo Chemical develops improved PMMA material for car front windows](https://window-to-japan.eu/2018/06/25/sumitomo-chemical-develops-improved-pmma-material-for-car-front-windows/) - The light and sturdy resin is based on polymethylmethacrylate (PMMA) which has high transparency but also high rigidity and toughness. The fracture behavior of this material was elucidated at the molecular level, and a higher order structure design was achieved. As a result, the flexural modulus was about 1.6 times and the Charpy impact strength
- [Bridgestone develops rubber composite with improved performance and fuel economy](https://window-to-japan.eu/2018/06/25/bridgestone-develops-rubber-composite-with-improved-performance-and-fuel-economy/) - The composite is based on a double network structure developed by Hokkaido University ‘s GUN Cheng Ping. It is prepared by tough polymerization of rubber materials and improves fuel economy and strength. Bridgestone claims to have achieved a completely new rubber material that improves the tire’s fuel economy characteristics by 15%, and the strength about
- [Morinaga Milk obtains permission for functional disply on yogurt to keep skin moisture.](https://window-to-japan.eu/2018/06/29/morinaga-milk-obtains-permission-for-functional-disply-on-yogurt-to-keep-skin-moisture/) - Morinaga’s Aloe Sterol Drink Yogurt may be labelled by “keeping skin moisture”. The functional components are aloe-derived rophenol and cycloalananol. Results of clinical trials that confirmed the function of “keeping moisture on the skin” were announced in a paper of June 2016 (Skin Pharmacol Physiol 2016, 29: 309-317). Morinaga Milk news release, June 29, 2018
- [Wind power generation in Japan is slowly increasing](https://window-to-japan.eu/2018/06/28/wind-power-generation-in-japan-is-slowly-increasing/) - By the end of FY 2017 (March 31, 2018), 2253 units were installed which produced about 3.5 GWatt. This was an increase of 2.5 % in number from FY 2016. NEDO news release, June 28, 2018
- [RIKEN’s supercomputer “Kyo” achieves world's highest level in graph analysis](https://window-to-japan.eu/2018/06/29/rikens-supercomputer-kyo-achieves-worlds-highest-level-in-graph-analysis/) - In the international performance ranking Graph 500, Kyo won the first place for the seventh consecutive term. Large-scale graph analysis is important in the analysis of big data requiring large-scale and complicated data processing. RIKEN news release, June 29, 2018
- [Cira’s Makoto IKEYA receives Gottfried Wagener Award 2018 by the German Chamber of Commerce and Industry, Tokyo](https://window-to-japan.eu/2018/06/29/ciras-makoto-ikeya-receives-gottfried-wagener-award-2018-by-the-german-chamber-of-commerce-and-industry-tokyo/) - The prize, created in 2008 by a number of technology-oriented German companies and the AHK Tokyo, was awarded for Ikeya’s work on “Research on drug discovery for progressive ossification fibrosis dysplasia (FOP) utilizing disease-specific iPS cells”. CiRA news release, June 29, 2018
- [Nipro applies for approval of mesenchymal stem cells STR 01 for treatment of spinal damage](https://window-to-japan.eu/2018/07/03/nipro-applies-for-approval-of-mesenchymal-stem-cells-str-01-for-treatment-of-spinal-damage/) - Autologous mesenchymal stem cells STR 01 co-developed with Sapporo Medical University. may be a magic bullet for spinal damage. The cellular drug obtained Sakigake designation for accelerated examination, in February 2016, patients with spinal cord injury received treatment, and Nipro filed for conditional market approval on June 29th 2018. Nipro news release, July 3, 2018
- [Japan proposes "Comprehensive Innovation Strategy" of 2018-2019](https://window-to-japan.eu/2018/07/03/japan-proposes-comprehensive-innovation-strategy-of-2018-2019/) - According to a "Nikkei Industry News" report, the Japanese government will highlight five key measures: university reform, strengthening government support for innovation, artificial intelligence, agricultural development, and environment/energy. The university reform will include introduction of the Japanese version of the Fraunhofer model. Concerning artificial intelligence, a shortage of talents in the fields of information technology
- [Tokyo-based Cykinso Co. to establish business on stable intestinal flora](https://window-to-japan.eu/2018/07/04/tokyo-based-cykinso-co-to-establish-business-on-stable-intestinal-flora/) - Analysis of temporal fluctuations of the intestinal flora of a Japanese cohort gathered through the web service of Cykinso Co. and the National Institute of Informatics showed that stability or instability at the individual level correlated with lifestyle and may be used for preventing lifestyle diseases. Nikkei Biotech news release, July 4, 2018
- [Hokkaido’s Kamui Pharma Co. starts on probiotic R&D](https://window-to-japan.eu/2018/07/04/hokkaidos-kamui-pharma-co-starts-on-probiotic-rd/) - The focus of the venture, established in April 2018, is to develop microbial therapies for inflammatory bowel diseases. Nikkei Biotech news release, July 4, 2018
- [Tokyo’s Noile-Immune Biotech to start CART cell therapy for solid cancer clinical trials within 2 years](https://window-to-japan.eu/2018/07/04/tokyos-noile-immune-biotech-to-start-cart-cell-therapy-for-solid-cancer-clinical-trials-within-2-years/) - The technology is based on CAR-T cells containing suicide genes that accumulate better in the cancer tissue and have high survival / proliferation ability and sustainability and was developed by Konji TAMADA of Yamaguchi University (WO / 2016/05 62228). Noile-Immune Biotech news release, July 4, 2018
- [NEDO-supported consortium inaugurates bagasse to ethanol demonstration plant in Thailand](https://window-to-japan.eu/2018/07/06/nedo-supported-consortium-inaugurates-bagasse-to-ethanol-demonstration-plant-in-thailand/) - A consortium of Toray Industries, Mitsui Sugar and Mitsui & Co. have developed technology to use bagasse for ethanol production, with a membrane process for ethanol separation from the fermentation medium. Processing capacity is 5,000 ton/year (as dried bagasse) , and cellulose sugar production is 1,400 tons/year (equivalent to bioethanol 700 kL/year). The plant will
- [Nissan Chemical concludes R&D contract with Osaka’s Luxna Biotech venture on antisense drugs](https://window-to-japan.eu/2018/07/06/nissan-chemical-concludes-rd-contract-with-osakas-luxna-biotech-venture-on-antisense-drugs/) - Luxna Biotech is a spin-out of Osaka University with a focus on modified nucleic acids through chemical modification of natural nucleic acid (DNA, RNA) with artificial functions not found in natural nucleic acids. Nissan Chemical has expertise in oligonucleotide research and manufacturing technology and Luxna Biotech’s leadership in nucleic acid chemistry. The research collaboration is
- [Fujifilm Holdings establishs artificial intelligence center at RIKEN](https://window-to-japan.eu/2018/07/09/fujifilm-holdings-establishs-artificial-intelligence-center-at-riken/) - Fujifilm Holdings Co., Ltd. has set up a "RIKEN AIP - FUJIFILM Collaboration Center" at RIKEN Innovation Center for Intelligent Integration. The center will focus on 1) R&D on next-generation medical AI by fusion of linguistic medical knowledge and image recognition, and 2) R & D on new and alternative materials through information science such
- [Silkworm venture Kaico starts with diagnostic agents and pet vaccines](https://window-to-japan.eu/2018/07/11/silkworm-venture-kaico-starts-with-diagnostic-agents-and-pet-vaccines/) - The spin-out of Kyushu University utilizes modified silkworms to prepare difficult-to-express proteins, diagnostics and animal vaccines. Nikkei Biotech news release, July 11, 2018
- [Kagome prepares for functional display of GABA on fresh tomato](https://window-to-japan.eu/2018/07/11/kagome-prepares-for-functional-display-of-gaba-on-fresh-tomato/) - The company has notified the consumer agency that they plan to label tomatos which they cultivate in Kochi prefecture by a display „This product contains GABA, reported for a function to lower the blood pressure of those with elevated blood pressure“. Nikkei Biotech news release, July 11, 2018
- [Terumo and others invests in Osaka cardiomyocyte venture Quorips](https://window-to-japan.eu/2018/07/11/terumo-and-others-invests-in-osaka-cardiomyocyte-venture-quorips/) - Quorips, a Tokyo venture aiming to commercialize allogenic iPS cell derived cardiomyocyte sheets, obtained about 1 billion yen venture capital from Daiichi Sankyo, Terumo, and Kyoto University Innovation Capital. Terumo press release, July 11, 2018
- [NAIST devvelops compact camera for self-diagnosis of retina](https://window-to-japan.eu/2018/06/24/naist-devvelops-compact-camera-for-self-diagnosis-of-retina/) - The group of Professor Atsushi OTA of the Advanced Science and Technology has presented a compact ocular fundus camaer that allows laymen to take a retina image using NIR light. It is expected to be used as a home healthcare device that can check not only one’s eyes but also detects lifestyle diseases such as
- [J-TEC develops autologous CART therapy for acute lymphoblastic leukemia](https://window-to-japan.eu/2018/06/21/j-tec-develops-autologous-cart-therapy-for-acute-lymphoblastic-leukemia/) - With a license from Nagoya University and Shinshu University, J-TEC plans to develop, manufacture and market its own CART for CD19 positive acute lymphoblastic leukemia (ALL). The CART developed uses the piggyBac transposon method, a non-viral vector which introduces the CAR gene into T cells. Because the piggyBac transposon method does not use a virus,
- [Organ Technologies raises 590 million Yen from ITOCHU and Mitsui Co. for R&D on regenerative medicine](https://window-to-japan.eu/2018/06/20/organ-technologies-raises-590-million-yen-from-itochu-and-mitsui-co-for-r-d-on-regenerative-medicine/) - Organ Technologies, a spin-out of RIKEN, has received 3d party investment in the framework of open innovation. Organ Technologies is aiming to regenerate hair follicles from mesenchymal stem cells and explores tooth germ and stem cells to regenerate periodontal tissue from iPS cells. In addition, the company has developed a human skin model for research
- [NEDO and Toshiba develop world's largest perovskite solar cell module](https://window-to-japan.eu/2018/06/18/nedo-and-toshiba-develop-worlds-largest-perovskite-solar-cell-module/) - The film type module 703 cm2 in size has a conversion efficiency of 11.7. It is flexible and lightweight and can be installed in buildings with low load bearing capacity, e. g., on walls. The consortium now aims at 900 cm2 films which are comparable in size to crystalline silicon solar cells. Ultimately, the aim
- [Ireland's ERS Genomics obtains broad claims in Japan for CRISPR/Cas9 basic patent](https://window-to-japan.eu/2018/06/15/irelands-ers-genomics-obtains-broad-claims-in-japan-for-crisprcas9-basic-patent/) - The patent was jointly filed by Dr. Emmanuelle Charpentier and ERS Genomics, Ireland, of which she is a co-founder. It contains a wide range of claims. ERS news release, June 15, 2018
- [NEDO initiates 2nd phase of R&D on improved Li batteries for EV applications](https://window-to-japan.eu/2018/06/15/nedo-initiates-2nd-phase-of-r-d-on-improved-li-batteries-for-ev-applications/) - In this project, 23 automobile, accumulator, material manufacturers and 15 universities/public research institutes cooperate to solve bottleneck problems of all solid-state lithium ion batteries, evaluating the characteristics of new materials and mass production processes. The focus will be on all solid-state lithium ion batteries (LIB) using an inorganic solid electrolyte, which have high flame retardancy
- [Tohoku University team develops a flexible, sensitive and highly durable type of robot hand](https://window-to-japan.eu/2018/06/14/tohoku-university-team-develops-a-flexible-sensitive-and-highly-durable-type-of-robot-hand/) - A team at Tohoku University has developed a bag-type robot hand which can grasp soft and hard objects equally well. Previous bag-like robot hands were able to grasp objects of various shapes, but with sharp objects, they were damaged, broken, and there was a problem in durability. It is expected that this new design will
- [NEDO speeds up social implementation of AI technology](https://window-to-japan.eu/2018/06/14/nedo-speeds-up-social-implementation-of-ai-technology/) - NEDO has started a new project for the early social implementation of AI technology and adopted six R&D themes. The objective is to shorten the introduction period of AI technology to one tenth as compared with the past in fields such as productivity" and "movement in space". The planned budget is 2.5 billion yen (20
- [Tokyo Institute of Technology team develops artificial photosynthesis based on common elements](https://window-to-japan.eu/2018/06/12/tokyo-institute-of-technology-team-develops-artificial-photosynthesis-based-on-common-elements/) - Most highly efficient CO2 reduction photocatalysts that have been developed so far have been made of precious metals such as ruthenium and rhenium (rare metals). The catalyst developed by Profs ISHITANI, MAEDA and ROBERT (Paris) is based on the semiconductor carbon nitride in combination with an iron complex. It efficiently reduces carbon dioxide (CO2) to
- [NEDO consortium presents prototype of world’s largest high-speed railway substructures using flame-retardant magnesium alloy](https://window-to-japan.eu/2018/06/12/nedo-consortium-presents-prototype-of-worlds-largest-high-speed-railway-substructures-using-flame-retardant-magnesium-alloy/) - The magnesium alloy used is unique in terms of improved flame retardancy, strength, processability, etc. As magnesium has 30% lower specific gravity than aluminum, it is expected that the weight of vehicle structures will be drastically reduced. The magnesium alloy is an alloy to which calcium is added to a general-purpose magnesium alloy (Mg -
- [Hitachi Zosen presents barge-type offshore wind power system](https://window-to-japan.eu/2018/06/08/hitachi-zosen-presents-barge-type-offshore-wind-power-system/) - Under a NEDO contract, Hitachi Zosen has developed a small and lightweight barge type floating body as carrier for wind turbines which can be installed in shallow waters of about 50 m. It will be equipped with a wind turbine near Kitakyushu this summer and demonstration operation will start this autumn. NEDO news release, June
- [Fuji Clean Co. completes Japan’s first dry methane fermentation facility](https://window-to-japan.eu/2018/06/07/fuji-clean-co-completes-japans-first-dry-methane-fermentation-facility/) - Based on a NEDO contract, Fuji Clean Co. completed a biomass plant equipped with Japan’s first vertical dry methane fermentation facility in its premises in Ayagawa Town, Kagawa Prefecture. The methane fermentation tank of 3,000 m3 scale uses various waste materials such as household garbage, food residues, livestock manure urine etc, and produces ´heat and
- [JST opens TogoVar, a genomic diversity database](https://window-to-japan.eu/2018/06/07/jst-opens-togovar-a-genomic-diversity-database/) - TogoVar (Japanese genomic diversity consolidated database) allows to search one-stop domestic and foreign databases and literature information on variants of Japanese individuals using genome sequences. Search targets includes frequency information of large variants tabulated from the genome data of Japanese registered in the NBDC human database. JST news release, June 7, 2018
- [Bayer opens “CoLaborator Kobe” for venture support](https://window-to-japan.eu/2018/06/06/bayer-opens-colaborator-kobe-for-venture-support/) - The laboratory structure will support venture companies within the Kobe International Business Center (KIBIC) in the Kobe Medical Industry City. The first venture companies will be Epigeneron, an Osaka University venture, aiming for epigenetic drug discovery, and Myolidge, a Kyoto University venture aiming to develop drug discovery tools using iPS cell derived cardiomyocytes. https://www.colaborator.bayer.com/en/locations/colaborator-kobe/
- [Organ Technologies Co. starts preclinical phase of human hair follicles from iPS cells](https://window-to-japan.eu/2018/06/05/organ-technologies-co-starts-preclinical-phase-of-human-hair-follicles-from-ips-cells/) - The RIKEN spinout studies regenerative medicine based on autologous follicular glands. It cooperates with Kyocera. The concept is based on the observation that mouse hair follicle epithelial stem cells and mouse dermal papilla cells derived from the beard hair follicles combined in a droplet of collagen transplanted into nude mice developed into grown hair follicles.
- [AMED starts operation of an “intractable disease platform”](https://window-to-japan.eu/2018/06/04/amed-starts-operation-of-an-intractable-disease-platform/) - The platform will link clinical information and omics results throughout Japan. AMED news release, June 4, 2018
- [STARCEL cellulose nanofiber composite (CNF) used in running shoes](https://window-to-japan.eu/2018/06/01/starcel-cellulose-nanofiber-composite-cnf-used-in-running-shoes/) - STARCEL, a cellulose nanofiber composite developed by Kyoto University and Starlight PMC Co. under a NEDO contract, has been adopted as a midsole material for running shoes. The CNF-reinforced resin material is composed of cellulose nanofibers treated with wood pulp and reinforced by polyethylene (PE) and polypropylene (PP). It is a lightweight material of high
- [Consortium for Immunoinflammatory Drug Discovery launched](https://window-to-japan.eu/2018/05/31/consortium-for-immunoinflammatory-drug-discovery-launched/) - Daiichi Sankyo, Tanabe Mitsubishi Pharmaceutical, Ono Pharmaceutical, Keio University, Kochi University, and the National Institute of Health and Nutrition have launched joint research on the pathophysiology of immunoinflammatory diseases and related research on drug discovery. Nikkei Biotech news release, May 31, 2018
- [Ministry of the Environment organizes CRISPR-CAS expert committee](https://window-to-japan.eu/2018/05/31/ministry-of-the-environment-organizes-crispr-cas-expert-committee/) - The committee will develop views whether genomic editing technology is the object of the Cartagena method from the viewpoint of proper operation of genetically modified organisms (Cartagena protocol). Nikkei Biotech news release, May 31, 2018
- [NEDO starts „space business investment matching platform“](https://window-to-japan.eu/2018/05/31/nedo-starts-space-business-investment-matching-platform/) - The government is working on revitalizing the space industry in Japan. The „S-Matching) is intended to facilitate matching between individuals and venture companies having new business ideas in the space field. Together with public and private sectors such as Japan Bank for Policy Development and Investment (DBJ) and the Industrial Innovation Organization (INCJ), it will
- [Chugai releases tocilizumab (Actemra) for treatment of cytokine-release syndrome (CRS)](https://window-to-japan.eu/2018/05/29/chugai-releases-tocilizumab-actemra-for-treatment-of-cytokine-release-syndrome-crs/) - Chugai Pharmaceutical announced that the humanized anti-human IL-6 receptor monoclonal antibody Actemra® for intravenous infusion 80 mg, 200 mg, 400 mg" : Tocilizumab (genetic recombination)] (hereinafter referred to as Actemra) was approved by the MHLW for an additional indication for "cytokine release syndrome associated with chimeric antigen receptor gene-introduced T cell infusion therapy". This application
- [PeptiStar Inc. constructs production site, claims to produce non-standard peptides at 98 % reduced cost](https://window-to-japan.eu/2018/05/29/peptistar-inc-constructs-production-site-claims-to-produce-non-standard-peptides-at-98-reduced-cost/) - The company manufactures non-standard peptides for pharmaceutical use as APIs and will operate a factory with a floor area of over 10,000 m2 in the Settsu factory of Shionogi & Co., which is also a shareholder, from autumn of 2019. An R & D laboratory will also be established, and 20 to 30 technicians will
- [Sekisui Chemical teams up with Cell Technology Co. on regenerative medicine](https://window-to-japan.eu/2018/05/29/sekisui-chemical-teams-up-with-cell-technology-co-on-regenerative-medicine/) - Cell Technology Co. has built a dental pulp cell bank. Sekisui has entered into a capital and business alliance with Cell Technology on joint research and development of dental pulp cells targeting periodontal diseases. Nikkei Biotech news release, May 29, 2018
- [Japan boosts 43 clinical trials on 38 regenerative medicine products](https://window-to-japan.eu/2018/05/28/japan-boosts-43-clinical-trials-on-38-regenerative-medicine-products/) - According to a review by Nikkei Biotech, this number relates to doctor-initiated and company clinical trials under control of the Pharmaceutical and Medical Devices Agency. Regenerative medicine is classified into cell medicine" which administers cells in loose state, "regenerative medicine" which transplant cells in a three-dimensional structure and "gene therapy" which administers genetically modified cells
- [ProteoBridge Corp. offers proteome analysis](https://window-to-japan.eu/2018/05/28/proteobridge-corp-offers-proteome-analysis/) - The spin-off of AIST started on May 1st, 2018 and offers proteome analysis within 3 days . The company uses a protein array with about 20,000 types of proteins for search on biomarkers etc. https://proteo-bridge.co.jp
- [GlyTech Inc. reports capital increase, partially from Italy’s MIAT SpA](https://window-to-japan.eu/2018/05/28/glytech-inc-reports-capital-increase-partially-from-italys-miat-spa/) - GlyTech is an Osaka venture founded in 2011. The business focus is on the synthesis of human-type glycosides applicable to the chemical synthesis of highly pure human glycoproteins, https://www.glytech.jp/jp/. Investment is from Nippon Shokubai, Fushimi Seiyaku, SBI Investment, Osaka University Venture Capital, and Italy’s MIAT SpA, a Milano-based chemical trader and investor. GlycoTech news release,
- [Kawasaki and NEDO to start innovation center K-NIC](https://window-to-japan.eu/2018/05/28/kawasaki-and-nedo-to-start-innovation-center-k-nic/) - The parties signed a MOU to start, by March 2019, a venture business support center which contains functions such as entrepreneurial experience, investors, consultation by experts in IP and marketing, a consultation window of NEDO and various support activities of Kawasaki city such as pitch events. NEDO news release, May 28, 2018
- [Shimadzu develops „high-precision metabolome analysis system“](https://window-to-japan.eu/2018/05/25/shimadzu-develops-high-precision-metabolome-analysis-system/) - Under a NEDO contract and jointly with Kobe University, Shimadzu Co. has introduced an automat that can simultaneously analyze 150 cell metabolites at high sensitivity. Sample pretreatment is included and allows for high throughput. Analysis is based on a triple quadrupole liquid chromatography mass spectrometer. The system can be combined with a multi-omics analysis package
- [Nagoya University spins out iBody venture](https://window-to-japan.eu/2018/05/24/nagoya-university-spins-out-ibody-venture/) - The company will commercialize their ecobody system" developed by Professor Hideo NAKANO. From singularized B-cells obtained from a trace amount of blood, mAbs can be produced in a cell-free E. coli system, and mAbs with high affinity and high selectivity for a target antigen are selected using recombinant E. coli. The whole process takes only
- [Kyoto University spins out aceRNA Technologies venture](https://window-to-japan.eu/2018/05/24/kyoto-university-spins-out-acerna-technologies-venture/) - The company's technology, developed by Hirohito SAITO of CiRA, is based on RNA switch" used for screening cells in regenerative medicine. An complementary RNA binds to miRNA in a cell or an RNA aptamer binds to a specific protein and thus responds to specific miRNAs present in the cell. miRNA is a single-stranded RNA molecule
- [Integriculture venture has raised 300 million Yen for development of meat from cell culture](https://window-to-japan.eu/2018/05/24/integriculture-venture-has-raised-300-million-yen-for-development-of-meat-from-cell-culture/) - The Tokyo-based venture https://integriculture.jp/?lang=ja founded in 2015 aims to commercialize cellular agricultural products such as meat obtained from cell culture technology. Integriculture’s Culnet System Technology is based on large-scale cell culture using a flow-type cell culture system and inexpensive serum-free medium. The company claims to have already reduced cell culture costs to 1/10000 of the
- [With Maki KAWAI the Chemical Society of Japan appoints the first woman president ever](https://window-to-japan.eu/2018/05/23/with-maki-kawai-the-chemical-society-of-japan-appoints-the-first-woman-president-ever/) - Professor Maki Kawai was introduced as the new president of CSJ on May 23. She has received numerous awards in recognition of her research on chemical reactions at surfaces, including the Medal of Honor with Purple Ribbon from the Japanese government (2017), The IUPAC 2015 Distinguished Women in Chemistry / Chemical Engineering（2015）and the Chemical Society
- [RIKEN launches Center for Life Science Research](https://window-to-japan.eu/2018/05/23/riken-launches-center-for-life-science-research/) - The center will be headquartered at RIKEN’s Bioresource Science Research Center (BDR) in Kobe City and comprise the Life System Research Center (QBiC), the Multicell System Research Center (CDB) and the Life Science Technology Infrastructure Research Center (CLST). RIKEN views BDR as a new virtual organization in the field of life science that tackles the
- [Digital Garage (DG)-initiated consortium launches „Open Network Lab BioHealth“](https://window-to-japan.eu/2018/05/23/digital-garage-dg-initiated-consortium-launches-open-network-lab-biohealth/) - Several business companies including major pharmaceutical companies, venture capital, and Digital Garage Co., a business context company, have formed a consortium to comprehensively support start-ups in the field of life science. Applicants are offered free of charge offices in Tokyo, a training camp in Kamakura, an incubation center in Digital Garage’s San Francisco location, and
- [Tavelmout Co. manufactures Spirulina for food products, manufactures in Brunei](https://window-to-japan.eu/2018/05/23/tavelmout-co-manufactures-spirulina-for-food-products-manufactures-in-brunei/) - Tavelmout https://www.tavelmout.jp/en/ has been founded in 2014 as a 100 % subsidiary of the Chitose group. The focus is on Spirulina-based health food products, sales in FY 2017 were close to 100 million Yen. Tavelmout has received 1.7 billion yen investment from the Industrial Innovation Organization and Mitsubishi Co. It presently produces Spirulina in photobioreactors
- [Kao might try again with diacyl glycerol cooking oils](https://window-to-japan.eu/2018/05/18/kao-might-try-again-with-diacyl-glycerol-cooking-oils/) - In 1999, Kao had introduced Econa, as a diet cooking oil with a food of specified health use (FOSHU) label and in peak times reached sales of 30 billion yen per year. Econa was a mixture of triglycerides and diacylglycerides produced by a 1,3-specific lipase from glycerol and undisclosed fatty acids. When a German laboratory
- [Fujifilm’s cancer peptide vaccine ITK-1 fails in phase III](https://window-to-japan.eu/2018/05/17/fujifilms-cancer-peptide-vaccine-itk-1-fails-in-phase-iii/) - On May 17, 2018, Fujifilm announced that the main endpoint could not be achieved for Phase III of cancer peptide vaccine ITK-1. Fujifilm news release, May 17, 2018
- [NEC starts selling PLA-based lacquerware with deep blackness and 3D feeling](https://window-to-japan.eu/2018/05/14/nec-starts-selling-pla-based-lacquerware-with-deep-blackness-and-3d-feeling/) - The luxury-type bioplastics (NeCycle R) is composed of polylactic acid and a grounded extract of cashew nuts containing cellulose and cardanol, a phenolic lipid based on anacardic acid. A blending technique of these ingredients was developed that keeps the optical properties of lacquer black and makes scratches less prone to rubbing with cloth and paper.
