Tokyo team develops „nanomachine“ which permits 100fold increased passage through the blood-brain-barrier (BBB)
The concept jointly developed by researchers at the University of Tokyo, Tokyo Medical and Dental University and others is based on physiologically safe nanoparticles of 30 nm diameter (a PEG-poly(α,β-aspartic acid) block copolymer with conjugated glucose) which are loaded with glucose) recognized by the GLUT1 transporter localized in cerebrovascular endothelial cells. The uptake by this […]