- [Fujifilm Holdings merges with Toyama Chemical Industries](https://window-to-japan.eu/2018/05/14/fujifilm-holdings-merges-with-toyama-chemical-industries/) - Fujifilm Holdings announced that both companies will merge by Oct. 1, 2018. At present, Fujifilm HD holds 66% of shares of Toyama Chemical Industries, and Taisho Pharmaceutical HD 34%. Fujifilm HD will purchase all shares from Taisho. Toyama Chemistry is engaged in the research and development of small molecule drugs targeting infectious diseases and Alzheimer's
- [Japan enacts next-generation medical infrastruture law using big data](https://window-to-japan.eu/2018/05/11/japan-enacts-next-generation-medical-infrastruture-law-using-big-data/) - The new law Act regulates the anonymous processing of medical information to contribute to R&D in the medical field. Data from medical institutions and other providers are anonymously processed and can be used by as universities and companies for large-scale research on drug efficacy and evaluation, drug discovery and development of new medical devices. Nikkei
- [METI will hold international hydrogen conference on minister level in autumn](https://window-to-japan.eu/2018/05/08/meti-will-hold-international-hydrogen-conference-on-minister-level-in-autumn/) - NEDO has published that an international conference on hydrogen utilization is planned for October 23, 2018 in Tokyo. In December 2017, japan has formulated the world's first hydrogen basic strategy", with the target to realize a "hydrogen society" that fully utilizes hydrogen as a new option for renewable energy." NEDO news release, May 8, 2018
- [NEDO initiates new project on light-weight material for transportation equipment such as automobiles](https://window-to-japan.eu/2018/05/08/nedo-initiates-new-project-on-light-weight-material-for-transportation-equipment-such-as-automobiles/) - NEDO will accelerate the practical application of steel sheets, aluminum materials, titanium and magnesium materials, carbon fibers, carbon fiber reinforced plastics (CFRP), etc., which had been promoted for lightweight development already in the past so far. The topics are: 1: Development of innovative design technology related to weight reduction of multimaterial bodies", 2: "Development of
- [Ireland's Shire AG may be acquired by Takeda Pharmaceutical for £ 46 billion](https://window-to-japan.eu/2018/05/08/irelands-shire-ag-may-be-acquired-by-takeda-pharmaceutical-for-46-billion/) - Shire is a global leader in pharmaceuticals for rare diseases, with a global turnover of 11.4 billion USD in 2016. The move is hotly debated in Japan, giving voice to Takeda becoming an international group with a reduced Japanese footprint. Other arguments are that the number of Japanese ventures iand the amount of invested funds
- [Siemet Co. presents the world's fastest sand-type 3D printer for large casting](https://window-to-japan.eu/2018/05/07/siemet-co-presents-the-worlds-fastest-sand-type-3d-printer-for-large-casting/) - Based on a NEDO contract, Siemet has commercialized a large-size sand-type 3D printer which molds at a level of 100,000 cm3 per hour. This speeds up modeling speed 10 fold and enlargs model size also 10 fold. The SCM-188 Sand Casting Meister will enhance the productivity of casting sites in various fields such as automobiles.
- [RIKEN team finds genetic deletion that suppresses amyloid ß production in mice](https://window-to-japan.eu/2018/05/04/riken-team-finds-genetic-deletion-that-suppresses-amyloid-ss-production-in-mice/) - A group around Kenichi NAGATA Generation has used an knock-in mouse model carrying a humanized Aβ sequence and edited the genome of the model zygotes using multiple combinations of CRISPR/Cas9 tools produces genetically mosaic animals with various App 3′-UTR deletions. An App knock-in mouse with a 34-bp deletion in a 52-bp regulatory element adjacent to
- [NEDO adopts demonstration project for ocean current power generation](https://window-to-japan.eu/2018/04/27/nedo-adopts-demonstration-project-for-ocean-current-power-generation/) - In this project, practicality of ocean current power generation will be tested. It could be utilized as a distributed power source for solitary islands, e. g., in the Kuroshio Sea area, and 18 prefectures are involved in the program. Power generation capacity, equipment durability and economy of the system will be scrutinized. Industrial contractor is
- [University of Tokyo team develops fluorescent dyes for intracellular pH measurement](https://window-to-japan.eu/2018/04/25/university-of-tokyo-team-develops-fluorescent-dyes-for-intracellular-ph-measurement/) - Yasutero URANO and colleagues have synthesized a group of dyes exhibiting a short absorption wavelength of about 80 nm while maintaining fluorescence by becoming acidic. The dyes exhibited high stability on light irradiation. Furthermore, by changing the chemical structure, the fluorescence color could be changed from deep red to near infrared light in response to
- [Daiichi Sankyo extends phase I/II test on novel treatment of Duchenne muscular dystrophy (DMD)](https://window-to-japan.eu/2018/04/25/daiichi-sankyo-extends-phase-iii-test-on-novel-treatment-of-duchenne-muscular-dystrophy-dmd/) - The drug, DS-5141, is a nucleic acid medicine and has been co-developed with Orrphan Disease Treatment Institute, Tokyo. As it was not possible to obtain the expected results with regard to the main endpoint of efficacy, the administration period for the same patient will be prolonged 4fold. Daiichi Sankyo news release, April 25, 2018
- [Clinical study on gene therapy for Duchenne muscular dystrophy (MDM)](https://window-to-japan.eu/2018/04/20/clinical-study-on-gene-therapy-for-duchenne-muscular-dystrophy-mdm/) - NS-065 / NCNP-01 is an exon-skipping nucleic acid drug created through joint research between National Center for Neurological and Medical Research (NCNP) and Nippon Shinyaku. Itt is targeted as a remedy for patients with DMD who have gene mutations responding to exons 53 skipping of the dystrophin gene. In this study, NS - 065 /
- [NEDO conducts successful field test to supply thermal and electric energy by hydrogen only](https://window-to-japan.eu/2018/04/20/nedo-conducts-successful-field-test-to-supply-thermal-and-electric-energy-by-hydrogen-only/) - On April 19th and 20th, hydrogen as a fuel was used as the only fuel to provide 2800 kW of heat to the two facilities of Kobe Port Island central civic hospital, to Port Island sports center, and to Kobe International Exhibition Hall. This included a total of 1100 kW of electricity. The performance of
- [NEDO starts AI chip program directed towards SMEs](https://window-to-japan.eu/2018/04/20/nedo-starts-ai-chip-program-directed-towards-smes/) - The R & D project will focus on (1) accelerating AI chip development and (2) "AI chip enabled high-efficiency and high-speed processing, aiming to realize "Connected Industries" through the creation of new added value by digitalization. NEDO also plans to dispatch experts so that small and medium-sized venture companies participating in this project can work
- [Dainippon Sumitomo (DS) Pharma Animal Health starts clinical trial on stem cell therapy for dogs](https://window-to-japan.eu/2018/04/19/dainippon-sumitomo-ds-pharma-animal-health-starts-clinical-trial-on-stem-cell-therapy-for-dogs/) - In the experimental design, mesenchymal stem cells are obtained from adipose tissue and applied to dogs who suffer from hernia. The company, a subsidiary of DS Pharma, cooperates with J-ARM Co., Osaka. DS Pharma Animal Health news release, April 19, 2018
- [iHeart Japan establishes cell culture processing center in Kyoto](https://window-to-japan.eu/2018/04/18/iheart-japan-establishes-cell-culture-processing-center-in-kyoto/) - IHeart Japan, who develops multilayered sheets of iPS cell derived cardiomyocytes, has established a cell culture processing facility (CPC) in Kamigyo Ward, Kyoto Prefecture,as a business base om April 17th, 2018. Nikkei Biotech, April 18, 2018
- [Fujifilm partners with LPixel on artificial intelligence and medical image information](https://window-to-japan.eu/2018/04/16/fujifilm-partners-with-lpixel-on-artificial-intelligence-and-medical-image-information/) - LPixel is a venture company spun out from the University of Tokyo, which has strengths in image analysis in medical areas. using AI technology. Fujifilm is planning to develop AI technology that can be utilized in various medical fields under the brand name „Rayleigh." Fujifilm news release, April 16, 2018
- [RIKEN venture Organ Technologies receives SME award for Advanced Skin""](https://window-to-japan.eu/2018/04/14/riken-venture-organ-technologies-receives-sme-award-for-advanced-skin/) - RIKEN's spin-out Organ Technologies, which received much publicity recently through cooperation with Kyocera for a project on stem-cell derived hair growth, is among the winners of The 30th Small and Medium Enterprise Excellent New Technology / New Product Award" offered by Nikkan Kogyo Shinbun, an industrial newspaper. The price was received for the company's product
- [Takeda Pharmaceutical holds opening ceremony for Shonan Health Innovation Park (Shonan Eye Park)](https://window-to-japan.eu/2018/04/13/takeda-pharmaceutical-holds-opening-ceremony-for-shonan-health-innovation-park-shonan-eye-park/) - Takeda opened its former Shonan Institute In October 2017 to other business and venture companies and academia researchers, transforming it into a center of open innovation. Currently, the park has 19 tenants, many oft hem venture companies. It is expected that it will take about 3 years to fill 90 % oft he park, and
- [Yakult joins ToMMo for studies on relationship of intestinal flora to morbidity](https://window-to-japan.eu/2018/04/12/yakult-joins-tommo-for-studies-on-relationship-of-intestinal-flora-to-morbidity/) - Yakult, a major probiotic manufacturer, has joined the Tohoku Medical and Mechanical Banking Organization (ToMMo) for participation in a 3 year cohort survey including approximately 2,500 adult participants in the detailed survey. Based on feces samples of the participants, . the study will analyze the intestinal bacterial flora in relation to physiological functions, disease, morbidity
- [BioWorks starts shipment of 100% pure PLA high-performance fibers](https://window-to-japan.eu/2018/04/11/bioworks-starts-shipment-of-100-pure-pla-high-performance-fibers/) - The Tokyo-based company actively involved in 3D bio printing uses proprietary modifiers to obtain fibers made from 100% polylactic acid (PLA) which are excellent in durability and dyeability. From 2019, such fibers will be available for apparel products such as T - shirts. Nikkei Biotech news release, April 11, 2018
- [RIKEN opens iPS cell drug discovery platform development collaboration base" in Keihanna Science City"](https://window-to-japan.eu/2018/04/09/riken-opens-ips-cell-drug-discovery-platform-development-collaboration-base-in-keihanna-science-city/) - The platform is under the RIKEN BioResource Research Center (BRC). It will develop fundamental technology for drug discovery and aim for commercialization, as a bridge between academia and industry with a focus on iPS cell technology. RIKEN news release, April 9, 2018
- [Takara Bio licenses TCR and CART therapy products out to Otsuka Pharma](https://window-to-japan.eu/2018/04/09/takara-bio-licenses-tcr-and-cart-therapy-products-out-to-otsuka-pharma/) - Takara Bio has announced on April 9 that two gene therapeutic agents for T cell therapy, NY-ESO-1 · siTCRTM, and NY-ESO- (TBI-1301, TBI-1301-A), and a CART cell product, CD 19 · CAR (TBI-1501), a chimeric antigen receptor transgenic T cell (CART) therapy targeting CD 19, jointly developed by both companies, will be exclusively sold by
- [AMED publishs report on medical device development in Japan](https://window-to-japan.eu/2018/04/06/amed-publishs-report-on-medical-device-development-in-japan/) - AMED's Review Committee on Medical Device Development has published a report on medical device development in Japan on March 22, 2018. It contains information on the impact of digital technologies such as artificial intelligence (AI), IoT (Internet of goods) and robot related technologies on medical devices, but also advances of standard technologies useful for medical
- [Japanese-German team visualizes terminal electron tansfer reaction in photosynthesis](https://window-to-japan.eu/2018/04/03/japanese-german-team-visualizes-terminal-electron-tansfer-reaction-in-photosynthesis/) - The groups of Genji KURISU at Osaka University's Protein Research Institute, in collaboration with Matthias RÖGNER of Bochum University, have used high-resolution x-ray images of photosystem I obtained at Osaka University's beamline at the RIKEN's synchrotron radiation facility SPring-8 to visualize how electrons obtained from water are transferred to photosystem I protein through the thylakoid
- [Ambicion acquires NKT cell therapy rights from RIKEN](https://window-to-japan.eu/2018/04/02/ambicion-acquires-nkt-cell-therapy-rights-from-riken/) - Ambicion, a Tokyo-based venture company, has obtained an exclusive worldwide license on RIKEN's patents on NKT cell activation therapy using novel αGalCer derivatives. According to the RIKEN procedures, after removing blood cell components from peripheral blood by apheresis, NKT cells are isolated by centrifugation and activated with newly identified αGalCer derivatives, cryopreserved, and later administered
- [Brightpass Biotech acquires rights on iPS cell-derived NKT cell therapy from RIKEN](https://window-to-japan.eu/2018/04/02/brightpass-biotech-acquires-rights-on-ips-cell-derived-nkt-cell-therapy-from-riken/) - NKT cells are used in cancer immunotherapy as they do not only exert an antitumor effect by killer T cells but also are able to kill MHC negative cancer cells which can not be attacked by T cells. NKT cells constitute only 0.01% to 0.1% of the T cells in peripheral blood, making it difficult
- [Concerning bio-ventures, Taiwan is more aggressive than Japan: interview](https://window-to-japan.eu/2018/03/28/concerning-bio-ventures-taiwan-is-more-aggressive-than-japan-interview/) - According to LEE Jong-ho, president of the Taiwan Biological Industry Development Organization, Taiwan now has 111 listed bio ventures (including medical equipment). Most of them develop pharmaceutical products, and seven out of these 111 companies have a market capitalization of US $ 1 billion. Nearly half of the companies are developing new drugs. There are
- [Kyoto University reacts to fraud at CiRA: dismissal of researcher](https://window-to-japan.eu/2018/03/28/kyoto-university-reacts-to-fraud-at-cira-dismissal-of-researcher/) - An investigation committee of Kyoto University found Assistant Professor YAMAMIZU Kohei of CiRA guilty of scientific fraud (forgery of 11 main figures in an article) and dismissed him from his position. CiRA’s head, Professor Shinya YAMANAKA, being the direct supervisor of YAMAMIZU, issued a statement that he is aware of the responsibility that could not
- [RIKEN – Tohoku team prepars iPS-cell derived retinal ganglion cells](https://window-to-japan.eu/2018/03/27/riken-tohoku-team-prepars-ips-cell-derived-retinal-ganglion-cells/) - In Japan about 1 in 20 people over 40 years suffer from glaucoma - the number one cause of blindness. In order to study human retinal ganglion cells, a team around Masayo TAKAHASHI of RIKEN Kobe Institute and Toru NAKAZAWA of Tohoku University Medical School developed iPS cell-derived retinal tissue and isolated and purified retinal
- [Daiichi Sankyo signs into custom manufacturing by Hitachi Chemical for investigational cell products in Japan](https://window-to-japan.eu/2018/03/19/daiichi-sankyo-signs-into-custom-manufacturing-by-hitachi-chemical-for-investigational-cell-products-in-japan/) - Daiichi Sankyo has signed a contract with Hitachi Chemical to manufacture investigational cell products derived from iPS or somatic cells at Hitachi Kazei’s Yamazaki Plant in Yokohama. Hitachi Chemical formed in May 2017 in the US a a wholly-owned subsidiary, Hitachi Chemical Advanced Therapeutics Solutions, LLC, one of the largest US companies in the field
- [Fujitsu and RIKEN optimize lithium battery composition using AI](https://window-to-japan.eu/2018/03/16/fujitsu-and-riken-optimize-lithium-battery-composition-using-ai/) - When a lithium electrolyte material was synthesized from three kinds of lithium-containing oxyacid salts, the optimum composition for realizing high lithium ion conductivity was predicted, using AI methods, and confirmed by experimental design. This is considered promising to develop new high-performance materials. Fujitsu news release, March 16, 2018
- [Kao Co. improves fumaric acid production in Rhizopus sp. by genome editing](https://window-to-japan.eu/2018/03/16/kao-co-improves-fumaric-acid-production-in-rhizopus-sp-by-genome-editing/) - A research team led by Kao’s Life Science Research Institute has developed a highly efficient homologous recombination procedure for Rhizopus sp., based on TALEN genomic editing with short-length single-stranded DNA. Using this technology, a pyruvate decarboxylase (pdc) gene behind an adh promoter was inserted into the Rhizopus genome, leading to 1,2-fold increase of fumaric acid
- [NEDO team succeeds in autonomous remote monitoring by drones](https://window-to-japan.eu/2018/03/15/nedo-team-succeeds-in-autonomous-remote-monitoring-by-drones/) - NEDO, KDDI, Teradrone and SECOM, utilizing a 4 G LTE standard, conducted security experiments on multiple autonomously flying drones in Kanagawa Prefecture and succeeded in remote patrol security. By remote monitoring of camera images installed in the drones from the operation control room, it was possible to identify suspicious individuals. It was also possible to
- [Kyoto Prefectural University reports clinical study on corneal endothelial cell transplantation against bullous keratopathy](https://window-to-japan.eu/2018/03/15/kyoto-prefectural-university-reports-clinical-study-on-corneal-endothelial-cell-transplantation-against-bullous-keratopathy/) - Bullous keratopathy is a condition where corneal endothelial cells, which do not normally proliferate in vivo, are extensively impaired by trauma, disease, surgery or the like and do not longer maintain the transparency of the cornea, leading to edema and turbidity. Kyoto Prefectural University of Medicine and Doshisha University jointly expanded corneal endothelial cells derived
- [JST to support venture Kyulux Co. for  further development of hyperfluorescence materials](https://window-to-japan.eu/2018/03/12/jst-to-support-venture-kyulux-co-for-further-development-of-hyperfluorescence-materials/) - Thermally activated delayed Fluorescence Materials (TADEFs) hold promise to further improve OLED-based designs. Kyulux is a Fukuoka-based startup founded by Chihaya ADACHI and has developed a new organic light emitting material that can convert energy of excitons to light with almost 100% efficiency without using rare metals, for low cost and high efficiency light emission,
- [Japan's government prepares public carefully for advent of genome-edited products](https://window-to-japan.eu/2018/03/10/japans-government-prepares-public-carefully-for-advent-of-genome-edited-products/) - At the Tsukuba NIAS Science Cafe, Satoko NONAKA, Assistant Professor at the University of Tsukuba, gave a lecture titled Increase GABA - increase the value of tomatoes by genome editing". A proposition of this lecture was "Giving plants the function to make people happy", and a brochure "Genome editing - new breeding technology -" was
- [Researchers at Kyoto University’s iCeMS develop low-cost synthetic culture medium for human iPS cells, > 80 % cost reduction](https://window-to-japan.eu/2018/03/09/researchers-at-kyoto-universitys-icems-develop-low-cost-synthetic-culture-medium-for-human-ips-cells-80-cost-reduction/) - The group of Koichi HASEGAWA at the Institute for Advanced Materials - Cellular Integration System (iCeMS) at Kyoto University describe in their paper Chemically defined and growth-factor-free culture system for the expansion and derivation of human pluripotent stem cells", to appear in Nature Biomedical Engineering, how expensive growth factors produced by recombinant E. coli can
- [Kaneka and Kobe University group develop vectors for synthetic biology in Pichia pastoris](https://window-to-japan.eu/2018/03/09/kaneka-and-kobe-university-group-develop-vectors-for-synthetic-biology-in-pichia-pastoris/) - At the 12th Annual Meeting of the Japanese Society of Genome Microbiology Association held in Kyoto City on March 5 to 7, 2018, Kaneka and Kobe University have jointly published a poster on „Efficient DNA multiassembling method using an autonomously replicating vector in P. pastoris“ Nishi Teruyuki et al., poster 2P-22
- [Topics of company awards at JSBBA 2018](https://window-to-japan.eu/2018/03/09/topics-of-company-awards-at-jsbba-2018/) - The Japanese Society for Bioscience, Biotechnology and Agricultural Chemistry (JSBBA), which will hold its Annual Meeting 2018 with about 4000 attendants from March 15 – 18 in Nagoya, has announced awards for presentations from industry (about half of the 10.000 society members are from companies). Three of the awards are: 1. Research and development for
- [Infarct treatment with Muse cells: mechanism further elucidated](https://window-to-japan.eu/2018/03/07/infarct-treatment-with-muse-cells-mechanism-further-elucidated/) - The teams of Shinya MINATO at Gifu University and Mari DEZAWA of Tohoku University have confirmed in rabbit tests that Muse cells (pluripotent stem cells) migrated to an infarct site and engrafted, differentiating into cardiomyocytes, and exerting effects such as cardiac function improvement for more than half a year. With allogenic MUSE cells, from other
- [Team at Nagoya University develops portable sensor for detection of  airborne bacteria](https://window-to-japan.eu/2018/03/06/team-at-nagoya-university-develops-portable-sensor-for-detection-of-airborne-bacteria/) - The sensor, developed by Yoshinobu BABA and colleagues, is based on the measurement of ionic microcurrents where noise from other environmental particles is suppresed by a circuit bridge in a simple, lightweight electromagnetic shield. Accuracy of size detection of Staphylococcus aureus (S. aureus) was equivalent to that obtained by SEM imaging. ACS publication doi 10.1021 / acssensors.8b00045
- [Asahi Glass (AGC) steps up animal cell capacity at CMC Biologics subsidiary in Berkeley](https://window-to-japan.eu/2018/03/06/asahi-glass-agc-steps-up-animal-cell-capacity-at-cmc-biologics-subsidiary-in-berkeley/) - With a single-use 2000 L culture tank for animal cells, the total culture capacity at CMC Biologics in Berkeley is now at 4000 L. At the company’s subsidiary in Coopenhagen, an additional 2000 L culture tank for animal cells was added in September 2017. Thus, AGC now owns, via CMC Biologics, CDMO facilities for producing
- [Astellas develops gene therapy based on oncolytic virus](https://window-to-japan.eu/2018/03/06/astellas-develops-gene-therapy-based-on-oncolytic-virus/) - The technology is based on a vaccinia virus which carries immunostimulatory genes. The technology has been developed by Takashi NAKAMURA at Tottori University, and Astellas has taken a worldwide exclusive license agrement. Astellas owns already ASP 8374/PTZ-201, immunity checkpoint inhibitor which introduced from Potenza Therapeutics, Inc.. ASP 8374/PTZ-201 is an antagonist against T-cell immunoreceptors with
- [Nitto Denko starts phase II for gene therapy of idiopathic pulmonary fibrosis (IPF) in the US](https://window-to-japan.eu/2018/03/05/nitto-denko-starts-phase-ii-for-gene-therapy-of-idiopathic-pulmonary-fibrosis-ipf-in-the-us/) - With the development number ND-L02-s0201, the intravenous preparation of a nucleic acid medicine is a siRNA, embedded in vitamin A containing liposome preparation, that suppresses the expression of the HSP 47 gene. The HSP 47 gene regulates collagen production and secretion responsible for fibrosis and is considered as a target molecule for a wide range
- [Tokyo University and RIKEN present atlas of mouse brain with 1 cell resolution](https://window-to-japan.eu/2018/03/03/tokyo-university-and-riken-present-atlas-of-mouse-brain-with-1-cell-resolution/) - The research group of Yasutaka UEDA identiied a reagent capable of simultaneous tissue swelling and rendering it transparent. When sheets of brains were analyzed by fluorescence microscopy, a complete atlas of a mouse brain could be displayed as a sort of pointillist painting. Two compounds were used: imidazole (tissue swelling agent) and antipyrine (tissue swelling
- [Ministry of Agriculture carefully prepares public for advent of genome-edited vegetables](https://window-to-japan.eu/2018/03/02/ministry-of-agriculture-carefully-prepares-public-for-advent-of-genome-edited-vegetables/) - At the Tsukuba NIAS Science Cafe, Satoko NONAKA, Assistant Professor at the University of Tsukuba, gave a lecture titled Increase GABA - increase the value of tomatoes by genome editing". A proposition of this lecture was "Giving plants the function to make people happy", and a brochure "Genome editing - new breeding technology -" was
- [RIKEN-led consortium finds stem-cell technology functions for retinal regeneration in mice](https://window-to-japan.eu/2018/03/02/riken-led-consortium-finds-stem-cell-technology-functions-for-retinal-regeneration-in-mice/) - A collaborative research group of RIKEN’s Kobe Center, Kyoto Institute of Technology, Kumamoto University and Dainippon Sumitomo Pharma used a severely immunodeficient, terminal retinal degeneration model (NOG-rd1) mouse model to verify the function of human retinal tissue after transplantation. When human retinal tissue derived from human ES cells was transplanted into NOG-rd1 mice, after 6
- [CureUp digital health venture raises 1.5 billion Yen](https://window-to-japan.eu/2018/03/01/cureup-digital-health-venture-raises-15-billion-yen/) - CureUp offers a “Treatment Application” app that allows patient treatment data to be obtained on a daily basis through mobile devices such as smartphones. This information is then analyzed using algorithms based on known medical information in order to provide personalized guidance for individual patients, https://cureapp.co.jp/en/index.html CureUp news release, February 28, 2018
- [MEDRx licenses percutaneous absorption technology to Daiichi Sankyo](https://window-to-japan.eu/2018/03/01/medrx-licenses-percutaneous-absorption-technology-to-daiichi-sankyo/) - MEDRx has announced that it will jointly develop with Daiichi Sankyo candidate products using its proprietary percutaneous absorption technology NCTSR (Nano Colloid Transdermal System), MEDRx news release, February 28, 2018
- [Dainippon Somuitomo opens manufacturing plant for regenerative medicine in Osaka](https://window-to-japan.eu/2018/03/01/dainippon-somuitomo-opens-manufacturing-plant-for-regenerative-medicine-in-osaka/) - The SMaRT plant (Sumitomo Dainippon Manufacturing Plant for Regenerative Medicine & Cell Therapy is claimed to be the world's first commercial facility dedicated to regenerative and cellular medicine derived from iPS cells and has 2 floors above ground and a total floor area of ​​2,915 m2. At present, the focus is on age-related macular degeneration,
- [Team at RIKEN and Institute of Agrobiological Sciences generates „activated silk“ using expanded genetic code](https://window-to-japan.eu/2018/03/01/team-at-riken-and-institute-of-agrobiological-sciences-generates-activated-silk-using-expanded-genetic-code/) - The group of Hidetoshi TERAMOTO et al. developed a bacterial system to screen for B. mori phenylalanyl-tRNA synthetases with altered amino-acid specificity. They created transgenic B. mori lines expressing the selected synthetase variants in silk glands, and found that some of them supported the efficient in vivo incorporation of azidophenylalanine into silk fiber. The obtained silk was bio-orthogonally reactive with fluorescent molecules,
- [Kyowa Kirin develops nucleic acid drug for KRAS using proprietary liquid nanoparticles](https://window-to-japan.eu/2018/03/01/kyowa-kirin-develops-nucleic-acid-drug-for-kras-using-proprietary-liquid-nanoparticles/) - KRAS is proto-oncogene corresponding to the oncogene first identified in Kirsten rat sarcoma virus,, and the gene product was first found as a p21 GTPase. Kyowa Hakko Kirin works on a nucleic acid medicine in which siRNA, targeting KRAS, is targeted to tumor-specific unique lipid nanoparticles (LNP), and has confirmed potent antitumor effects in animal experiments.
- [Nagoya University team turns human ES cells into vasopression-secreting neurons, applications for Diabetes insipidus](https://window-to-japan.eu/2018/02/26/nagoya-university-team-turns-human-es-cells-into-vasopression-secreting-neurons-applications-for-diabetes-insipidus/) - When the function of the hypothalamus and the posterior pituitary gland is insufficient, vasopressin secretion decreases, and urine secretion is largely increased (Diabetes insipidus). A group around Hiroshi ARIMA succeeded in maturing hypothalamic precursor cells derived from human ES cells and differentiating them into hormone-producing neurons. From the dorsal hypothalamus , vasopressin neurons could be
- [AMED starts new center for „Image analysis by AI“](https://window-to-japan.eu/2018/02/26/amed-starts-new-center-for-image-analysis-by-ai/) - AMED’s Medical Big Data Research Center is based on an earlier cooperation of the National Institute of Informatics (NII) with the Universities of Tokyo, Kyushu University, and Nagoya University. Proposals submitted to the Japanese Society of Gastrointestinal Endoscopy, Japan Pathology Association, and Japan Medical Radiology Association, respectively, were adopted as research themes in FY 2016,
- [Japanese steel consortium achieves reduction of CO2 emissions by 30 %](https://window-to-japan.eu/2018/02/23/japanese-steel-consortium-achieves-reduction-of-co2-emissions-by-30/) - CO2 emissions from the Japanese steel industry are about 180 million t per year. NEDO, in collaboration with Kobe Steel, JFE Steel Corporation, Nippon Steel Sumikin and Nissin Steel completed four test runs of a verification test of CO2 emissions in the world's largest test blast furnace (capacity 12 m3) built in a steelworks premises.
- [Kaneka acquires University of Tokyo patent on suspended iPS cell cultivation](https://window-to-japan.eu/2018/02/22/kaneka-acquires-university-of-tokyo-patent-on-suspended-ips-cell-cultivation/) - Kaneka acquired a domestic patent on technology to cultivate in a large scale suspended pluripotent stem cells such as iPS cells using lysophospholipids. The technology was developed by Yasuyuki SAKAI of the University of Tokyo. Kaneka news release, February 22, 2018
- [LSI Medience and National Cancer Center will establish patient-derived xenograft (PDX) library](https://window-to-japan.eu/2018/02/21/lsi-medience-and-national-cancer-center-will-establish-patient-derived-xeongraft-pdx-library/) - In order to prepare PDX, specimen of tumors of cancer patients collected by biopsy or surgical operation are transplanted into immunocompromised mice. After the cancer cells proliferate in the mouse body, passages are done two or three times with another mouse. The cell line for PDX thus obtained is stored frozen, thawing the cell when
- [AIST develops new method to synthesize polysiloxanes of controlled molecular weight and terminal structure](https://window-to-japan.eu/2018/02/20/aist-develops-new-method-to-synthesize-polysiloxanes-of-controlled-molecular-weight-and-terminal-structure/) - In the new scheme, a guanidine catalyst is used for ring-opening polymerization instead of an organolithium compound. In this method, water can be used, making operations simple. Depending on the ratio of cyclic trisiloxane and water, the average molecular weight of the polysiloxane can be controlled, up to an average molecular weight of at least
- [Dai Nippon Printing develops on-skin sensors for continuous health monitoring](https://window-to-japan.eu/2018/02/18/dai-nippon-printing-develops-on-skin-sensors-for-continuous-health-monitoring/) - In collaboration with the University of Tokyo, the company developed a thin and stretchable skin display. With a unique mounting technology, 16 × 24 px micro light emitting diodes and stretchable wires were mounted on a rubber sheet. The size of the micro LED is 1 x 0.5 mm, the emission wavelength is 630 nanometers
- [MHLW appoints 11 core hospitals for cancer genome medical care](https://window-to-japan.eu/2018/02/18/mhlw-appoints-11-core-hospitals-for-cancer-genome-medical-care/) - In addition to the Central Hospital (Tokyo · Central) and East Hospital (Kashiwa City, Chiba Prefecture) selected by the National Cancer Research Center as the core bases, Hokkaido University, Tohoku University, Keio University, Tokyo University, Nagoya University, Kyoto University, Osaka University, Okayama University, and Kyushu University Hospitals have been appointed. Genomic medicine examines genes of
- [Mitsubishi Electric pioneers SiC-based Modular High Voltage Direct Current (HDVC) converter, reduces power loss by 50%](https://window-to-japan.eu/2018/02/18/mitsubishi-electric-pioneers-sic-based-modular-high-voltage-direct-current-hdvc-converter-reduces-power-loss-by-50/) - Power loss of converters, their size and weight is a limiting factor to reach high efficiency of long distance/large capacity power transmission from offshore wind wheels and offshore platforms. The company built a 3.3 kV SiC power semiconductor module of modular design as HVDC, with parallelized modules to suppress the resistance inside the converter cell.
- [Tokyo Medical and Dental University identifies FABP4 as biomarker for metabolic liver cancer](https://window-to-japan.eu/2018/02/16/tokyo-medical-and-dental-university-identifies-fabp4-as-biomarker-for-metabolic-liver-cancer/) - The team used (MC4R-KO) mice as metabolic liver cancer onset model and performed clustering analysis of surgical specimen from human liver cancers and MC4R-KO mouse liver cancer. Among 9 genes that were commonly and highly expressed in metabolic liver cancer, FABP4 (fatty acid binding protein 4) was specifically overexpressed in intratumorally activated hepatic stellate cells.
- [Japan forms Government Advisory Board on gene therapy medical practice](https://window-to-japan.eu/2018/02/16/japan-forms-government-advisory-board-on-gene-therapy-medical-practice/) - Topics are to promote gene therapy R&D including genome editing. Already in 2017, an advisory board discussed the career path of genomic medical personnel, and summarized the results at the end of the year in order to develop government policies. Nikkei Biotech news release, February 16, 2018
- [Kyushu University group obtains approval for carbonate apatite as dental implants](https://window-to-japan.eu/2018/02/15/kyushu-university-group-obtains-approval-for-carbonate-apatite-as-dental-implants/) - The inorganic component of bone is carbonate apatite, in which part of the phosphate group of hydroxyapatite is replaced with a carbonate group. Carbonate apatite powder, however, leads to inflammation after transplantation. A consortium around Kunio ISHIKAWA, Kyushu University, and GC Corporation found a method to prepare crystalline carbonate apatite from a thermodynamically stable phase
- [Kyoto University: satellite big data for Tsunami risk prediction and water resources management](https://window-to-japan.eu/2018/02/15/kyoto-university-satellite-big-data-for-tsunami-risk-prediction-and-water-resources-management/) - In cooperation with two Japanese space-related research organizations, researchers at the school of bioinformatics of Kyoto University have developed a „world mesh code“ with world position information linked with latitude, longitude and area division, linked to satellite big data compressed to 1/337 at high speed. The global land area altitude data were taken from ASTER
- [PeptiDream and Bristol-Myers Squibb (BMS) study PET tracer for tumor bio-imaging](https://window-to-japan.eu/2018/02/15/peptidream-and-bristol-myers-squibb-bms-study-pet-tracer-for-tumor-bio-imaging/) - The PET tracer being advanced in clinical testing was discovered by Bristol-Myers Squibb starting from an active lead macrocyclic peptide identified by PeptiDream using its PDPS technology. The PET tracer consists of a macrocyclic peptide conjugated to a radioligand. The macrocyclic peptide portion of the PET tracer binds to an antigen over-expressed on tumor cells
- [Number of postdocs in Japan is diminishing](https://window-to-japan.eu/2018/02/14/number-of-postdocs-in-japan-is-diminishing/) - The National Institute of Science and Technology · Academic Policy (NISTEP) conducts every 3 years a „Survey on employment and career of postdoctoral fellows. The FY 2015 results, just published, show that among 15,910 postdocs, the number of Japanese was 11,465 (72.1%), of foreigners 4435 (27.9%). 70 % of foreign postdoctoral fellows come from Asian
- [Ikeda Rika Co introduces cost-saving smart cell processing unit""](https://window-to-japan.eu/2018/02/14/ikeda-rika-co-introduces-cost-saving-smart-cell-processing-unit/) - The smart CP unit" cleanroom combines, in a space-saving space, an automatic cell culture apparatus P4CS made by Kaneka and a safety cabinet for carrying out operations such as bags and medium exchange. It is combined with an automatic "Quantum cell proliferation system" made by Terumo, an aseptic bonding system (TSCD-II), and a cell concentration
- [Helios invests in Gaia BioMedicine for NK](https://window-to-japan.eu/2018/02/14/helios-invests-in-gaia-biomedicine-for-nk/) - Through this investment, Helios develops a strategic partnership that aims at synergistic effects of the development of cancer immunity cell therapy centered on Gaia BioMedicine’s know-how on NK cells, and Helios’ own specialized stem cell technology. In addition, Helios will purchase shares of Gaia Biochemical Corporation. Natural killer (NK) cells are a naturally occurring defense
- [Astellas acquires Seattle’s Universal Cells for about 11 billion Yen](https://window-to-japan.eu/2018/02/14/astellas-acquires-seattles-universal-cells-for-about-11-billion-yen/) - Universal Cells Corp. has proprietary technology to suppress cell rejection due to leukocyte type antigen (HLA) incompatibility, andthus owns a universal donor cell technology, capable of creating cellular medical products that can be used for the treatment of all patients. Astellas’ Institute for Regenerative Medicine (AIRM) and Universal Cells cooperated on one indication since October
- [Teijin cancels exclusive license from SanBio on a cell medicine for treatment of strokes](https://window-to-japan.eu/2018/02/14/teijin-cancels-exclusive-license-from-sanbio-on-a-cell-medicine-for-treatment-of-strokes/) - The agreement is on a modified mesenchymal stem cell preparation (SB623) for the treatment of chronic cerebral infarctions. Teijin, who is invested in SanBio, had initiated discussions with the Pharmaceuticals and Medical Devices Agency (PMDA) since 2012 and developed, in 2016, consultations on clinical development plan aiming for early approval. Based on differences in development
- [Kawasumi Chemicals develops abdominal aortic aneurysm stent](https://window-to-japan.eu/2018/02/08/kawasumi-chemicals-develops-abdominal-aortic-aneurysm-stent/) - Jointly with Jikei University, Mani Inc., Asahi Kasei and the Japan Medical Devices Development Organization (JOMDD), a stent graft with a smaller diameter and less invasive treatment will be developed. Regulatory approval will be sought at the same time in Japan, the United States and Europe, and preclinical studies should be completed in 2020. Kawasumi
- [NEDO consortium develops high-purity carbon nanotubes (CNT) for printing electronics](https://window-to-japan.eu/2018/02/08/nedo-consortium-develops-high-purity-carbon-nanotubes-cnt-for-printing-electronics/) - The consortium which involves NEC, Nagasaki NanoCarrier and others, developed a single layer CNT separation technique without using an ionic surfactant. By Electric Field Induced Layer Formation (ELF)", they succeeded in separating semiconducting CNTs with a purity of 99% or more. This allows to manufacture high performance ink materials without using dispersants that adversely affect
- [PeptiDream ends successfully preclinical trials of iHA-24, an anti-influenza peptide](https://window-to-japan.eu/2018/02/08/peptidream-ends-preclinical-trials-of-iha-24-an-anti-influenza-drug-successfully/) - Based on PeptiDreams PDPS (Peptide Discovery Platform System), the macrocyclic peptide iHA-24 was found effective in preventing both viral infection and viral proliferation in both cell-based experiments and mouse-based animal studies. iHA-24 was also found to exhibit inhibition activity equal to or even higher than that of the current neuraminidase inhibitors. Peptide iHA-24 also exhibited
- [Fujifilm and Takeda to jointly commercialize iPS cell-derived cardiomyocytes](https://window-to-japan.eu/2018/02/08/fujifilm-and-takeda-to-jointly-commercialize-ips-cell-derived-cardiomyocytes/) - Fujifilm's owns iPS cell technology and sophisticated engineering technology c through its US subsidiary, Cellular Dynamics International, and Takeda Pharmaceutical does joint research (T - CiRA) with Kyoto University iPS cell research institute (CiRA). Both companies will jointly develop and commercialize regenerative medical products using iPS cell derived cardiomyocytes. Fujifilm news release, February 8, 2018
- [Nipro enters CarT developments wit Scotlands TC BioPharm](https://window-to-japan.eu/2018/02/07/nipro-enters-cart-developments-wit-scotlands-tc-biopharm/) - TC BioPharm is a UK company developing the field of cancer immunotherapy and aims to acquire approval for the manufacture and sale of ImmuniCell ™", a cellular medicine using self-immunizing cells. The company has developed chimeric antigen receptor (CAR) modified gamma-delta T cells (GDT) and owns a unique technology with a demonstrable safety profile and
- [NEC develops luxury lacquer-like „urushi“ bioplastic with exquisite printed designs](https://window-to-japan.eu/2018/02/06/nec-develops-luxury-lacquer-like-urushi-bioplastic-with-exquisite-printed-designs/) - In collaboration with Mr. Yutaro Shimode, a professor at Kyoto Sangyo University, NEC has developed a lacquer black tone with the beauty of urushi-like traditional craft lacquerware. The bioplastic (NeCycle R) is composed of polylactic acid and a grounded extract of cashew nuts containing cellulose and cardanol, a phenolic lipid based on anacardic acid. A
- [RIKEN and Osaka University find geneetic factors for lifestyle diseases using genome-wide association analysis (GWAS)](https://window-to-japan.eu/2018/02/06/riken-and-osaka-university-find-geneetic-factors-for-lifestyle-diseases-using-genome-wide-association-analysis-gwas/) - Based on the genetic information of 160,000 Japanese including 6 million data on 58 clinically relevant items (blood test,s physiological function tests such as blood pressure/ electrocardiogram etc.), a GWAS targeting genetic variations was carrdied out. As a result, 1,400 genetic variations affecting clinical laboratory values ​​were identified. In addition, epigenomic information from 220 types
- [Hitachi Chemical licenses stem cell medium from Israel Accellta](https://window-to-japan.eu/2018/02/05/hitachi-chemical-licenses-stem-cell-medium-from-israel-accellta/) - The medium developed by Axelta can cultivate large amount of cells by floating them in a liquid medium, without using a carrier. As a result, cells can be removing cells without separation from a carrier, reducing cell damage and improving their quality. By this technical licensing, Hitachi Kasei will strengthen its technical capabilities in contract
- [Kyoto University launches clinical trial of wound-dressing material using silk elastin](https://window-to-japan.eu/2018/02/02/kyoto-university-launches-clinical-trial-of-wound-dressing-material-using-silk-elastin/) - Silk elastin is a new material for coating jointly developed by Kyoto University and Sanyo Chemical Industries, and combines two proteins, elastin which is a component of human elastic fibers, and silk fibroin which is a protein of silk It is an artificial protein. They could be produced together in recombinant silkworms. The purpose of
- [A three-generation cohort for the Tohoku Medical Megabank Program has been successfully established](https://window-to-japan.eu/2018/02/01/a-three-generation-cohort-for-the-tohoku-medical-megabank-program-has-been-successfully-established/) - The world's first three-generation birth cohort survey with pedigree infomation carried out at the Tohoku Medical and Mega Bank program has resulted in the registration of over 73,000 people. Pregnant women occupy a large proportion among all pregnant women in Miyagi prefecture. Moreover, the number of trios (three children and parents) was > 10,000, forming
- [Takara Bio expands vector production capacity to the 2000 L scale](https://window-to-japan.eu/2018/02/01/takara-bio-expands-vector-production-capacity-to-the-2000-l-scale/) - Takara will construct a new facility at its head offices in Kusatsu, Shiga Prefecture. In the new facility, the production volume of the vector increases from the conventional 50 L scale to a 2000 L scale. It will allow the manufacture of retroviruses, lentiviruses, herpes viruses, adenoviruses, adeno-associated viruses, and Sendai viruses. In addition, the
- [Toshiba and Chiba University detect lymph node metastasis of gastric cancer by AI software](https://window-to-japan.eu/2018/02/01/toshiba-and-chiba-university-detect-lymph-node-metastasis-of-gastric-cancer-by-ai-software/) - In a collaborative research with Hideki HAYASHI, Chiba University, Toshiba Digital Solutions researchers found that the diagnosis of metastatic lymph nodes in images of tissues, after AI analysis, led to a quality of diagnosis equal or higher than by pathologists. Toshiba Analytics’ SATLYS ™" system used in these experiments provides highly accurate identification, prediction, factor
- [Cultivecs Co. builds manufacturing facility for antibody drugs](https://window-to-japan.eu/2018/01/31/cultivecs-co-builds-manufacturing-facility-for-antibody-drugs/) - Cultivecs is a joint venture between Mitsubishi Gas Chemical and Nippon Kayaku formed for contract manufacturing of antibody drugs and other biopharmaceuticals. The company has built a manufacturing facility for antibody drugs at the Mitsubishi Gas Chemicals factory in Niigata which will be delivered in February, 2018, for cultivating CHO cells. According to information by
- [AIST explores prediction of yield of catalytic reactions by AI](https://window-to-japan.eu/2018/01/31/aist-explores-prediction-of-yield-of-catalytic-reactions-by-ai/) - In this NEDO project, the National Institute of Advanced Industrial Science and Technology (NAIST) has developed a method to predict the yield of catalytic reactions by computer simulation based on catalyst structure and actual yields. In a halogen-free epoxidation reaction, 14 types of phosphonic acid molecules were characterised by atomic charge, infrared absorption and 30
- [Team of Nagoya University develops curved and decorated nanographene", medical applications"](https://window-to-japan.eu/2018/01/31/team-of-nagoya-university-develops-curved-and-decorated-nanographene-medical-applications/) - In the framework of the ERATO Itami Molecular Nanocarbon Project, researchers at Nagoya University around Kenichiro ITAMI have established a method for the chemical modification of curved nanographene", which led to a range of water-soluble graphene derivatives. It was shown that appropriately decorated water-soluble curved nanographenes are incorporated into cells and can induce cell death
- [JSR acquires exclusive rights from Keio University on intestinal bacteria R&D](https://window-to-japan.eu/2018/01/30/jsr-acquires-exclusive-rights-from-keio-university-on-intestinal-bacteria-r-d/) - Through research at JSR · Keio University Medical Chemistry Innovation Center (JKiC), JSR will promote the development of technologies and diagnostic agents related to maintaining homeostasis of intestinal flora. One example is to fight Klebsiella bacteria which may colonize the oral cavity and the digestive tract if homeostasis is disturbed, leading to inflammatory bowel disease.
- [Nikon ties up with the Cell Technology Group on master cell bank from pulp cells](https://window-to-japan.eu/2018/01/29/nikon-ties-up-with-the-cell-technology-group-on-master-cell-bank-from-pulp-cells/) - The Cell Technology Group cooperates with approximately 2,200 dental clinics in Japan and operates the first domestic dental pulp cell storage project. The company works on practical application of regenerative medicine using stockpiled dental pulp cells. Nikon concluded a business alliance agreement for constructing a clinical master cell bank (MCB) for use of dental pulp
- [Varinos Co.: analysis of intra-uterine microbiome prior to in-vitro fertilization](https://window-to-japan.eu/2018/01/28/varinos-co-analysis-of-intra-uterine-microbiome-prior-to-in-vitro-fertilization/) - The Tokyo-based company was established in 2017 and is developing clinical tests in the field of reproductive medicine and gynecology. Currently, they are focused on the analysis of the microflora in the uterus which should be controlled during in-vitro fertilization. The technology is based on next-generation sequencing. Varinos news release, January 29, 2018
- [Otsuka acquires all shares of DIATRANZ, develops encapsulated porcine islets](https://window-to-japan.eu/2018/01/25/otsuka-acquires-all-shares-of-diatranz-develops-encapsulated-porcine-islets/) - On January 25, Otsuka Pharmaceutical Factory acquired all remaining shares (50%) owned by New Zealand Living Cell Technologies (LCT), a company holding, in favor of its joint venture company DIATRANZ OTSUKA, which is engaged in the development of encapsulated porcine pancreatic islet cells DIABECELL". DIABECELL are islets isolated from specific pathogen free (DPF) newborn pigs
- [Kyoto University team sets up pilot plant for diatom algae cultivation from CO2 and sewage nitrogen](https://window-to-japan.eu/2018/01/25/kyoto-university-team-sets-up-pilot-plant-for-diatom-algae-cultivation-from-co2-and-sewage-nitrogen/) - A 3.5 x 6 meters pool type culture tank and a 2 x 10 meters race way type culture tank were installed in a greenhouse, and allow cultivation of about 5 ~ 8 tons of diatom Chaetoceros gracilis algae. The plant is located in a sewage plant in Himeji which allows the inflow of nutrients
- [Kyoto’s CiRA must weather scientific fraud](https://window-to-japan.eu/2018/01/24/kyotos-cira-must-weather-mit-scientific-fraud/) - In a paper that creates a blood-brain barrier model using cells derived from artificial pluripotent stem cells (iPS cells), with the responsible author Assistant Professor YAMAMIZU Kohei of CiRA, all six figures and five of the supplementary figures were admitted to have been forged or tampered with. Director Shinya Yamanaka is not a co-author of
- [Snow Brand obtains permission for functional display of visceral fat reduction by yoghurt](https://window-to-japan.eu/2018/01/24/snow-brand-obtains-permission-for-functional-display-of-visceral-fat-reduction-by-yoghurt/) - The strain used for Yoghurt production is Lactobacillus gasseri SP, and 100 g/day should be consumed for fat reduction. It further supports to strengthen immunity and counteract inflammation Snow Brand news release, December 21, 2017
- [Cancer Research Center finds new measurement method for risk of carcinogenesis](https://window-to-japan.eu/2018/01/23/cancer-research-center-finds-new-measurement-method-for-risk-of-carcinogenesis/) - In a study on genetic and epigenetic alterations in normal tissues, a group at the National Cancer Research Center found differential impacts on cancer risk: in the esophagus, both mutations and DNA methylation abnormalities increased as the carcinogenic risk rose, whereas mainly DNA methylation abnormalities increased the risk of stomach cancer. For esophageal cancer prevention,
- [RIKEN and Malaysia State University publish research database of natural rubber tree](https://window-to-japan.eu/2018/01/22/riken-and-malaysia-state-university-publish-research-database-of-natural-rubber-tree/) - The database of Para rubber trees consists of information based on genome sequences such as genes and their functional predictions, and transcription-related information that examines when, where, and how these genes work. All sequence data can be viewed from the genome browser. By preparing diagrams of important latex synthesis pathways in Para rubber tree, it
- [Anges MG applies to MHLW for preliminary approval of HGF gene therapy](https://window-to-japan.eu/2018/01/22/anges-mg-applies-to-mhlw-for-preliminary-approval-of-hgf-gene-therapy/) - The therapy is based on a gene for hepatocyte growth factor applied as a plasmid. Its intended action is the gene therapy of peripheral vascular diseases including severe ischemic limbs. Anges has exclusive distribution agreements with Mitsubishi Tanabe Pharma Co., Ltd. in Japan and the United States. Anges MG news release, January 22, 2018
- [NEDO-supported consortium develops photocatalytic panel reactor for artificial photosynthesis](https://window-to-japan.eu/2018/01/19/nedo-supported-consortium-develops-photocatalytic-panel-reactor-for-artificial-photosynthesis/) - The consortium, named Artificial Photosynthetic Chemistry Process Technology Research Association (ARPChem), comprises the University of Tokyo, TOTO Co., and Mitsubishi Chemical Corporation, and develops new photocatalysts for artificial photosynthetic systems. As a milestone result, a 1 m2 reactor was developed which decomposes thin layers of water (1 mm) into hydrogen and oxygen under natural sunlight
- [SalivaTec Co. to start metabolome analysis for early detection of cancer in saliva](https://window-to-japan.eu/2018/01/18/salivatec-co-to-start-metabolome-analysis-for-early-detection-of-cancer-in-saliva/) - SalivaTec, a startup in Yamagata prefecture, is working on a “Saliva checker” which detects markers for pancreatic and colon cancer early using metabolomics. In September 2017, the company tied up with Nippon Life Insurance Co. At present, a cohort of 1000 employees of Nippon Life will provide saliva samples for validation of SalivaTec’s approach. Nikkei
- [Kobe Medical Center reports adverse events in retinal iPS study](https://window-to-japan.eu/2018/01/16/kobe-medical-center-reports-adverse-events-in-retinal-ips-study/) - Kobe City Medical Center Hospital which does clinical research on transplantation of allogenic retinal pigment epithelial (RPE) cells for the treatment of exudative age-related macular degeneration announced that one patient had developed retinal edema. On January 15, 2018, the patient underwent surgery to remove the retinal frontal membrane which is thought to be the cause
- [Shimadzu launches collaboration with NCI on cancer light immunotherapy](https://window-to-japan.eu/2018/01/15/shimadzu-launches-collaboration-with-nci-on-cancer-light-immunotherapy/) - The cancer light immunotherapy, done in the near infrared (NIR-PIT), is developed at Shimadzu by Hisataka KOBAYASHI and will be further developed with US National Cancer Institute. Shimadzu news release, January 15, 2018
- [Mitsubishi Life Science Institute prepares for exploratory clinical trials on MUSE cells](https://window-to-japan.eu/2018/01/15/mitsubishi-life-science-institute-prepares-for-exploratory-clinical-trials-on-muse-cells/) - Using its regenerative medical product “CL 2020”, the trials are directed towards secondary prevention after treatment of acute myocardial infarction. The safety, tolerability and effectiveness at a single administration of CLIOs MUSE-cells (Multilineage-differentiating Stress Enduring cell) will be studied in 6 subject cases for one and a half year. After another trial, it is aimed
- [Toshiba launches Japonica Array ® v2 which calculates HLA genotype"](https://window-to-japan.eu/2018/01/15/toshiba-launches-japonica-array-v2-which-calculates-hla-genotype/) - Toshiba’s “Japonica Array”, which is widely used in Japan, e. g., within ToMMo, the Tohoku Medical Megabank Project, is now available in a version 2 which contains 7,000 SNPs in the HLA region, associated with graft-versus-host rejections, autoimmune diseases and drug responsiveness at the time of organ transplantation. Using a software for genotype analysis of
- [Team at Tokyo Medical and Dental University develops culture method to maintain human skeletal muscle cells in an undifferentiated state](https://window-to-japan.eu/2018/01/12/team-at-tokyo-medical-and-dental-university-develops-culture-method-to-maintain-human-skeletal-muscle-cells-in-an-undifferentiated-state/) - The group of Tomohiro AZAWA of Tokyo University of Medical and Dental University and colleagues used the laminin E8 fragment, developed at Osaka University by protein engineering, and observed that undifferentiated human skeletal muscle satellite cells proliferated and divided, reproducing on culture dishes in the liquid phase. When transplanted into immunosuppressed mice, they grafted as
- [Appropriately treated, egg white may form strong hydrogel with 150 fold increased compressive strength](https://window-to-japan.eu/2018/01/10/appropriately-treated-egg-white-may-form-strong-hydrogel-with-150-fold-increased-compressive-strength/) - The group of Tatsuya NOJIMA and Tomokazu HAYATA at Tokyo Institute of Technology and Southeast University have shown that egg white proteins can be condensed at regular intervals by reaction with specific anionic and cationic surfactant. When heating the emulsion in this state, a biodegradable gel material was obtained which showed 150 times more compressive
- [Teikyo University and Fuji Soft start clinical research on otitis media using regenerated cartilage](https://window-to-japan.eu/2018/01/08/teikyo-university-and-fuji-soft-start-clinical-research-on-otitis-media-using-regenerated-cartilage/) - Chondritis, or inflammation of the cartilage, may occur in the outer ear and lead to otitis media. The group around Ken ITO at Teikyo University has launched a clinical study to reconstruct resected parts of the ear with implanted regenerated cartilage, developed by Fuji Software. Doctor-led clinical trials are scheduled for 2020. Nikkei Biotech news
- [Takara Bio starts cell culture processing center at Life Innovation Center (LIC) in Kawasaki](https://window-to-japan.eu/2018/01/05/takara-bio-starts-cell-culture-processing-center-at-life-innovation-center-lic-in-kawasaki/) - The facility complies with GMP/GCTP standards and has been used as a demonstration facility for gene therapy projects. Due to a recent permission by the Ministry of Health, Labor and Welfare, it ican also be used for clinical cell processing services such as stem cells and transgenic cells. Since October 2014, Takara Bio operates a
- [Tohoku University team produces hydrogen by reacting hot spring water with aluminum](https://window-to-japan.eu/2018/01/03/tohoku-university-finds-technique-to-produce-hydrogen-from-reacting-hot-spring-water-with-aluminum/) - The group of Noriyoshi TSUKITA at Tohoku University has produced hydrogen from Tamagawa Hot Spring water at Semboku by reacting it with aluminum at 50 °C. The Tamagawa hot spring water has pH 1. As expected, no carbon dioxide was developed. As this and other hot springs spit with about 9000 l per spout, this
- [Keio University group transplants human colon stem cells into mouse intestinal tract, a new model to study inflammatory bowel diseases](https://window-to-japan.eu/2017/12/29/keio-university-group-transplants-human-colon-stem-cells-into-mouse-intestinal-tract-a-new-model-to-study-inflammatory-bowel-diseases/) - The group around Toshiro SATO has succeeded to culture human adult normal colon stem cells into mice and grow them for 10 months or longer. By genome editing techniques, GFP was introduced into the human stem cells before transplantation. As a result, their growth in mice could be observed by fluorescence. It was shown that
- [Industrial consortium around Organ Technologies Co. and RIKEN start research on disease markers in human hair](https://window-to-japan.eu/2017/12/27/ndustrial-consortium-around-organ-technologies-co-and-riken-start-research-on-disease-markers-in-human-hair/) - The hair shaft contains minerals and proteins, lipids, hormones, melanin pigments, etc. It has been reported that ingredients contained in hair change with the onset of diseases. Thus, there is a tendency that the concentration of iodine in the hair of cancer patients tends to be high, and the hair of diabetic patients tend to
- [Megakaryon raises 3.7 billion funding for human platelet formation from iPS cells](https://window-to-japan.eu/2017/12/25/megakaryon-raises-37-billion-funding-for-human-platelet-formation-from-ips-cells/) - Megakaryon was founded in 2011 aiming at the clinical application of platelets produced by megakaryocytes derived from human iPS cells. It owns intellectual property of immortalizing and storing frozen megakaryocytes derived from human iPS cells. In August 2017, the company formed a consortium from 13 companies towards commercialization of this technology for transfusion blood products.
- [RIKEN team develops high-throughput analysis of individual E. coli cells (E. coli capsule hotel")"](https://window-to-japan.eu/2017/12/23/riken-team-develops-high-throughput-analysis-of-individual-e-coli-cells-e-coli-capsule-hotel/) - The group around Yuichi TANIGUCHI at RIKEN has developed a method to observe individual E. coli cells. Using electron beam technology, a capsule-like pattern of dips 4 × 0.6 × 0.5 μm size was drawn on a photoresist coat on the surface of a silicon wafer, and this surface was cut with plasma. The silicon
- [Solar Frontier Co. develops thin-film solar cell with 22.9 % conversion efficiency](https://window-to-japan.eu/2017/12/20/solar-frontier-co-develops-thin-film-solar-cell-with-229-conversion-efficiency/) - Under a NEDO contract, the company improved the CIS light absorbing layer and surface treatment of light absorption. CIS solar cell use copper, indium, selenium, etc. as a light absorbing layer and have a structure in which a transparent conductive film/buffer layer/light absorbing layer/back electrode are laminated on a glass substrate. The present improvement is
- [Terumo introduces patch-type insulin pump](https://window-to-japan.eu/2017/12/17/terumo-introduces-patch-type-insulin-pump/) - Terumo’s product name is Medisafe With", weighs 34 g and has a body slightly larger than a match box. It must be replaced every 3 days. From the main body, a plastic needle stabs into the skin. Insulin is injected from here, and adjusted using a remote control touch panel. Using the control panel, basal
- [Tohoku University team establish human placental stem cell culture (TS cells)](https://window-to-japan.eu/2017/12/15/tohoku-university-team-establish-human-placental-stem-cell-culture-ts-cells/) - A team around Takahiro ARIMA at Tohoku University has succeeded to establish human TS cells from placental trophoblast. Trophoblasts with high purity were isolated from human placenta and genes and factors were identified that control their growth. Based on this information, human TS cells were cultured for more than 5 months, and even after prolonged
- [NEDO consortium manufactures golf balls from Eucommia-derived biomass](https://window-to-japan.eu/2017/12/13/nedo-consortium-manufactures-golf-balls-from-eucommia-derived-biomass/) - A group from Hitachi Zosen and Casco Co., under a NEDO contract, used a Eucommia (Euophorbia)-derived trans-polyisoprene polymer as a new biomaterial to prepare golf balls („Biospin“) which will be marketed from April 2018. The process includes vulcanization and silanization. In future, this type of biocomposite with high impact resistance and toughness is expected to
- [Kyushu group develops bioreactor for continuous production of glycolic from oxalic acid](https://window-to-japan.eu/2017/12/13/kyushu-group-develops-bioreactor-for-continuous-production-of-glycolic-from-oxalic-acid/) - A group around Tadashi AKIAKI of Kyushu University found that titanium dioxide catalyst was effective for the electrochemical synthesis of glycolic acid from oxalic acid. A membrane-electrode assembly with enhanced substrate permeability and a solid polymer-type electrode covered with TiO2 were used to transform oxalic acid continuously into glycolic acid. JST news, December 13, 2017
- [Hyogo and Hokkaido University Hospital start clinical trial on cell therapy for Crohn’s disease](https://window-to-japan.eu/2017/12/12/hyogo-and-hokkaido-university-hospital-start-clinical-trial-on-cell-therapy-for-crohns-disease/) - In the Phase I/II clinical trial, pregnant women's amniotic membrane („medical waste“) are used for mass culture of mesenchymal stem cells (MSC) and investigated for the treatment of Crohn’s disease and acute graft-versus-host disease (GVHD). In preclinical studies on amniotic MSC it was clarified that amniotic MSC have multipotency and immunosuppressive ability like bone marrow
- [Kobe initiates on Port Island demonstration test of a thermoelectric power supply system by hydrogen](https://window-to-japan.eu/2017/12/11/kobe-initiates-on-port-island-demonstration-test-of-a-thermoelectric-power-supply-system-by-hydrogen/) - In the NEDO project, Obayashi Corporation and Kawasaki Heavy Industries use a system that supplies heat and electricity by hydrogen in an urban area of Kobe neighboring to public facilities such as hospitals and an exhibition center. The 1 MW hydrogen gas turbine power plant (hydrogen cogeneration system (CGS) can be fueled by hydrogen only
- [Terumo obtains approval for Japan’s first patch-type insulin pump](https://window-to-japan.eu/2017/12/11/terumo-obtains-approval-for-japans-first-patch-type-insulin-pump/) - Terumo’s product name is Medisafe With", weighs 34 g and has a body slightly larger than a match box. It must be replaced every 3 days. From the main body, a plastic needle stabs into the skin. Insulin is injected from here, and adjusted using a remote control touch panel. " Terumo news release, December
- [Masayo Takahashi elected international member of the US National Academy of Medicine](https://window-to-japan.eu/2017/12/09/masayo-takahashi-elected-international-member-of-the-us-national-academy-of-medicine/) - Masayo Takahashi is project leader at RIKEN’s Center for Developmental Biology in Kobe and heads the Laboratory for Retinal Regeneration. In 2015, her team completed the first successful transplant of iPS-derived retinal cells into the eye of a patient suffering from advanced wet age-related macular degeneration RIKEN news release, December 1, 2017
- [Sekisui and LanzaTech develop „waste-to-ethanol“ technology](https://window-to-japan.eu/2017/12/09/sekisui-and-lanzatech-develop-waste-to-ethanol-technology/) - The technology allows to use garbage from disposal facilities without sorting. The garbage is first gasified to CO, H2 etc. under anoxic conditions. As gases obtained from garbage may contain contaminants toxic for microbial catalysts, gas purification technologies are applied which identify contaminants (about 400 species) contained in gas and remove toxic components. Moreover, control
- [MAFF’s Forestry Research Institute might develop non-allergenic cedar trees by genome editing](https://window-to-japan.eu/2017/12/08/maffs-forestry-research-institute-might-develop-non-allergenic-cedar-trees-by-genome-editing/) - As announced by Makoto NISHIGUCHI of the laboratory’s Tree Molecular Geetics Research Division, genome editing procedures have been developed for Cryptomeria japonica, the Japanese coniferous cedar tree. In view of the rapid rise of cedar pollinosis in Japan – beliebed to be due to various proteins and enzymes in µm-size cedar pollen grains, it is
- [Mouse experiments suggest fast and sensitive detection of breast cancer using a fluorescent probe](https://window-to-japan.eu/2017/12/07/mouse-experiments-suggest-fast-and-sensitive-detection-of-breast-cancer-using-a-fluorescent-probe/) - The group of Yasuaki URANO at the University of Tokyo has developed a diagnostic system where gamma-gltamyl transpeptidase (GGT) active in many cancer tissues splits an imaging reagent liberating green fluorescence. Using a mouse model, small cancers of 1 mm or less were thus visualized within seconds, and surgical specimen of human breast cancer provided
- [JST team develops rescue drones based on sound detection](https://window-to-japan.eu/2017/12/07/jst-team-develops-rescue-drones-based-on-sound-detection/) - Most search engine technologies based on drones use cameras which may fail when people are under rubbles or at night or in dark places. The new development put forward by Tokyo Institute of Technology, Kumamoto and Waseda University under a JST contract, uses search drones based on sound detection to get around such problems. The
- [Karydo TherapeutiX offers D-iOrgans Atlas, a body-wide dataset on drug interactions](https://window-to-japan.eu/2017/12/07/karydo-therapeutix-offers-d-iorgans-atlas-a-body-wide-dataset-on-drug-interactions/) - As a result of JST’s ERATO „SATO Live Bio-Forecasting Project“, which attempts to decipher cross-talk and the maintenance of homeostasis among organs in higher organisms, Tom Sato, Director of the BioMEC-X Laboratories at Advanced Telecommunications Research Institute International in Kyoto, has founded Karydo TherapeutiX Inc. in 2015. The company which offers support on drugg effects
- [Sekisui develops „waste-to-ethanol“ technology based on Lanza Tech](https://window-to-japan.eu/2017/12/06/sekisui-develops-waste-to-ethanol-technology-based-on-lanza-tech/) - The technology allows to use garbage from disposal facilities without sorting. The garbage is first gasified to CO, H2 etc. under anoxic conditions. As gases obtained from garbage may contain contaminants toxic for microbial catalysts, gas purification technologies are applied which identify contaminants (about 400 species) contained in gas and remove toxic components. Moreover, control
- [Public-private consortium develops mass production of mini-livers from iPS cells](https://window-to-japan.eu/2017/12/06/public-private-consortium-develops-mass-production-of-mini-livers-from-ips-cells/) - The JST-/AMED-funded consortium consortium consisting of Helios, Kuraray, Ajinomoto, Nikon, Carl Zeiss Japan and led by Yokohama City University (Profs. Hideki TANIGUCHI and Takebe TAKANORI) succeeded in developing a method for mass production. The team started from HLA homologous donor iPS cells (for research) established by CiRA, Kyoto University which are of a highly immunocompatible
- [Kagome introduces double functional tomato J product line](https://window-to-japan.eu/2017/12/05/kagome-introduces-double-functional-tomato-j-product-line/) - The tomato juice products contains functional displays for lycopene increasesblood HDL (good) cholesterol" and GABA (γ aminobutyric acid) "which lowers blood pressure of person whose blood pressure is high". Sales of 11 billion Yen are expected for 2018." Kagome news release, December 5, 2017
- [Philips Japan obtains approval for digitalization equipment of pathological images](https://window-to-japan.eu/2017/12/05/philips-japan-obtains-approval-for-digitalization-equipment-of-pathological-images/) - The company has obtained approval in Japan for Philips IntelliSite Pathology Solution, a medical device that transforms slides of a pathological biopsy specimen into digital images which can be used for diagnosis. Philips Japan news release, December 5, 2017
- [Daiichi Sankyo turns Kitasato vaccine joint venture into wholly owned subsidiary](https://window-to-japan.eu/2017/12/01/daiichi-sankyo-turns-kitasato-vaccine-joint-venture-into-wholly-owned-subsidiary/) - Daiichi Sankyo acquired 6.7 % of shares of Kitasato Daiichi Sankyo Vaccine owned by Kitasato, making it a fully owned subsidiary. Daiichi Sanky news release, December 1, 2017
- [RIKEN team achieves cleavage of carbon-nitrogen bonds with TiH2 under mild condidtions](https://window-to-japan.eu/2017/11/30/riken-team-achieves-cleavage-of-carbon-nitrogen-bonds-with-tih2-under-mild-condidtions/) - The new process aims at removing nitrogen from nitrogen-containing aromatic compounds such as pyridine and quinoline and is important in refining petroleum, shale oil or biomass as it improves the efficiency of hydrocracking. An international research team at RIKEN which included Chinese researchers from Dalian University of Science and Technology, China, mixed the highly active
- [Tokyo team achieves in-vivo transplantation of iPS-derived nephron progenitor cells to functional kidney cells in animal experiments](https://window-to-japan.eu/2017/11/29/tokyo-team-achieves-in-vivo-transplantation-of-ips-derived-nephron-progenitor-cells-to-functional-kidney-cells-in-animal-experiments/) - The group of Takashi Yokoo at Tokyo Jikei University's school of medicine has succeeded to mature foreign iPS-derived nephron progenitor cells. To this end, they injected renal progenitor cells induced from iPS into the nephrogenic zone of the mouse metanephros, where injected cells are continuously developed at later stages of kidney development. When rat-derived progenitor
- [Mitsubishi Chemicals will start clinical trials with Muse cells in FY2017](https://window-to-japan.eu/2017/11/29/mitsubishi-chemicals-will-start-clinical-trials-with-muse-cells-in-2017/) - Multi-lineage differentiating Stress Enduring cells (Muse) provide an alternative to stem cell technology and do not require recombinant processing for cell differentiation. They were developed by Tohoku University and its spin-off CLIO which was acquired by Mitsubishi Chemical Holding in 2015. According to a recent business meeting, clinical trials for myocardial infarction will begin in
- [Konica Minolta steps into health monitoring using tunneling magnetoresistance (TMR)](https://window-to-japan.eu/2017/11/29/konica-minolta-steps-into-health-monitoring-using-tunneling-magnetoresistance-tmr/) - In cooperation with Tohoku University, Konica Minolta is pioneering devices for simple measurement of brain and heart functions based on TMR. A novel type of magnetic sensor which operates at room temperature records alpha waves of brain with high sensitivity and high resolution. Also, the cardiac magnetic field can be measured in real-time and applied
- [DRIVEtheArc": Japanese consortium completes rapid charging station network at 25 locations for EV drivers in California"](https://window-to-japan.eu/2017/11/28/drivethearc-japanese-consortium-completes-rapid-charging-station-network-at-25-locations-for-ev-drivers-in-california/) - Nissan Motor and Kanematsu, under a contract with NEDO, have completed 55 large-scale (50 kW) rapid charging stations at 25 locations in California, in a corridor from Monterey to Lake Tahoe. For Nissan EV drivers, a real-time smartphone app DRIVEtheARC" is available. In this demonstration project, data of behavior patterns of EV owners such as
- [Kobe Eye Center" opens, specialized in iPS-related ophthalmology"](https://window-to-japan.eu/2017/11/26/kobe-eye-center-opens-specialized-in-ips-related-ophthalmology/) - The Kobe Eye Center consists of an ophthalmologic hospital and laboratory, a cell culture processing facility (CPC), and a floor conducting low vision care (rehabilitation for visually handicapped persons). A RIKEN-operated laboratory and CPC will be on the 5th and 6th floor of the center which is located in Kobe Medical Industry City" on Kobe
- [Kyoto's CiRA establishs screening system for Alzheimer (AD)-related drugs](https://window-to-japan.eu/2017/11/22/kyotos-cira-establishs-screening-system-for-alzheimer-ad-related-drugs/) - The sceening developed by Haruhisa INOUE at Kyoto University's Center for (CiRA) is based on cerebral cortical neurons derived from Alzheimer patients and uses compound libraries that are known to reduce amyloid β (Aβ). The cerebral cortical neurons used in the screening are obtained from iPS cells derived from AD patients by introducing the neural
- [Genomix Co. raises 1 billion Yen by 3d party allotment](https://window-to-japan.eu/2017/11/21/genomix-co-raises-1-billion-yen-3d-party-allotment/) - The company is engaged in R&D that promotes healing and regeneration of injured tissue by activating bone marrow-derived stem cells and accumulating them in the affected area via circulation of peripheral blood. https://genomix.co.jp
- [New inducible mouse model for nonalcoholic steatohepatitis (NASH)](https://window-to-japan.eu/2017/11/21/new-inducible-mouse-model-for-nanalcoholic-steatohepatitis-nash/) - A team at Kyoto Dental University and Kyushu University has bred a model mouse that develops this disease upon administration of hepatotoxic drugs in a very short time period. Nikkei Biotech, November 21, 2017
- [TherMAT and Furukawa Electric Industry develop novel U-shaped module for thermoelectric conversion](https://window-to-japan.eu/2017/11/17/thermat-and-furukawa-electric-industry-develop-novel-u-shaped-module-for-thermoelectric-conversion/) - Under a NEDO contract, the Thermal Energy Innovative Utilization Technology Research Association (TherMAT) and Furukawa Electric Industry have realized a high power thermoelectric power generator that converts unutilized thermal energy in the temperature range of 200 ~ 800 ° C, such as waste heat of industrial furnaces or automobile engines, into electric power. The electrode-less
- [NEDO consortium finds new high performance porous thermoelectric materials](https://window-to-japan.eu/2017/11/17/nedo-consortium-finds-new-high-performance-porous-thermoelectric-materials/) - The porous p-type magnesium silicide-based thermoelectric material (Mg – Si- Sn) exceeds the performance of conventional materials by more than 60% and will allow to realize a low cost, high durability thermoelectric conversion module that converts unutilized thermal energy of 300 ~ 400 ° C into electric power, using waste heat of automobile engine production
- [Teijin offers wearable electrode cloth which measures ECG](https://window-to-japan.eu/2017/11/16/teijin-offers-wearable-electrode-cloth-which-measures-ecc/) - Teijin has notified the Pharmaceuticals and Medical Devices Agency, PMDA, to introduce in spring 2018 a wearable cloth as general medical equipment (Class I). The Techno sensor ER" is capable to measure an electrocardiogram by 12 electordes. Technology is based on Nishijin’s textile technology." Teijin news release, November 16, 2017
- [Naked mole rats, which exhibit anti-aging and cancer resistance features, selected as novel test animals in Kumamoto](https://window-to-japan.eu/2017/11/16/naked-mole-rats-which-exhibit-anti-aging-and-cancer-resistance-features-selected-as-novel-test-animals-in-kumamoto/) - The mole rat, native to East Africa, lacks pain sensitivity in its skin, and has very low metabolic and respiratory rates. The mole rat is also remarkable for its longevity and its resistance to cancer and oxygen deprivation. Kumamoto University will construct a mass breeding facility to exploit the unique features of this animal for pharmaceutical and cosmetic projects. Nikkei Biotech news
- [METI launches study group on dialogue among ventures and investors](https://window-to-japan.eu/2017/11/16/meti-launches-study-group-on-dialogue-among-ventures-and-investors/) - The study group will meet about five times in FY2017 and formulate a bio venture investment guidance“, to promote dialogue between domestic and foreign investors and domestic bio ventures." Nikkei Biotech news release, November 16, 2017
- [RIKEN’s Shoubou (iris) system B is number 1 energy-saver among world’s top 500 supercomputers](https://window-to-japan.eu/2017/11/16/rikens-shoubou-iris-system-b-is-number-1-energy-saver-among-worlds-top-500-supercomputers/) - In cooperation with ExaScaler Co. and PEZY Computing Co., an entirely new immersion cooling system was established at RIKEN which lowered the energy requirements of the computer (2 petaflop class) to 17.009 gigaflops/W. RIKEN plans optimization work to realize even better power consumption performance. RIKEN news release, November 16, 2017
- [NEDO starts new program on carbon capture and utilization (CCU) technologies](https://window-to-japan.eu/2017/11/14/nedo-starts-new-program-on-carbon-capture-and-utilization-ccu-technologies/) - In the program, NEC Solution Innovator Co. and others will explore to produce methane from exhaust CO2 by means of electrochemically produced „green“ hydrogen technology and thus replace part of the methane in imported natural gas. Within the program, there will also be R&D of CO2-based land farming technology, efficiently dissolving high concentration CO2 contained
- [Otsuka Pharmaceutical and US Proteus Digital Health get FDA permission for first „digital drug“ incorporating a sensor](https://window-to-japan.eu/2017/11/14/otsuka-pharmaceutical-and-us-proteus-digital-health-get-fda-permission-for-first-digital-drug-incorporating-a-sensor/) - In the design, Otsuka’s orally taken antipsychotic drug ABILIFY" (aripiprazole) incorporates a miniature sensor which records, via a wearable device and a web-based portal for healthcare providers and caregivers, if the drug is ingested and data on activity level of the patient, as well as self-reported rest and mood. In a first step, Otsuka will
- [Hokkaido University starts clinical trial for stem cell transplantation for patients with acute phase of cerebral infarction](https://window-to-japan.eu/2017/11/10/hokkaido-university-starts-clinical-trial-for-stem-cell-transplantation-for-patients-with-acute-phase-of-cerebral-infarction/) - In a first successful surgery, bone marrow stem cells were taken from the iliac bone of the patient shortly after onset of cerebral infarction, and cultured and proliferated cells were administered directly into the brain using special equipment. In addition, cultured blood platelets obtained from healthy volunteers were also transplanted. The target number of cases
- [Ono Pharmaceutical Co. partners with Swiss Neurimmune on antibodies for neurogenerative diseases](https://window-to-japan.eu/2017/11/09/ono-pharmaceutical-co-partners-with-swiss-neurimmune-on-antibodies-for-neurogenerative-diseases/) - Ono Pharmaceutical Industry has concluded a partnership agreement with Neurimmune Holding, Inc. of Switzerland for discovering novel antibody medicine targeted for neurodegenerative diseases and create human monoclonal antibodies against drug discovery targets selected by Ono. Neurimmune is a bio venture founded in 2006 as a spin-off from the University of Zurich. Neurimmune's Reverse Translational Medicine
- [Osaka University team studies CAR-T cell therapy of multiple myeloma based on integrin β7](https://window-to-japan.eu/2017/11/07/osaka-university-team-studies-car-t-cell-therapy-of-multiple-myeloma-based-on-integrin-7/) - A team at the Graduate School of Medicine, Osaka University, has found that integrin β7 with an active structure is highly expressed specifically in multiple myeloma. Out of over 10,000 monoclonal antibodies that bound to myeloma cells, they identified MMG 49, an antibody that binds to myeloma cells but not to normal blood cells. The
- [Demonstration project on underwater inspection utilizing floating robot](https://window-to-japan.eu/2017/11/07/demonstration-project-on-underwater-inspection-utilizing-floating-robot/) - In a cooperation of Osaka Prefecture with Asahi Kao Co., supported by NEDO, the company will use a floating robot equipped with various cameras and sensors for underwater inspection. While navigating rivers and dams, this robot will survey riverbed and dam bottoms, creating precise three-dimensional shapes, and acquirie images of underwater management facilities. The aim
- [Kumamoto opens new silkworm R&D facility](https://window-to-japan.eu/2017/11/07/kumamoto-opens-new-silkworm-r-d-facility/) - Yamaga City in Kumamoto Prefecture officially opened its new silkworm development facility. Targets are new developments on recombinant silk as an advanced material for textiles, and on protein expression in recombinant silkworms. In the program, silkworms can be raised in sterile and contained facilities. Silk Summit 2017, https://silk-on-valley-yamaga.jp/news/press/post17.html
- [Sendai team develops cyber suit for disaster rescue dogs](https://window-to-japan.eu/2017/11/02/sendai-team-develops-cyber-suit-for-disaster-rescue-dogs/) - The suit measures the activity level of a rescue dog (best weight: 1,5 kg) by combination of ECG, an inertia sensor, a microphone and a GPS sensor providing telemetric information on location and on the comfort or discomfort of the animal. It was shown that a reliable correlation exists between heart rate variability (HRV) obtained
- [Chiba University offers online view on consequences of population decline](https://window-to-japan.eu/2017/10/30/chiba-university-offers-online-view-on-prefectural-consequences-of-population-decline/) - Japan’s hyper-aging society will have enormous effects on industry, medical services, nursing etc. The JST-supported project carried out by Chiba University allows a preview on 2040 for the consequences of population decline for each prefecture. JST news release, October 30, 2017
- [Toyota commercializes „GRAS-Di“ DNA marker technology which facilitates marker breeding](https://window-to-japan.eu/2017/10/30/toyota-commercializes-gras-di-dna-marker-technology-which-facilitates-marker-breeding/) - In cooperation with Kazusa DNA Research Institute, Eurofins and Genebay, Toyota will commercialize this technology developed in its Bioresearch Institute in Miyoshi. The technology is based on Genotyping by Random Amplicon Sequencing and allows the genetic screening of thousands of breeding variants of plants or animals at low cost. It was already successfully applied to
- [RIKEN team develops fluorescent probe that visualizes the complete cell cycle in real time](https://window-to-japan.eu/2017/10/29/riken-team-develops-fluorescent-probe-that-visualizes-the-complete-cell-cycle-in-real-time/) - The groups of Atsushi MIYAWAKI and Asako SAKAGAMI at RIKEN have developed an improved flurescent probe (FUCCI (CA) ) whose fluorescence differs once a cell is in phase S, G2 or M phase of its cell cycle. The technology is based on cell-cycle dependent ubiquitin-mediated proteolysis and can be applied to observe the life cycles
- [RIKEN group develops novel pathway to maleic acid in E. coli](https://window-to-japan.eu/2017/10/27/riken-group-develops-novel-pathway-to-maleic-acid-in-e-coli/) - The group of Akihiro KONDO at RIKEN has used synthetic biology to produce maleic acid from glucose in recombinant E. coli by a novel pathway. The research team combined 3-hydroxybenzoic acid synthetase (Hyg5) derived from Streptomyces hygroscopicus, 3-hydroxybenzoic acid 6-hydroxylase (3HB6H) derived from Rhodococcus jostii RHA, and maleyl pyruvate synthase (MPS) from Rhodococcus sp. NCIMB
- [JCR Pharma develops proprietary technology for treatment of Hurler syndrome](https://window-to-japan.eu/2017/10/27/jcr-pharma-develops-proprietary-technology-for-treatment-of-hurler-syndrome/) - Hurler syndrome (mucopolysaccharidosis type I) is a lysosomal storage disorder characterized by deficiency of a specific enzyme, alpha-L-iduronidase, responsible for the degradation of glycosaminglycans (GAGs), and results in excessive buildup of GAGs throughout the body, leading to symptoms also in the central nervous system (CNS). JCR has developed technology to penetrate the blood-brain barrier (J-Brain
- [RIKEN team finds model for improved treatment of acute myelogenous leukemia](https://window-to-japan.eu/2017/10/26/riken-team-finds-model-for-improved-treatment-of-acute-myelogenous-leukemia/) - Acute lymphocytic leukemia is common in children, while acute myelogenous leukemia is more common in adults and has a higher recurrence rate. A RIKEN group around Fumihiko ISHIKAWA has found in experiments with humanized mice (non-immune mice to which human progenitor cells with a mutation in the FLT3 gene were transplanted, leading to the onset
- [„Future hyrogen society“: NEDO-supported team develops non-fluorine electrolyte membrane for fuel cells](https://window-to-japan.eu/2017/10/26/future-hyrogen-society-nedo-supported-team-develops-non-fluorine-electrolyte-membrane-for-fuel-cells/) - Kenji MIYATTI of the University of Yamanashi and colleagues have developed a high performance non-fluorine-based electrolyte membrane for fuel cells based on polyphenylene electrolyte (SPP - QP). The membrane has excellent chemical durability and provides fuel cells with initial power generation characteristics equivalent to those of current fluorinated electrolyte membranes. At present, fluorinated electrolyte membranes
- [NEDO-supported group develops blue-laser 3D printer for pure copper](https://window-to-japan.eu/2017/10/24/nedo-supported-group-develops-3d-printer-for-pure-copper/) - In the NEDO project, Osaka University’s group of Professor Masahiro Tsukamoto, collaborating with Shimadzu Co., Nichia Corporation and Muratani Machinery Works has developed a blue-laser 3D printer that can print layers of pure copper by a laminating high-quality blue semiconductor laser. This technology will be applied to process parts for aerospace, space and electric car
- [NEDO starts desalination project in Qatar, using coolant seawater](https://window-to-japan.eu/2017/10/20/nedo-starts-desalination-project-in-qatar-using-coolant-seawater/) - In the project, seawater used in Ras Laffan industrial city as cooling water for facilities and discharged to the sea at a maximum of about 45 ° C will be used as the water resource for seawater desalination by a reverse osmosis membrane process developed in Japan. It is expected to save 80% or more
- [Toyobo and Human Metabolome Technologies (HMT) develop enzyme kit for depression biomarker](https://window-to-japan.eu/2017/10/20/toyobo-and-human-metabolome-technologies-hmt-develop-enzyme-kit-for-depression-biomarker/) - Research by HMT and others has revealed that the concentration of ethanolamine phosphate (PEA) in blood fluctuates according to the medical condition of depression, suggesting its utility as a biomarker to support depression diagnosis. HMT has developed an enzyme kit for PEA detection, and Toyobo will provide suitable enzymes such as ethanolamine phosphate lyase. Toyobo
- [Tokyo team develops „nanomachine“ which permits 100fold increased passage through the blood-brain-barrier (BBB)](https://window-to-japan.eu/2017/10/19/tokyo-team-develops-nanomachine-which-permits-100fold-increased-passage-through-the-blood-brain-barrier-bbb/) - The concept jointly developed by researchers at the University of Tokyo, Tokyo Medical and Dental University and others is based on physiologically safe nanoparticles of 30 nm diameter (a PEG-poly(α,β-aspartic acid) block copolymer with conjugated glucose) which are loaded with glucose) recognized by the GLUT1 transporter localized in cerebrovascular endothelial cells. The uptake by this
- [NEDO starts weather observation test by drones in Fukushima Prefecture](https://window-to-japan.eu/2017/10/18/nedo-starts-weather-observation-test-by-drones-in-fukushima-prefecture/) - In this pilot project carried out at Minamisoma, Fukushima Prefecture, meteorological weather data at altitudes of 50 m, 100 m and 140 m will be observed by flying a drone equipped with weather sensors. Accuracy will be verified by comparing the results with Doppler lidar weather observation, aiming to expand the use of drones and
- [Takeda transforms Shonan Research Institute into „Shonan Health Innovation Park“](https://window-to-japan.eu/2017/10/18/takeda-transforms-ist-shonan-research-institute-into-shonan-health-innovation-park/) - Takeda Pharmaceutical Industries will build a Shonan Health Innovation Park" inviting external venture companies and academia researchers into its Shonan Research Laboratory. The model is Boston’s BioCluster where researchers interact with each other at cafes and where collaborative research is started and research ideas are born. In order to achieve such an environment, it is
- [NEDO-supported consortium reports successful manufacture of weldable automobile chassis in 1 minute using thermoplastic carbon-fiber reinforced plastics (CFRP)](https://window-to-japan.eu/2017/10/16/nedo-supported-consortium-reports-successful-manufacture-of-weldable-automobile-chassis-in-1-minute-using-thermoplastic-carbon-fiber-reinforced-plastics-cfrp/) - The Nagoya-based team used the LFT-D method, a method for manufacturing fiber-reinforced plastics conceived in the Fraunhofer Institute of Chemical Technology ICT in Pfinztal. By this method, carbon fibers are continuously fed and kneaded with thermoplastic resin pellets. If heating and pressure molding of composite parts are carried out in an autoclave, intermediate steps become
- [Tokyo bioventure Dante offers male semen analysis to predict reproductive health](https://window-to-japan.eu/2017/10/13/tokyo-bioventure-dante-offers-male-semen-analysis-to-predict-reproductive-health/) - The Tokyo-based company analyzes testosterone, zinc, spermine and creatine and offers a test kit that can be mailed at ambient temperature. Semen analysis from 80 healthy men aged 23 to 58 years showed that testosterone concentration in semen declined by half from age 20 to 30 and gradually further until the 50ies, whereas the oxidative
- [Nano-Innovation Laboratories NIL Corp. develop “super nanoparticle” manufacturing technology for functional ingredients in cosmetics](https://window-to-japan.eu/2017/10/12/nano-innovation-laboratories-nil-corp-develop-super-nanoparticle-manufacturing-technology-for-functional-ingredients-in-cosmetics/) - Within a NEDO-supported project, NIL Corporation developed an innovative super nanoparticle (SNP) manufacturing technology that maximizes the effectiveness of functional ingredients. SNP particle size is extremely small, surface area is large, particle size distribution is narrow, dispersion stability is good and highly concentrated dispersions can be prepared. In addition, the surface of the SNPs can
- [RIKEN team elucidates genome mutations in iPS cells](https://window-to-japan.eu/2017/10/11/riken-team-elucidates-genome-mutations-in-ips-cells/) - In a collaborative program with several university groups, Yoshihiro YOSHIHARA of RIKEN’s Life Science Center for Functional Genomics has elucidated the hot spots of genome mutations in induced pluripotent stem cells (iPS cells). The distribution pattern showed point mutation of low density in the regulatory regions coding for promoters and enhancers. Many other genomic mutations
- [Astellas Pharma, Daiichi Sankyo and Mitsubishi Tanabe Pharma to re-evaluate compound libraries through universities and ventures](https://window-to-japan.eu/2017/10/11/astellas-pharma-daiichi-sankyo-and-mitsubishi-tanabe-pharma-to-re-evaluate-compound-libraries-through-universities-and-ventures/) - In the joint program “JOINUS”, the 3 companies will commission work to universities and ventures to reevaluate compound libraries that have already shown pharmacological activity and basic safety in non-clinical studies. More than 50 kinds of mechanisms of action are targeted, and the number of concrete compounds is not disclosed. Astellas news release, October 11,
- [Yakult launches Synbiotics Yakult W, a prebiotic-containing combination drink](https://window-to-japan.eu/2017/10/11/yakult-launches-synbiotics-yakult-w-a-prebiotic-containing-combination-drink/) - The drink contains Lactobacillus casei Shirota, vitamin C and 2.5 g galactooligosaccharide, a prebiotic which increases the level of bifidobacteria in the intestine.The combination is expected to enhance the functionality of this zero-fat probiotic drink. Sales goal is 70,000 units per day. Yakult news release, October 11, 2017
- [Konica Minolta enters ultrasound diagnostic market, acquires Japan business from Siemens Healthcare](https://window-to-japan.eu/2017/10/10/konica-minolta-enters-ultrasound-diagnostic-market-acquires-japan-business-from-siemens-healthcare/) - Following a general trend of Japanese camera makers to enter the medical field, in view of shrinking business due to mobile phone camera competition, Konica Minolta Japan has acquired the Japanese business of transvaginal ultrasound imaging diagnostic equipment from Siemens Healthcare, and will enter the ultrasound imaging diagnostic market in the field of obstetrics and
- [JCR Pharma and NanoCarrier Co. announce research agreement on intracereberally delivered drugs](https://window-to-japan.eu/2017/10/10/jcr-pharma-and-nanocarrier-co-announce-research-agreement-on-intracereberally-delivered-drugs/) - JCR Pharma has developed „J-Brain Cargo“, a passage technology fort he blood-brain barrier (BBB) based on antibodies and peptides binding to proteins expressed on endothelial cells of brain capillaries such as the human transferrin recepetor (hTfR). NanoCarrier has designed micellized nanoparticles as drug delivery system which can transport nucleic acids or toxic anticancer drugs. Both
- [Bayer Pharmaceutical opens incubation lab for ventures in Kobe](https://window-to-japan.eu/2017/10/08/bayer-pharmaceutical-opens-incubation-lab-for-ventures-in-kobe/) - Within its program for open innovation, Bayer will open an Innovation Center Japan (ICJ) „CoLaborator Kobe“ (tentative name) which will host 5 companies, 3 of them in the first half of 2018. PRTimes, October 10, 2017
- [Matsumoto Dental University Hospital installs CPC, starts alveolar bone regeneration from bone marrow](https://window-to-japan.eu/2017/10/06/matsumoto-dental-university-hospital-installs-cpc-starts-alveolar-bone-regeneration-from-bone-marrow/) - The research hospital has established a cell culture processing facility based on Kaneka’s automatic cell culture device, and has started clinical research on autologous cell products isolated from stromal cells of a patient’s bone marrow and transformed into alveolar bone cells. Matsumoto Dental University press release, October 6, 2017
- [NEDO consortium starts demonstration project on automatic travel system](https://window-to-japan.eu/2017/10/03/nedo-consortium-starts-demonstration-project-on-automatic-travel-system/) - The core of the program is the development and test of a highly accurate 3D digital map („dynamic map“) necessary for automatic driving. It will be tested on expressways, ordinary roads, public roads, etc. and information security, e. g., inter-vehicle communication technology (V2P) and pedestrian high precision positioning/action prediction are key factors. About 50 companies
- [Japan erprobt nächsten Schritt zu „grünem Wasserstoff“](https://window-to-japan.eu/2017/10/03/japan-erprobt-nachsten-schritt-zu-grunem-wasserstoff/) - Ein vom Projektträger NEDO des Industrieministeriums unterstütztes Projekt sieht vor, an einer bereits existierenden Windkraft-Anlage in Hokkaido ein neuartiges Geschäftsmodell zur Nutzung überschüssiger Windenergie als Wärme zu erproben. Dabei will man vorausberechnen, welcher Teil der Windenergie bei unterschiedlicher Nachfrage und Wetterschwankungen stabil im Grid verkauft werden kann, und die Überschußenergie zur Erzeugung von H2 nutzen.
- [AdipoSeeds develops blood platelets derived from adipose tissue](https://window-to-japan.eu/2017/10/02/adiposeeds-develops-blood-platelets-derived-from-adipose-tissue/) - The Keio University spin-off has prepared a stable and homogeneous mesenchymal stem cell line ASCL (Adipose-derived Mesenchymal Stem/stromal Cell Line) which can be cryopreserved and differentiated into platelets within about 2 weeks, using a transcription factor NF-E2. Using this technology, one package of adult blood ready for transfusion might be produced from 0.5 g of
- [Farmers in Gunma prefecture obtain permission to breed recombinant silkworms in open facility, manufacture fluorescent silk](https://window-to-japan.eu/2017/09/29/farmers-in-gunma-prefecture-obtain-permission-to-breed-recombinant-silkworms-in-open-facility-manufacture-flurescent-silk/) - Both the Silkworm Technology Center in Gunma Prefecture and sericulture farmers in Maebashi City obtained permission from the Ministry of Agriculture and the Ministry of the Environment to produce fluorescent silk, containing GFP, from genetically modified silkworms in an open system, following the rules of the Cartagena Protocol. The silkworms had been hatched from their
- [Toyota-led consortium starts wind power to hydrogen project in Hokkaido](https://window-to-japan.eu/2017/09/29/toyota-led-consortium-starts-wind-power-to-hydrogen-project-in-hokkaido/) - The NEDO-led consortium which besides Toyota Tsusho includes NTT, Kawasaki Heavy Industries, Flein Energy, Technoba Co. and the Muroran Institute of Technology, will establish a new business model where wind power will be converted into hydrogen leading to thermal energy. Specifically, the electric power system will be optimized by predicting the amount of electricity that
- [Keio University develops dual robotic arm with precise haptics technology](https://window-to-japan.eu/2017/09/28/keio-university-develops-dual-robotic-arm-with-precise-haptics-technology/) - The system, developed under a NEDO contract, is based on a master – slave concept where an operater, as the master, makes the slave reproduce the same movements. In addition, when the slave touches something, the haptic feeling is communicated through the master, and presents the feeling to the operator as if he would touch
- [NEDO publishes technical guideline for regional biomass energy use](https://window-to-japan.eu/2017/09/28/nedo-publishes-technical-guideline-for-regional-biomass-energy-use/) - The guideline contains 3 chapters: Chapter I Concept of Sustainable Energy Business Chapter II Introduction Requirements (Woody Biomass)(Wet Biomass) Chapter III Technical Guidelines (Woody biomass edition). It is based on interviews with business operators and experts and relevant reference materials and provides information for regional business operators considering entry into biomass energy projects. NEDO news
- [Fujifilm invests 430 million Yen in NC Medical Research Co. on MS cell technology](https://window-to-japan.eu/2017/09/27/fujifilm-invests-430-million-yen-in-nc-medical-research-co-on-ms-cell-technology/) - NCMR is a subsidiary of e-Solutions Co. and engaged in R&D of regenerative medicine products for the treatment of acute cerebral infaction (NCS-01). The mesenchymal stem cells (MSC) are derived from human bone marrow. The present thrombolytic therapy for acute cerebral infaction is limited to within 4,5 hours after the onset, whereas MSC can be
- [Sumitomo Chemical invests in nucleic acid drug company Bonac](https://window-to-japan.eu/2017/09/26/sumitomo-chemical-invests-in-nucleic-acid-drug-company-bonac/) - The investment is 4 billion Yen and expands Sumitomo’s share in the company to 19,55 %. Bonac is a specialist for modified RNA synthesis (Bonac nucleic acids) which exhibit good stability and may lead to novel mucleic acid drugs. Bonac news release, September 26, 2017
- [Asahi Glass expands production capacity of its Danish subsidiary, CMC Biologics](https://window-to-japan.eu/2017/09/25/asahi-glass-expands-production-capacity-of-its-danish-subsidiary-cmc-biologics/) - CMC Biologics Inc., a US CDMO with a subsidiary in Copenhagen, Denmark, will establish 5 additional 2000 L animal cell culture tanks at its Danish subsidiary and thus, with its present 2000 L culture tank, will be able to handle a total of 12,000 L of animal cells for contracting partners. Asahi Glass news release,
- [Asahi Kasei obtains license for bone regenerative cell therapy](https://window-to-japan.eu/2017/09/22/asahi-kasei-obtains-license-for-bone-regenerative-cell-therapy/) - The license, exclusive for Japan, Korea, China and Taiwan, comes from Belgium’s Bone Therapeutics, Inc., and is directed to the cellular drug PREOB. PREOB is an autologous cell product produced from the patient's bone marrow. Osteoblasts contained in PREOB promote bone regeneration, and application to intractable bone diseases is being studied. Currently, Phase 3 clinical
- [iLPixel and Singapore's iGroup launch image fraud detection service for life science research](https://window-to-japan.eu/2017/09/22/ilpixel-and-singapores-igroup-launch-image-fraud-detection-service-for-life-science-research/) - The Tokyo-based company, a leader in the application of AI to the analysis of scientific images, has formed a joint-venture with Singapore-based iGroup which offers ImaChek, an image fraud detection service for life science research. ImaCheck applies cutting edge image processing technology to detect unnatural parts processed or reused in images. iLPixel news release, Sept.
- [RIKEN/Tokyo University team develop ultra-thin organic solar cell which can be stretched and laundered](https://window-to-japan.eu/2017/09/19/rikentokyo-university-team-develop-ultra-thin-organic-solar-cell-which-can-be-stretched-and-laundered/) - The super-flexible organic solar cell is based on PNTz 4 as an organic semiconductor polymer covered by parylene and utilizes a substrate film and a sealing film of only 1 micrometer thickness. It works even when bended or crushed and shows high energy conversion efficiency and high water resistance. Short-circuit current density (JSC) when irradiated
- [Kikkoman releases salt-reduced soy sauce with functional ingredient](https://window-to-japan.eu/2017/09/19/kikkoman-releases-salt-reduced-soy-sauce-with-functional-ingredient/) - The new recepy contains less salt and, as functional ingredient, soybean peptides which tend to lower blood pressure. The product shows a functional display. Kikkoman news release, September 19, 2017
- [Shionogi: positive outcome of phase III of S-033188, a CAP-snatching inhibitor of influenza virus](https://window-to-japan.eu/2017/09/17/shionogi-positive-outcome-of-phase-iii-of-s-033188-a-cap-snatching-inhibitor-of-influenza-virus/) - S-033188 is the world's first inhibitor against influenza virus with cap-like structure (CAP) -dependent endonuclease activity. The results showed that the symptom relief time (TTAS) was significantly reduced compared with placebo, and other important secondary clinical end points (such as reduced virus titer) also achieved positive results. Preclinical study data for A / H7N9 (avian
- [Siemens Japan starts selling POCcelerator", an open data management system for POC inspection"](https://window-to-japan.eu/2017/09/14/siemens-japan-starts-selling-poccelerator-an-open-data-management-system-for-poc-inspection/) - Siemens Healthcare Diagnostics Co., Japan, offers its data management system wich can be connected to 160 major POC inspection devices from 40 major manufacturers. POCcelerator centrally manages the POC examination devices distributed in various medical fields, and concatenates them with HIS/LIS data management, thus improving the efficiency of diagnostic services and the administration department. Siemens
- [Genome editing might speed up flower breeding](https://window-to-japan.eu/2017/09/14/genome-editing-might-speed-up-flower-breeding/) - A team at the University of Tsukuba has used the CRISPR/Cas9 genome editing method to produce white and other coloured variants of the Japanese morning glory (Ipomoea (Pharbitis) nile). Dihydroflavonol-4-reductase-B (DFR-B), a key enzyme of anthocyanin biosynthesis, was selected as the target. Approximately 75 % of the transgenic plants produced anthocyanin-free white flowers with bi-all
- [Actory Co. develops hybrid solar energy converter with 65 % efficiency](https://window-to-japan.eu/2017/09/13/actory-co-develops-hybrid-solar-energy-converter-with-65-efficiency/) - The gantry type hybrid system simultaneously performs power generation by solar power and heat recovery of solar generating high temperature water of 60 ° C or more. Four parabolic reflecting mirrors are equipped with GPS and arranged in one row, and each row changes its direction toward the sun, so energy recovery is high. The
- [Ricoh establishs new drug granulation based on inkjet technology](https://window-to-japan.eu/2017/09/11/ricoh-establishs-new-drug-granulation-based-on-inkjet-technology/) - In the process, co-developed with Shizuoka Prefectural University's Rieko ONOE, fine particles of about 5 μm are extruded at high frequency from a nozzle using piezoelectric forces, creating a uniform powder by drying at high speed. https://blog.ricoh.co.jp/RISB/technology/post_218.html
- [JST: Chinese patent applications from universities exceed those of Japan 19 times](https://window-to-japan.eu/2017/09/11/jst-chinese-patent-applications-from-universities-exceed-those-of-japan-19-times/) - The number of patent applications in China exceeded one million for the first time in 2015 and rose to 1,339,000 in 2016, more than twice as many as 600,000 in the US, and more than 4 fold the 318,000 in Japan; China's world's share exceeded 40%. Basic patents are increasing due to the improvement of
- [Nihon TRIM Co. develops umbilical cord-derived mesenchymal stem cells for treatment of severe acute graft-versus-host disease](https://window-to-japan.eu/2017/09/10/nihon-trim-co-develops-umbilical-cord-derived-mesenchymal-stem-cells-for-treatment-of-severe-acute-graft-versus-host-disease/) - Main product of the company is electrolyzed reduced water (ERW) which is claimed to have antioxidant properties. Its newly founded subsidiary, Human Life Cord Japan, will develop regenerative medicine products. The first project is with the University of Tokyo Institute of Medical Science on MSC derived from umbilical cord, and further projects concern rare diseases
- [TBM introduces 100 KVA mobile power generator based on fats and oils](https://window-to-japan.eu/2017/09/08/tbm-introduces-100-kva-mobile-power-generator-based-on-fats-and-oils/) - The concept is based on collecting fat and oil residues from grease blockers installed at restaurants, food stores, sewage plants etc., and use this „trap grease“ fuel in a power generator mounted on a car. TBM Corporation is a leading turbine blade manufacturer. In a test supported by NEDO, fats and oils from food stores
- [CellSource Co. and Rohto cooperate on mesenchymal stem cell (MSC) preparation from adipose tissue](https://window-to-japan.eu/2017/09/08/cellsource-co-and-rohto-cooperate-on-mesenchymal-stem-cell-msc-preparation-from-adipose-tissue/) - Under the contract, CellSource, which operates a cell-processing center (CPC), will evaluate methods to prepare MSC preparations from adipose tissue provided by medical institutions, and how to transport these preparations to Rohto for evaluation in pharmaceutical studies. CellSource news release, September 8, 2017
- [Number of functional displays on food in Japan rises to 1049 cases](https://window-to-japan.eu/2017/09/08/number-of-functional-displays-on-food-in-japan-rises-to-1049-cases/) - The latest entry was Kaos „Hercia W Coffee“. The coffee is rich in chlorogenic acid, a compound which enhances fat metabolism. In addition, oxidants such as hydroxyhydroquinones in blood are reduced. Thus claims on reducing body fat and control of blood pressure are warranted, and the sugar-free black coffee is distributed under the label „Rhythm
- [NEDO to support 6 AI venture companies](https://window-to-japan.eu/2017/09/06/nedo-to-support-6-ai-venture-companies/) - Out of a competition with 57 competitors, the 6 winner companies and their topics are: 1. Hmcomm.com, a spinout of NAIST, https://hmcom.co.jp/?lang=en International voice recognition AI for conference purposes 2. A.R.I. Co. https://ari-jp.com AI system for interview of outpatients guiding them to an appropriate medical department 3. SOINN.com, https://soinn.com Classification of unstructured data on smartphone
- [Takeda Pharmaceuticals invests in Noile-Immune Biotech on CAR-T](https://window-to-japan.eu/2017/09/05/takeda-pharmaceuticals-invests-in-noile-immune-biotech-on-car-t/) - Noile-Immune Biotech, https://www.noile-immune.com/english/home/, a spin-out of Yamaguchi University founded in 2015, has tied up with Takeda Pharmaceuticals on antigen receptor expressing T cell (CAR-T) therapy. Noile- Immune Biotech holds the exclusive license on a patent on the augmentation of gene-engineered T cell function for appropriate expansion, accumulation, and inducible memory function to solid cancer issued to Yamaguchi
- [Mitsubishi Tanabe and Osaka University establish JV BIKEN Co. Ltd.](https://window-to-japan.eu/2017/09/04/mitsubishi-tanabe-and-osaka-university-establish-jv-biken-co-ltd/) - Osaka University’s BIKEN Foundation sold 33,4 of its shares to Mitsubishi Tanabe Pharma and agreed to initiate a joint venture as of Sept. 1 which will manufacture and sell vaccines. Mitsubishi Tanabe has been the distributor of BIKEN Foundation vaccines for over 50 years. Mitsubishi Tanabe news release, September 4, 2017
- [NEDO exhibits six new support systems for handicapped people at International Welfare Equipment exhibition 2017](https://window-to-japan.eu/2017/09/01/nedo-exhibits-six-new-support-systems-for-handicapped-people-at-international-welfare-equipment-exhibition-2017/) - The products, intended for handicapped, were 1. QD Laser, https://www.qdlaser.com Retinal Scanning Laser Eyewear 2. Enfasys Co., https://www.emfasys.co.jp eye switch" that allows a handicapped person to manipulate external equipment by gaze movement and eyelid movement
- [Yamaha Motors develops picking device for 3D culture of cells](https://window-to-japan.eu/2017/09/01/yamaha-motors-develops-picking-device-for-3d-culture-of-cells/) - The picking and imaging system „Cell Handler“ uses an image reader on high-density culture plates or suspended cultured cell clumps and picks up and distributes individual cells on culture plates. Yamaha Motors news release, Sept. 1, 2017
- [3DMatrix offers iPSC neuronal cultures for toxicity assays](https://window-to-japan.eu/2017/09/01/3dmatrix-offers-ipsc-neuronal-cultures-for-toxicity-assays/) - Using 3D ProSeedTM hydrogels for 3D culture of iPSC-derived CNS.4U neural cells and confocal high-content imaging, the company has developed a quantitative high-throughput assay which enables assessment of the viability and morphological changes in 3D neuronal cultures. Higher resolution and multi-parametric analysis allows neurite and single cell counting and statistically characterizes neurite development and branching
- [University team synthesize seleno-insulin analog, retains physiological function and lasts longer](https://window-to-japan.eu/2017/08/31/university-team-synthesize-seleno-insulin-analog-retains-physiological-function-and-lasts-longer/) - In a joint project, groups at Tokai University, Tohoku University and Osaka University have synthesized an insulin analog where one of the disulfide bonds linking the A- and B-chain is replaced by diselenide bonds („seleno-insulin“). X-ray analysis revealed a similar structure, but degradation in vitro by insulin-degrading enzyme IDE (a protease) was much slower (45
- [NEDO establishes additional consortium for „smart cell industry“ based on microbial cells](https://window-to-japan.eu/2017/08/31/nedo-establishes-additional-consortium-for-smart-cell-industry-based-on-microbial-cells/) - The target is on improved production of industrial materials by microorganisms, and the topics are clustered around substance production technology (Design), high-speed DNA synthesis / evaluation technology (Build), non destructive / minimally invasive cell evaluation technology (Test), and building a knowledge database using AI (Learn). The project will run for 3 years, and partners are
- [2 years functional study of human iPS-derived dopamine neural progenitor cells transplanted in primate Parkinson model confirm reduced symptoms](https://window-to-japan.eu/2017/08/31/2-years-functional-study-of-human-ips-derived-dopamine-neural-progenitor-cells-transplanted-in-primate-model-confirm-effect/) - In a preclinical study lasting two years, the group of Jun TAKAHASHI at Kyoto University’s CiRA transplanted human iPS cell derived dopaminergic neurons into 7 Macaca monkeys treated with the neurotoxin MPTP, as a Parkinson disease (PD) model. Video-observations and MRI- and PET-imaging showed that PD symptoms were reduced over time, as compared to 3
- [Telepsychiatry" may help to identify dementia by remote tests and AI"](https://window-to-japan.eu/2017/08/30/telepsychiatry-may-help-to-identify-dementia-by-remote-tests-and-ai/) - Nippon Tect Systems is developing a diagnostic support system for dementia using AI. Currently, doctor's dementia examination is performed using quantitative data such as neuropsychological examination and image analysis (MRI), and qualitative indicators such as facial expression and voice (videophone). In the system to be developed, the doctors will be supported by AI in order
- [Nippon Shinyaku develops antisense drug against Duchenne and Fukuyama muscular dystrophy](https://window-to-japan.eu/2017/08/29/nippon-shinyaku-develops-antisense-drug-against-duchenne-and-fukuyama-muscular-dystrophy/) - Nippon Shinyaku had developed long-strand DNA synthesis in the late 1990ies and started collaboration with the National Center for Mental and Neurological Medicine to develop an antisense RNA (NS-065/NCNP-01) with exon skipping action against DMD. The synthetic double-stranded RNA polyI: polyC is prepared using a novel RNA synthesis method (2-cyanoethoxymethyl or CEM method) and delivered
- [NEDO starts demonstration project with large EV buses in Malaysia](https://window-to-japan.eu/2017/08/28/nedo-starts-demonstration-project-with-large-ev-bus-in-malaysia/) - The bus is equipped with a long-life and ultra-fast chargeable secondary battery to improve the efficiency of the city's transportation. It can be charged within 10 min, for a operation distance of 30 km. The NEDO-project is carried out by Toshiba Infrastructure Systems, Hasetech and Pues and located in Putrajay City, Malaysia. NEDO news release,
- [Tohoku Medical and Mechanical Banking Organization (ToMMo) starts selling biological samples and genomic information](https://window-to-japan.eu/2017/08/28/tohoku-medical-and-mechanical-banking-organization-tommo-starts-selling-biological-samples-and-genomic-information/) - Biological samples and the transcriptomes from a 3-generation cohort of 23,000 people obtained from a DNA Japonica microarray and reconstructed by a statistical imputation method into pseudo-genomes based on the genome sequences of 2000 Japanese) are now offered to domestic academia and corporate researchers for the identification of biomarkers etc. Intellectual property rights obtained by
- [IHI completes 100 kW class ocean current power generation](https://window-to-japan.eu/2017/08/25/ihi-completes-100-kw-class-ocean-current-power-generation/) - Under a NEDO contract, the company installed the world's first submerged floating power generation system off the coast of Kagoshima. During the test, an autonomous control system kept the system floating at depth of about 30 to 50 m in the Kuroshio current, resulting in a maximum of about 30 kW power generation. Practical application
- [Asano ERATO project finds algorithm to ensure expression of soluble enzymes](https://window-to-japan.eu/2017/08/25/asano-erato-project-finds-algorithm-to-ensure-expression-of-soluble-enzymes/) - 80 to 90 % of enzymes derived from animals and plants will become insoluble and inactive when heterologously expressed in microorganisms. With a new software (INTMS Align) which identifies aggregation hotspots based on secondary structure and amino acid hydrophobicity Asano’s group succeeded to predict changes realised via protein engineering which lead to soluble, active enzymes.
- [Light Touch Technology Co. measures blood glucose without taking blood](https://window-to-japan.eu/2017/08/24/light-touch-technology-co-measures-blood-glucose-without-taking-blood/) - In the mid-infrared region, glucose can be measured relatively easily. As conventional light sources such as ceramic heaters have extremely low brightness in this region, the company developed a palm-sized high-intensity mid-infrared laser by fusing solid-state laser technology and optical parametric oscillation technology. Using this system, the measurement accuracy for glucose specified by ISO could
- [SACLA's X-ray free electron laser (XFEL) solves 3D structures of 2 seleno-methionine tagged proteins from microcrystals](https://window-to-japan.eu/2017/08/23/saclas-x-ray-free-electron-laser-xfel-solves-3d-structures-of-2-seleno-methionine-tagged-proteins-from-microcrystals/) - The measurements at SACLA are based on serial femtosecond crystal structure analysis which continuously measures one diffraction image from one microcrystal which is destroyed during measurmenet. With two proteins, modified at one single methionine residue by seleno-methionine, highly accurate data were acquired from as little as 30,000 or 60,000 micrometer size microcrystals, respectively, and 3D
- [Panasonic launches iPS cell automatic incubator](https://window-to-japan.eu/2017/08/23/panasonic-launches-ips-cell-automatic-incubator/) - In the culture apparatus, medium exchange, cell observation, and passage work of human iPS cells is automated using robot technology. The monitoring oft he shape of cells allows for optimal expansion time. Passages were repeated 20 times, and iPS cells could be cultured stably for 60 days. Due to the use of HEPA filters and
- [University of Tsukuba starts greenhouse project using AI and robot technology](https://window-to-japan.eu/2017/08/23/university-of-tsukuba-starts-greenhouse-project-using-ai-and-robot-technology/) - The University of Tsukuba has a genetic experiment center that promotes improvement of crops with new functions making full use of genetic modification and genome editing. In the AI ​​robot greenhouse, cultivation with high precision will be realized, expanding the potential of vertical agriculture. Nikkei Biotech news release, August 23, 2017
- [Nestle Japan introduces first food product with functional display – containing guar gum for improving bowel movements](https://window-to-japan.eu/2017/08/22/nestle-japan-introduces-first-food-product-with-functional-display-containing-guar-gum-for-improving-bowel-movements/) - The product named „BOOST Everyday Intestinal Activity“ is based on guar gum decomposition products and is claimed to increase the number of stool times/defecation volume and improve bowel movement. BOOST" was introduced in the United States in 1995 by Glaxo as a dietary supplement for medical institutions. In the United States, it is estimated that
- [MCBI venture gets Shimadzu and Taiyo Life Insurance investment on blood test for early detection of mild cognitive impairment (MCI)](https://window-to-japan.eu/2017/08/22/mcbi-venture-gets-shimadzu-and-taiyo-life-insurance-investment-on-blood-test-for-early-detection-of-mild-cognitive-impairment-mci/) - The spinoff of Tsukuba University was founded in 2003 and develops and sells in-vitro diagnostic systems. They have developed an MCI blood test which is offered in about 1800 Japanese institutions. The test combines three protein markers whose blood concentrations change with Alzheimer's disease and MCI and estimates the degree of cognitive impairment by statistical
- [MEXT National Institute of Science and Technology Policy (NISTEP) publishes S&T indicator report 2017](https://window-to-japan.eu/2017/08/18/mext-national-institute-of-science-and-technology-policy-nistep-publishes-s-t-indicator-report-2017/) - The comprehensive 200 page report which is based on Science and Technology Indicators collected by NISTEP comes to the conclusion that the number and quality of refereed papers published by Japanese institutions has declined rather dramatically over the past 20 years. In average of 2013 – 2015, Japan ranked at position 4 of all scientific
- [PeptiDream partners with Shionogi on peptide therapeutics](https://window-to-japan.eu/2017/08/13/peptidream-partners-with-shionogi-on-peptide-therapeutics/) - PeptiDream, Shionogi and Sekisui Chemical have announced that they will establish PeptiStar Inc as a joint venture, a CMO for research and commercial manufacture of peptide therapeutics. The factory and laboratory are located within Shionogi’s in Osaka Prefecture. PeptiDream news release, August 7, 2017
- [Megakarion forms consortium for creating value chain for blood platelet production](https://window-to-japan.eu/2017/08/07/megakarion-forms-consortium-for-creating-value-chain-for-blood-platelet-production/) - Megakarion, a spin-off of Kyoto University’s Center for iPS Cell Research (CiRA) will begin clinical trials on iPS cell-derived blood platelets and aims for commercialization in 2020. In addition, the company has built a consortium of six companies to build a value-chain for commercialization of the technology. The members and their role are as follows:
- [Asahi Kasei builds demonstration plant for new polycarbonate production process](https://window-to-japan.eu/2017/08/07/asahi-kasei-builds-demonstration-plant-for-new-polycarbonate-production-process/) - In the conventional PC manufacturing process, highly toxic phosgene is used in a process of high energy consumption. Asahi Kasei Corporation, under a NEDO contract, has developed a new process based on dialkyl carbonate (DRC) which is transformed into diphenyl carbonate (DPC) and on to polycarbonate in the presence of bisphenol A. Continuous operation of
- [Miura Co. starts sale of 4.2 kW solid oxide fuel cell (SOFC) for business use from October 2017](https://window-to-japan.eu/2017/08/07/miura-co-starts-sale-of-42-kw-solid-oxide-fuel-cell-sofc-for-business-use-from-october-2017/) - The 780 kg SOFC works on city gas and achieves overall energy efficiency of 90 % (power generation + heat recovery). The footprint is rather small (dimensions (mm): 1,880 (W) × 810 (D) × 1,780 (H)). Its market potential for bars, restaurants, sports and welfare facilities is estimated at about 100,000 units. The project was
- [Daiichi Sankyo invests in Cuorips Inc., an iPS-to-cardiomyocyte based venture company](https://window-to-japan.eu/2017/08/07/daiichi-sankyo-invests-in-cuorips-inc-an-ips-to-cardiomyocyte-based-venture-company/) - Cuorips, a startup in Yokohama, has been founded in March 2017 by California-based DEFTA partners, a global investment company. Technology is based on the work of Professor Yoshiki SAWA, a cardiovascular surgeon at Osaka University Graduate School of Medicine, who has developed an allogenic human iPS cell derived cardiomyocyte sheet for the treatment of heart
- [RIKEN team observes mechanism of RNA polymerase by cryo-electron microscopy](https://window-to-japan.eu/2017/08/04/riken-team-observes-mechanism-of-rna-polymerase-by-cryo-electron-microscopy/) - RNA polymerase consists of 12 proteins and pinches DNA with crab scissors" while transcribing it in RNA. Four more proteins are bound in this process. Using cryo-electron microscopy, researchers around Seiki Shunichi and Ehara Haruhiko at RIKENs Structural Biology Group have elucidated the precise mechanism of this complex process." RIKEN news release, August 4, 2017
- [Try-Fu Co., Yokohama, to commercialize “Neonisin-e” tooth paste](https://window-to-japan.eu/2017/08/04/try-fu-co-yokohama-to-commercialize-neonisin-e-tooth-paste/) - Neonisin-e is an oral care product based on nisin, an antibiotic, which shows antibacterial activity against, e. g., Candida albicans which causes oral candidiasis, an opportunistic infection. The product, developed by Kenji Sonomoto’s group at Kyushu University, will be marketed by the Yokohama-based venture Try-Fu Co. from autumn 2017. Nikkei Biotech news release, August 4,
- [NEDO team develops reliable concrete crack detection system based on image analysis and AI](https://window-to-japan.eu/2017/08/03/nedo-team-develops-reliable-concrete-crack-detection-system-based-on-image-analysis-by-ai/) - In a team of Capital High Technology Co., NAIST and Tohoku University, a machine learning system for concrete crack detection was developed using image analysis of characteristic patterns specific to cracks. Cracks of 0.2 mm or more were detected with high accuracy of 80% or more even when covered by dirt or scratches on the
- [NEDO initiates hydrogen-based „power-to-gas“ projects](https://window-to-japan.eu/2017/08/01/nedo-initiates-hydrogen-based-power-to-gas-projects/) - In order to maximize utilization of renewable energy-derived electric power, the project will develop a cooperative control system for hydrogen production from water electrolysis, storage batteries and hydrogen co-fired engines. Fluctuations in business that sells hydrogen will be mitigated and followed by full-fledged demonstration tests including equipment introduction, technology development, and validation. Demonstration of this
- [Cosmetic company Kosé establishs research base in Lyon, France](https://window-to-japan.eu/2017/08/01/cosmetic-company-kose-establishs-research-base-in-lyon-france/) - Kosé, a cosmetic company, will set up a research branch office in Lyon, France. It will be installed in the research facility of Lyon’s CTI BIOTECH, a specialist in stem cell technology and skin research. Kosé news release, July 31, 2017
- [Takeda Pharmaceutical launches Seedsupply Co., a venture company for drug discovery](https://window-to-japan.eu/2017/08/01/takeda-pharmaceutical-launches-seedsupply-co-a-venture-company-for-drug-discovery/) - Initiated through Takeda’s Entrepreneurship Venture Program (EVP) initiative, SEEDSUPPLY will offer discovery screening services to global pharmaceutical companies and will be based in Takeda’s Shonan Research Center. Screening services will include state-of-the-art and unique binder selection technology. The EVP initiative was created to provide significant therapeutic options and healthcare solutions in areas outside of Takeda’s
- [Sequencing venture Varinos Co. will focus on microflora analysis in relation to human infertility](https://window-to-japan.eu/2017/07/31/sequencing-venture-varinos-co-will-focus-on-microflora-analysis-in-relation-to-human-infertility/) - The Tokyo-based company, newly formed by former employees of Illumina Japan, will use next-generation sequencing technology to analyze the vaginal and intra-uterine flora, e. g., in the context of in-vitro fertilization. https://varinos.strikingly.com Nikkei Biotech news release, July 31, 2017
- [Tsukuba Team creates blue chrysanthemums by anthocyanin B-ring hydroxylation and glucosylation](https://window-to-japan.eu/2017/07/28/tsukuba-team-creates-blue-chrysanthemums-by-anthocyanin-b-ring-hydroxylation-and-glucosylation/) - The group of Nanobu NODA at NARO’s Institute of Vegetable and Floriculture Science in Tsukuba succeeded to generate chrysantemums of a natural blue color when they overexpressed the Canterbury bell gene encoding flavonoid 3′,5′-hydroxylase (F3′5′H), the key enzyme for delphinidin biosynthesis, and a gene encoding for UDP–glucose:anthocyanin 3′,5′-O-glucosyltransferase from butterfly pea. As shown earlier by
- [Rohto Pharmaceutical starts clinical trial of decompensated liver cirrhosis by fat-derived mesenchymal stem cells (ADR-1)](https://window-to-japan.eu/2017/07/28/rohto-pharmaceutical-starts-clinical-trial-of-decompensated-liver-cirrhosis-by-fat-derived-mesenchymal-stem-cells-adr-1/) - The phase I/II clinical trial on 15 patients with moderate liver cirrhosis will be supervised by Professor Terui TERAI of Niigata University School of Medicine. For the treatment of liver cirrhosis, lysis of excessive extracellular matrix causing fibrosis, proliferation of hepatocytes, activation of hepatic progenitor cells, suppression of inflammatory response, etc. are effective, and such
- [University team engineers „bionic humanoid“ for training in microsurgery](https://window-to-japan.eu/2017/07/27/university-team-engineers-bionic-humanoid-for-training-in-microsurgery/) - The JST-funded program strives to build a robot modeled on human anatomy. It is equipped with sensors which provide feedback, e. g., on being pressed, and with realistic models of organs. A major objective is to use the humanoid for medical training, e. g., in „supermicrosurgery“. https://www.youtube.com/watch?v=lDUq8M9uhN0 Nikkei Digital Health, July 27, 2017
- [Takeda licenses ovarian cancer drug Niraparib from US TESARO](https://window-to-japan.eu/2017/07/27/takeda-licenses-ovarian-cancer-drug-niraparib-from-us-tesaro/) - The poly ADP-ribose polymerase (PARP) inhibitor (MK - 4827) is marketed in the US by TESARO Inc. as an oral drug for ovarian cancer maintenance therapy which can be administered independent of BRCA status of the patient. The agreement includes the development of niraparib for the treatment of all tumor types in Japan, and all
- [NEDO starts program to reduce cost of wind power by 40 % in 2020](https://window-to-japan.eu/2017/07/27/nedo-starts-program-to-reduce-cost-of-wind-power-by-40-in-2020/) - Members of the consortium are Yoshidado Co., Japan Ocean Drilling Co., Japan Marine United Co., Hitachi Zosen Corp., Kyoto University, Toyo Construction Co., TEPCO Holdings Co., Oobayashi Corp., TEPCO Design Co., Hitachi, Ltd., University of Tokyo, Kyushu University, Maeda Construction Industry Co., Glocal Corp., Koga Construction Co., Power Development Co., Maritime / Harbor / Aeronautical
- [Japanese consortium to start international hydrogen supply chain from Brunei in 2020](https://window-to-japan.eu/2017/07/27/japanese-consortium-to-start-international-hydrogen-supply-chain-from-brunei-in-2020/) - Under a NEDO contract, a consortium of Chiyoda Co., Mitsubishi Co., Mitsui & Co., and NYK Line Corporation, in collaboration with Brunei Darussalam, will pioneer the world's first maritime hydrogen supply chain. By 2019, a hydrogenation plant will be completed in Brunei, and a dehydrogenation plant in ​​Kawasaki. From 2020, methylcyclohexane, a liquid hydrogen carrier
- [J-PARC Center resolves structure of orthosilicic acid, the extremely unstable basic structural element of glass and silicone](https://window-to-japan.eu/2017/07/27/j-parc-center-resolves-structure-of-orthosilicic-acid-the-extremely-unstable-basic-structure-of-glass-and-silicone/) - As orthosilicic acid, a basic element of glass, silicones and zeolites, is unstable in water and can not be isolated, it was synthesized in an amide solvent using a palladium/carbon catalyst for hydrocracking from a silicon compounds having 4 benzyloxy groups, obtaining orthosilicic acid at 96% yield. Orthosilicic acid was very stably in the absence
- [Fujifilm to invest 500 million Yen in Bonac Co., a nucleic acid company](https://window-to-japan.eu/2017/07/27/fujifilm-to-invest-500-million-yen-in-bonac-co-a-nucleic-acid-company/) - The two companies will do joint research on nucleic acid biomedicines and liposome preparations. Fujifilm news release, July 27, 2017
- [Osaka University team submits provisional plan for clinical study on iPS cell-derived cardiomyocytes transplanted to patients suffering from severe heart failure.](https://window-to-japan.eu/2017/07/26/osaka-university-team-submit-provisional-plan-for-clinical-study-on-ips-cell-derived-cardiomyocytes-transplanted-to-patients-suffering-from-severe-heart-failure/) - The team comprises Professors Yoshiki SAWA and Shigemi MIYAGAWA from the Cardiovascular Surgery Department of Osaka University, Dept. of Medicine. The study will be done with cell sheets from cardiomyocytes generated from iPS cells of each of the 3 patients considered. Compared with the myoblast sheets offered by Terumo Co. and derived from the patient’s
- [Takeda contdracts with US BioSurfaces Inc. on nanomaterials for treatment of GI diseases](https://window-to-japan.eu/2017/07/26/takeda-contdracts-with-us-biosurfaces-inc-on-nanomaterials-for-treatment-of-gi-diseases/) - Massachusetts-based BioSurfaces has developed a process for producing nanofibrous materials out of commonly used FDA-approved polymers. These materials can incorporate drugs or other bioactive agents for localized release. Application of such technology has the potential to help prevent strictures and promote healing of fistulas, which are common manifestations of GI diseases. Takeda news release, July
- [Hitachi Zosen achieves 90 % efficiency in 4000 hrs field test of 20 kW SOFC](https://window-to-japan.eu/2017/07/25/hitachi-zosen-achieves-90-efficiency-in-4000-hrs-field-test-of-20-kw-sofc/) - The test at Osaka Institute of Industrial Science and Technology provided 50 % energy and 40 % heat recovery efficiency. The 2.2 × 4.3 × 2.8 m size fuel cell uses hydrogen obtained by reforming city gas containing methane as a main fuel component. It is seen as power generation equipment for food supermarkets, convenience
- [Medical Data Card Co. starts offering smartphone app for storage and exchange of medical data](https://window-to-japan.eu/2017/07/25/medical-data-card-co-starts-offering-smartphone-app-for-storage-and-exchange-of-medical-data/) - The Tokyo-based venture (MEDACA Co.) offers to use Amazon's web services including transport layer security to store individual medical data in a smartphone app. Using this app, a customer can exchange personal medical data with doctors, hospitals, pharmacies and ambulances. The project was financially supported by JST's Success program. JST news release, July 26, 2017
- [Shionogi's influenza drug S-033188 achieves main endpoint in global phase III](https://window-to-japan.eu/2017/07/25/shionogis-influenza-drug-s-033188-achieves-main-endpoint-in-global-phase-iii/) - The endonuclease inhibitor (Peramivir, a neuraminidase inhibitor) shortened disease duration of influenza patients lowering the virus titer superior to Tamiflu Shionogi press release, July 25, 2017
- [RIKEN and Kyowa Hakko Kirin develop variabody" antibody-drug-complex technology"](https://window-to-japan.eu/2017/07/24/riken-and-kyowa-hakko-kirin-develop-variabody-antibody-drug-complex-technology/) - In this technology, genetic code expansion is used to introduce drugs into antibody Fab fragments. As a proof of concept, the researchers introduced, by a degenerate codon, an azide-loaded lysine derivative at particular sites of Trastuzumab Fab fragments and loaded the fragments with emtansine (DM1), an anticancer drug. In-vitro tests with appropriate cell lines showed
- [Nippon Boehringer Ingelheim (NBI) and Kyoto University cooperate on chronic obstructive pulmonary disease (COPD)](https://window-to-japan.eu/2017/07/21/nippon-boehringer-ingelheim-nbi-and-kyoto-university-cooperate-on-chronic-obstructive-pulmonary-disease-copd/) - COPD is a life-threatining lung disease originating mainly from tobacco smoking. The partner at Kyoto University is Professor SATO Atsushi at Kyoto University's School of Medicine whose research focus is on COPD. Topics of the 2 years cooperative project are in the early diagnosis and a new treatment of COPD. The program is operated by
- [Calpis offers pet food containing L-92 lactic acid bacteria](https://window-to-japan.eu/2017/07/21/calpis-offers-pet-food-containing-l-92-lactic-acid-bacteria/) - Calpis, a former member of the Ajinomoto Group, has been purchased by Asahi and offers a range of probiotic products for humans, including a product containing lactotripeptide from Lactobacillus gasseri CP1563 which is claimed to lower blood pressure. Calpis has now launched a product Pet Lab" Skin Health Support" which is claimed to improve the
- [Shanghai Institute of Advanced Studies inaugurates Stem Cell Research Center" - built by Japanese NEDO consortium!"](https://window-to-japan.eu/2017/07/21/shanghai-institute-of-advanced-studies-inaugurates-stem-cell-research-center-built-by-japanese-nedo-consortium/) - Yasui Building Design Office Co., Pacific Consultants Co., and Sanki Engineering Co. under a NEDO contract, have completed the 16,000 m2 Shanghai Stem Cell Regenerative Medicine Research Building" contracted by Shanghai Institute of Advanced Studies. Highlights of the construction and energy control elements are:
- [Xenoma starts sale of movement-monitoring e-skin" shirts"](https://window-to-japan.eu/2017/07/19/xenoma-starts-sale-of-movement-monitoring-e-skin-shirts/) - The shirts carry 14 ultrathin flexible stretch sensors which are connected by nanocolloid printed ink. Wearing such shirts allows to monitor movements in, e. g., VR games, golf sport, gymnastics, etc., without a camera in real time. The shirts can be machine washed and will be available at a price of 479 US-$ through the
- [Anges MG submits clinical trial note on DNA vaccine against hypertension to Australian Regulatory Authority](https://window-to-japan.eu/2017/07/19/anges-mg-submits-clinical-trial-note-on-dna-vaccine-against-hypertension-to-australian-regulatory-authority/) - Anges MG's high-blood pressure DNA vaccine creates an antibody to angiotensin II", a protein involved in blood pressure increase. Whereas present medications must be taken every day, the injection DNA vaccine is administered only once and acts over a long period of time. Anges MG is preparing for Phase I II clinical trials in Australia."

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- [News_](https://window-to-japan.eu/news_/) - [et_pb_section bb_built="1" admin_label="Hero" fullwidth="on" disabled_on="off|off|off" _builder_version="3.0.77" background_color="#1f1f1f" parallax="on" custom_padding="|||" transparent_background="on" next_background_color="#ffffff"][et_pb_fullwidth_header title="News" text_orientation="center" scroll_down_icon_color="#ffffff" scroll_down_icon_size="32px" background_overlay_color="rgba(153,153,153,0.85)" subhead_font_color="#bebebe" _builder_version="3.8" title_font="Playfair Display||||" title_text_color="#ffffff" title_font_size="72px" title_line_height="1.3em" title_line_height_last_edited="off|desktop" content_font="Montserrat||||" content_text_color="#bfbfbf" content_font_size="19px" content_line_height="1.8em" subhead_font="Montserrat||||" subhead_text_color="#bebebe" subhead_line_height="1.8em" background_image="https://window-to-japan.eu/wp-content/uploads/2018/04/black-and-white-data-folded-158651.jpg" custom_margin="-2%||-3%|" custom_padding="-2%||-3%|" animation_style="zoom" animation_duration="1500ms" animation_intensity_zoom="4%" child_filter_brightness="140%"] Our news cover the latest topics from the past 30 days, as retrieved from Japanese-language press releases and other information
- [Privacy_](https://window-to-japan.eu/privacy_/) - [et_pb_section bb_built="1"][et_pb_row][et_pb_column type="4_4"][et_pb_text _builder_version="3.8"] Privacy - scope of application [/et_pb_text][et_pb_text _builder_version="3.8"] This data protection declaration is intended to inform the users of this website about its type, scope and purpose in accordance with the Federal Data Protection Act and the Telemedia Act. We take your data protection very seriously and treat your personal data confidentially
- [Imprint_](https://window-to-japan.eu/imprint2/) - [et_pb_section bb_built="1" _builder_version="3.0.47"][et_pb_row _builder_version="3.0.47" background_size="initial" background_position="top_left" background_repeat="repeat"][et_pb_column type="4_4"][et_pb_text _builder_version="3.9" background_size="initial" background_position="top_left" background_repeat="repeat"] Imprint “window-to-japan.eu” is the website of Bio4Business Jagdweg 3, D-70569, Stuttgart, Germany, UID DE 162899378. The founder of Bio4Business, Professor Dr Rolf D Schmid, has 50 years of experience in dealing with bio-related academic and company issues. Name and address of company Bio4Business,
- [Home_](https://window-to-japan.eu/about-window-to-qingdao/) - [et_pb_section fb_built="1" fullwidth="on" _builder_version="4.16" custom_padding="0|0px|0px|0px|false|false" global_colors_info="{}"][et_pb_fullwidth_code admin_label="Newsticker_Fullwidth Code" _builder_version="4.16" custom_css_main_element="font-size: 200%" global_colors_info="{}"]Cs-contaminated Fukushima soil shown to be decontaminated by heat treatment with NaCl under vacuumCategories: Environmental solutions,NewsUmami Bioworks organizes sensory evaluation meeting of cultured eel and other fish products in TokyoCategories: Biotech & biomedicine,NewsA Japanese consortium presents a hydrogen-fuelled engine for shipsCategories: Environmental solutions,News,UncategorizedA synthetic
- [Searches and Archives](https://window-to-japan.eu/archive/) - [et_pb_section fb_built="1" _builder_version="4.16" global_colors_info="{}"][et_pb_row column_structure="4_4,4_4" _builder_version="4.16" background_size="initial" background_position="top_left" background_repeat="repeat" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.16" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_blurb title="Archives" admin_label="Archive" _builder_version="4.16" global_colors_info="{}"][/et_pb_blurb][/et_pb_column][et_pb_column type="4_4" _builder_version="4.16" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_divider _builder_version="4.16" global_colors_info="{}"][/et_pb_divider][/et_pb_column][/et_pb_row][et_pb_row column_structure="1_2,1_2" _builder_version="4.16" background_size="initial" background_position="top_left" background_repeat="repeat" global_colors_info="{}"][et_pb_column type="1_2" _builder_version="4.16" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_sidebar area="et_pb_widget_area_3" _builder_version="4.16" global_colors_info="{}"][/et_pb_sidebar][et_pb_post_title meta="off" featured_image="off" _builder_version="4.17.3" _module_preset="default" title_font="|700|||||||" display_conditions="W3siaWQiOiJlNDFmM2JlZi1lMjk4LTQyM2EtOTFiMi1mMTQ3ZjhkZGZiYmQiLCJjb25kaXRpb24iOiJjYXRlZ29yaWVzIiwiY29uZGl0aW9uU2V0dGluZ3MiOnsiZGlzcGxheVJ1bGUiOiJpcyIsImNhdGVnb3JpZXMiOlt7ImxhYmVsIjoiTW9udGhuZXdzIiwidmFsdWUiOiI0NCIsImdyb3VwIjoiQ2F0ZWdvcmllcyIsImdyb3VwU2x1ZyI6ImNhdGVnb3J5IiwiaXNDYXRjaEFsbCI6ZmFsc2V9XSwiYWRtaW5MYWJlbCI6IlBvc3QgQ2F0ZWdvcnkiLCJlbmFibGVDb25kaXRpb24iOiJvbiJ9LCJvcGVyYXRvciI6Ik9SIn1d" global_colors_info="{}"][/et_pb_post_title][et_pb_blog include_categories="1,18,42,2" show_thumbnail="off" show_author="off" show_date="off" show_categories="off" _builder_version="4.17.3" _module_preset="default" global_colors_info="{}"][/et_pb_blog][/et_pb_column][et_pb_column
- [News of the month](https://window-to-japan.eu/newsofthemonth/) - [et_pb_section fb_built="1" _builder_version="4.16" global_colors_info="{}"][et_pb_row column_structure="4_4,4_4" _builder_version="4.16" background_size="initial" background_position="top_left" background_repeat="repeat" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.16" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_blurb title="Archives" admin_label="Archive" _builder_version="4.16" global_colors_info="{}"][/et_pb_blurb][/et_pb_column][et_pb_column type="4_4" _builder_version="4.16" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_divider _builder_version="4.16" global_colors_info="{}"][/et_pb_divider][/et_pb_column][/et_pb_row][et_pb_row column_structure="1_2,1_2" _builder_version="4.16" background_size="initial" background_position="top_left" background_repeat="repeat" global_colors_info="{}"][et_pb_column type="1_2" _builder_version="4.16" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_sidebar area="et_pb_widget_area_3" _builder_version="4.16" global_colors_info="{}"][/et_pb_sidebar][et_pb_text _builder_version="4.17.3" _module_preset="default" global_colors_info="{}"] News of the month [/et_pb_text][et_pb_blog include_categories="44" show_thumbnail="off" excerpt_length="120" show_author="off" show_date="off" show_categories="off" show_pagination="off"
- [Technology news Archive](https://window-to-japan.eu/technology-news-archive/) - [et_pb_section fb_built="1" _builder_version="4.17.0" _module_preset="default" global_colors_info="{}"][et_pb_row column_structure="1_4,3_4" _builder_version="4.16" _module_preset="default" global_colors_info="{}"][et_pb_column type="1_4" _builder_version="4.16" _module_preset="default" global_colors_info="{}"][et_pb_button button_text="Back to Home" _builder_version="4.17.0" _module_preset="default" button_url="https://window-to-japan.eu" hover_enabled="0" sticky_enabled="0"][/et_pb_button][et_pb_text _builder_version="4.16" _module_preset="default" global_colors_info="{}"] Picture of the month [/et_pb_text][et_pb_image src="https://window-to-japan.eu/wp-content/uploads/2022/04/Nissin-reports-on-Japans-first-cultured-steak-meat-with-original-flavor-and-texture.png" alt="Nissin reports on Japan’s first cultured steak meat with original flavor and texture" title_text="Nissin reports on Japan’s first cultured steak meat with original flavor and
- [Downloads](https://window-to-japan.eu/downloads/) - [et_pb_section fb_built="1" fullwidth="on" _builder_version="3.22" global_colors_info="{}"][et_pb_fullwidth_header title="Downloads " text_orientation="center" _builder_version="3.16" title_font="|700|||||||" background_color="rgba(255, 255, 255, 0)" background_image="https://window-to-japan.eu/wp-content/uploads/2018/04/book-shelves-book-stack-bookcase-207662small.jpg" background_layout="light" child_filter_saturate="40%" child_filter_brightness="40%" child_filter_contrast="40%" child_filter_opacity="10%" child_filter_blur="10px" child_mix_blend_mode="soft-light" global_colors_info="{}" button_one_text_size__hover_enabled="off" button_two_text_size__hover_enabled="off" button_one_text_color__hover_enabled="off" button_two_text_color__hover_enabled="off" button_one_border_width__hover_enabled="off" button_two_border_width__hover_enabled="off" button_one_border_color__hover_enabled="off" button_two_border_color__hover_enabled="off" button_one_border_radius__hover_enabled="off" button_two_border_radius__hover_enabled="off" button_one_letter_spacing__hover_enabled="off" button_two_letter_spacing__hover_enabled="off" button_one_bg_color__hover_enabled="off" button_two_bg_color__hover_enabled="off"][/et_pb_fullwidth_header][/et_pb_section][et_pb_section fb_built="1" _builder_version="3.22" global_colors_info="{}"][et_pb_row _builder_version="3.25" background_size="initial" background_position="top_left" background_repeat="repeat" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="3.25" custom_padding="|||" global_colors_info="{}" custom_padding__hover="|||"][et_pb_text _builder_version="3.27.4" global_colors_info="{}"] Downloads [/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row _builder_version="3.25"
- [news-complete](https://window-to-japan.eu/news-complete/) - [et_pb_section bb_built="1"][et_pb_row][et_pb_column type="4_4"][et_pb_blurb admin_label="Window-to-Japan List of all blogs" _builder_version="3.8" title="Window-to-Japan" header_text_align="left" header_font="|700|||||||" header_text_color="#3366cc"] Full content list of all entries in News [/et_pb_blurb][et_pb_divider _builder_version="3.6" /][/et_pb_column][et_pb_column type="4_4"][et_pb_blog _builder_version="3.8.1" posts_number="20" include_categories="18" show_content="on" show_author="off" show_categories="off" /][/et_pb_column][/et_pb_row][/et_pb_section]

## My Templates

- [Elementor Footer #11840](https://window-to-japan.eu/?elementor_library=elementor-footer-11840) - ein Service von Bio4Business Linkedin Privacy Imprint Cookie Policy (EU) X © COPYRIGHT 2022 WINDOW TO Japan / bio4business
- [Elementor Header #11814](https://window-to-japan.eu/?elementor_library=elementor-header-11814)
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- [Default Kit](https://window-to-japan.eu/?elementor_library=default-kit)
- [Elementor Single Post #11381](https://window-to-japan.eu/?elementor_library=elementor-single-post-11381) - Most popular posts:
- [search](https://window-to-japan.eu/?elementor_library=search) - SEARCH
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## News Tickers

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## Categories

- [Uncategorized](https://window-to-japan.eu/category/uncategorized/)
- [News](https://window-to-japan.eu/category/news/)
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